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Chinese Annals of Mathematics,Series B 2022年第5期43卷 643-658页

作者： liting you Huijuan SONG Jingxue YIN School of Mathematical Sciences South China Normal UniversityGuangzhou 510631China School of Mathematics and Statistics Jiangxi Normal UniversityNanchang 330022China

In this paper,the authors study the multiplicity of solutions to the weighted p-Laplacian with isolated singularity and diffusion suppressed by convection-div(|x|^(α)|■u|^(p-2)■u)+λ^(1)/|x|β|■u|^(p-2)■u·x=|x|^(γ)g(|x|)in B{0}subject to nonlinear Robin boundary value condition|x|^(α)|■u|^(p-2)■u·n=A-ρu on■B,whereλ>0,B■RN(N≥2)is the unit ball centered at the origin,α>0,p>1,β∈R,γ>-N,g∈C(0,1])with g(0)>0,A∈R,ρ>0 and n is the unit outward *** same problem with diffusion promoted by convection,namely λ≤0,has already been discussed by the last two authors(Song-Yin(2012)),where the existence,nonexistence and classification of singularities for solutions are *** different from[Song,*** Yin,J.X.,Removable isolated singularities of solutions to the weighted p-Laplacian with singular convection,***.,35,2012,1089-1100],in the present caseλ>0,namely the diffusion is suppressed by the convection,non-singular solutions are not only existent but also may be infinite which vary according only to the values of solutions at the isolated singular *** the same time,the singular solutions may exist only if the diffusion dominates the convection.

关键词： Weighted p-Laplacian Multiplicity of solutions Isolated singularities Convection

Expression and prognosis analyses of Dectin-1 cluster genes in patients with lung adenocarcinoma (LUAD) and the association with immune checkpoint molecules

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BIOCELL 2021年第3期45卷 649-663页

作者： liting you FEIFEI NA JUAN ZHOU LIN JIAO YI ZHOU BINWU YING West China School of Medicine West China HospitalSichuan UniversityChengdu610041China Department of Thoracic Cancer West China HospitalSichuan UniversityChengdu610041China Department of Laboratory Medicine West China HospitalSichuan UniversityChengdu610041China

Reviews The Dectin-1 cluster comprises seven members:CLEC-12A,CLEC-12B,CLEC-1A,CLEC-7A,CLEC-2,CLEC-9A and *** members have been demonstrated to be involved in the tumorigenesis,progression,and metastasis of several ***,little is known about their roles in human lung adenocarcinoma(LUAD).The expression patterns of the Dectin-1 cluster were analyzed via the ONCOMINE and GEPIA *** evaluated the prognostic value of the Dectin-1 cluster in patients with LUAD using the Kaplan-Meier plotter and *** expression was validated with the EMBL-EBI database,and protein expression was analyzed with the HPA *** addition,protein-protein interaction network,GO,and KEGG analyses were ***,the correlations between CLEC-12A and immune molecules(immune inhibitors and MHC molecules)were investigated via TISIDB and *** expression levels of Dectin-1 cluster genes were downregulated in LUAD tissues compared to those in normal lung *** expression levels of CLEC-12A,CLEC-12B,CLEC-2,and CLEC-9A correlated with tumor stage,and CLEC-12A and CLEC-12B were significantly associated with survival in patients with *** seven genes mostly participated in immune regulation processes and were involved in autoimmune disorders and hematological ***,correlation analyses revealed CLEC-12A expression was associated with most immune inhibitors and ***-12A was positively related to PD-1,PD-L1,PD-L2,CTLA4,TIM3,and *** conclusion,our findings suggest that CLEC-12A and CLEC-12B can be used as prognostic biomarkers in ***-12A expression was associated with immune checkpoint molecules,and CLEC-12A may be a potential assistant target to improve the efficacy of immune checkpoint inhibitors immunotherapy.

关键词： CLEC-12A CLEC-12B Lung cancer Prognosis Immune regulation

Novel directions of precision oncology:circulating microbial DNA emerging in cancer-microbiome areas

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Precision Clinical Medicine 2022年第1期5卷 46-62页

作者： liting you Juan Zhou Zhaodan Xin J.Spencer Hauck Feifei Na Jie Tang Xiaohan Zhou Zichen Lei Binwu Ying Department of Laboratory Medicine West China HospitalSichuan UniversityChengdu 610041China Department of Pathology Duke University School of MedicineDurhamNC 27710USA Department of Thoracic Cancer West China HospitalSichuan UniversityChengdu 610041China Department of Clinical Laboratory Mianyang Central HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaMianyang 621000China

Microbiome research has extended into the cancer area in the past *** can affect oncogenesis,progression,and treatment response through various mechanisms,including direct regulation and indirect ***-associated detectionmethods and agents have been developed to facilitate cancer diagnosis and ***,the cancermicrobiome has recently been *** identification of intra-tumoral microbes and cancer-related circulating microbial DNA(cmDNA)has promoted novel research in the cancer–microbiome *** this review,we define the human system of commensal microbes and the cancer microbiome from a brand-new perspective and emphasize the potential value of cmDNA as a promising biomarker in cancer liquid *** outline all existing studies on the relationship between cmDNA and cancer and the outlook for potential preclinical and clinical applications of cmDNA in cancer precision medicine,as well as critical problems to be overcome in this burgeoning field.

关键词： circulating microbial DNA liquid biopsy cancer-microbiome-immunity intra-tumor microbiome cancer precision diagnosis and therapy

口腔微生物组与肺癌发生、发展的研究现状与展望

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科学通报 2024年第3期69卷 381-393页

作者：马琼曾潇李雪珂由丽婷付西由凤鸣任益锋成都中医药大学附属医院代谢性疾病中医药调控四川省重点实验室成都610075 成都中医药大学肿瘤研究所成都610075 四川大学华西医院检验科成都610041

“微生物组在健康和疾病中扮演什么角色?”这一热点话题作为全世界最前沿的125个科学问题之一,近年来持续受到了广泛关注.口腔内含有位点特异性微生物组已是共识,其与宿主细胞的相互作用调节了机体多种生理病理过程.新近证据表明,口腔... 详细信息

“微生物组在健康和疾病中扮演什么角色?”这一热点话题作为全世界最前沿的125个科学问题之一,近年来持续受到了广泛关注.口腔内含有位点特异性微生物组已是共识,其与宿主细胞的相互作用调节了机体多种生理病理过程.新近证据表明,口腔微生态失调与肺癌风险具有密切的联系,特定口腔微生物及其代谢产物可通过直接/间接的机制在促进或阻延肺癌发生、发展中扮演了重要角色,如诱导炎性微环境、促进肿瘤细胞免疫逃逸和影响细胞相关增殖凋亡信号通路等.上述研究亦支持了口腔微生物在肺癌临床诊疗中的应用潜力.据此,本综述旨在概述口腔微生物组-肺癌研究的前沿进展,探讨当前存在的问题和未来的发展方向,以期激发研究者对这一新兴领域更大的兴趣和更深入的研究.

关键词：口腔微生物组肺癌生物标志物

基于微流控技术的类器官芯片在肺癌精准治疗中的应用

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科学通报 2023年第13期68卷 1666-1676页

作者：曾潇马琼李雪珂由丽婷李佳付西任益锋由凤鸣成都中医药大学附属医院成都610072 四川大学华西医院检验科成都610041 成都中医药大学肿瘤研究所成都610072

肺癌是全球范围内发病率和死亡率均居首位的恶性肿瘤,具有显著的个体化特征和遗传异质性.无疑,以患者为中心的个性化药物筛选和新药研发对提高总体生存率至关重要.近年来,由于类器官模型具有培养周期短、操作便捷和拟合度高等优势,能够... 详细信息

肺癌是全球范围内发病率和死亡率均居首位的恶性肿瘤,具有显著的个体化特征和遗传异质性.无疑,以患者为中心的个性化药物筛选和新药研发对提高总体生存率至关重要.近年来,由于类器官模型具有培养周期短、操作便捷和拟合度高等优势,能够真实保留患者肿瘤的遗传信息,在模型构建和个性化药物筛选中扮演着越来越重要的角色.然而,传统类器官稳定性差、肿瘤微环境单一、通量低等固有缺陷限制了其进一步的临床转化与应用.基于微流控技术的类器官芯片是类器官在生物技术维度的延伸,可以实现对理化环境因素的精准控制、高度模拟肿瘤微环境、显著提高药物筛选通量,有效弥补了传统类器官培养技术的不足,开启了肿瘤个体化治疗新纪元.本文总结了微流控类器官芯片作为个性化药物筛选模型的优势特征,并结合在肺癌研究中的最新进展,探讨了类器官芯片在肺癌精准治疗中的转化价值和未来的发展方向.

关键词：肺癌患者源性类器官药物筛选微流控类器官芯片

Flexible Strain Sensors with Ultra-High Sensitivity and Wide Range Enabled by Crack-Modulated Electrical Pathways

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NANO-MICRO LETTERS 2025年第1期17卷 1-19页

作者： Bai, Yunzhao Zhou, Yunlei Wu, Xuanyu Yin, Mengfei Yin, liting Qu, Shiyuan Zhang, Fan Li, Kan Huang, Yongan Huazhong Univ Sci & Technol State Key Lab Intelligent Mfg Equipment & Technol Wuhan 430074 Peoples R China Huazhong Univ Sci & Technol Flexible Elect Res Ctr Wuhan 430074 Peoples R China Xidian Univ Hangzhou Inst Technol Hangzhou 311200 Peoples R China Xidian Univ Sch Mechanoelect Engn Xian 710071 Peoples R China Univ Southern Calif Dept Aerosp & Mech Engn Los Angeles CA 90089 USA

This study presents a breakthrough in flexible strain sensor technology with the development of an ultra-high sensitivity and wide-range sensor, addressing the critical challenge of reconciling sensitivity with measurement range. Inspired by the structure of bamboo slips, we introduce a novel approach that utilises liquid metal to modulate the electrical pathways within a cracked platinum fabric electrode. The resulting sensor demonstrates a gauge factor greater than 108 and a strain measurement capability exceeding 100%. The integration of patterned liquid metal enables customisable tuning of the sensor's response, while the porous fabric structure ensures superior comfort and air permeability for the wearer. Our design not only optimises the sensor's performance but also enhances the electrical stability that is essential for practical applications. Through systematic investigation, we reveal the intrinsic mechanisms governing the sensor's response, offering valuable insights for the design of wearable strain sensors. The sensor's exceptional performance across a spectrum of applications, from micro-strain to large-strain detection, highlights its potential for a wide range of real-world uses, demonstrating a significant advancement in the field of flexible electronics.

关键词： Flexible strain sensor Fabric Crack Response regulation Epidermal device

“Zero‑Strain” NiNb_(2)O_(6) Fibers for All‑Climate Lithium Storage

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Nano-Micro Letters 2025年第1期17卷 348-360页

作者： Yan Zhao Qiang Yuan liting Yang Guisheng Liang Yifeng Cheng Limin Wu Chunfu Lin Renchao Che College of Physics Donghua UniversityShanghai 201620People’s Republic of China School of Materials Science and Engineering Institute of Materials for Energy and EnvironmentQingdao UniversityQingdao 266071People’s Republic of China Laboratory of Advanced Materials Shanghai Key Laboratory of Molecular Catalysis and Innovative MaterialsAcademy for Engineering&TechnologyFudan UniversityShanghai 200438People’s Republic of China Zhejiang Laboratory Hangzhou 311100People’s Republic of China Inner Mongolia University Hohhot 010021People’s Republic of China

Niobates are promising all-climate Li^(+)-storage anode material due to their fast charge transport,large specific capacities,and resistance to electrolyte ***,their moderate unit-cellvolume expansion(generally 5%–10%)during Li^(+)storage causes unsatisfactory long-term ***,“zero-strain”NiNb_(2)O_(6) fibers are explored as a new anode material with comprehensively good electrochemical *** Li^(+)storage,the expansion of electrochemical inactive NiO_(6) octahedra almost fully offsets the shrinkage of active NbO_(6) octahedra through reversible O *** superior volume-accommodation capability of the NiO_(6) layers guarantees the“zero-strain”behavior of NiNb_(2)O_(6) in a broad temperature range(0.53%//0.51%//0.74%at 25//−10//60℃),leading to the excellent cyclability of the NiNb_(2)O_(6) fibers(92.8%//99.2%//91.1%capacity retention after 1000//2000//1000 cycles at 10C and 25//−10//60℃).This NiNb_(2)O_(6) material further exhibits a large reversible capacity(300//184//318 mAh g−1 at 0.1C and 25//−10//60℃)and outstanding rate performance(10 to 0.5C capacity percentage of 64.3%//50.0%//65.4%at 25//−10//60℃).Therefore,the NiNb_(2)O_(6) fibers are especially suitable for large-capacity,fast-charging,long-life,and all-climate lithium-ion batteries.

关键词： NiNb_(2)O_(6)porous fiber “Zero-strain”mechanism Electrochemical property Harsh-temperature operation Operando characterization

Self‑Assembly MXene‑rGO/CoNi Film with Massive Continuous Heterointerfaces and Enhanced Magnetic Coupling for Superior Microwave Absorber

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Nano-Micro Letters 2022年第5期14卷 20-33页

作者： Xiao Li Zhengchen Wu Wenbin you liting Yang Renchao Che Laboratory of Advanced Materials Shanghai Key Lab of Molecular Catalysis and Innovative MaterialsFudan UniversityShanghai 200438People’s Republic of China Department of Materials Science Fudan UniversityShanghai 200438People’s Republic of China

MXene, as a rising star of two-dimensional(2 D) materials, has been widely applied in fields of microwave absorption and electromagnetic shielding to cope with the arrival of the 5 G era. However, challenges arise due to the excessively high permittivity and the difficulty of surface modification of few-layered MXenes severely, which infect the microwave absorption performance. Herein, for the first time, a carefully designed and optimized electrostatic selfassembly strategy to fabricate magnetized MXene-r GO/Co Ni film was reported. Inside the synthesized composite film, r GO nanosheets decorated with highly dispersed Co Ni nanoparticles are interclacted into MXene layers, which effectively suppresses the originally self-restacked of MXene nanosheets, resulting in a reduction of high permittivity. In addition, owing to the strong magnetic coupling between the magnetic Fe Co alloy nanoparticles on the r GO substrate, the entire MXener GO/Co Ni film exhibits a strong magnetic loss capability. Moreover, the local dielectric polarized fields exist at the continuous heterointerfaces between 2 D MXene and r GO further improve the capacity of microwave loss. Hence, the synthesized composite film exhibits excellent microwave absorption property with a maximum reflection loss value of-54.1 d B at 13.28 GHz. The electromagnetic synergy strategy is expected to guide future exploration of high-efficiency MXene-based microwave absorption materials.

关键词： MXene Microwave absorption Composite materials Graphene Electron holography

Direct imaging of stress-induced magnetic behavior transitions

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Journal of Materials Science & Technology 2023年第15期146卷 72-79页

作者： Wenbin you Gangjie Lian liting Yang Ke Pei Yuyang Wu Jincang Zhang Renchao Che Laboratory of Advanced Materials Shanghai Key Lab of Molecular Catalysis and Innovative MaterialsDepartment of Materials ScienceFudan UniversityShanghai 200438China Zhejiang Laboratory Hangzhou 311100China Materials Genome Institute Shanghai UniversityShanghai 200444China

Stress induction plays a special role in performance control for material *** far,it has remained challenging to systematically investigate magnetoelectric effect under stress-mediated *** we constructed a magnetoelectric device with piezoelectric stress induction,in which the stress plays a crucial intermediate role during the controllable modification of the magnetic behavior transitions under the magnetic field or current pulse driven *** compressive stress was found to make the above process easier and reduce energy consumption via changing the magnetic domain energy ***,both the domain distribution and domain-wall driven process are sensitive to stress *** magnetoelectric device integrated the advantages of voltage-stress and spin-current for the control of magnetic behavior transition with the help of micro-nano *** the stress-induced magnetic behavior in magnetic materials was directly imaged and quantificationally investigated,the complex interactions between stress,magnetic domain motion,magnetic field,and spin current have been clarified.

关键词： Magnetic behavior Voltage-stress:spin-current Energy consumption

3D Seed-Germination-Like MXene with In Situ Growing CNTs/Ni Heterojunction for Enhanced Microwave Absorption via Polarization and Magnetization

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Nano-Micro Letters 2021年第10期13卷 252-265页

作者： Xiao Li Wenbin you Chunyang Xu Lei Wang liting Yang Yuesheng Li Renchao Che Laboratory of Advanced Materials Shanghai Key Lab of Molecular Catalysis and Innovative MaterialsFudan UniversityShanghai 200438People’s Republic of China Department of Materials Science Fudan UniversityShanghai 200438People’s Republic of China

Ti_(3)C_(2)Tx MXene is widely regarded as a potential micro-wave absorber due to its dielectric multi-layered ***,missing magnetic loss capability of pure MXene leads to the unmatched electromagnetic parameters and unsatisfied impedance matching ***,with the inspiration from dielectric-magnetic synergy,this obstruction is solved by fabricating magnetic CNTs/Ni hetero-structure decorated MXene substrate via a facile in situ induced growth ***2+ions are successfully attached on the surface and interlamination of each MXene unit by intensive electrostatic *** from the possible“seed-germination”effect,the“seeds”Ni^(2+)grow into“buds”Ni nanoparticles and“stem”carbon nanotubes(CNTs)from the enlarged“soil”of MXene *** to the improved impedance matching con-dition,the MXene-CNTs/Ni hybrid holds a superior microwave absorp-tion performance of−56.4 dB at only 2.4 mm *** a distinctive 3D architecture endows the hybrids:(i)a large-scale 3D magnetic coupling network in each dielectric unit that leading to the enhanced magnetic loss capability,(ii)a massive multi-heterojunction interface structure that resulting in the reinforced polarization loss capability,confirmed by the off-axis electron *** outstanding results provide novel ideas for developing magnetic MXene-based absorbers.

关键词： Microwave absorption Two-dimensional materials MXene Magnetic coupling network Synergistic effect