检索结果-南通市图书馆

中医学报 2024年第9期39卷 1992-2009页

作者：李越董博袁普卫刘德玉康武林陕西中医药大学第一临床医学院西安交通大学附属红会医院陕西中医药大学附属医院

目的：探讨铜死亡相关基因在脑胶质瘤发生发展中的作用及其与预后的关系，并筛选出可能影响这些基因表达或功能的中药。方法：获取脑胶质瘤相关数据集；采用R、Perl语言评估铜死亡相关基因的表达、变异；分别进行铜死亡基因分型、预后... 详细信息

目的：探讨铜死亡相关基因在脑胶质瘤发生发展中的作用及其与预后的关系，并筛选出可能影响这些基因表达或功能的中药。方法：获取脑胶质瘤相关数据集；采用R、Perl语言评估铜死亡相关基因的表达、变异；分别进行铜死亡基因分型、预后差异基因分型、多组学分析；构建预后模型、风险评分。按照风险评分分组，亚组多组学分析，检验生存预测能力；以铜死亡相关基因为靶点，采用传统中药系统药理学数据库（Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform, TCMSP）和Cytoscape软件构建“铜死亡靶点-成分-中药”网络，得出核心中药和核心成分。结果：大多数铜死亡相关基因在脑胶质瘤中表达异常，并能发生拷贝数变异，突变基因有NLR家族焦糖样域含有蛋白3（NOD-like receptor family pyrin domain containing 3,NLRP3）(1%)、铜输送ATP酶1（ATPase copper transporting alpha, ATP7A）(1%)、周期蛋白依赖性激酶抑制因子2A（cyclin-dependent kinase inhibitor 2A,CDKN2A）(1%)、铜输送ATP酶2（ATPase copper transporting beta, ATP7B）(1%)、金属调节转录因子1（metal regulatory transcription factor 1,MTF1）(1%)、谷氨酰胺合成酶（glutaminase, GLS）(1%);预后相关基因有ATP7A（P<0.001）、二肽基转移酶（dihydrolipoamide branched chain transacylase E2,DBT）(P=0.012)、甘油酸缩合酶（glycine cleavage system H protein, GCSH）(P<0.001)、核因子E2相关因子2（nuclear factor erythroid 2-related factor 2,NFE2L2）(P<0.001)、NLR家族焦糖样域含有蛋白3（NOD-like receptor family pyrin domain containing 3,NLRP3）(P<0.013),对铜死亡相关基因表达量数据经过聚类分析，差异有统计学意义（P<0.001）。在铜死亡分型中，A亚型的患者预后相对较好，该亚型在铜死亡及免疫相关通路中低表达，即活化的CD4+T淋巴细胞、活化的CD8+T淋巴细胞、活化的树突状细胞等免疫细胞呈低表达（P<0.001）。相反，铜死亡分型中的B亚型患者预后相对较差，与A亚型患者比较，差异有统计学意义（P<0.05）。A亚型与B亚型患者的差异性基因数量达到598个。通过将不同的铜死亡基因进行重新聚类分析，可以区分出3个不同的基因型（P<0.001）。在这些铜死亡预后差异基因分型中，3组的曲线下面积（area under the curve, AUC）值均大于0.7,其中B亚型患者预后最佳，而C亚型患者预后最差。B亚型的特点主要是铜死亡基因的低表达，而C亚型则主要是铜死亡基因高表达（P<0.001）。预后模型风险评分将患者分为高风险组、低风险组，低风险组铜死亡基因低表达、预后好，高风险组相反。通过列线图可对患者不同临床特征进行预后评估（女性、年龄49岁、低风险评分的患者预后得分为95.3分，其1年、3年、5年生存率分别为97.0%、85.5%、74.7%）;免疫细胞与风险评分相关性多呈负相关（P<0.05）;肿瘤微环境中基质细胞、免疫细胞及总评分均为低风险组更低，肿瘤突变负荷则高风险组更高（P<0.001）;干细胞与风险得分呈负相关（P<0.05）。“铜死亡靶点-成分-中药”网络得出核心成分主要包括鞣花酸、黄芩素、香叶木素、黄连碱、汉黄芩素、番茄红素等；核心中药主要包括牛膝、木蝴蝶、黄芩、银杏叶、赤芍、旋覆花等。归经主要在肝经（66次）、脾经（49次）、肺经（58次）、胃经（46次）,四气以平（36次）、温（34次）、寒（33次）为主，五味主要以苦（86次）、甘（51次）、辛（45次）为主。结论：铜死亡相关基因影响脑胶质瘤患者免疫和预后，牛膝、木蝴蝶、黄芩、银杏叶等中药可调节该基因在脑胶质瘤中的作用。

关键词：脑胶质瘤铜死亡基因生物信息学多组学分析预后模型

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Instant formation of excellent oxygen evolution catalyst film via controlled spray pyrolysis for electrocatalytic and photoelectrochemical water splitting

引用

Journal of Energy Chemistry 2022年第3期31卷 657-665,I0018页

作者： Na An Hengzheng Tian Yang Zhou Yalong Zou Hao Xiu Yufeng Cao Ying Wang Jianming Li deyu liu Yongbo Kuang School of Materials Science and Chemical Engineering Ningbo UniversityNingbo 315211ZhejiangChina Ningbo Institute of Materials Technology and Engineering Chinese Academy of SciencesNingbo 315201ZhejiangChina Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100000China Petroleum Geology Research and Laboratory Center Research Institute of Petroleum Exploration&Development(RIPED)PetroChinaBeijing 100083China

The retarded kinetics of oxygen evolution on electrodes is a bottleneck for electrochemical energy conversion and storage ***-based electrocatalysts provide a cost-effective choice to confront this ***,there is a lack of facile techniques for depositing compact catalytic films of high coverage and possessing a state-of-the-art performance,which is especially desired in photoelectrochemical(PEC)***,we demonstrate a spray pyrolysis(SP)route to address this issue,featuring the kinetic selective preparation towards the desired catalytic-active *** from reported SP protocols which only produce inactive oxides,this approach directly generates a unique composite film consisting of NiFe layered oxyhydroxides and amorphous oxides,exhibiting an overpotential as small as 255 mV(10 mA cm^(−2))and a turnover frequency of∼0.4 s^(−1)per metal *** using such a facile protocol,the surface rate-limiting issue of BiVO_(4)photoanodes can be effectively resolved,resulting in a charge injection efficiency of over 90%.Considering this deposition directly start from simple nitrates but only takes several seconds to complete,we believe it can be developed as a widely applicable and welcomed functionalization technique for diverse electrochemical devices.

关键词： Spray pyrolysis Oxygen evolution catalysts Layered oxyhydroxide Heterogeneous structure Thin film

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

大田种植园区数字化平台初探与设计

引用

智慧农业导刊 2024年第1期4卷 1-5页

作者：刘德余仲宝才郭茗月夏磊张翀唐梁尧成都东软学院计算机与软件学院软件工程系成都611844 成都东软学院计算机与软件学院智能科学与技术系成都611844

大田种植园区是实现乡村振兴的路径之一,但因其种植规模大,存在需大量劳动力完成园区管理、农事活动、资源滥用等问题。在农业现代化建设进程中,现代化信息技术正逐步应用于农业生产中。因此,该文根据大田种植园区实际发展需求将物联网... 详细信息

大田种植园区是实现乡村振兴的路径之一,但因其种植规模大,存在需大量劳动力完成园区管理、农事活动、资源滥用等问题。在农业现代化建设进程中,现代化信息技术正逐步应用于农业生产中。因此,该文根据大田种植园区实际发展需求将物联网、5G、大数据和遥感等数字化技术与大田种植园区管理需求、农业生产全流程深度融合,以园区数字化,数字赋能服务于园区为理念,以数据为中心,构建大田种植园区数字平台。同时,通过建设数据采集系统、园区数字大脑系统、园区一张图系统、农情监测系统和智能决策系统五大业务系统,实现数据采集、传输、汇聚、治理、存储和应用;在线远程查看园区情况及农作物生长状况;精准化、智能化进行农事活动。通过该平台的建设与应用,将盘活园区资源,进一步激发生产活力,助力农业数字化转型升级。

关键词：农业现代化大田种植园区数字化技术数字平台农业数字化

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Synthesis and High Electrocatalytic Performance of Hexagram Shaped Gold Particles Having an Open Surface Structure with Kinks

引用

Nano Research 2011年第6期4卷 612-622页

作者： Qingning Jiang Zhiyuan Jiang Lei Zhang Haixin Lin Ning Yang Huan Li deyu liu Zhaoxiong Xie Zhongqun Tian State Key Laboratory for Physical Chemistry of Solid Surfaces Department of Chemistry College of Chemistry and Chemical EngineeringXiamen University Xiamen 361005 China

Hexagram shaped gold particles and their analogues enclosed by high index facets with kinks have been successfully synthesized by reducing HAuCl4 with ascorbic acid （AA） in the presence of poly（diallyldimethylammonium chloride） at room temperature. By using electron microscopy, the surfaces of the hexagram shaped Au particle were found to be {541} planes, which contain high-density steps and kinks. In addition, it was found that hexagonal shield-like and other kind of particles present in the product were analogues of the hexagram shaped Au particles structure, in that they had the same surface structure. In order to confirm the surface structure of all the prepared particles, surface structure sensitive underpotential deposition of Pb was carried out, and the cyclic voltammetric profile was in accordance with the proposed {541} surface. Finally, structure-property relationships of the Au hexagrams were experimentally analyzed by employing the electrocatalytic oxidation of AA as a probe reaction. The electrocatalytic reactions of gold cubes with low-index {100} facets and gold trioctahedra with {221} facets were studied as references. The experimental results showed that the hexagram shaped Au particles and their analogues with exposed {541} facets have the highest catalytic activity among the three kinds of gold particles, owing to the high density of kink atoms. This study should motivate us to further explore methods for the preparation of other well-defined polyhedral metal nanocrystals enclosed by high index surfaces.

关键词： Hexagram shaped gold particles surface structure high index facets with kinks structure-property relationship electrocatalysis crystal growth

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Electricity-Heat-Based Integrated Demand Response Considering Double Auction Energy Market with Multi-Energy Storage for Interconnected Areas

引用

CSEE Journal of Power and Energy Systems 2024年第4期10卷 1688-1700页

作者： Dan Wang deyu Huang Qing'e Hu Hongjie Jia Bo liu Yang Lei Key Laboratory of Smart Grid of Ministry of Education Tianjin UniversityTianjin 300072China Key Laboratory of Smart Energy&Information Technology of Tianjin Municipality Tianjin 30072China

With development of integrated energy systems and energy markets,transactive energy has received increasing attention from society and academia,and realization of energy distribution and integrated demand response through market transactions has become a current research *** on optimized operation of a distributed energy station as a regional energy supply center is of great significance for improving flexibility and reliability of the *** on retail-side energy trading market,this study first establishes a framework of combined electric and heating energy markets and analyses a double auction market mechanism model of interconnected distributed energy *** study establishes a mechanism model of energy market participants,and establishes the electric heating combined market-clearing model to maximize global surplus considering multi-energy ***,in the case study,a typical user energy consumption scenario in winter is selected,showing market-clearing results and demand response effects on a typical *** of transmission line constraints,energy supply equipment capacity,and other factors on clearing results and global surplus are compared and analyzed,verifying the effects of the proposed method on improving global surplus,enhancing interests of market participants and realizing coordination and optimal allocation of both supply and demand resources through energy complementarity between regions.

关键词： Double auction energy market integrated energy system interconnected energy stations multi-energy storage

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Lactobacillus plantarum KLDS1.0386 with antioxidant capacity ameliorates the lipopolysaccharide-induced acute liver injury in mice by NF-κB and Nrf2 pathway

引用

Food Bioscience 2022年第3期47卷 184-196页

作者： Jiahuan Dong Lijun Ping Qinggang Xie deyu liu Li Zhao Smith Etareri Evivie Zhongjiang Wang Bailiang Li Guicheng Huo Key Laboratory of Dairy Science Ministry of EducationNortheast Agricultural UniversityHarbin150030China Food College Northeast Agricultural UniversityHarbin150030China Heilongjiang Feihe Dairy Co. LtdQiqihaer164800China Department of Food Science and Human Nutrition Faculty of AgricultureUniversity of BeninBenin City300001Nigeria Department of Animal Science Faculty of AgricultureUniversity of BeninBenin City300001Nigeria

The Lactobacillus is of great interest as a natural antioxidant to ameliorate liver injury for its antioxidant *** a previous experiment,Lactobacillus plantarum KLDS 1.0386 was excellent in adhesion and *** research assessed the antioxidant capacity of *** KLDS 1.0386 and how it ameliorates the LPS-induced acute liver *** vitro results showed that *** KLDS 1.0386 had potential antioxidant capacity with 27 genes,and it had better capacities in hydroxyl radicals scavenging and lipid antioxidant than the reference strain *** WCFS1 (P < 0.05).In vivo results,*** KLDS 1.0386 significantly reduced hepatic tissue injury,pro-inflammatory cytokines (TNF-α,IL-6),myeloperoxidase (MPO) activities and biochemical indicators of hepatotoxicity (ALT,AST,ALP) (P < 0.05),compared with the LPS-treated ***,*** KLDS 1.0386 increased the relative abundance of the genera,including Lachnospiraceae_NK4A136_group,Muribaculaceae and Alistipes,which significantly increased the level of acetic acid and butyric acid (P < 0.05).The results also showed *** KLDS 1.0386 significantly adjusted the expression of HO-1,NQO1,CAT,NF-κB,TLR4 and IκB-α in the liver (P < 0.05).Overall,these results indicated that *** KLDS 1.0386 had great functionality in reducing LPS-induced acute liver injury.

关键词： Lactobacillus plantarum Genomic analysis Lipid antioxidant Hydroxyl radical scavenging Gut microbiota SCFAs

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

刘德玉“四辨”论治非创伤性股骨头坏死的中医药保髋治疗经验

引用

长春中医药大学学报 2023年第10期39卷 1095-1100页

作者：刘楠王军威刘德玉陕西中医药大学第一临床医学院陕西咸阳712000 陕西中医药大学陕西咸阳712000 陕西中医药大学附属医院陕西咸阳712000

非创伤性股骨头坏死是临床常见且难治疾病。刘德玉教授认为,非创伤性股骨头坏死病病机主要包括瘀、痰、虚三方面,由气滞血瘀、肝肾亏虚及痰瘀蕴结而致的经络痹阻,骨失濡养。并提出“补肾活血生骨法”的治疗大法。在临证治疗中重视灵活... 详细信息

非创伤性股骨头坏死是临床常见且难治疾病。刘德玉教授认为,非创伤性股骨头坏死病病机主要包括瘀、痰、虚三方面,由气滞血瘀、肝肾亏虚及痰瘀蕴结而致的经络痹阻,骨失濡养。并提出“补肾活血生骨法”的治疗大法。在临证治疗中重视灵活运用关中李氏骨伤流派四辨思想对非创伤性股骨头坏死病进行论治,即辨证-辨中医证型,施治法方药;辨病-准确诊断,分期治疗;辨位-精确病位,精准治疗;辨体-辨体质特征,行个体化调护。为早中期非创伤性股骨头坏死的保髋治疗提供中医药的新思路及方法。

关键词：非创伤性股骨头坏死四辨思想保髋治疗关中李氏骨伤流派

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Solution-processed all-inorganic lead halide perovskite/layered double hydroxides superlattices

引用

Science China Chemistry 2024年第9期67卷 2904-2910页

作者： deyu Li Mingming Zhang Lulu Wei Shubing Tian Mingze Sun Kang liu Jixiang Xu Lei Wang Jun Xing Key Laboratory of Eco-chemical Engineering Ministry of EducationCollege of Chemistry and Molecular EngineeringQingdao University of Science&TechnologyQingdao 266042China College of Sino-German Science and Technology Qingdao University of Science&TechnologyQingdao 266042China

Quantum wells and superlattices are key building blocks in the semiconductor industry,normally fabricated using epitaxial growth techniques,such as vapor phase epitaxy,metalorganic chemical vapor deposition and molecular beam ***,these complicated preparation processes,as well as their high cost,limit their extensive *** is essential to develop a simple solution process for building ***,we demonstrate an ion exchange strategy for synthesizing an allinorganic superlattice cesium lead bromide/layered double hydroxides(CsPbBr_3/LDH)in *** room temperature,the perovskite ions diffuse into the interlayer of LDH and assemble into layered perovskite with various *** with traditional organic-inorganic hybrid perovskite superlattice,the all-inorganic perovskite superlattice CsPbBr_(3)/LDH has weak quantum confinement,which exhibits narrow emission line-widths of 20 nm,high quantum yields of 55%,and radiative lifetimes of several *** findings offer a new route to synthesize novel perovskite superlattices and enrich the perovskite supercrystal platform for electronics,photonics and optoelectronics devices.

关键词： halide perovskite superlattice layered double hydroxides 2D

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Analysis of clinical symptoms and signs in cases of oral submucous fibrosis which have transformed into squamous cell carcinoma

引用

Open Journal of Stomatology 2013年第3期3卷 235-240页

作者： Xinchun Jian Xieshan Huang deyu liu Pu Xu Xiacheng liu Department of Dental Implant Affiliated Haikou Hospital Xiangya Medical School Central South University Haikou Hainan China Department of Oral and Maxillofacial Surgery Affiliated Haikou Hospital Xiangya Medical School Central South University Haikou China

To analyze the clinical symptoms and signs in cases of oral submucous fibrosis which has transformed into squamous cell carcinoma, twenty-nine patients with squamous cell carcinoma correlated with oral submucous fibrosis, leukoplakia, lichen planus were taken biopsy for positive diagnosis. The clinical and pathological diagnosis of oral submucous fibrosis depended on clinical and pathological diagnostic standards. The oral submucous fibrosis involving different portions and size in the mouth was observed and recorded. The portions of oral cancer, clinical findings and symptoms, cancerous size, the conditions of the local lymphatic nodes and of oral submucous fibrosis correlated with squamous cell carcinoma in the mouth, oral leukoplakia, lichen planus were also observed and recorded. In twenty-nine patients with oral squamous cell carcinoma, duration from oral submucous fibrosis transformed into oral cancer ranged from 2 to 15 years with an average year of 6.69. The serious degrees of oral submucous fibrosis in the patients with oral cancer were that the moderately advanced stage was found in 3 cases (10.34%) and the advanced stage was found in 26 cases (89.65%). The cancerous portion was that the buccal mucosa was found in 9 cases (31.03%);the tongue was found in 14 cases (48.27%);the other portion was found in the rest 6 cases (20.68%). Among the twenty-nine patients twenty-three patients with squamous cell carcinoma were associated with leukoplakia (79.31%), five patients were associated with lichen planus (17.24%). Twenty-seven patients (93.1%) had habits of betel quid chewing, smoked cigarette and drank alcohol, the rest two patients had habits of betel quid chewing and cigarette smoking. The present study demonstrates that oral submucous fibrosis is a real precancerous lesion and may transform into squamous cell carcinoma in the mouth.

关键词： Oral Cancer Oral Submucous Fibrosis Oral Leukoplakia Oral Linchen Planus Oral Precancerous Lesion

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

淫羊藿中山柰酚防治骨质疏松症的机制的研究进展

引用

中国医药导报 2024年第10期21卷 189-192页

作者：郝庆飞袁普卫孟庆豪赵怡凡刘德玉王占魁余红超陕西中医药大学研究生院陕西咸阳712000 陕西中医药大学附属医院骨病科陕西咸阳712000

山柰酚是小檗科植物淫羊藿中主要有效成分,可调控成骨细胞、破骨细胞的增殖分化,促进骨髓间充质干细胞向成骨分化,从而调节骨代谢平衡。本文通过检索近年来有关山柰酚治疗骨质疏松症的文献进行综述,发现山柰酚主要是通过抑制白细胞介素... 详细信息

山柰酚是小檗科植物淫羊藿中主要有效成分,可调控成骨细胞、破骨细胞的增殖分化,促进骨髓间充质干细胞向成骨分化,从而调节骨代谢平衡。本文通过检索近年来有关山柰酚治疗骨质疏松症的文献进行综述,发现山柰酚主要是通过抑制白细胞介素、肿瘤坏死因子、JUN等炎症因子,调控核因子κB、雌激素受体、骨形态生成蛋白/Smads、Runx2等相关通路,继而影响成骨细胞、破骨细胞、骨髓间充质干细胞的分化成熟,抑制骨质疏松症的进程。本文为治疗骨质疏松症和研究新药物提供新的方案和依据。

关键词：山柰酚骨质疏松症成骨细胞破骨细胞机制

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：