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Knowledge and risk factors of intestinal parasitic infections among women in Makurdi,Benue State

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Asian Pacific Journal of Tropical Medicine 2010年第12期3卷 993-996页

作者： Amuta EU Houmsou RS Mker sd Department of Biological Sciences University of AgricultureMakurdiBenue StateNigeria Department of Biological Sciences Taraba State UniversityPMB 1167 JalingoTarba StateNigeria Department of Biological Sciences Benue State UniversityMakurdiNigeria

Objective:To assess women’s perceptions and risk factors that could expose them to intestinal parasitic infections in Makurdi,Benue ***:A total of 750 faecal samples were collected from women at different reproductive stages(*** and post-menstrual), and the faeces were tested by the formol ether concentration ***:A total of 426(56.8%) samples were found positive for various intestinal parasites with hookworm (4.8%),Ascaris lumbricoides(9.3%),Taenia sp(2.1%),Entamoeba histolytica(18.9%) and Entamoeba coli(21.6%).Women at pre-menstrual and post-menstrual stages recorded higher prevalence rates with 72.8%and 63.9%,*** significant difference in prevalence was observed between women at different reproductive stages and women infected by different parasites(χ~2=30.6.P> 0.05).Sweet things,rotten fruits and improperly cooked meat were perceived as the causes of intestinal parasitic infections among the pre and post menstrual *** of drinking water like river,well,water bought from vendors and patronizing food vendors were observed as risk factors contributing to the prevalence of intestinal parasitic infections among *** like not washing hands before eating and after defaecation,use of leaves and ordinary papers for cleaning after defaecation were also observed to be contributing to the prevalence of intestinal parasitic ***:Persuasive health education and rigorous hygiene measures should be employed in schools,maternity clinics and among the populace to reduce transmission and infection with intestinal parasites.

关键词： Intestinal parasites Menstrual Ascaris lumbricoides Makurdi Nigeria

Nitric oxide synthase distribution in esophageal mucosa and hemodynamic changes in rats with cirrhosis

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World Journal of Gastroenterology 1999年第3期5卷 213-216页

作者： Huang YQ Xiao sd Zhang DZ Mo JZ Gen Hosp Benxi Iron & Steel Co Dept Gastroenterol Benxi 117000 Peoples R China Shanghai Second Med Univ Shanghai Inst Digest Dis Renji Hosp Shanghai 200001 Peoples R China

AIM To observe the nitric oxide synthase (NOS) distribution in the esophageal mucosa andhemodynamic changes in cirrhotic *** NOS distribution in the loweresophagus of rats with carbon tetrachlorideinduced cirrhosis was assessed by using NADPHdiaphorase (NADPH-d ) histochemical *** of NO in serum were measured byfluorometric assay. Mean arterial pressure(MAP), cardiac output (CO), cardiac index (CI),splanchnic vascular resistance (SVR ), andsplanchnic blood flow (SBF ) were alsodetermined using 5’CO-labeled *** Intensity of NOS staining in theesophageal epithelium of cirrhotic rats wassignificantly stronger than that in *** was a NOS--positive staining area in theendothelia of esophageal submucosal vessels ofcirrhotic rats, but the NOS staining was negativein normal rats. NO concentration of serum incirrhotic rats were significantly higher incomparison with that of controls. Cirrhotic ratshad significantly lower MAP, SVR and higherSBF than those of the *** SPlanchnic hyperdynamiccirculatory state was observed in rats withcirrhosis. The endogenous NO may play animportant role in development of esophagealvarices and in changes of hemodynamics incirrhosis.

关键词： NADPH Nitric oxide synthase distribution in esophageal mucosa and hemodynamic changes in rats with cirrhosis

Transient elastography for the assessment of chronic liver disease: Ready for the clinic?

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World Journal of Gastroenterology 2007年第36期13卷 4791-4797页

作者： JFL Cobbold S Morin sd Taylor-Robinson Division of Medicine Faculty of Medicine Imperial College London London United Kingdom

Transient elastography is a recently developed non- invasive technique for the assessment of hepatic fi brosis. The technique has been subject to rigorous evaluation in a number of studies in patients with chronic liver disease of varying aetiology. Transient elastography has been compared with histological assessment of percutaneous liver biopsy, with high sensitivity and specificity for the diagnosis of cirrhosis, and has also been used to assess pre-cirrhotic disease. However, the cut-off values between different histological stages vary substantially in different studies, patient groups and aetiology of liver disease. More recent studies have examined the possible place of transient elastography in clinical practice, including risk stratifi cation for the development of complications of cirrhosis. This review describes the technique of transient elastography and discusses the interpretation of recent studies, emphasizing its applicability in the clinical setting.

关键词： FibroScan Transient elastography Liver stiffness measurement Hepatic fibrosis Hepatitis

Antitumoral activity of low density lipoprotein-aclacinomycin complex in mice bearing H_(22) tumor

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World Journal of Gastroenterology 2000年第1期6卷 140-142页

作者： Bi WX Xu sd Zhang PH Kong F Department of Biochemistry Shandong Medical UniversityJinan250012Shandong ProvinceChina Department of Gynaecology and Obstetrics First Affiliated Hospital of Shandong Medical UniversityJinan 250012Shandong ProvinceChina Department of Biochemistry Shandong Medical UniversityJinan 250012Shandong ProvinceChina

INTRODUCTIONCancer cells,which proliferate rapidly need largeamounts of cholesterol for new membrane synthesis,and high LDL receptor (LDLR) *** hasbeen proposed as a useful discriminatory vehicle forthe delivery of cy... 详细信息

关键词： Subject headings hepatoma cells lipoprotein low density aclacinomycin LDL receptor mice

慢性肌筋膜触发点模型大鼠的尿液代谢组学分析

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中国组织工程研究 2025年第8期29卷 1585-1592页

作者：刘琳刘世轩陆馨悦王侃南京体育学院运动健康学院江苏省南京市210014

背景:慢性肌筋膜触发点通过非靶向代谢组学技术可识别差异性代谢物变化,有助于从内源性小分子代谢物层面理解并进一步探究慢性肌筋膜触发点的病理生理过程和发病机制。目的:以慢性肌筋膜触发点模型大鼠为研究对象,基于尿液代谢组学寻找... 详细信息

背景:慢性肌筋膜触发点通过非靶向代谢组学技术可识别差异性代谢物变化,有助于从内源性小分子代谢物层面理解并进一步探究慢性肌筋膜触发点的病理生理过程和发病机制。目的:以慢性肌筋膜触发点模型大鼠为研究对象,基于尿液代谢组学寻找潜在生物标志物及相关代谢通路。方法:将16只sd大鼠随机分为造模组和正常组,造模组大鼠采用钝性打击结合离心运动(跑台坡度为-16°,跑速为16 m/min,训练时间为90 min/次)方式建立慢性肌筋膜触发点动物模型,每周1次,连续干预8周,休息4周;正常组大鼠不做干预。12周造模结束后,采用代谢笼法收集大鼠造模后24 h尿液,利用液相色谱-质谱联用非靶向代谢组学技术对尿样进行代谢图谱检测,筛选出共同差异代谢物,并进行生物信息学分析。结果与结论:①与正常组相比,造模组有32个差异代谢标志物,其中上调21个、下调11个;依据变量权重值>3,共14个差异代谢物被认定为潜在生物标志物;②京都基因与基因组百科全书富集分析表明,慢性肌筋膜触发点的形成与初级胆汁酸生物合成、花生四烯酸代谢通路密切相关。

关键词：肌筋膜触发点大鼠尿液代谢组学生物信息学生物标志物差异代谢物代谢笼法运动损伤

Chinese urbanization 2050： sd modeling and process simulation

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Science China Earth Sciences 2017年第6期60卷 1067-1082页

作者： GU ChaoLin GUAN WeiHua liu HeLin School of Architecture Tsinghua University Beijing 100084 China School of Architecture and Urban Planning Huazhong University of Science & Technology Wuhan 430074 China School of Geographical Sciences Nanjing Normal University Nanjing 210023 China

Is Chinese urbanization going to take a long time, or can its development goal be achieved by the government in a short time? What is the highest stable urbanization level that China can reach? When can China complete its urbanization? To answer these questions, this paper presents a system dynamic(sd) model of Chinese urbanization, and its validity and simulation are justified by a stock-flow test and a sensitivity analysis using real data from 1998 to 2013. Setting the initial conditions of the simulation by referring to the real data of 2013, the multi-scenario analysis from 2013 to 2050 reveals that Chinese urbanization will reach a level higher than 70% in 2035 and then proceed to a slow urbanization stage regardless of the population policy and GDP growth rate settings; in 2050, Chinese urbanization levels will reach approximately 75%, which is a stable and equilibrium level for China. Thus, it can be argued that Chinese urbanization is a long social development process that will require approximately20 years to complete and that the ultimate urbanization level will be 75–80%, which means that in the distant future, 20–25% of China's population will still settle in rural regions of China.

关键词： Chinese urbanization System dynamic (sd) model Scenario simulation

Endophytic fungi:a source of potential anticancer compounds

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Studies in Fungi 2021年第1期6卷 188-203页

作者： Palwe sd Borde MY Sonawane HB Department of Botany MGV’s ASC College SurganaDist.-Nashik-422211India Mycology Laboratory Department of Botany Savitribai Phule Pune UniversityGaneshkhindPune-411007India PG Research Centre in Botany PDEA’s Prof.Ramkrishna More ACS College AkurdiPune-411044India

Bioactive metabolites produced by different endophytic fungi have wide range of applications in pharmaceutical and herbal medicine *** contrast to plants,they are barely investigated to their boundless possibilities as storehouses of novel bioactive *** produce diverse metabolites by different biosynthetic pathways with the host *** for endophytes as a characteristic asset for new drugs was roused by the disclosure of paclitaxel-producing endophytic *** activity is by and large connected with the cytotoxicity of the compounds present in the endophytic *** classification of endophytic fungi is of great interest to mycologists as they can produce novel bioactive compounds with antitumor *** article audits anticancer compounds derived from endophytic fungi disengaged from the separate host *** endophytic fungi have been grouped by their host plants and anticancer compound synthesized.

关键词： antitumor activity bioactive metabolites classification host plant isolation

Modeling the impacts of drying trend scenarios on land systems in northern China using an integrated sd and CA model

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Science China Earth Sciences 2014年第4期57卷 839-854页

作者： HUANG QingXu HE ChunYang liu ZhiFeng SHI PeiJun State Key Laboratory of Earth Surface Processes and Resource Ecology (Beijing Normal University)

Climate-induced drought has exerted obvious impacts on land systems in northern *** recent reports by the Intergovernmental Panel on Climate Change(IPCC) have suggested a high possibility of climate-induced drought in northern China,the potential impacts of such drying trends on land systems are still *** use models are powerful tools for assessing the impacts of future climate *** this study,we first developed a land use scenario dynamic model(iLUsd) by integrating system dynamics and cellular ***,we designed three drying trend scenarios(reversed drying trend,gradual drying trend,and acceleration of drying trend) for the next 25 years based on the IPCC emission scenarios and considering regional climatic predictions in northern ***,the impacts of drying trend scenarios on the land system were simulated and *** accuracy assessment with historic data covering 2000 to 2005 indicated that the developed model is competent and reliable for understanding complex changes in the land use *** results showed that water resources varied from 441.64 to 330.71 billion m3 among different drying trend scenarios,suggesting that future drying trends will have a significant influence on water resource and socioeconomic *** the pressures of climate change,water scarcity,and socioeconomic development,the ecotone(i.e.,transition zone between cropping area and nomadic area) in northern China will become increasingly vulnerable and hotspots for land-use *** land and grassland would have the most prominent response to the drying *** land will expand around major metropolitan areas and the conflict between urban and cultivated land will become more *** results also show that previous ecological control measures adopted by the government in these areas will play an important role in rehabilitating the *** order to achieve a sustainable development in northern China,issues need to be

关键词： water resource constraints land use dynamics climate change scenario simulation drying trends in northern China

普伐他汀对大鼠坐骨神经压碎损伤功能恢复的影响

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中国组织工程研究 2025年第5期29卷 942-950页

作者：刘赞安冉李宝成内蒙古科技大学包头医学院内蒙古自治区包头市014000 内蒙古科技大学包头医学院第一附属医院手足踝外科内蒙古自治区包头市014010

背景:普伐他汀是临床上治疗高胆固醇血症的有效药物,目前发现其在中枢神经损伤的治疗上也能发挥有益作用,然而其机制仍未可知。目的:探究普伐他汀治疗能否加速坐骨神经压碎损伤的功能恢复及其潜在作用机制。方法:将雄性sd大鼠随机分为... 详细信息

背景:普伐他汀是临床上治疗高胆固醇血症的有效药物,目前发现其在中枢神经损伤的治疗上也能发挥有益作用,然而其机制仍未可知。目的:探究普伐他汀治疗能否加速坐骨神经压碎损伤的功能恢复及其潜在作用机制。方法:将雄性sd大鼠随机分为假手术组(坐骨神经暴露但不损伤+生理盐水灌胃)、阴性对照组(坐骨神经压碎损伤+生理盐水灌胃)、普伐他汀组(坐骨神经压碎损伤+普伐他汀灌胃)。普伐他汀组大鼠术后普伐他汀(5 mg/kg)灌胃治疗1周,其余两组大鼠给予等量生理盐水灌胃。术后观察各组大鼠一般情况;术后第2,4,6,8周末测量各组大鼠的坐骨功能指数;术后8周末测量腓肠肌湿质量比;ELISA法检测血清中炎症细胞因子的水平;组织形态计量学分析坐骨神经有髓神经纤维数目、纤维直径、轴突直径、髓鞘厚度;RT-qPCR检测神经生长因子、脑源性神经营养因子的mRNA表达量,Western blot法检测生长相关蛋白43的蛋白表达量。结果与结论:与阴性对照组相比,普伐他汀组坐骨神经功能指数恢复更快(P<0.05),更接近于假手术组水平,血清中炎症细胞因子肿瘤坏死因子α及白细胞介素6表达更低(P<0.05)且接近假手术组,坐骨神经中神经生长因子、脑源性神经营养因子的mRNA相对表达量增加(P<0.05或P<0.01),坐骨神经中生长相关蛋白43的蛋白相对表达量也明显增加(P<0.05),有髓神经纤维数目增加更多,纤维直径、轴突直径及髓鞘厚度数值更大(P<0.01)且与假手术组更接近。结果说明,普伐他汀的治疗加速了坐骨神经压碎损伤的功能恢复,其可能机制是抑制炎症细胞因子肿瘤坏死因子α及白细胞介素6的表达及促进神经营养因子神经生长因子、脑源性神经营养因子的分泌。

关键词：周围神经损伤普伐他汀功能恢复神经营养因子坐骨神经功能指数