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Internal Controllability for Parabolic Systems Involving Analytic Non-local Terms

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Chinese Annals of Mathematics,Series B 2018年第2期39卷 281-296页

作者： Pierre lissy Enrique ZUAZUA This article is dedicated to Phillippe G. Ciarlet in the occasion of his 80th birthday with gratitude and admiration/or his mastery and continuous support. Merci Philipp

This paper deals with the problem of internal controllability of a system of heat equations posed on a bounded domain with Dirichlet boundary conditions and perturbed with analytic non-local coupling terms. Each component of the system may be controlled in a different subdomain. Assuming that the unperturbed system is controUable--a property that has been recently characterized in terms of a Kalman-like rank condition--the authors give a necessary and sufficient condition for the controllability of the coupled system under the form of a unique continuation property for the corresponding elliptic eigenvalue system. The proof relies on a compactness-uniqueness argument, which is quite unusual in the context of parabolic systems, previously developed for scalar parabolic equations. The general result is illustrated by two simple examples.

关键词： Parabolic systems Non-local potentials Analyticity Null controllability Kalma~ rank condition Spectral unique continuation

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Evaluation of Albuminated Curcumin as Soluble Drug Form to Control Growth of Cancer Cells <i>in Vitro</i>

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journal of Cancer Therapy 2014年第7期5卷 723-734页

作者： Christina Thomas Lakshmi Sreedharan Pillai lissy Krishnan Thrombosis Research Unit Biomedical Technology Wing Sree Chitra Tirunal Institute for Medical Sciences & Technology Trivandrum India

Curcumin (Curc) is well known for its anticancer activity, but its poor solubility in aqueous medium is a major concern for little therapeutic outcome. Therefore, the effort to improve its bioavailability is a major research interest. The current study aimed at conjugation of Curc to serum albumin (Alb) to increase aqueous solubility of the former without affecting its drug action on cancer cell lines and primary cells in culture. Conditions for preparation of albumin-curcumin (Alb-Curc) conjugate were standardized to obtain pure and stable drug. The product was obtained in sufficient quantity to test its effect on cells in culture at different doses. Briefly, the conjugate was prepared by mixing Curc dissolved in DMSO with the Alb dissolved in phosphate buffered saline;conjugate was purified by gel filtration chromatography and was analyzed using UV-Vis spectroscopy for characteristic peaks of both molecules. The conjugate was added to culture medium to identify the effect of conjugate on cell cycling and apoptosis. Albuminated curcumin that showed 100-fold higher solubility than free Curc was stable and inhibitory to proliferation, induced cell cycle arrest and apoptosis. The conjugate showed apoptotic effects on endothelial cells indicating its anti angiogenic property. Primary fibroblast growth was also inhibited but at the higher dose. The in vitro results suggest that Alb-Curc which is free of insoluble native drug may find application in cancer therapy after appropriate in vivo evaluations.

关键词： Curcumin Anticancer Drug Aqueous Solubility Bioavailability Albumin Drug Conjugation

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适应90年代生态学的清洗系统设计

电镀与环保 1993年第4期13卷 23-24页

作者： Gus lissy 李栖阁 GLA精饰系统公司

清洗系统的设计,因需考虑机内所用的物料,但更要考虑流入城市下水道的物质,才能符合今天生态学的标准。金属精饰处理系统目前办用两在化学品.

关键词：清洗系统设计生态学

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欧洲儿科胃肠病学、肝病学和营养协会儿童及青少年炎症性肠病诊断的改良波尔图标准(2014年版)

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中华儿科杂志 2016年第10期54卷 728-732页

作者： Arie Levine Sibylle Koletzko Dan Turner johanna C.Escher Salvatore Cucchiara lissy de Ridder Kaija-Leena Kolho Gabor Veres Richard K.Russell Anders Paerregaard Stephan Buderus Mary-Louise C.Greer jorge A.Dias Gigi Veereman-Wauters Paolo Lionetti Malgorzata Sladek javier Martin de Carpi Annamaria Staiano Frank M.Ruemmele David C.Wilson 罗优优陈洁 Pediatric Gastroenterology and Nutrition Unit Wolfson Medical CenterSackler School of MedicineTel-Aviv University the Dr von Hauner Children's Hospital Ludwig Maximilians University the Pediatric Gastroenterology Unit Shaare Zedek Medical CenterThe Hebrew University of Jerusalem the Pediatric Gastroenterology Department of PediatricsErasmus MC-Sophia Children's Hospital 5. the Pediatric Gastroenterology and Liver UnitSapienza University of Rome 6. the Children's HospitalUniversity of Helsinki 7. the Semmelweis University 8. the Department of Paediatric Gastroenterology and NutritionYorkhill Children's Hospital 9. the Department of PaediatricsHvidovre University Hospital 10. the St.Marien-HospitalDepartment of Pediatrics 11. the Department of Diagnostic ImagingThe Hospital for Sick Childrenthe Department of Medical ImagingUniversity of Toronto 12. the Hospital S.Joao 13. the-Pediatric Gastroenterology and Nutrition 14. the Departement NeurofarbaUniversity of FlorenceMeyer Children Hospital 15. the Department of PediatricsGastroenterology and NutritionJagiellonian University Medical College 16. the Department of Pediatric GastroenterologyHepatology and NutritionHospital Sant Joan de De'u 17. the Department of Translational Medical SciencesSection of PediatricsUniversit

炎症性肠病(IBD)包括克罗恩病(CD)、溃疡性结肠炎(UC)和未分型IBD(IBDU)。IBD的确切诊断需综合病史、体检、实验室检查、内镜以及影像学的检查,并严格排除肠道感染、过敏性疾病或原发性免疫缺陷病(PID)。近年对儿童期起病的IBD(PIBD)的... 详细信息

炎症性肠病(IBD)包括克罗恩病(CD)、溃疡性结肠炎(UC)和未分型IBD(IBDU)。IBD的确切诊断需综合病史、体检、实验室检查、内镜以及影像学的检查,并严格排除肠道感染、过敏性疾病或原发性免疫缺陷病(PID)。近年对儿童期起病的IBD(PIBD)的研究高度提示3种PIBD的亚型均存在不典型的表型。本标准对2005年波尔图标准进行改良,利用循证方法,整合最新证据,包括诊断方法、以巴黎分型为基础的PIBD亚型的定义以及诊断误区,为新一代的PIBD提供优质的个体化管理以及可靠的诊断、评估和预后。

关键词：体检实验室检查内镜