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Single-site Baseline and Short-term Outcomes of Clinical Characteristics and Life Quality Evaluation of Chinese Wet Age-related Macular Degeneration Patients in Routine Clinical Practice

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Chinese Medical Journal 2015年第9期128卷 1154-1159页

作者： Li-Li Wang Wen-Jia liu hai-yun liu Xun Xu Department of Ophthalmology Shanghai First People@s Hospital Shanghai 200080 China

Background：Age-related macular degeneration （AMD） is the leading cause of irreversible vision loss among the older *** China,treatment of age-related ocular diseases is becoming a priority in eye care *** study was to investigate the clinical characteristics and quality of life of Chinese patients with wet AMD and current treatment types,to evaluate short-term gains in different treatments,and to investigate associations between visual function and vision-related quality of life （VRQoL）.Methods：A prospective,observational,noninterventional study was *** data were collected from patients with clinical diagnoses of wet AMD before clinical assessments at *** was measured with the Chinese version of the National Eye Institute Visual Function Questionnaire-25 （NEI VFQ-25）.Correlations of the NEI VFQ-25 subscale scores with best-corrected visual acuity （BCVA） and between-group differences were ***：A total of 80 wet AMD patients were enrolled,with the mean age of 68.40 *** one-quarter ofwetAMD patients received intravitreal （IVT） ranibizumab treatment,and 67％ of them were treated on apro re nata *** visual acuity of patients treated with IVT ranibizumab at month 3 after treatment was significantly increased,whereas patients treated with traditional Chinese medicine achieved no significant ***＇s α for the NEI VFQ-25 subscales ranged from 0.697 to *** subscale and overall composite scores were moderately correlated with the BCVA of the better-seeing *** differences in the overall NEI VFQ-25 scores and other subscales were observed between patients with BCVA in the better-seeing eye of less than 50 letters and the ***：Patients treated with IVT ranibizumab experienced better vision improvement at short-term *** Chinese version of the NEI VFQ-25 is a valid and reliable tool for assessing the VRQoL of Chinese wet AMD patients.

关键词： Chinese Version of National Eye Institute Visual Function Questionnaire-25 Ranibizumab Vision-related Quality of Life Wet Age-related Macular Degeneration

Growth and Characterization of High-Quality Single Crystals of Ni- and Zn-Doped Bi_(2)Sr_(2)Ca(Cu_(2−x)M_(x))O_(8+δ)(M=Ni or Zn) High-Temperature Superconductors

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Chinese Physics Letters 2012年第8期29卷 237-240页

作者： liu Shan-Yu ZHANG Wen-Tao ZHAO Lin liu hai-yun WU Yue liu Guo-Dong DONG Xiao-Li ZHOU Xing-Jiang National Laboratory for Superconductivity Beijing National Laboratory for Condensed Matter PhysicsInstitute of PhysicsChinese Academy of SciencesBeijing 100190

High-quality large single crystals of Ni-and Zn-doped Bi_(2)Sr_(2)Ca(Cu_(2−x)M_(x))O_(8+δ)(M=Ni or Zn)have been successfully grown by the traveling solvent floating zone *** single crystals are characterized by compositional and structural analyses and their physical properties are investigated by magnetic susceptibility and resistivity measurements.A record high critical temperature with a T_(c)=97.5 K has been achieved in the annealed pristine Bi2212 single *** of Cu by Ni or Zn reduces the superconducting transition temperature when compared with pristine Bi_(2)Sr_(2)CaCu_(2)O_(8+δ)(Bi2212)grown under similar *** successful growth of such pristine Ni-and Zn-doped Bi2212 single crystals will facilitate studies of the relationship between the magnetism and superconductivity in high-temperature cuprate superconductors.

关键词： technique conditions Bi2212

LH Plays a Role to Enhance the Nuclear and Cytoplasm Synchronization During In vitro Maturation of Ovine Oocytes

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Agricultural Sciences in China 2011年第1期10卷 136-141页

作者： LI Kai NI He-min liu yun-hai ZHAO Yan-wei QU Yang-yan LI Xiao-yan GUO Yong Department of Animal Science ＆ Technology Beijing University o[ Agriculture Beijing 102206 P.R.China

This study is aimed to investigate the effect of luteinizing hormone （LH） on maturation and fertilization in vitro of ovine oocytes. The ovine oocytes were cultured in vitro in medium with or without LH, and then checked by confocal laser scanning microscope to observe the distribution of cortical granules stained with FITC-LCA during different maturation periods. Similarly, some in vitro matured oocytes were also fertilized in vitro for analysis of their developmental potentiality further. After being cultured in vitro for 4 h, there were significant differences about the rate of germinal vesicle break down （GVBD） between the treatment （with LH） and the control groups （without any hormones）（36.76% vs 18%, P〈0.05）. Further, there were also significant differences of the cleavage and blastocyst rates between these two groups （67.15% vs 42.37%, 21.9% vs 12.71%, P〈0.05, respectively）. The distribution of cortical granules appeared to spread from the edges to the central site of sheep oocytes following their delaying durations of maturation in vitro. It can be concluded that LH may play a role to delay the occurence of GVBD, prolong the maturation duration of cytoplasm, and enhance the nuclear and cytoplasm synchronization of ovine oocytes matured in vitro and finally improve their in vitro developmental potentiality.

关键词： ovine oocyte luteinizing hormone in vitro maturation in vitro fertilization distribution of cortical granules

Posterior vitreous cortex contributes to macular hole in highly myopic eyes with retinal detachment

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Chinese Medical Journal 2011年第16期000卷 2474-2479页

作者： liu hai-yun ZOU hai-dong liu Kun SONG Zheng-yu XU Xun an SUN Xiao-dong Department of Ophthalmology Shanghai First People's HospitalShanghai Jiao Tong University Shanghai 200080 China Shanghai Key Laboratory of Ocular Fundus Diseases Science andTechnology Commission of Shanghai Municipality Shanghai200080 China

Background It was well known that tangential vitreoretinal traction and epiretinal membrane play important roles during the formation of macular hole （MH） associated with retinal detachment （RD） in highly myopic eyes. But it was not clear about the correlations between anteroposterior traction, posterior vitreous cortex （PVC） and MH-RD. The vitreous status in highly myopic eyes were analyzed to explore the effect of PVC in the role of MH-RD formation. Methods Sixteen consecutive highly myopic eyes with RD due to MH were retrospectively analyzed from January 2009 to April 2009. The preoperative examinations for detecting posterior vitreous detachment （PVD） and vitreoretinal traction included B-mode ultrasonography and optical coherence tomography （OCT）. The residual PVC and PVD were confirmed intraoperatively during triamcinolone acetonide （TA） assisted vitrectomy. Results Under ultrasonography, the preoperative PVD patterns were stratified as： complete PVD in three （19%） eyes, partial PVD in eight （50%） eyes, and no PVD in five （31%） eyes. OCT confirmed vitreoretinal traction and no complete PVD in 10 （63%） eyes, including anteroposterior traction in four eyes and tangential traction in six eyes. During TA-assisted vitrectomy, it was confirmed that no complete PVD existed in 16 eyes, including six eyes （38%） finally diagnosed of partial PVD, and five （31%） eyes with vitreoschisis. Anteroposterior vitreoretinal traction around MH is always in conjunction with partial PVD （67%）, and high proportion （80%） of vitreoschisis is associated with tangential vitreoretinal traction. Comparing with the precision of TA staining of PVD diagnosis, the coincidence rate of ultrasonography was 69% （P=0.02）, and that of OCT was 63% （P 〈0.01）. Conclusions The residual PVC due to partial PVD or vitreoschisis may cause the anteroposterior or tangential traction of macular area, which contributes to the formation of MH and subsequent RD in highly myopic eyes. And it is necessary to realiz

关键词： posterior vitreous detachment macular hole myopia retinal detachment

MTBE(甲基叔丁基醚)装置醇烯比控制方案

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化工自动化及仪表 1999年第5期26卷 16-18页

作者：刘海云金陵石化炼油厂仪表车间南京210033

ＭＴＢＥ装置醇烯比是关系到整个生产装置的平稳操作、产品质量、优化生产的一个关键，着重讨论了如何利用Ｃ４馏分原料流量控制。

关键词： MTBE 醇烯比比值控制控制方案

资源论与跨国公司研究与开发(R&D)的全球化与合作化

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科研管理 2000年第6期21卷 8-14页

作者：刘海云华中科技大学经济学院武汉430074

跨国公司研究与开发 (R&D)的全球化与合作化是九十年代以来世界经济中最突出的现象之一。对此 ,传统的观点更多地从生产和市场国际化的角度进行解释。本文则运用资源理论 ,从跨国公司形成“核心能力”的角度进行分析。

关键词：资源论全球化合作化 R&D 跨国公司核心能力

国家国际分工地位及其影响因素——基于“GVC地位指数”的实证分析

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国际经贸探索 2015年第8期31卷 44-53页

作者：刘海云毛海欧华中科技大学经济学院湖北武汉430074

使用2000～2011年世界投入产出表数据测算包括中国在内39个国家的GVC地位指数，分析各国国际分工地位的动态变化．研究结果表明，发展中国家的国际分工地位低于发达国家。但前者呈现上升态势，后者出现下降趋势。利用面板回归和门槛回... 详细信息

使用2000～2011年世界投入产出表数据测算包括中国在内39个国家的GVC地位指数，分析各国国际分工地位的动态变化．研究结果表明，发展中国家的国际分工地位低于发达国家。但前者呈现上升态势，后者出现下降趋势。利用面板回归和门槛回归方法考察主要影响因素对国际分工地位的作用规律．发现：随着技术创新水平的提升，国际分工地位得到提升，但影响逐渐递减；交易费用下降促进国际分工地位上升，但作用效果随其降低逐渐下降；当人力资本达到一定水平后，其对国际分工地位才有显著正向影响；当外商直接投资达到门槛水平后，其对国家分工地位的正向作用消失；公共产品的增加有利于一国国际分工地位的提升。

关键词：国际分工地位动态比较优势全球价值链

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制造业OFDI对出口增加值的影响

中国工业经济 2016年第7期 91-108页

作者：刘海云毛海欧华中科技大学经济学院

本文将OFDI对出口增加值的影响分为规模效应和结构效应,认为水平OFDI和垂直OFDI的影响具有差异性,并运用跨国面板数据进行实证分析,主要结论为:就规模效应而言,中国制造业的水平和垂直OFDI均促进了出口增加值提升,但垂直OFDI的促进作用... 详细信息

本文将OFDI对出口增加值的影响分为规模效应和结构效应,认为水平OFDI和垂直OFDI的影响具有差异性,并运用跨国面板数据进行实证分析,主要结论为:就规模效应而言,中国制造业的水平和垂直OFDI均促进了出口增加值提升,但垂直OFDI的促进作用大于水平OFDI。进一步分析OFDI影响出口增加值的滞后效应发现,对发展中国家样本,水平OFDI较垂直OFDI对出口增加值的促进作用更加持久,而对发达国家样本,垂直OFDI较水平OFDI对出口增加值的促进作用更加持久,说明中国对发达国家下游生产环节布局型垂直OFDI具有较强的互补效应。就结构效应而言,水平OFDI通过跨国产业转移、要素跨行业流动等渠道降低了母国出口增加值中资源行业占比,提升了生产性服务业增加值占比,优化了中国制造业出口增加值结构。垂直OFDI促进了生产性服务业占比提升,对高端生产性服务业占比的促进作用尤其突出,说明垂直OFDI有利于母国形成"总部服务经济",促进出口增加值结构改善。本文建议,应当重视制造业OFDI的出口增加值效应,特别是结构效应及其与产业升级的关系,针对不同行业和不同类型OFDI制定差异化的对外直接投资政策。

关键词：对外直接投资水平型OFDI 垂直型OFDI 出口增加值

基于城镇化门槛模型的中国OFDI的碳排放效应研究

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中国人口·资源与环境 2016年第9期26卷 123-131页

作者：聂飞刘海云华中农业大学经济管理学院湖北武汉430070 华中科技大学经济学院湖北武汉430074

由于以城镇化为重点的经济发展被视为对外直接投资的基本条件,且城镇化、跨国投资的碳排放效应在现有文献中已被证实,构建包含以上三者的一体化分析框架是本文的主要目标。在我国新型城镇化发展背景下,研究如何更好通过"走出去"来实现... 详细信息

由于以城镇化为重点的经济发展被视为对外直接投资的基本条件,且城镇化、跨国投资的碳排放效应在现有文献中已被证实,构建包含以上三者的一体化分析框架是本文的主要目标。在我国新型城镇化发展背景下,研究如何更好通过"走出去"来实现城镇碳减排和经济集约化发展,具有必要性和现实意义。基于此,本文采用2003—2012年间中国30个省份的面板数据,在探讨各城镇化阶段对外直接投资影响母国碳排放发生机制的基础上,通过构建城镇化面板门槛模型和碳排放拓展模型,对中国城镇化进程中对外直接投资的碳排放效应的阶段性差异及其产生原因进行实证分析。研究表明,对外直接投资的碳排放效应存在城镇化率门槛值的制约,处于中高城镇化阶段的地区通过对外直接投资降低城镇碳排放水平的效果较之于处于低城镇化阶段的地区更为显著。具体看来,在中游城镇化率区段,对外直接投资能实现过剩产能输出和产业链升级,规模效应和结构效应构成了对外直接投资的碳排放效应的传导路径;在高度城镇化率区段,对外直接投资能实现污染密集型产业输出和技术溢出,规模效应和技术效应则构成了对外直接投资的碳排放效应的传导路径。进一步对城镇化集聚成本门槛效应分析发现,对外直接投资的规模效应、结构效应和技术效应分别是高度城镇化人口拥挤成本、竞争加剧成本和环境治理成本阶段的碳排放水平下降的主要原因。这意味着,要想充分发挥对外直接投资对碳减排的作用,城镇化率较高的地区尤其需要"因势利导"加快传统产业资本输出,优化资源配置和推动结构升级,实施创新驱动发展战略。同时,城镇化率较低的地区则应在工业化过程中,注意避免沦为高碳产业资本的污染"避难所"。

关键词： OFDI 碳排放城镇化门槛回归