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Unlocking the future:Mitochondrial genes and neural networks in predicting ovarian cancer prognosis and immunotherapy response

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World Journal of Clinical Oncology 2025年第1期16卷 43-52页

作者： Zhi-jian Tang Yuan-Ming Pan Wei Li Rui-Qiong Ma jian-liu Wang Department of Obstetrics and Gynecology Peking University People’s HospitalBeijing 100044China Cancer Research Center Beijing Chest HospitalBeijing 101149China Department of Thoracic Surgery Sichuan Provincial People's HospitalChengdu 610072Sichuan ProvinceChina

BACKGROUND Mitochondrial genes are involved in tumor metabolism in ovarian cancer(OC)and affect immune cell infiltration and treatment *** To predict prognosis and immunotherapy response in patients diagnosed with OC using mitochondrial genes and neural *** Prognosis,immunotherapy efficacy,and next-generation sequencing data of patients with OC were downloaded from The Cancer Genome Atlas and Gene Expression *** genes were sourced from the MitoCarta3.0 *** discovery cohort for model construction was created from 70% of the patients,whereas the remaining 30% constituted the validation *** the expression of mitochondrial genes as the predictor variable and based on neural network algorithm,the overall survival time and immunotherapy efficacy(complete or partial response)of patients were *** In total,375 patients with OC were included to construct the prognostic model,and 26 patients were included to construct the immune efficacy *** average area under the receiver operating characteristic curve of the prognostic model was 0.7268[95% confidence interval(CI):0.7258-0.7278]in the discovery cohort and 0.6475(95%CI:0.6466-0.6484)in the validation *** average area under the receiver operating characteristic curve of the immunotherapy efficacy model was 0.9444(95%CI:0.8333-1.0000)in the discovery cohort and 0.9167(95%CI:0.6667-1.0000)in the validation *** The application of mitochondrial genes and neural networks has the potential to predict prognosis and immunotherapy response in patients with OC,providing valuable insights into personalized treatment strategies.

关键词： Ovarian cancer Mitochondria Prognosis Immunotherapy Neural network

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On Nonlinearity of S-Boxes and Their Related Binary Codes

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Chinese Journal of Electronics 2016年第1期25卷 167-173页

作者： liu jian CHEN Lusheng School of Mathematical Sciences Nankai University

The nonlinearity of S-boxes and their related supercodes of the first order Reed-Muller code are discussed. Based on the properties of multi-output bent functions and almost bent functions, we determine the maximum size of linear supercodes of the first order ReedMuller code which have optimal or suboptimal minimum distance, and we also give the weight distributions of these supercodes which achieve the best possible size. Furthermore, an upper bound on the minimum distance of a class of binary linear codes is presented, which yields a new upper bound on the nonlinearity of S-boxes. The new bound on nonlinearity improves a bound given by Carlet et al. in 2007.

关键词： S-boxes Nonlinearity Bent functions Almost bent functions Reed-Muller codes

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Analytic Solutions of an Iterative Differential Equation under Brjuno Condition

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Acta Mathematica Sinica,English Series 2009年第9期25卷 1469-1482页

作者： jian liu jian Guo SI School of Science University of Ji'nan Ji'nan 250022 P.R. China School of Mathematics Shandong University Ji'nan 250100 P.R. China

In this paper, the differential equation involving iterates of the unknown function,x＇（z）=[a^2-x^2（z）]x^[m]（z）with a complex parameter a, is investigated in the complex field C for the existence of analytic solutions. First of all, we discuss the existence and the continuous dependence on the parameter a of analytic solution for the above equation, by making use of Banach fixed point theorem. Then, as well as in many previous works, we reduce the equation with the SchrSder transformation x（z） = y（αy^-1（z）） to the following another functional differential equation without iteration of the unknown functionαy＇（αz）=[a^2-y^2（αz）]y＇（z）y（α^mz）,which is called an auxiliary equation. By constructing local invertible analytic solutions of the auxiliary equation, analytic solutions of the form y（αy^-1 （z）） for the original iterative differential equation are obtained. We discuss not only these α given in SchrSder transformation in the hyperbolic case 0 〈｜α｜〈 1 and resonance, i.e., at a root of the unity, but also those α near resonance （i.e., near a root of the unity） under Brjuno condition. Finally, we introduce explicit analytic solutions for the original iterative differential equation by means of a recurrent formula, and give some particular solutions in the form of power functions when a = 0.

关键词： iterative differential equation analytic solution Banach fixed point theorem resonance Diophantine condition Brjuno condition

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Terahertz detector for imaging in 180-nm standard CMOS process

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Science China(Information Sciences) 2017年第8期60卷 202-210页

作者： Zhaoyang liu Liyuan liu Zhao ZHANG jian liu Nanjian WU State Key Laboratory of Superlattices and Microstructures Institute of SemiconductorsChinese Academy of Sciences University of Chinese Academy of Sciences

A CMOS terahertz(THz) detector implemented in a 180-nm standard CMOS process is proposed,and room-temperature detection of 0.94-THz radiation is demonstrated. The detector consists of an integrated on-chip patch antenna and a source-feeding NMOS transistor as the rectifying element. To improve the power transfer efficiency between the patch antenna and NMOS transistor, a novel short-stub matching network is proposed. An open quarter-wavelength microstrip transmission line connecting gate is proposed to eliminate the influence of the bonding wire and pad on the antenna-transistor impedance matching. Illuminated by a 0.94-THz BWO source, the measured voltage responsivity(Rv) and noise equivalent power(NEP) of the detector are 31 V/W and 1.1 n W/Hz1/2, respectively.

关键词： terahertz detector terahertz imaging CMOS patch antenna matching network

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Effects of Particle Size on Nitridation Kinetics of Manganese Powder

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Journal of Iron and Steel Research International 2015年第6期22卷 543-550页

作者： Ting LUO jian-hua liu Hong-bo liu jian liu Research Institute of Metallurgy Engineering University of Science and Technology Beijing

Isothermal thermo-gravimetric analysis was applied to investigate the nitridation kinetics of manganese powder with different particle sizes at 800, 900 and 1000 ℃. The apparent activation energy and nitridation kinetics equations of manganese powder with different particle sizes were obtained from unreacted shrinking core model and Arrhenius formula. It was found that the nitridation mechanism was controlied by interracial chemical reaction. The apparent activation energy and the apparent rate constant of nitridation reaction were affected by particle sizes. With the decrease of particle size, the apparent activation energy decreased whilst the apparent rate constant increased. It was suggested that the refinement of the manganese powder contributed to the increase of molar surface energy, which accounted for the lower apparent activation energy.

关键词： manganese powder nitridation isothermal thermo-gravimetric analysis apparent activation energy kinetics

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Lump and interaction solutions to the (3+1)-dimensional Burgers equation

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Chinese Physics B 2020年第3期29卷 50-54页

作者： jian liu jian-Wen Wu Department of Mathematics and Physics Quzhou UniversityQuzhou 324000China Department of Physics Zhejiang Normal UniversityJinhua 321004China

The(3+1)-dimensional Burgers equation, which describes nonlinear waves in turbulence and the interface dynamics,is considered. Two types of semi-rational solutions, namely, the lump–kink solution and the lump–two kinks solution, are constructed from the quadratic function ansatz. Some interesting features of interactions between lumps and other solitons are revealed analytically and shown graphically, such as fusion and fission processes.

关键词： (3+1)-dimensional Burgers equation lump solution interaction wave solution bilinear form

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A Navigation Method for Multiple Robots Based on a Single Mobile Node

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机器人 2012年第6期34卷 764-768页

作者： JI Daxiong liu jian The State Key Laboratory of Robotics Shenyang Institute of Automation Chinese Academy of Sciences Shenyang 110016 China Graduate University of Chinese Academy of Sciences Beijing 100049 China

To satisfy the requirements of independent navigation in low cost multiple robots,a navigation frame of masterslave robots with only one master robot is introduced briefly.A range-only navigation algorithm for slave robots of low cost is presented for the navigation in unknown *** algorithm only needs a master *** master is just a single mobile node which has high navigation *** of this master-salve system is theoretically *** conditions of slave robot trajectory under which observability is guaranteed are evaluated by a slave robot in *** slave takes appropriate action to control its heading to achieve observability if observability is lost on the current *** navigation algorithm is implemented by a standard extended Kalman filter,and it is able to acquire accurate estimation of robot's *** simulation results show its effectiveness of the proposed algorithm.

关键词：摘要编辑部编辑工作读者

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Phase transformation behavior of titanium during carbothermic reduction of titanomagnetite ironsand

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International Journal of Minerals,Metallurgy and Materials 2016年第7期23卷 760-768页

作者： Yi-ran liu jian-liang Zhang Zheng-jian liu Xiang-dong Xing School of Metallurgical and Ecological Engineering University of Science and Technology Beijing School of Metallurgical Engineering Xi'an University of Architecture and Technology

The reduction of titanomagnetite（TTM） ironsand, which contains 11.41wt% TiO_2 and 55.63wt% total Fe, by graphite was performed using a thermogravimetric analysis system under an argon gas atmosphere at 1423–1623 K. The behavior and effects of titanium in TTM ironsand during the reduction process were investigated by means of thermogravimetric analysis, X-ray diffraction, scanning electron microscopy, and energy-dispersive X-ray spectroscopy. During the reduction procedure, the titanium concentrated in the slag phase, where the phase transformation followed this sequence： Fe O ＋ FeTiO_3 → Fe_2 TiO_4 → FeTiO_3 → FeTi_2O_5 → TiO_2. The calculated results for the reduction kinetics showed that the carbothermic reduction was controlled by the diffusion of ions through the product layer. Furthermore, the apparent activation energy was 170.35 k J·mol^（-1）.

关键词： titanomagnetite carbothermic reduction apparent activation energy phase transformation

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Relationship between the Permeation-Diffusion Parameters of a Single-File Channel

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Chinese Physics Letters 2012年第1期29卷 41-44页

作者： liu jian FAN jian-Fen College of Chemistry Chemical Engineering and Materials ScienceSoochow UniversitySuzhou 215123 Shanghai Institute of Applied Physics Chinese Academy of SciencesPO Box 800-204Shanghai 201800

Two sets of widely used parameters can describe the molecular permeation through a *** is permeation rate j and its diffusion Dn,and the other is flow and net *** establish a relationship between the two sets for a single-file nenochannel,as well as its dependence on the temperature and pressure difference between the two ends of a single-file channel,based on the Brownian motion theories and verified with molecular dynamics simulations for the water diffusion in a transmembrane (6,6) armchair carbon *** results are in excellent agreement with our predictions.

关键词： permeation diffusion Brownian

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Automated,economical,and environmentally-friendly asphalt mix design based on machine learning and multi-objective grey wolf optimization

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Journal of Traffic and Transportation Engineering(English Edition) 2024年第3期11卷 381-405页

作者： jian liu Fangyu liu Linbing Wang Department of Civil and Environmental Engineering Virginia Polytechnic Institute and State UniversityBlacksburgVA 24061USA School of Environmental CivilAgricultural and Mechanical EngineeringUniversity of GeorgiaAthensGA 30602USA Illinois Center for Transportation Department of Civil and Environmental EngineeringUniversity of Illinois Urbana-ChampaignUrbanaIL 61801USA

The increasing impact of the greenhouse effect on ecosystems is prompting transportation agencies to seek methods for reducing CO_(2)emissions during pavement construction and ***,the laboratory mix design process,which involves selecting aggregate gradation and binder content,is time-consuming and *** accelerate the traditional mix design procedure,this study presented a mix design procedure that can automatically determine gradation and binder content based on machine learning(ML)and a meta-heuristic ***,ML approaches were employed to model the relationship between volumetric properties(mixture bulk specific gravity(Gmb)and air void(VV))and both mixture component properties and mixture proportion,based on a dataset collected from literature with 660 mixture *** with the prediction of ML models and the modified multi-objective grey wolf optimization(MOGWO)algorithm,an automatic asphalt mix design was proposed to pursue three goals,including VV,cost,and CO_(2)*** results indicated that least squares support vector regression(LSSVR)and e Xtreme gradient boosting(XGBoost)achieved the highest prediction accuracies(correlation coefficient:0.92 for VV and 0.96 for Gmb).The MOGWO algorithm successfully found the 26 optimal mix designs for the case of VV *** ***_(2)*** to the traditional laboratory design,the optimal mixture with VV of4%achieves a cost saving of 2.46%and a reduction of 4.03%in carbon *** volumetric properties of the mixtures output by the approach also align closely with values measured in a laboratory.

关键词： Asphalt mix design Machine learning MOGWO CO_(2)emission Volumetric properties

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