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Marine bacterial surfactin CS30-2 induced necrosis-like cell death in Huh7.5 liver cancer cells

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Journal of Oceanology and Limnology 2020年第3期38卷 826-833页

作者： ZHOU Shengnan liu ge WU Shimei College of Life Sciences Qingdao UniversityQingdao 266071China Key Laboratory of Experimental Marine Biology Institute of OceanologyChinese Academy of SciencesQingdao 266071China Laboratory for Marine Biology and Biotechnology Qingdao National Laboratory for Marine Science and TechnologyQingdao 266071China

Marine bacterial strain Bacillus ***30 exhibited high anticancer activity against Huh7.5 human liver *** purified the corresponding anticancer agent by sequential acidic precipitation,methanol extraction,Sephadex LH-20 chromatography,and reversed phase high-performance liquid chromatography(RP-HPLC),then analyzed it in mass *** on the results of purification and mass spectrometry,we deduced that the anticancer agent was the same component as our previously purified antifungal agent surfactin ***,to the best of our knowledge,this is the first report on the surfactin possessing both antifungal and anticancer *** CS30-2 was demonstrated to exhibit high anticancer activity in a dose-dependent manner against Huh7.5 liver cancer *** investigation showed that surfactin CS30-2 induced the increased generation of reactive oxygen species(ROS)and severe disruption of cell membrane,thus leading to cell ***,unlike previously reported surfactins,surfactin CS30-2 caused cancer cell death via necrosis instead of apoptosis.

关键词： Bacillus surfactin anticancer activity reactive oxygen species(ROS)

Synthesis of LiFePO_4 /C as cathode material by a novel optimized hydrothermal method

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Rare Metals 2011年第5期30卷 433-438页

作者： GAO ge liu Aifang HU Zhonghua XU Yuanyuan liu Yafei Department of Chemistry Tongii University Shanghai 200092 China

Olivine LiFePO 4 , as a cathode material for lithium ion batteries, was prepared by a novel optimized hydrothermal method; afterwards, the product mixed with glucose was two-step （350℃ and 700℃） calcinated under high-purity N 2 atmosphere to obtain the LiFePO 4 /C composite. The study on the hydrothermal preparation method, which focused on the influences of molar ratios, initial pH value, reaction temperature, and duration, was made to promote the resultant performances and to investigate the relations between the performances and the reaction conditions. The resultant samples were characterized by X-ray diffraction （XRD）, scanning electron microscopy （SEM）, and electrochemical tests, which include charge-discharge, electrochemical impedance spectroscopy, and cyclic voltammetry. The result shows that the optimal hydrothermal condition is to set the Li：Fe：P molar ratio at 3：1：1 and the reaction temperature at 180℃ for 5 h duration with an initial pH value of 7. The optimized sample, with an average particle size of 100 to 300 nm and a discharge capacity of 118.2 mAh·g-1 at 0.1C, exhibits a stable and narrow-gapped charge-discharge platform and small capacity losses after cycles.

关键词： lithium ion batteries cathode materials phosphates olivine carbon deposition hydrothermal synthesis

East Asian-North Indian Ocean thermal contrast and variation in the East Asian summer monsoon for the past 2650 years

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Science China Earth Sciences 2011年第5期54卷 773-779页

作者： liu ge ZHAO Ping ZHOU XiuJi Chinese Academy of Meteorological Sciences Beijing 100081 China National Meteorological Information Centre Beijing 100081 China

Using observational data, the East Asian-North Indian Ocean index （]EANI）, which reflects a tropospheric thermal contrast, is found to correlate well with the East Asian summer monsoon （EASM） and associated rainfall over eastern China. Corresponding to a higher （lower） IEANI, the EASM at mid-latitudes is stronger （weaker）, and there is more （less） rainfall in North China and less （more） rainfall near the Yangtze River valley. To investigate long-term variation in the EASM, we reconstructed the BC 665AD 1985 IEANI based on reconstructed temperatures in Beijing and Tasmania, Australia. Over the past 2000 years, the reconstructed/EANI generally represents centennial-scale variations in the EASM and rainfall over eastem China. The correlation pattern between the reconstructed IEANI and rainfall over eastern China is similar to modem observations, implying that the correlation feature at centennial scales also occurred over the past 2000 years. With respect to longer-scale （several hundreds to one thousand years） IEANI variations and their correlations with rainfall, further verifications should be performed using various paleoclimatic proxy data.

关键词： East Asian summer monsoon thermal contrast reconstruction rainfall

POLY(MALEIC ANHYDRIDE-CO-ACRYLIC ACID)/POLY(ETHYLENE GLYCOL)HYDROgeLS WITH pH- AND IONIC-STRENGTH-RESPONSES

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Chinese Journal of Polymer Science 2010年第6期28卷 951-959页

作者： Meng Yang Bo-tian liu ge Gao Xiao-li liu Feng-qi liu College of Chemistry and Macdiarmid Laboratory Jilin University Changchun 130012 China

Poly（maleic anhydride-coacrylic acid）,P（MA-AA）,was synthesized by the free-radical copolymerization of maleic anhydride with acrylic acid,and fast responsive pH-sensitive poly（maleic anhydride-co-acrylic acid）/polyethylene glycol,P（MA-AA）/PEG,hydrogels were prepared using PEG as macromolecular cross-linking ***-IR and ~1H-NMR spectrometry were applied to characterize the structure of P（MA-AA）.The influences of pH and ionic strength on the swelling behavior of P（MA-AA）/PEG hydrogels and the swelling-deswelling changes along with the repeated changes between acid and alkali conditions were *** results showed that there was a hundredfold difference in the swelling ratios between the conditions of acid and alkali,and the swelling capability could not be weakened after multiple swelling-deswelling *** results of swelling kinetics demonstrated that the response rate of P（MA-AA）/PEG hydrogels was very fast,because the swelling transition points always occurred at 10 *** pH-responsive hydrogels reported here might be a smart material for potentially applications in many areas,including biosensors,drug-delivery devices and tissue engineering.

关键词： pH-response P(MA-AA) Macromolecular cross-linking agent External cross-linking

Decadal-centennial-scale change in Asian-Pacific summer thermal contrast and solar activity

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Chinese Science Bulletin 2011年第28期56卷 3012-3018页

作者： ZHAO Ping ZHOU XiuJi liu ge National Meteorological Information Centre Beijing 100081 China Chinese Academy of Meteorological Sciences Beijing 100081 China

To study the temporally varying features of summer thermal contrast between the Asian continent and the adjacent ocean on decadal-centennial time scales and the links between thermal contrast and solar irradiance, we used a time series of the reconstructed Asian-Pacific oscillation index and solar irradiance over the past millennium. The results showed that thermal contrast in the Asian monsoon region has quasi-90-year, 10-13-year, and 3-7-year periods. On the centennial time scale, thermal contrast showed three abrupt changes, occurring in 1305-1315, 1420-1430, and 1625-1635. There is a significant positive correlation between thermal contrast and solar irradiance, which is particularly strong at 250-year, 120-160-year, 60-70-year, and quasi-15-year periods. The three abrupt changes in thermal contrast corresponded to a significantly weakening or strengthening of solar irradiance, lagging 12-22 years behind the solar irradiance, which possibly reflects an effect of solar irradiance on the abrupt change in Asian monsoon climate on the centennial time scale. On the decadal time scale, the abrupt change in the thermal contrast was not closely associated with solar irradiance, which implies that solar activity may not be a major factor affecting the decadal abrupt change in Asian-Pacific thermal contrast. Relative to thermal contrast, the decadal abrupt change in Northern Hemispheric annual mean surface temperature is more closely associated with solar activity, while its centennial abrupt change has a weaker relationship with solar

关键词：太阳活动对比度年代际夏季热亚太地区百年尺度太阳辐照度时间尺度

High Precision Orbit Determination of CHAMP Satellite

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geo-Spatial Information Science 2006年第3期9卷 180-186页

作者： ZHAO Qile liu Jingnan ge Maorong Wuhan University 129 Luoyu Road Wuhan 430079 China.

The precision orbit determination of challenging minisatellite payload(CHAMP) satellite was done based on position and navigation data analyst(PANDA) software which is developed in Wuhan University, using the onboard GPS data of year 2002 from day 126 to 131. The orbit accuracy was assessed by analyzing the difference from GFZ post-processed science orbits (PSO), the GPS carrier and pseudo-range data residuals and the satellite laser ranging (SLR) residuals.

关键词： precision orbit determination CHAMP satellite onboard GPS data

Synergistic Contribution of Precipitation Anomalies over Northwestern India and the South China Sea to High Temperature over the Yangtze River Valley

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Advances in Atmospheric Sciences 2015年第9期32卷 1255-1265页

作者： liu ge WU Renguang SUN Shuqing WANG Huimei Chinese Academy of Meteorological Sciences Institute of Space and Earth Information Science/Department of geography and Resource Management/Shenzhen Research Institute Chinese University of Hong Kong Center for Monsoon System Research Institute of Atmospheric PhysicsChinese Academy of Sciences State Key Laboratory of Numerical Modeling for Atmospheric Sciences and geophysical Fluid Dynamics Institute of Atmospheric PhysicsChinese Academy of Sciences

This study explores the characteristics of high temperature anomalies over eastern China and associated influencing factors using observations and model *** show that more long-duration（over 8 days） high temperature events occur over the middle and lower reaches of the Yangtze River Valley（YRV） than over the surrounding regions,and control most of the interannual variation of summer mean temperature in *** synergistic effect of summer precipitation over the South China Sea（SCS） region（18°–27°N,115°–124°E） and the northwestern India and Arabian Sea（IAS） region（18°–27°N,60°–80°E） contributes more significantly to the variation of summer YRV temperature,relative to the respective SCS or IAS precipitation *** precipitation（enhanced condensational heating） over the SCS region strengthens the western Pacific subtropical high（WPSH） and simultaneously weakens the westerly trough over the east coast of Asia,and accordingly results in associated high temperature anomalies over the YRV region through stimulating an East Asia–Pacific（EAP） *** precipitation over the IAS region further adjusts the variations of the WPSH and westerly trough,and eventually reinforces high temperature anomalies over the YRV ***,the condensational heating related to more IAS precipitation can adjust upper-tropospheric easterly anomalies over the YRV region by exciting a circumglobal teleconnection,inducing cold horizontal temperature advection and related anomalous descent,which is also conducive to the YRV high temperature *** reproduction of the above association in the model results indicates that the above results can be explained both statistically and dynamically.

关键词： high temperature events Yangtze River Valley precipitation ECHAM5

The Summer Snow Cover Anomaly over the Tibetan Plateau and Its Association with Simultaneous Precipitation over the Mei-yu–Baiu region

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Advances in Atmospheric Sciences 2014年第4期31卷 755-764页

作者： liu ge WU Renguang ZHANG Yuanzhi NAN Sulan Chinese Academy of Meteorological Sciences Institute of Space and Earth Information Science and Shenzhen Research Institute the Chinese University of Hong Kong National Astronomical Observatories Chinese Academy of Sciences

The summer snow anomalies over the Tibetan Plateau （TP） and their effects on climate variability are often overlooked,possibly due to the fact that some datasets cannot properly capture summer snow cover over high *** satellite-derived Equal-Area Scalable Earth grid （EASE-grid） dataset shows that snow still exists in summer in the western part and along the southem flank of the *** demonstrates that the summer snow cover area proportion （SCAP） over the TP has a significant positive correlation with simultaneous precipitation over the mei-yu-baiu （MB） region on the interannual time *** close relationship between the summer SCAP and summer precipitation over the MB region could not be simply considered as a simultaneous response to the Silk Road pattern and the SST anomalies in the tropical Indian Ocean and tropical central-eastern *** SCAP anomaly has an independent effect and may directly modulate the land surface heating and,consequently,vertical motion over the western TP,and concurrently induce anomalous vertical motion over the North Indian Ocean via a meridional vertical *** a zonal vertical circulation over the tropics and a Kelvin wave-type response,anomalous vertical motion over the North Indian Ocean may result in an anomalous high over the western North Pacific and modulate the convective activity in the western Pacific warm pool,which stimulates the East Asia-Pacific （EAP） pattern and eventually affects summer precipitation over the MB region.

关键词： snow cover Tibetan Plateau mei-yu baiu precipitation

Asian-Pacific Oscillation index and variation of East Asian summer monsoon over the past millennium

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Chinese Science Bulletin 2009年第20期54卷 3768-3771页

作者： ZHOU XiuJi ZHAO Ping liu ge Chinese Academy of Meteorological Sciences Beijing 100081 China National Meteorological Information Centre Beijing 100081 China

To study the long-term variation of the East Asian summer monsoon(EASM),the Asian-Pacific Oscillation index(IAPO),representing a zonal thermal contrast between Asia and the North Pacific,is recon-structed over the past *** the Little Ice Age(LIA),the variability of the reconstructed IAPO is closely linked to dry-wet anomalies in eastern China on the centennial *** correlation pattern is consistent with the observation during the current period,which suggests that the reconstructed IAPO may generally represent the centennialscale variation of the EASM and rainfall anomalies over eastern China during the LIA.

关键词：东亚夏季风北太平洋夏季季风亚洲指数涛动中国东部地区降水异常