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Neural Regeneration Research 2011年第33期6卷 2605-2609页

作者： liting zhu Zhonghan Li Bin Xu Chen Xia Jie Cheng Xiaoren Xiang Yi zhu Department of Acupuncture and Massage Second Clinical College Nanjing University of Traditional Chinese Medicine Nanjing 210046 Jiangsu Province China National Key Laboratory of Acupuncture and Medicine of China Nanjing 210029 Jiangsu Province China Department of Acupuncture and Rehabilitation Jiangsu Province Chinese Medicine Hospital Nanjing 210029 Jiangsu Province China

We studied the effects of electroacupuncture at Zusanli （ST 36） on neurons in the colonic myenteric plexus and on defecation in rats with irritable bowel syndrome with constipation （IBS-C）. We also used intragastric administration of pinaverium bromide as a positive control treatment to reveal the pathway mediating the onset of IBS-C. Both electroacupuncture and pinaverium bromide greatly improved defecation in rats with IBS-C. Immunohistochemical staining of the enteric nervous system neuronal marker protein gene product 9.5 in the colonic myenteric plexus showed that electroacupuncture by itself, or in combination with pinaverium bromide, increased the number of neurons and the staining intensity of protein gene product 9.5 in the colonic myenteric plexus. We conclude that visceral hypersensitivity is likely to be a primary cause of constipation in IBS-C rats.

关键词： electroacupuncture irritable bowel syndrome with constipation colonic myenteric plexus neurons pinaverium bromide defecation neural regeneration

Wear Characteristics of the Nuclear Control Rod Drive Mechanism(CRDM)Movable Latch Serviced in High Temperature Water

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Chinese Journal of Mechanical Engineering 2022年第2期35卷 111-120页

作者： Tianda Yu Guozhong Fu Yanqing Yu liting zhu Maofu Liu Wei Li Qiang Deng Zhenbing Cai The State Key Laboratory of Power Transmission Equipment&System Security and New Technology Chongqing UniversityChongqing 4000442China Science and Technology on Reactor System Design Technology Laboratory Nuclear Power Institute of ChinaChengdu 610041China Tribology Research Institute Southwest Jiaotong UniversityChengdu 610031China Sichuan Huadu Nuclear Equipment Manufacturing Co. LtdDujiangyan 611830China

The current research of nuclear control rod drive mechanism(CRDM)movable latch only makes a simple measurement of wear *** wear volume and difference in various claw surfaces are ignored and the degradation mechanism of each claw surface is not *** this paper,a detailed degradation analysis was carried out on each claw surface of movable latch combined with wear result and worn *** indicate that the boundary of carbide is preferred for corrosion because carbide presents a nobler Volta potential compared to the metal matrix or boundary *** to the oscillation of drive shaft between the claw surfaces of movable latch,the dominant wear mechanism on the upper surface of claw(USC)and lower surface of claw(LSC)is plastic deformation caused by impact *** impact wear will cause the fragmentation of carbides because of the high hardness and low ductility of *** promotes the broken carbides to fall off from the metal *** generated fine carbides(abrasive particles)cause extra abrasive wear on USC when the movable brings the drive shaft upward or *** a result,USC has a higher wear volume than *** research proposes a method to evaluate the wear on the whole movable latches using a 3D full-size scanner.

关键词： CRDM Movable latch Degradation analysis Wear characteristics Carbide

Effects of Nourishing “Yin”-Removing “Fire” Chinese Herb Mixture on the Expression of GABAB Receptors in Hypothalamus of Precocious Puberty Female Rats

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Chinese Medicine 2016年第2期7卷 55-66页

作者： Zhejun Chen Zehui Meng Shiran Wang liting zhu Zhanzhuang Tian Department of Integrative Medicine and Neurobiology Institute of Acupuncture Research Institutes of Brain Science Collaborative Innovation Center for Brain Science State Key Laboratory of Medical Neurobiology Shanghai Medical College of Fudan University Shanghai China

Objectives: To investigate the potential role of GABAB Receptors (GABABRs) involved in the effect of Nourishing “Yin”-Removing “Fire” Chinese herb mixture (TCM) treatment on precocious puberty. Methods: Female Sprague-Dawley rats were randomly divided into four groups: normal (N), central precocious puberty (CPP) model (M), CPP fed with normal saline (S) and CPP fed with Nourishing “Yin”-Removing “Fire” Chinese herb mixture (TCM). Rats of postnatal day 5 were given a single subcutaneous injection of 240 μg danazol to establish CPP model rats. Rats of S and TCM groups were continuously administered with saline or nourishing “Yin”-removing “Fire” Chinese herb mixture since postnatal day 15. The expression of GABABRs was detected by means of real-time PCR and immunohistochemistry. Results: The expression of hypothalamic GnRH mRNA in M was significantly increased on the day of pre-puberty when compared with that of N (P B1 receptor (GABABR1) immunoreactive cells in the arcuate nucleus (ARN) was decreased in M when compared with that of N (P B2 receptor (GABABR2) immunoreactive cells in the ARN, MS and diagnonal band of broca (DBB) were decreased in M when compared with those of N (P < 0.05) and increased in TCM compared

关键词： Precocious Puberty GABAB Receptors Chinese Herb Medicine Danazol Rats

Electroacupuncture (EA) Speeds Up the Regulation of Hypothalamic Pituitary Adrenal Axis Dysfunction in Acute Surgical Trauma Rats: Mediated by Hypothalamic Gamma-Aminobutyric Acid (GABA)<sub>A</sub>Receptors

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Journal of Behavioral and Brain Science 2018年第12期8卷 697-710页

作者： liting zhu Jing zhu Zhejun Chen Zehui Meng Mingda Ju Mizhen Zhang Gencheng Wu Zhanzhuang Tian Department of Integrative Medicine and Neurobiology School of Basic Medical Sciences State Key Laboratory of Medical Neurobiology Institutes of Brain Science Institute of Acupuncture Research Academy of Integrative Medicine Fudan University Shanghai China Department of Anatomy School of Basic Medicine Shanghai University of Traditional Chinese Medicine Shanghai China

Hypothalamic Corticotropin-releasing factor (CRF) directly activates the hypothalamic pituitary adrenal axis (HPA axis) during the surgical trauma induced stress response. Electroacupuncture (EA) has been demonstrated to have stress relieving effects in breast surgery, colorectal surgery, prostatectomy and craniotomy. This study was aimed to investigate the hypothesis that EA could regulate hypothalamic CRF in surgical trauma rats. In experiment one, Sprague-Dawley (SD) male rats were divided into intact, model (10% partial hepatectomy), sham EA and EA group. Rats from the Sham EA and EA group were stimulated at ST36-Zusanli and SP6-Sanyiniiao acupoints twice, 24 hours before the surgery and immediately after the surgery. Expressions of hypothalamic CRF and CRFR, GABA receptors, glutamate decarboxylase (GAD), serum adrenocorticotropic hormone (ACTH) and Corticosterone (CORT) were observed at 2, 4, 8 and 24 h after the surgery by radioimmunoassay (RIA), western blot, real-time PCR and immunohistochemistry. In the experiment two, SD male rats were divided into the intact, model, model + vehicle, model + L-838,417 EA and EA + L838,417 group. It was found that hypothalamus CRF, serum ACTH and CORT levels were increased in model group compared with the intact group, and those in the EA group decreased in comparison with the model group. Compared with the model group, hypothalamus-aminobutyric acid (GABA) receptor Aα3 mRNA and protein expressions of the EA group raised strikingly. In conclusion, EA alleviated surgical stress response by improving the GABA synthesis in hypothalamus, thus enhancing GABA receptors’ inhibitory regulation of the HPA axis dysfunction in rats with acute surgical trauma.

关键词： Electroacupuncture Hypothalamic Pituitary Adrenal Axis γ-Aminobutyric Acid (GABA) Receptor Corticotropin Releasing Factor Surgery

基于几何约束优化的重复控制器及PMSM电流谐波抑制应用

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电工技术学报 2024年第4期39卷 1059-1073页

作者：朱元朱醴亭肖明康孟令同济大学汽车学院上海201804

重复控制器凭借其具有多个谐振峰而广泛应用于电流谐波抑制领域,然而在实际电机控制系统中,由于系统采样频率固定而电流谐波频率随电机转速而变化,会导致重复控制器中出现分数阶延时环节,而该环节在实际控制器中无法实现。对此,该文针... 详细信息

重复控制器凭借其具有多个谐振峰而广泛应用于电流谐波抑制领域,然而在实际电机控制系统中,由于系统采样频率固定而电流谐波频率随电机转速而变化,会导致重复控制器中出现分数阶延时环节,而该环节在实际控制器中无法实现。对此,该文针对现有分数阶处理方法进行讨论,分析了插值逼近方法中插值系数对重复控制器整体频率特性的作用,据此提出基于几何约束优化的分数阶重复控制器,通过优化各插值系数,电机在全转速范围内都可以保证谐振频率和电流谐波频率相吻合,并且谐振峰值更符合电机谐波组成规律;还分析了滤波器所处反馈回路位置对频率特性的影响,作为组合滤波器设计依据;为保证系统稳定,对包含PI、重复控制器以及离散电机模型的电流控制系统进行稳定性分析,并作为控制参数选取依据。最后,通过台架实验验证了该文所提出的方法的谐波抑制性能是更优的。

关键词：分数阶延时环节重复控制器控制稳定性谐波抑制永磁同步电机(PMSM)

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激光微加工设备模块化设计

应用激光 2009年第2期29卷 120-122页

作者：朱立汀张伟上海市激光技术研究所上海200233 上海市激光束精细加工重点实验室上海200233

近年来,激光精细加工技术在我国的先进制造业特别是微加工领域得到了迅猛的发展,作为一种新兴的加工技术,其有非接触、无磨损、无污染、效率高、附加值高等传统技术无法比拟的先进性和优越性,正在逐步取代现有技术成为精细加工技术主流... 详细信息

近年来,激光精细加工技术在我国的先进制造业特别是微加工领域得到了迅猛的发展,作为一种新兴的加工技术,其有非接触、无磨损、无污染、效率高、附加值高等传统技术无法比拟的先进性和优越性,正在逐步取代现有技术成为精细加工技术主流。研究首先介绍了激光精细加工设备模块化设计的发展背景及重要性。然后,重点分析了各个基础模块,介绍了关键功能模块。接着,论述了模块的一体化控制技术和通讯接口技术。最后,对研究作了总结。

关键词：激光微加工模块化功能模块通讯接口

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涂层锆合金冲击-滑动磨蚀损伤行为

中国表面工程 2022年第4期35卷 21-29页

作者：张强李思功周腾朱丽婷中广核研究院有限公司深圳518000 西南交通大学摩擦学研究所成都610031

磨损是核电厂燃料元件失效的主要形式之一。燃料棒与定位格架磨损可能导致包壳破损和裂变产物泄露,引起一回路剂量超标,影响核电厂安全运行。在实际工况中,流体湍流引起格架和燃料棒之间的相对运动,其界面发生的位移可能是往复滑动,间... 详细信息

磨损是核电厂燃料元件失效的主要形式之一。燃料棒与定位格架磨损可能导致包壳破损和裂变产物泄露,引起一回路剂量超标,影响核电厂安全运行。在实际工况中,流体湍流引起格架和燃料棒之间的相对运动,其界面发生的位移可能是往复滑动,间歇冲击或数个运动的组合,即冲击-滑动摩擦磨损。涂层锆合金是事故容错燃料最有应用潜质的候选包壳,其磨损研究尚不够系统和全面。采用新型可控能量冲击-滑动磨损试验机,研究冲击能量和循环次数对锆合金Cr涂层磨蚀损伤行为的影响,并且对试验后试样进行白光干涉仪、扫描电镜(SEM)及电子探针(EPMA)等的表征,阐述锆合金Cr涂层磨蚀损伤的行为规律。结果表明:试样磨损随着循环次数的增加而增大,但随着冲击能量的增大而减小;Cr涂层提高了界面的接触刚度和接触正压力值,并且减少了冲击过程中的接触时间,从而减小了包壳管材料的磨损。关注锆合金Cr涂层在低速高频模式下的耐磨损性能,可以为材料的工程应用提供试验数据。

关键词：锆合金 Cr涂层冲击-滑动磨蚀

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北京市顺义区3~6岁儿童屈光状态与眼球生物性参数相关关系的调查研究

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中华眼科杂志 2023年第8期59卷 636-642页

作者：袁静徐庆诸立婷蒋爱民北京市顺义区医院眼科北京101300

目的探讨北京市顺义区学龄前儿童屈光状态与眼球生物学参数的关系。方法横断面研究。采用随机整群分层抽样的方法(抽签法),对北京市顺义区11所幼儿园的3~6岁儿童采用光学生物测量仪测量眼轴长度(AL)、角膜曲率(CR)、前房深度、角膜水平... 详细信息

目的探讨北京市顺义区学龄前儿童屈光状态与眼球生物学参数的关系。方法横断面研究。采用随机整群分层抽样的方法(抽签法),对北京市顺义区11所幼儿园的3~6岁儿童采用光学生物测量仪测量眼轴长度(AL)、角膜曲率(CR)、前房深度、角膜水平径(WTW),计算AL与角膜曲率半径的比值(AL/CR)。1%盐酸环喷托酯麻痹睫状肌后电脑验光,计算等效球镜度数(SE)。比较不同年龄和屈光状态儿童的眼生物学参数,并对SE及眼各生物学参数进行相关性分析及回归分析。结果1142名儿童完成检查,年龄为(4.52±0.87)岁,包括3岁119人,4岁487人,5岁362人,6岁174人。其中男童554人,女童588人。受检儿童SE为(1.19±0.81)D,AL为(22.27±0.67)mm,角膜曲率半径为(7.73±0.25)mm,前房深度为(3.33±0.67)mm。3、4、5、6岁的受检儿童平均SE分别为1.18、1.19、1.21、1.13 D。SE与AL、AL/CR、前房深度均存在相关性(r=-0.350,-0.542,-0.083;均P0.05)。不同屈光状态的儿童中,近视、远视、高度远视儿童的SE与AL、AL/CR相关性较正视儿童强;年龄越大的儿童的SE与AL、AL/CR相关趋势越强。SE与AL、AL/CR直线回归方程分别为SE=10.64-0.42·AL、SE=21.48-7.043·AL/CR。结论北京市顺义区3~6岁儿童的屈光度数变化较小,近视儿童表现为AL更长,前房更深,角膜略陡。

关键词：屈光,眼轴长度,眼生物测量学儿童北京

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高一呼油画风景的色彩语言及地域性风格研究

龙岩学院学报 2019年第6期37卷 93-98页

作者：朱荔婷龙岩学院

高一呼是福建现代油画史上重要的代表性画家。他在福建地域文化的浸润之下,驻足本土,潜心探索和实践,发掘了福建风景相对完整的光色谱系,并由此在艺术面貌上形成了抒情写实风格,为当下中国油画语言的本土文化的探索和构建,呈现了一个有... 详细信息

高一呼是福建现代油画史上重要的代表性画家。他在福建地域文化的浸润之下,驻足本土,潜心探索和实践,发掘了福建风景相对完整的光色谱系,并由此在艺术面貌上形成了抒情写实风格,为当下中国油画语言的本土文化的探索和构建,呈现了一个有意义的视觉文本路径。他的油画风景色彩语言可以从绿色的发掘与表达、光色的表现与融合、色彩语言的嫁接与转换三个维度挖掘其特质。高一呼在福建地域文化情境中,创造出了具有独特的福建亚热带样式的油画风景色彩语言,形成了抒情的写实主义画风。

关键词：高一呼油画风景色彩语言地域性风格

我国货币政策是否关注资产价格？--基于马尔科夫区制转换BEKK多元GARCH模型

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金融研究 2017年第11期 1-17页

作者：王曦朱立挺王凯立中山大学岭南学院广东广州510275 东海大学管理学院中国台湾台中

本文借鉴并扩展现有宏观经济模型,导出含有多种资产价格关注特征的货币政策规则。然后分别将房地产、股票价格以及金融状况指数(FCI)作为资产价格变量,使用包含马尔科夫区制转换的BEKK多元GARCH模型来研究我国货币政策对资产价格的反应... 详细信息

本文借鉴并扩展现有宏观经济模型,导出含有多种资产价格关注特征的货币政策规则。然后分别将房地产、股票价格以及金融状况指数(FCI)作为资产价格变量,使用包含马尔科夫区制转换的BEKK多元GARCH模型来研究我国货币政策对资产价格的反应,以捕捉货币政策的时变特征。研究发现:(1)货币政策对资产价格的关注具有马尔科夫区制转换特征;(2)使用综合性的FCI指标,效果要优于使用单一的房价指数或股价指数;(3)货币政策仅在资产价格波动剧烈时才对其进行关注,在其他时期仍符合传统泰勒规则,仅关注产出缺口和通货膨胀率。分时段检验发现以上结论是稳健的。这说明,央行确实关注了资产价格并体现出维护金融稳定的宏观审慎管理特征。

关键词：货币政策资产价格马尔科夫区制转换