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Exploring the mechanism of Buxue Yimu Pill on hemorrhagic anemia through molecular docking, network pharmacology and experimental validation

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Chinese Journal of Natural Medicines 2021年第12期19卷 900-911页

作者： XIONG Yan CAO Xu-yuan liu bo-yu DAI Yong-Qi ZHOU Heng-Jun HE Juan-Juan GONG yun WU Xue-Wen TANG Huai-bo Department of Chemical and Pharmaceutical Engineering School of Chemical EngineeringXiangtan UniversityXiangtan 411105China Zhuzhou Qianjin Pharmaceutical Co. Ltd.Zhuzhou 412000China Department of Chemistry School of ChemistryXiangtan UniversityXiangtan 411105China

Buxue Yimu Pill(BYP) is a classic gynecological medicine in China, which is composed of Angelica sinensis(Oliv.)Diels, Leonurus japonicus Houtt, Astragalus membranaceus(Fisch.) Bunge, Colla corii asini and Citrus reticulata Blanco. It has been widely used in clinical therapy with the function of enriching Blood, nourishing Qi, and removing blood stasis. The current study was designed to determine the bioactive molecules and therapeutic mechanism of BYP against hemorrhagic anemia. Herein, GC-MS and UPLC/Q-TOF-MS/MS were employed to identify the chemical compounds from BYP. The genecards database(https://***/) was used to obtain the potential target proteins related to hemorrhagic anemia. Autodock/Vina was adopted to evaluate the binding ability of protein receptors and chemical ligands. Gene ontology and KEGG pathway enrichment analysis were conducted using the Cluster Profiler. As a result, a total of 62 candidate molecules were identified and 152 targets related to hemorrhagic anemia were obtained. Furthermore, 34 active molecules and 140 targets were obtained through the virtual screening experiment. The data of molecular-target(M-T), target-pathway(T-P), and molecular-target-pathway(M-T-P) network suggested that 32 active molecules enhanced hematopoiesis and activated the immune system by regulating 57 important targets. Pharmacological experiments showed that BYP significantly increased the counts of RBC, HGB, and HCT, and significantly down-regulated the expression of EPO, IL-6, CSF3,NOS2, VEGFA, PDGFRB, and TGFB1. The results also showed that leonurine, leonuriside B, leosibiricin, ononin, rutin, astragaloside I, riligustilide and levistolide A, were the active molecules closely related to enriching Blood. In conclusion, based on molecular docking, network pharmacology and validation experiment results, the enriching blood effect of BYP on hemorrhagic anemia may be associated with hematopoiesis, anti-inflammation, and immunity enhancement.

关键词： Buxue Yimu Pill Hemorrhagic anemia GC-MS UPLC/Q-TOF-MS/MS Molecular docking Network pharmacology Experimental pharmacology

ALLELE DISTRIBUTION OF FIVE X-CHROMOSOME SHORT TANDEM REPEAT LOCI IN EWENKE POPULATION OF NORTH CHINA

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Chinese Medical Sciences Journal 2005年第4期20卷 237-241,页

作者： Shan-zhi Gu Teng Chen Qing-bo liu Bing yu Sheng-bin Li Key Laboratory of Environment and Genes Related to Diseases of Ministry of Education Xi＇an Jiaotong University Xi＇an 710061

Objective To study the allele genetic polymorphism of five short tandem repeat （STR） loci on X-chromosome in Ewenke population of north China and to provide basic data for forensic identification. Methods Genomic DNA was extracted from EDTA-whole blood of Ewenke population by Chelex-100. The DNA samples were amplified by PCR and were analyzed by polyacrylamide gel electrophoresis and silver staining. The sequence length variations of DXS6799, DXS8378, DXS101, HPRTB, and DXS6789 loci on X-chromosome in 98 unrelated Ewenke individuals were investigated. Results All five loci analyzed showed high polymorphism and genetic stability. The data of the five X-chromosome STR loci in Ewenke ethnic group of China was in accordance with Hardy-Weinberg equilibrium by Chi-square test. Conchusion Allele polymorphism of five X-chromosome STR loci can be used as a genetic marker for forensic identification and population genetic research.

关键词： allele distribution X-chromosome short tandem repeat Ewenke population

Situations and Countermeasures of CNPC Energy Saving and Consumption Reduction

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China Oil & Gas 2011年第2期18卷 34-39,52页

作者： Chen Youwang liu bo yu Jiqing PetroChina Planning and Engineering Institute

Situations and challenges China＇s energy-saving policies In the ＂Outline of the llth Five-Year Plan for National Economic ＆ Social Development of the People＇s Republic of China＂, China made energy saving one of its basic national policies and aimed to reduce energy consumption per unit GDP by 20% by the end of the ＂I lth Five-Year Plan＂ period. To achieve this goal, China has adopted a series of policies, releasing the statistical index system,

关键词：中国石油天然气集团公司节能降耗统计指标体系节能政策国家经济

The Application of Microcapsule in the Infrared Stealth Camouflage

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青岛大学学报（自然科学版） 2018年第B9期31卷 19-22页

作者： ZHANG Juan liu bo-yu liu Bei WANG Yao College of Mechanical Engineering Inner Mongolia University for the Nationalities

Infrared radiation is one of the main exposure symptoms of military targets. Infrared radiation differences between targets and backgrounds should be eliminated to the greatest extent to fight against all kinds of infrared reconnaissance. In addition to the employment of the camouflage paint with low emissivity, reducing the surface temperature of targets is an urgent and difficult challenge. PCM (phase-change material) can be used to effectively solve this problem. The application of microcapsule in the infrared stealth materials greatly promotes the development of infrared stealth technology.

关键词： PCM (phase-change material) microcapsule infrared stealth

Failed Transcatheter Closure of a Giant Ruptured Sinus of Valsalva Aneurysm

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Chinese Medical Journal 2015年第14期128卷 1985-1986页

作者： bo Zhang Yong Sun Jian Wu Jing-Yi Zhu Rui Cao Xiang-Lan liu bo yu Department of Cardiology Second Affiliated Hospital of Harbin Medical University Harbin Heilongjiang 150081 China

To the Editor： I want to introduce to you a very unusual case today. A 24-year-old man consulted us because of a 2-year history of palpitations and shortness of breath after physical exertion. Physical examination revealed a heart rate of 80 beats/min and blood pressure of 150/70 mmHg. Heart auscultation revealed diastolic and systolic （class Ⅵ） murmurs between the 3^rd and 4^th ribs at the left sternal border.

关键词： Failed Transcatheter Closure Giant Ruptured Sinus

Effect of Tanshitone on prevention and treatment of retinoic acid-induced osteoporosis in mice

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沈阳药科大学学报 2008年第S1期25卷 113-114页

作者： ZHOU Yan-meng,liu yu-bo,GAO yun-sheng(Pharmacy Department,Taishan Medical University,Tai’an 271016,China)

Objective To observe the prevention and therapeutic effects of tanshitone(TAN)on retinoic acid induced osteoporosis in *** The mice osteoporosis was induced by given retinoic acid intragasttrically for two *** histomorphological features of bone were observed and biochemical indexes in serum(Ca,P,ALP,TRAP,E2,BGP)were determined after mice were given TAN at the dose of 40,80,160 mg·kg-1 *** Tanshitone can induce high conversion of *** levels of P,ALP,TRAP and BGP in the TAN groups were lower than the model group,while the E2 level was higher than the model *** Tanshitone can prevent the loss bone in the experimental *** mechanism may be that it improves the level of estrogenic hormone and inhibits the high bone turnover.

关键词： tanshitone retinoic acid osteoporosis mice

韶关电网一次停电事故分析及其技术改造优化方案研究

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电力系统保护与控制 2011年第2期39卷 137-141页

作者：柳玉波甄卫国余涛广东电网公司韶关供电局广东韶关512026 华南理工大学电力学院广东广州510640

变电站备自投装置的优化配置对于一个地区电网的供电可靠性的提高作用显著。以韶关电网墨江片一起停电事故为例,应用BPA暂态稳定分析程序,分析了事故前后电网的运行特点及失电原因,研究了提高变电站供电可靠性的优化方案,针对该站的特... 详细信息

变电站备自投装置的优化配置对于一个地区电网的供电可靠性的提高作用显著。以韶关电网墨江片一起停电事故为例,应用BPA暂态稳定分析程序,分析了事故前后电网的运行特点及失电原因,研究了提高变电站供电可靠性的优化方案,针对该站的特殊情况设计备自投装置的动作逻辑和控制策略。动态仿真分析结果显示,所提方案使电网在同样事故条件,在不同运行方式下均能有效快速恢复片区供电,电压及频率恢复稳定至正常运行范围内,提高了电网的供电可靠性,方案可行。

关键词：备自投暂态稳定性动态稳定性 BPA仿真供电可靠性

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电动汽车车载电源LLC谐振变换器滑模控制

电机与控制学报 2020年第3期24卷 131-137页

作者：刘宇博王旭东哈尔滨理工大学电气与电子工程学院哈尔滨150080

为了增强电动汽车车载电源对负载扰动的鲁棒性,有效抑制系统输出电压的过冲,将一种改进的滑模控制策略应用于电动汽车车载电源控制系统中。为减少系统开关损耗,提高系统效率,车载电源采用LLC谐振变换器拓扑结构。利用扩展描述函数法建立... 详细信息

为了增强电动汽车车载电源对负载扰动的鲁棒性,有效抑制系统输出电压的过冲,将一种改进的滑模控制策略应用于电动汽车车载电源控制系统中。为减少系统开关损耗,提高系统效率,车载电源采用LLC谐振变换器拓扑结构。利用扩展描述函数法建立LLC谐振变换器的非线性模型,并在此基础上设计滑模控制方法。选取全局积分滑模面,通过动态的非线性滑模面,设计了整个运动过程中的滑动模态运动,显著地改善了对负载扰动的动态响应。通过仿真和实验证明了所提出的滑模控制策略有效解决了传统PI控制器在负载扰动较大情况下输出电压过冲过大的问题,提高了电动汽车车载电源控制系统动态品质。

关键词： LLC谐振变换器扩展描述函数法滑模控制全局积分滑模面车载电源

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套筒式张线天平的研制

实验流体力学 2012年第4期26卷 101-104页

作者：张平赵长辉刘博宇中国航空工业空气动力研究院沈阳110034

根据民机张线测力试验的特殊要求,研制了一台套筒结构形式的张线天平。详细介绍了该天平在研制中遇到的难点、关键技术的解决措施以及研制的结果。天平元件布置在58mm的外套筒上,内杆直径为44mm,外套筒和内杆通过楔块焊接在一起。... 详细信息

根据民机张线测力试验的特殊要求,研制了一台套筒结构形式的张线天平。详细介绍了该天平在研制中遇到的难点、关键技术的解决措施以及研制的结果。天平元件布置在58mm的外套筒上,内杆直径为44mm,外套筒和内杆通过楔块焊接在一起。法向力、俯仰力矩和滚转力矩为拉压变形,横向力和偏航力矩为'S'形变形,轴向力为弯曲变形,元件支撑部分受拉压变形且刚度较强。通过对天平进行有限元分析,在法向力和俯仰力矩作用下,得出的应变结果与实际输出基本吻合。风洞试验结果表明:天平设计合理,天平外套筒、内杆及张线支撑系统刚度好,天平各分量测量精度高。

关键词：张线天平张线支撑天平元件设计天平刚度风洞试验