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OsNAC5 orchestrates OsABI5 to fine-tune cold tolerance in rice

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Journal of Integrative Plant Biology 2024年第4期66卷 660-682页

作者： Ruiqing Li Yue Song Xueqiang Wang Chenfan Zheng bo liu Huali Zhang Jian Ke Xuejing Wu Liquan Wu Ruifang Yang Meng Jiang College of Agronomy Anhui Agricultural UniversityHefei 230036China Hainan Institute Yazhou Bay Sci-Tech CityZhejiang UniversitySanya 572025China National Key Laboratory of Rice Biology Advanced Seed InstituteZhejiang UniversityHangzhou 311225China State Key Laboratory of Rice Biology and Chinese National Center for Rice Improvement China National Rice Research InstituteHangzhou 311401China Key Laboratory of Germplasm Innovation and Genetic Improvement of Grain and Oil Crops(Co-Construction by Ministry and Province) Ministry of Agriculture and Rural AffairsCrop Breeding and Cultivation Research InstituteShanghai Academy of Agricultural SciencesShanghai 201106China

Due to its tropical origins,rice(Oryza sativa)is susceptible to cold stress,which poses severe threats to ***5,a NAC-type transcription factor,participates in the cold stress response of rice,but the detailed mechanisms remain poorly ***,we demonstrate that OsNAC5 positively regulates cold tolerance at germination and in seedlings by directly activating the expression of ABSCISIC ACID INSENSITIVE 5(OsABI5).Haplotype analysis indicated that single nucleotide polymorphisms in a NAC-binding site in the OsABI5 promoter are strongly associated with cold ***5 also enhanced OsABI5 stability,thus regulating the expression of cold-responsive(COR)genes,enabling fine-tuned control of OsABI5 action for rapid,precise plant responses to cold *** affinity purification sequencing coupled with transcriptome deep sequencing identified several OsABI5 target genes involved in COR expression,including DEHYDRATION-RESPONSIVE ELEMENT BINDING FACTOR 1A(OsDREB1A),OsMYB20,and PEROXIDASE 70(OsPRX70).In vivo and in vitro analyses suggested that OsABI5 positively regulates COR gene transcription,with marked COR upregulation in OsNAC5-overexpressing lines and downregulation in osnac5 and/or osabi5 knockout *** study extends our understanding of cold tolerance regulation via OsNAC5 through the OsABI5-CORs transcription module,which may be used to ameliorate cold tolerance in rice via advanced breeding.

关键词： ABA signaling ABI5 cold tolerance DREB NAC5 rice

Enhanced potency of an IgM-like nanobody targeting conserved epitope in SARS-CoV-2 spike N-terminal domain

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Signal Transduction and Targeted Therapy 2024年第6期9卷 2726-2737页

作者： bo liu Honghui liu Pu Han Xiaoyun Wang Chunmei Wang Xinxin Yan Wenwen Lei Ke Xu Jianjie Zhou Jianxun Qi Ruiwen Fan Guizhen Wu Wen-xia Tian George F.Gao Qihui Wang College of Veterinary Medicine Shanxi Agricultural University030801 JinzhongChina CAS Key Laboratory of Pathogen Microbiology and Immunology Institute of MicrobiologyChinese Academy of Sciences(CAS)100101 BeijingChina School of Life Sciences Yunnan University650504 KunmingYunnan ProvinceChina NHC Key Laboratory of Biosafety National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and Prevention(China CDC)102206 BeijingChina Savaid Medical School University of Chinese Academy of Sciences101408 BeijingChina

Almost all the neutralizing antibodies targeting the receptor-binding domain(RBD)of spike(S)protein show weakened or lost efficacy against severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)emerged or emerging variants,such as Omicron and its *** suggests that highly conserved epitopes are crucial for the development of neutralizing ***,we present one nanobody,N235,displaying broad neutralization against the SARS-CoV-2 prototype and multiple variants,including the newly emerged Omicron and its ***-electron microscopy demonstrates N235 binds a novel,conserved,cryptic epitope in the N-terminal domain(NTD)of the S protein,which interferes with the RBD in the neighboring S *** neutralization mechanism interpreted via flow cytometry and Western blot shows that N235 appears to induce the S1 subunit shedding from the trimeric S ***,a nano-IgM construct(MN235),engineered by fusing N235 with the human IgM Fc region,displays prevention via inducing S1 shedding and cross-linking virus *** to N235,MN235 exhibits varied enhancement in neutralization against pseudotyped and authentic viruses in *** intranasal administration of MN235 in low doses can effectively prevent the infection of Omicron sub-variant BA.1 and XBB in vivo,suggesting that it can be developed as a promising prophylactic antibody to cope with the ongoing and future infection.

关键词： doses prevention conserved

Hydromassage of macular hole edges for large and persistent full-thickness macular holes

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International Journal of Ophthalmology(English edition) 2024年第3期17卷 551-557页

作者： Yi Cai Wen-bo liu Duo Wei Xun Deng Xiao-Xin Li Ming-Wei Zhao Xuan Shi Jian-Hong Liang Department of Ophthalmology Peking University People’s HospitalBeijing 100044China Eye Diseases and Optometry Institute Beijing 100044China Beijing Key Laboratory of Diagnosis and Therapy of Retinal and Choroid Diseases Beijing 100044China College of Optometry Peking University Health Science CenterBeijing 100044China Xiamen Eye Center of Xiamen University Xiamen 361102Fujian ProvinceChina Department of Ophthalmology the Second Hospital of Lanzhou UniversityLanzhou 730030Gansu ProvinceChina

●AIM:To introduce the macular hole(MH)hydromassage technique as a potentially beneficial approach for the treatment of large or persistent MH.●METHODS:This retrospective observational case series comprised 16 consecutive patients(17 eyes)diagnosed with *** criteria involved a hole aperture diameter larger than 600μm or the presence of an unclosed MH larger than 600μm following the previous *** MH repair procedures were administered in all cases,involving the manipulation and aspiration of the hole margin through the application of water flow with a soft-tip flute needle.A comprehensive assessment was conducted for each case before and after surgery,and optical coherence tomography(OCT)images were captured at every follow-up point.●RESULTS:The mean preoperative aperture diameter was 747±156μm(range 611-1180μm),with a mean base diameter of 1390±435μm(range 578-2220μm).Following surgery,all cases achieved complete anatomical closure of MH,with 13 cases(76.5%)exhibiting type 1 closure and 4 cases(23.5%)demonstrating type 2 *** significant differences were observed in the preoperative OCT variables between the two closure *** with type 1 closure showed a significantly improved visual acuity(0.70±0.10,range 0.50-0.80)compared to those with type 2 closure(0.90±0.12,range 0.80-1.00,P=0.014).●CONCLUSION:The MH hydromassage technique demonstrates promising results,achieving acceptable closure rates in cases of large or persistent *** technique may serve as an effective adjunctive maneuver during challenging MH surgery.

关键词： macular hole large macular hole persistent macular hole optical coherence tomography surgical technique hydromassage

Isolation and characterization of spike S2-specific monoclonal antibodies with reactivity to pan-coronaviruses

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Virologica Sinica 2024年第1期39卷 169-172页

作者： Yabin Hu Jun Chen Jing Yang Zhanpeng liu Xiaoyue Zhang Qian Wu Lulu liu Shishan Teng Rongzhang He bo liu Xingyu Zheng Rui Lu Dong Pan You Wang Liting Peng Hongying chen Yi-Ping Li Wenpei liu Xiaowang Qu College of Basic Medical Sciences Hengyang Medical SchoolUniversity of South China&MOE Key Lab of Rare Pediatric DiseasesHengyang421001China Translational Medicine Institute The First People's Hospital of ChenzhouHengyang Medical SchoolUniversity of South ChinaChenzhou423000China College of Life Sciences Northwest A&F UniversityYangling712100China Institute of Human Virology Department of Pathogen Biology and Biosecurityand Key Laboratory of Tropical Disease Control of Ministry of EducationZhongshan School of MedicineSun Yat-sen UniversityGuangzhou510080China School of Public Health University of South ChinaHengyang421001China

Dear Editor,Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),theseventh coronavirus known to jump from intermediate hosts to humans,has resulted in a worldwide pandemic and caused immense economicdamage(Tan et al.,2020;Zhu et al.,2020).It is believed that coronavirus spillover may occur again in the *** exposure to a bat coro-navirus has been serologically confimed in a rural area of China,indi-cating that the coronavirus spillover occurred,although the origin andfrequency of spillovers are unclear(Wang et al.,2018).

关键词： monoclonal acute

Individualized anti-thrombotic therapy for acute myocardial infarction complicated with left ventricular thrombus: A case report

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World Journal of Clinical Cases 2024年第4期12卷 835-841页

作者： Yan Song Hua Li Xia Zhang Lei Wang Hong-Yan Xu Zhi-Chao Lu Xiao-Gang Wang bo liu Department of Clinical Pharmacy Zibo Municipal HospitalZibo 255400Shandong ProvinceChina Department of Cardiology Zibo Municipal HospitalZibo 255400Shandong ProvinceChina Department of Pharmacy Zibo Municipal HospitalZibo 255400Shandong ProvinceChina Department of Imaging Zibo Municipal HospitalZibo 255400Shandong ProvinceChina Department of Pulmonary and Critical Care Medicine Department of Clinical MicrobiologyZibo City Key Laboratory of Respiratory Infection and Clinical MicrobiologyZibo City Engineering Technology Research Center of Etiology Molecular DiagnosisZibo Municipal HospitalZibo 255400Shandong ProvinceChina

BACKGROUND Presently,there is no established standard anti-blood clot therapy for patients facing acute myocardial infarction(AMI)complicated by left ventricular thrombus(LVT).While vitamin K antagonists are the preferred choice for oral blood thinning,determining the best course of blood-thinning medication remains *** is unclear if non-vitamin K antagonist oral blood thinners have different effectiveness in treating *** study significantly contributes to the medical *** SUMMARY The blood-thinning treatment of a patient with AMI and LVT was *** blood-thinning therapy included daily enteric-coated aspirin tablets at 0.1 g,daily clopidogrel hydrogen sulfate at 75 mg,and dabigatran etexilate at 110 mg twice *** 15 d,the patient’s LVT did not decrease but instead *** pharmacists comprehensively analyzed the cases from the perspective of the patient’s disease status and drug *** drug regimen was reformulated for the patient,replacing dabigatran etexilate with warfarin,and was administered for six *** clinical pharmacist provided the patient with professional and standardized pharmaceutical *** patient’s condition was discharged after meeting the international normalized ratio value(2-3)*** patient fully complied with the follow-up,and the time in the therapeutic range was 78.57%,with no serious adverse effects during pharmaceutical *** Warfarin proves to be an effective drug for patients with AMI complicated by LVT,and its blood-thinning course lasts for six months.

关键词： Myocardial infarction Left ventricular thrombus Dabigatran etexilate Warfarin Clinical pharmacist Case report

基于改进BiSeNet V2的手机盖板缺陷检测方法

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光学学报 2024年第16期44卷 213-224页

作者：刘波王婷婷刘杰河海大学机电工程学院江苏常州213200

为实现手机盖板表面缺陷自动化检测,提出一种基于改进BiSeNet V2语义分割缺陷检测方法。首先,融合加权图像差分方法进行缺陷特征增强以便于网络模型提取缺陷特征;然后,用分组膨胀卷积层来提取细节分支网络不同尺度的缺陷特征以减少浅层... 详细信息

为实现手机盖板表面缺陷自动化检测,提出一种基于改进BiSeNet V2语义分割缺陷检测方法。首先,融合加权图像差分方法进行缺陷特征增强以便于网络模型提取缺陷特征;然后,用分组膨胀卷积层来提取细节分支网络不同尺度的缺陷特征以减少浅层细节信息的损失,引入通道注意力机制,自适应学习并校准缺陷特征通道之间的相关性,增强网络模型提取缺陷特征的能力;最后,解码网络采用多尺度特征融合方法,恢复特征提取过程中损失的局部细节信息,提高缺陷检测的分割精度和准确率。由实验结果可知,所提方法的缺陷检测准确率为91.27%,误分类率为5.02%,缺陷检出率为96.29%,缺陷漏检率为3.71%,正常样本误检率为1.00%,因此所提改进的网络模型对手机盖板表面各类缺陷具有较好的检测效果。

关键词：机器视觉手机盖板缺陷检测语义分割 BiSeNet V2

全覆盖处方点评对门、急诊抗菌药物合理应用的影响

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中国抗生素杂志 2024年第4期49卷 476-480页

作者：刘波成都市第二人民医院药学部成都610011

目的观察对门、急诊所有抗菌药物处方进行全覆盖大样本量的点评对医院抗菌药物合理用药影响。方法对门、急诊所有抗菌药物处方进行点评,本文通过实践前后对照的方法,将点评模式优化前(2022年)、优化后(2023年)的点评结果即不合格率进行... 详细信息

目的观察对门、急诊所有抗菌药物处方进行全覆盖大样本量的点评对医院抗菌药物合理用药影响。方法对门、急诊所有抗菌药物处方进行点评,本文通过实践前后对照的方法,将点评模式优化前(2022年)、优化后(2023年)的点评结果即不合格率进行比较和统计学处理,计数资料采用χ2检验。结果对比优化前,门急诊抗菌药物处方不合格率进一步降低。2023年与2022年相比明显降低,差异有统计学意义(P<0.05)。结论通过全覆盖处方点评、人工点评结合软件点评、学术交流和行政干预并行等措施可显著降低抗菌药物处方不合格率,持续改进不合理用药现象。

关键词：处方点评抗菌药物不合理使用全覆盖

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基于改进粒子滤波的锂离子电池剩余寿命预测

电力系统保护与控制 2024年第9期52卷 123-131页

作者：刘博尹杰李然哈尔滨理工大学传感器与可靠性工程研究所黑龙江哈尔滨150080 汽车电子驱动控制与系统集成教育部工程研究中心黑龙江哈尔滨150080

针对锂离子电池剩余寿命预测精度低、泛化能力差等问题,提出基于改进粒子滤波的预测方案。首先,提出双高斯模型作为退化经验模型,拟合锂离子电池的容量退化过程。然后,通过先验知识设置退化模型的初始参数,并利用粒子滤波方法进行参数... 详细信息

针对锂离子电池剩余寿命预测精度低、泛化能力差等问题,提出基于改进粒子滤波的预测方案。首先,提出双高斯模型作为退化经验模型,拟合锂离子电池的容量退化过程。然后,通过先验知识设置退化模型的初始参数,并利用粒子滤波方法进行参数更新。针对预测过程中出现的粒子退化问题,提出高斯混合方法进行粒子重采样,拟合重采样过程中粒子复杂的非线性分布和长尾分布,保证预测结果的概率密度分布状况均匀且集中。最后在不同的数据集上进行了实验验证,结果表明所提出的改进粒子滤波方案具有较高的精度和较强的鲁棒性。

关键词：锂离子电池剩余寿命预测粒子滤波高斯混合模型

以“生命政治”之名:在数字时代重思福柯的治理术

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理论与改革 2024年第1期 85-96页

作者：柳亦博中国海洋大学国际事务与公共管理学院

治理术是理解福柯治理思想的重要切面,通过对不同时代治理术的剖析,可以找到福柯有关生命政治思想的诞生源头。治理术可以被划分为16世纪之前的治理权术、16至19世纪的治理技艺、20世纪以来的治理算术,它们分别由统治权力、规训权力和... 详细信息

治理术是理解福柯治理思想的重要切面,通过对不同时代治理术的剖析,可以找到福柯有关生命政治思想的诞生源头。治理术可以被划分为16世纪之前的治理权术、16至19世纪的治理技艺、20世纪以来的治理算术,它们分别由统治权力、规训权力和摆置权力创制,旨在实现的治理则分别为“对人口的治理”“对国家的治理”以及“对想象力的治理”。其中,治理算术作为数字时代治理术的被异化形式,以一种隐蔽但强力的方式操纵社会,并由此产生了许多自身难以化解的风险。数字时代的治理应当重新回到“人的解放”这个核心议题,将实现“生命平等”和提高“生命质量”作为建构一种新治理术的核心主张。这种新治理术的实质是一种政治哲学,而福柯的“生命政治”概念则为建构这种政治哲学提供了相当充分的思想资源。

关键词：治理术生命政治福柯对人的治理治理哲学

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