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Eight new cytotoxic annonaceous acetogenins from the seeds of Annona squamosa

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Chinese Journal of Natural Medicines 2019年第4期17卷 291-297页

作者： MA Cheng-Yao LU Jia-hui LI Xiang liu Xiao CHEN Jian-Wei Pharmaceutical Institute Nanjing University of Chinese Medicine Engineering Center of State Ministry of Education for Standardization of Chinese Medicine Processing

Eight new annonaceous acetogenins, squamotin A–D(1–4), annosquatin IV–V(5 and 6), muricin O(7) and squamosten B(8), together with four known ones(9–12) were isolated from the seeds of Annona squamosa. Their structures were elucidated by chemical methods and spectral data. The inhibitory activities of compound 1–9 against three multidrug resistance cell lines were evaluated. All tested compounds showed strong cytotoxicity.

关键词： Annona squamosa Annonaceous acetogenins Cytotoxicity Multidrug resistance

Wheel‐Shape Heterometallic Ti10M2‐oxo Clusters (M = Ni, Co) with Effective Visible Light Absorption

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Chinese Journal of Chemistry 2019年第3期37卷 233-236页

作者： Xiao-Xue liu Wei-hui Fang Shumei Chen Lei Zhang Jian Zhang College of Chemistry Fuzhou UniversityFuzhouFujian 350116China State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhouFujian 350002China

Summary of main observation and conclusion In order to make visible light harvest crystalline polyoxo‐titanium clusters, we initially used transition metal pivalate complexes in this system and prepared successfully two isostructural compounds,[Ti10M2(PPO)4(μ3‐O)8(μ2‐O)4(PA)12(MeCN)4]·4HPA (PPOA = phenylphosphonic acid, HPA = propionic acid, M = Ni, PTC‐52‐Ni;M = Co PTC‐52‐Co). Single‐crystal X‐ray diffraction study showed that these two complexes possessed wheel‐shape heterometallic Ti10M2‐oxo clusters. The absorption bands of these two compounds shift effectively toward the visible‐light region. Furthermore, their photocurrent response has also been studied.

关键词： Shape Ni titanium response shape shift PTC has

Impacts of Fertilization Alternatives and Crop Straw Incorporation on N_2O Emissions from a Spring Maize Field in Northeastern China

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Journal of Integrative Agriculture 2014年第4期13卷 881-892页

作者： YANG Li WANG Li-gang LI Hu QIU Jian-jun liu hui-ying Key Laboratory of Non-Point Source Pollution Control Ministry of Agriculture/CAAS-UNH Joint Laboratory for Sustainable Agro-Ecosystem Research/Institute of Agricultural Resources and Regional PlanningChinese Academy of Agricultural Sciences Institute of Plant Nutrition and Environmental Resources Liaoning Academy of Agricultural Sciences

Spring maize is one of the most popular crops planted in northeastem China. The cropping systems involving spring maize have been maintaining high production through intensive management practices. However, the high rates of nitrogen （N） fertilizers application could have introduced a great amount of nitrous oxide （N2O） into the atmosphere. It is crucial for sustaining the maize production systems to reduce N2O emissions meanwhile maintaining the optimum yields by adopting alternative farming management practices. The goal of this study was to evaluate effects of alternative fertilization and crop residue management practices on N2O emission as well as crop yield for a typical maize field in northeastern China. Field experiments were conducted during the 2010-2011 maize growing seasons （from early May to late September） in Liaoning Province, northeastern China. N2O fluxes were measured at the field plots with six different treatments including no N fertilizer use （CK）, farmers＇ conventional N fertilizer application rate （FP）, reduced N fertilizer rate （OPT）, reduced N fertilizer rate combined with crop straw amendment （OPTS）, slow-release N fertilizer （CRF）, and reduced N fertilizer rate combined with nitrification inhibitor （OPT＋DCD）. The static chamber method combined with gas chromatography technique was employed to conduct the measurements of N2O fluxes. The field data showed that N2O emissions varied across the treatments. During the maize growing season in 2010, the total N2O emissions under the treatments of CK, FP, OPT, OPTS, and CRF were 0.63, 1.11, 1.03, 1.26, and 0.98 kg N ha-1, respectively. The seasonal cumulative N2O emissions were 0.54, 1.07, 0.96, 1.12, and 0.84 kg N ha1, respectively, under CK, FP, OPT, OPTS, and OPT＋DCD in 2011. In comparison with FP, CRF or OPT＋DCD reduced the N2O emissions by 12 or 21%, respectively, while the crop yields remained unchanged. The results indicate that the reduction of N-fertilizer application rate in combination w

关键词： nitrogen fertilization straw incorporation nitrous oxide crop yield spring maize

Statistical Downscaling Prediction of Summer Precipitation in Southeastern China

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Atmospheric and Oceanic Science Letters 2011年第3期4卷 173-180页

作者： liu Ying FAN Ke WANG hui-Jun Nansen-Zhu International Research Centre Institute of Atmospheric Physics Chinese Academy of Sciences Beijing 100029 China Graduate University of the Chinese Academy of Scienees Beijing 100049 China

A statistical downscaling approach based on multiple-linear-regression(MLR) for the prediction of summer precipitation anomaly in southeastern China was established,which was based on the outputs of seven operational dynamical models of Development of a European Multi-model Ensemble System for Seasonal to Interannual Prediction(DEMETER) and observed *** was found that the anomaly correlation coefficients(ACCs) spatial pattern of June-July-August(JJA) precipitation over southeastern China between the seven models and the observation were increased significantly;especially in the central and the northeastern areas,the ACCs were all larger than 0.42(above 95% level) and 0.53(above 99% level).Meanwhile,the root-mean-square errors(RMSE) were reduced in each model along with the multi-model ensemble(MME) for some of the stations in the northeastern area;additionally,the value of RMSE difference between before and after downscaling at some stations were larger than 1 mm *** averaged JJA rainfall anomaly temporal series of the downscaling scheme can capture the main characteristics of observation,while the correlation coefficients(CCs) between the temporal variations of the observation and downscaling results varied from 0.52 to 0.69 with corresponding variations from-0.27 to 0.22 for CCs between the observation and outputs of the models.

关键词： statistical downscaling DEMETER south-eastern China summer precipitation anomaly

Oxymatrine reduces neuroinflammation in rat brain A signaling pathway

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Neural Regeneration Research 2012年第30期7卷 2333-2339页

作者： Jiahui Mao Yae Hu Ailing zhou Bing Zheng Yi liu Yueming Du Jia Li Jinyang Lu Pengcheng zhou Department of Pathophysiology Medical School of Nantong University Nantong 226001 Jiangsu Province China Department of Urology the First People's Hospital of Nantong Nantong 226001 Jiangsu Province China Undergraduate of Medical School of Nantong University Nantong 226001 Jiangsu Province China

Cerebral neuroinflammation models were established by injecting 10μg lipopolysaccharide into the hippocampus of male Sprague-Dawley rats. The rats were treated with an intraperitoneal injection of 120, 90, or 60 mg/kg oxymatrine daily for three days prior to the lipopolysaccharide injection. Twenty-four hours after model induction, the hippocampus was analyzed by real-time quantitative PCR, and the cerebral cortex was analyzed by enzyme-linked immunosorbent assay and western blot assay. The results of the enzyme-linked immunosorbent assay and the real-time quantitative PCR showed that the secretion and mRNA expression of the pro-inflammatory cytokines interleukin-113 and tumor necrosis factor-a were significantly decreased in the hippocampus and cerebral cortex of model rats treated with oxymatrine. Western blot assay and real-time quantitative PCR analysis indicated that toll-like receptor 4 mRNA and protein expression were significantly decreased in the groups receiving different doses of oxymatrine. Additionally, 120 and 90 mg/kg oxymatrine were shown to reduce protein levels of nuclear factor-KB p65 in the nucleus and of phosphorylated IKBa in the cytoplasm of brain cells, as detected by western blot assay. Experimental findings indicate that oxymatrine may inhibit neuroinflammation in rat brain via downregulating the expression of molecules in the toll-like receptor 4/nuclear factor-KB signaling Dathwav.

关键词： oxymatrine neuroinflammation toll-like receptor 4 nuclear factor-KB signaling pathway inflammatory factors lipopolysaccharide hippocampus cerebral cortex neural regeneration

Mechanism of hamstring muscle strain injury in sprinting

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Journal of Sport and Health Science 2017年第2期6卷 130-132页

作者： Bing Yu hui liu William E.Garrett Center for Human Movement Science The University of North Carolina at Chapel Hill Biomechanics Laboratory Beijing Sport University Duke Sports Medicine Center Duke University

Hamstring muscle strain injury is one of the most common injuries in sports involving sprinting and *** muscle strain injuries occur at a high rate and have a high re-injury rate,which results in loss of training and competition time,which has a significant impact on the quality of life of the injured athletes.~1Preventing and rehabilitating hamstring muscle strain injury is an important task for clinicians and scientists in sports *** the mechanisms underlying hamstring injury is critical for developing appropriate strategies to prevent and rehabilitate hamstring *** the

关键词：拉伤短跑肌机制时间损失质量产生运动医学临床医生

Trans-kingdom RNAs and their fates in recipient cells: advances, utilization, and perspectives

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Plant Communications 2021年第2期2卷 29-37页

作者： Jian-Hua Zhao Tao Zhang Qing-Yan liu hui-Shan Guo State Key Laboratory of Plant Genomics Institute of MicrobiologyChinese Academy of SciencesCAS Center for Excellence in Biotic InteractionsUniversity of the Chinese Academy of SciencesBeijing 100049China

The phenomenon and potential mechanisms of trans-kingdom RNA silencing(or RNA interference,RNAi)are among the most exciting topics in science *** on trans-kingdom RNAi,host-induced gene silencing(HIGS)has been widely applied to create crops with resistance to various pests and pathogens,overcoming the limitations of resistant ***,a lack of transformation technology in many crops limits the application of ***,we describe the various fates of trans-kingdom RNAs in recipient *** on the assumption that small RNAs can be transferred between the host and its microbiome or among microbiome members,we propose a possible alternative strategy for plant protection against pathogens without the need for crop genetic modification.

关键词： trans-kingdom RNA sRNA HIGS microbiome RNAi

Supercritical Characteristics of a Relaxation Oscillator

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Chinese Physics Letters 1991年第1期8卷 1-4页

作者： JI Feng liu hui YANG Zhenghai SHI Kangjie HE Daren WANG Dalcai Department of Physics Northwestern UniversityXi’an 710069

A relaxation oscillator can be described by two maps:one circle and one inverse *** order of map depends on the function form of the modulation *** behaviors of the oscillator were studied experimentally and *** scaling laws S(f)∝f^(-δ) and τ∝|f-f_(c)|^(-γ) were *** the scaling exponents δ and γ2 increase when the order m getting larger.

关键词： oscillator scaling Oscillator

Computed tomography perfusion imaging evaluation of angiogenesis in patients with pancreatic adenocarcinoma

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World Journal of Clinical Cases 2022年第8期10卷 2393-2403页

作者： Wen liu Bo Yin Zong-hui Liang Yang Yu Na Lu Department of Radiology Jinshan HospitalFudan UniversityShanghai 201508China Department of Radiology Huashan HospitalFudan UniversityShanghai 200000China Department of Radiology Huashan Hospital NorthFudan UniversityShanghai 200000China Department of Radiology Shanghai Jing’an District Central HospitalHuashan Hospital Jing’an BranchFudan UniversityShanghai 200000China

BACKGROUND Pancreatic adenocarcinoma is one of the most common malignant tumors of the digestive *** than 80%of patients with pancreatic adenocarcinoma are not diagnosed until late stage and have distant or local *** To investigate the value of computed tomography(CT)perfusion imaging in the evaluation of angiogenesis in pancreatic adenocarcinoma *** This is a retrospective cohort *** with pancreatic adenocarcinoma and volunteers without pancreatic diseases underwent CT perfusion imaging from December 2014 to August 2017 in Huashan Hospital,Fudan University Shanghai,*** A total number of 35 pancreatic adenocarcinoma patients and 33 volunteers were *** relative blood flow(r BF),and relative blood volume(r BV)were significantly lower in patients with pancreatic adenocarcinoma than in the control group(P<0.05).Conversely,the relative permeability in patients with pancreatic adenocarcinoma was significantly higher than that in controls(P<0.05).In addition,r BF,r BV,and the vascular maturity index(VMI)were significantly lower in gradeⅢ-Ⅳpancreatic adenocarcinoma than in gradeⅠ-Ⅱpancreatic adenocarcinoma(P<0.05).Vascular endothelial growth factor(VEGF),CD105-MVD,CD34-MVD,and angiogenesis rate(AR)were significantly higher in gradeⅢ-Ⅳpancreatic adenocarcinoma than in gradeⅠ-Ⅱpancreatic adenocarcinoma(P<0.05).Significant correlations between r BF and VEGF,CD105-MVD,AR,and VMI(P<0.01)were ***,the levels of r BV were statistically significantly correlated with those of VEGF,CD105-MVD,CD34-MVD,and VMI(P<0.01).CONCLUSION Perfusion CT imaging may be an appropriate approach for quantitative assessment of tumor angiogenesis in pancreatic adenocarcinoma.

关键词： Pancreatic adenocarcinoma Perfusion computed tomography Angiogenesis Evaluation Imaging Quantitative assessment