检索结果-南通市图书馆

Evaluation of the forest ecosystem health in Beijing area

在线全文

学校读者我要写书评

暂无评论

Forestry Studies in China 2007年第2期9卷 157-163页

作者： Ma Li Han Hai-rong Ma Qin-yan liu hong-wen xia Wei-wei Cheng xiao-qin Key Laboratory for Silviculture and Conservation of Ministry of Education College of Natural Resources and Environment BeijingForestry University Beijing 100083 P. R. China

The evaluation of ecosystem health has become one of the main research topics of ecosystem science, thus more and more assessment methods and frameworks have been put forward in recent years. However, the attention people pay to ecosystem health is actually more about what the social functions the ecosystem affords, which depend on the integrity and maintenance of the ecosystem structure and function, and the intensity of disturbance from outside. Accordingly, this research commenced from three main aspects, selected the evaluation indices, and then established the Evaluation Index System of Beijing Forest Ecosystem Health （EIS-BFEH）. In the EIS-BFEH, each of the three foundations contained an easily-operated and standard sub-index system, which compounded the specific natural and social conditions of Beijing and was concrete enough to measure and evaluate. Then with the method of the Analytical Hierarchy Process （AHP）, the comprehensive index （CI） could be obtained, which represented the health of the forest ecosystem. As a case study, the forest ecosystems in the Badaling area were sampled, evaluated, compared and ranked by use of the EIS-BFEH. The result show that the health of natural forests is much better than that of plantations in the Badaling forest center： the average comprehensive index of the former is 7.9, while the latter is only 6.6. From the results, it could also be found that there are nine units in the healthy state, two units in the subhealthy state, and only one unit of Robiniapseudoacacia in the morbid state.

关键词： Beijing area forest ecosystem health evaluation Badaling Forest Center

Asperuloside Promotes Apoptosis of Cervical Cancer Cells through Endoplasmic Reticulum Stress-Mitochondrial Pathway

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Integrative Medicine 2024年第1期30卷 34-41页

作者： QI Zhi-min WANG xia liu xia ZHAO Juan Medical Examination Center Hebei Province Hospital of Chinese MedicineShijiazhuang(050011)China Department of Gynaecology and Obstetrics Hebei Province Hospital of Chinese MedicineShijiazhuang(050011)China Experimental Center for Teaching Hebei Medical UniversityShijiazhuang(050017)China

Objective: To investigate the effects of asperuloside on cervical cancer based on endoplasmic reticulum(ER) stress and mitochondrial pathway. Methods: Different doses(12.5–800 μg/mL) of asperuloside were used to treat cervical cancer cell lines Hela and CaSki to calculate the half maximal inhibitory concentration(IC_(50)) of asperuloside. The cell proliferation was analyzed by clone formation assay. Cell apoptosis, intracellular reactive oxygen species(ROS) and mitochondrial membrane potential were determined by flow cytometry. The protein expressions of cleaved-caspase-3, Bcl-2, Bax, Cyt-c, cleaved-caspase-4 and glucose-regulated protein 78(GRP78) were analyzed by Western blot. And the inhibitor of ER stress, 4-phenyl butyric acid(4-PBA) was used to treat cervical cancer cells to further verify the role of ER stress in the apoptosis of cervical cancer cells induced by asperuloside. Results: Asperuloside of 325, 650, and 1300 μg/mL significantly inhibited the proliferation and promoted apoptosis of Hela and CaSki cells(P<0.01). All doses of asperuloside significantly increased intracellular ROS levels, reduced mitochondrial membrane potential, significantly reduced Bcl-2 protein expression level, and increased Bax, Cyt-c, GRP78 and cleaved-caspase-4 expressions(P<0.01). In addition, 10 mmol/L 4-PBA treatment significantly promoted cell proliferation and reduced apoptosis(P<0.05), and 650 μg/mL asperuloside could reverse 4-PBA-induced increased cell proliferation, decreased apoptosis and cleaved-caspase-3,-4 and GRP78 protein expressions(P<0.05). Conclusion: Our study revealed the role of asperuloside in cervical cancer, suggesting that asperuloside promotes apoptosis of cervical cancer cells through ER stress-mitochondrial pathway.

关键词： asperuloside Chinese medicine cervical cancer endoplasmic reticulum stress mitochondrial damage apoptosis

A Scoping Review of Real-World Study in Vaccine Evaluation

在线全文

学校读者我要写书评

暂无评论

China CDC weekly 2024年第16期6卷 357-362页

作者： Lei Wang hong Yang Lanfang xia Quanwei Song Na liu Guomin Zhang Fuzhen Wang Huaqing Wang National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases(NITFID) BeijingChina National Immunization Program Chinese Center for Disease Control and PreventionBeijingChina

Real-world study(RWS)gained prominence starting with a significant investigation on ramipril’s impact on hypertension in 1993(1).A key advancement for the Food and Drug Administration(FDA)occurred with the enactment of the 21st Century Cures Act in 2016,emphasizing RWS(2).The FDA’s Real-world Evidence Program establishes real-world data(RWD)as“data relating to patient health status and/or the delivery of health care routinely collected from a variety of sources”,while real-world evidence(RWE)is“clinical evidence about the usage and potential benefits or risks of a medical product derived from analysis of RWD”(3).The proliferation of big data,electronic medical records(EMR),electronic health records(EHR),and medical claims data offers vast information resources facilitating *** access to RWD allows for worldwide monitoring of the impacts of various public health initiatives like vaccination *** randomized clinical trials(RCTs)traditionally gauge vaccine efficacy and shortterm safety,RWS can assess vaccine performance and safety across larger,more diverse populations and are adept at identifying rare events not easily discernible in RCTs due to their infrequency.

关键词： routine gained traditionally

Personalized and continuous care intervention affects rehabilitation,living quality,and negative emotions of patients with breast cancer

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Psychiatry 2024年第6期14卷 876-883页

作者： Ling-xia Kong Yan-hong Zhao Zhi-Lin Feng Ting-Ting liu Department of Breast Surgery The First Affiliated Hospital of Hebei North UniversityZhangjiakou 075000Hebei ProvinceChina Operating Room The First Affiliated Hospital of Hebei North UniversityZhangjiakou 075000Hebei ProvinceChina

BACKGROUND Breast cancer is among the most common malignancies *** progress in treatment methods and levels,the overall survival period has been prolonged,and the demand for quality care has *** To investigate the effect of individualized and continuous care intervention in patients with breast *** Two hundred patients with breast cancer who received systemic therapy at The First Affiliated Hospital of Hebei North University(January 2021 to July 2023)were retrospectively selected as research *** them,134 received routine care intervention(routing group)and 66 received personalized and continuous care(intervention group).Self-rating anxiety scale(SAS),self-rating depression scale(SDS),and Functional Assessment of Cancer Therapy-Breast(FACT-B)scores,including limb shoulder joint activity,complication rate,and care satisfaction,were compared between both groups after *** SAS and SDS scores were lower in the intervention group than in the routing group at one and three months after *** total FACT-B scores and five dimensions in the intervention group were higher than those in the routing group at three months of *** range of motion of shoulder anteflexion,posterior extension,abduction,internal rotation,and external rotation in the intervention group was higher than that in the routing group one month after *** incidence of postoperative complications was 18.18%lower in the intervention group than in the routing group(34.33%;P<0.05).Satisfaction with care was 90.91% higher in the intervention group than in the routing group(78.36%;P<0.05).CONCLUSION Personalized and continuous care can alleviate negative emotions in patients with breast cancer,quicken rehabilitation of limb function,decrease the incidence of complications,and improve living quality and care satisfaction.

关键词： Breast cancer Personalized care Continuous care Negative emotions Living quality Rehabilitation effect

TCD脑血流监测在颈动脉内膜剥脱术中指导血压调控的应用

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

生物医学工程与临床 2024年第2期28卷 215-220页

作者：王彦李俊青郭全周刘红霞宋志俊李丹苗振华邢台市第三医院麻醉科河北邢台054000 邢台市第三医院功能科河北邢台054000 邢台市第三医院神经外科河北邢台054000

目的探讨经颅彩色超声多普勒系统(TCD)监测脑血流在颈动脉内膜剥脱术(CEA)中指导血压个体化调控的作用。方法选择2018年12月至2020年12月在邢台市第三医院收治的140例拟行CEA治疗的颈动脉狭窄患者,其中男性74例,女性66例;年龄45~65岁,... 详细信息

目的探讨经颅彩色超声多普勒系统(TCD)监测脑血流在颈动脉内膜剥脱术(CEA)中指导血压个体化调控的作用。方法选择2018年12月至2020年12月在邢台市第三医院收治的140例拟行CEA治疗的颈动脉狭窄患者,其中男性74例,女性66例;年龄45~65岁,平均年龄57.41岁;糖尿病10例,高血压12例;美国麻醉师协会(ASA)分级:Ⅱ级30例,Ⅲ级110例。采用随机数字表法分为研究组和对照组,每组分为70例。对照组采用传统手段控制血压,研究组根据TCD脑血流参数指导调节血压。术中连续监测两组患者的有创动脉压力并对大脑中动脉平均血流速度进行监测。记录两组各个时刻点大脑中动脉血流速度(Vm)及外周有创动脉收缩压,比较两组患者围术期相关指标,统计术中心动过速/心动过缓发生次数及术后心脑血管事件发生情况。结果研究组术中硝酸甘油、去甲肾上腺素用量低于对照组[(34.87±10.27)μg vs(48.56±6.92)μg、(15.97±4.54)μg vs(24.15±3.99)μg。P0.05)。在T1和T2时,研究组Vm值和收缩压明显低于对照组[T1:(38.87±6.19)cm/s vs(44.42±4.16)cm/s,(119.84±8.12)mmHg vs(150.78±6.51)mmHg;T2:(29.46±4.58)cm/s vs(34.94±3.64)cm/s,(142.04±10.91)mmHg vs(152.23±5.84)mmHg。P<0.05]。其中两组患者在T2时Vm值显著下降[(29.46±4.58)cm/s vs(34.94±3.64)cm/s。P<0.05],收缩压值显著上升[(142.04±10.91)mmHg vs(152.23±5.84)mmHg。P<0.05]。研究组术后并发症发生率低于对照组(7.14%vs 20.90%。P<0.05)。研究组CEA后颈动脉超声心动图改变或术后再狭窄<50%、50%~69%和继发血栓形成的患者数明显少于对照组(2.86%vs 11.94%、2.86%vs 13.43%、1.43%vs 8.96%、0.00%vs 5.97%。P<0.05)。结论TCD监测颈动脉狭窄患者脑血管血流动力学对CEA麻醉中血压的调控具有较好的指导意义,有利于实现血压个体化调控,提高血压调控准确率,减少心脑血管事件的出现。

关键词：颈动脉内膜剥脱术经颅多普勒彩色超声检测系统术中监测脑血流血压个体化调控

Numerical simulations for radon migration and exhalation behavior during measuring radon exhalation rate with closed-loop method

在线全文

学校读者我要写书评

暂无评论

Nuclear Science and Techniques 2024年第1期35卷 81-95页

作者： Ming xia Yong-Jun Ye Shu-Yuan liu School of Resources Environment and Safety Engineering University of South ChinaHengyang 421001China Key Discipline Laboratory for National Defense for Biotechnology in Uranium Mining and Hydrometallurgy University of South ChinaHengyang 421001China

Accurate measurements of the radon exhalation rate help identify and evaluate radon risk regions in the *** these measurement methods,the closed-loop method is frequently ***,traditional experiments are insufficient or cannot analyze the radon migration and exhalation patterns at the gas–solid interface in the accumulation *** CFD-based technique was applied to predict the radon concentration distribution in a limited space,allowing radon accumulation and exhalation inside the chamber intuitively and *** this study,three radon exhalation rates were defined,and two structural ventilation tubes were designed for the *** consistency of the simulated results with the variation in the radon exhalation rate in a previous experiment or analytical solution was *** effects of the vent tube structure and flow rate on the radon uniformity in the chamber;permeability,insertion depth,and flow rate on the radon exhalation rate and the effective diffusion coefficient on back-diffusion were *** on the results,increasing the inser-tion depth from 1 to 5 cm decreased the effective decay constant by 19.55%,whereas the curve-fitted radon exhalation rate decreased(lower than the initial value)as the deviation from the initial value increased by approximately 7%.Increasing the effective diffusion coefficient from 2.77×10^(-7) to 7.77×10^(-6) m^(2) s^(-1) made the deviation expand from 2.14 to 15.96%.The conclusion is that an increased insertion depth helps reduce leakage in the chamber,subject to notable back-diffusion,and that the closed-loop method is reasonably used for porous media with a low effective diffusion coefficient in view of the back-diffusion *** CFD-based simulation is expected to provide guidance for the optimization of the radon exhalation rate measurement method and,thus,the accurate measurement of the radon exhalation rate.

关键词： Radon exhalation Numerical simulation Accumulation chamber

BCCLR:A Skeleton-Based Action Recognition with Graph Convolutional Network Combining Behavior Dependence and Context Clues

在线全文

学校读者我要写书评

暂无评论

Computers, Materials & Continua 2024年第3期78卷 4489-4507页

作者： Yunhe Wang Yuxin xia Shuai liu College of Information Science and Engineering Institute of Interdisciplinary StudiesHunan Normal UniversityChangsha410081China School of Educational Sciences Institute of Interdisciplinary StudiesHunan Normal UniversityChangsha410081China

In recent years,skeleton-based action recognition has made great achievements in Computer Vision.A graph convolutional network(GCN)is effective for action recognition,modelling the human skeleton as a spatio-temporal *** GCNs define the graph topology by physical relations of the human ***,this predefined graph ignores the spatial relationship between non-adjacent joint pairs in special actions and the behavior dependence between joint pairs,resulting in a low recognition rate for specific actions with implicit correlation between joint *** addition,existing methods ignore the trend correlation between adjacent frames within an action and context clues,leading to erroneous action recognition with similar ***,this study proposes a learnable GCN based on behavior dependence,which considers implicit joint correlation by constructing a dynamic learnable graph with extraction of specific behavior dependence of joint *** using the weight relationship between the joint pairs,an adaptive model is *** also designs a self-attention module to obtain their inter-frame topological relationship for exploring the context of *** the shared topology and the multi-head self-attention map,the module obtains the context-based clue topology to update the dynamic graph convolution,achieving accurate recognition of different actions with similar *** experiments on public datasets demonstrate that the proposed method achieves better results and realizes higher quality representation of actions under various evaluation protocols compared to state-of-the-art methods.

关键词： Action recognition deep learning GCN behavior dependence context clue self-attention

A dynamical neural network approach for distributionally robust chance-constrained Markov decision process

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China Mathematics 2024年第6期67卷 1395-1418页

作者： Tian xia Jia liu Zhiping Chen School of Mathematics and Statistics Xi’an Jiaotong UniversityXi’an710049China

In this paper,we study the distributionally robust joint chance-constrained Markov decision *** the logarithmic transformation technique,we derive its deterministic reformulation with bi-convex terms under the moment-based uncertainty *** cope with the non-convexity and improve the robustness of the solution,we propose a dynamical neural network approach to solve the reformulated optimization *** results on a machine replacement problem demonstrate the efficiency of the proposed dynamical neural network approach when compared with the sequential convex approximation approach.

关键词： Markov decision process chance constraints distributionally robust optimization moment-based ambiguity set dynamical neural network

Interface engineering via molecules/ions/groups for electrocatalytic water splitting

在线全文

学校读者我要写书评

暂无评论

Nano Research 2024年第9期17卷 7864-7879页

作者： Defang Ding Youwen liu Fan xia Engineering Research Center of Nano-Geomaterials of Ministry of Education Faculty of Materials Science and ChemistryChina University of GeosciencesWuhan 430074China State Key Laboratory of Materials Processing and Die&Mould Technology and School of Materials Science and Engineering Huazhong University of Science and Technology WuhanHubei 430074China

The electrochemical water splitting to produce hydrogen converts electric energy into clean hydrogen energy,which is a groundbreaking concept of energy *** achieve high efficiency,numerous strategies have been developed to enhance the performance of *** these,interface engineering with molecules/ions/groups,serves as a versatile approach for optimizing the performance of electrocatalysts in water *** the basis of numerous achievements in high-performance electrocatalysts engineered through molecules/ions/groups at interface,a comprehensive understanding of these advancements is crucial for guiding future ***,after providing a concise overview of the background,the interface engineering via molecules/ions/groups for electrocatalytic water splitting is demonstrated from three ***,the engineering of electronic state of electrocatalysts by molecules/ions/groups at interface to reduce the Gibbs free energy of the corresponding ***,the modification of local microenvironment surrounding electrocatalysts via molecules/ions/groups at interface to enhance the transfer of reactants and ***,the protection of electrocatalysts with molecule/ion/group fences improves their durability,including protecting active sites from leaching and defending them against harmful *** fundamental principles of these three aspects are outlined for each,along with pertinent ***,several research directions and challenges are proposed.

关键词： electrocatalyst water splitting interface engineering molecules/ions/groups