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New insights into diet breadth of polyphagous and oligophagous aphids on two Arabidopsis ecotypes

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Insect Science 2019年第4期26卷 753-769页

作者： Christopher Wattier Amelie Turbant lisa Sargos-Vallade Jerome Pelloux Christine Rusterucci Anas Cherqui CRRBM (Centre de Ressources Regionales en Biologie Moleculaire) Universite de Picardie Jules Verne Amiens Cedex France EA 3900 BIOPI (Biologie des Plantes et Innovation) Universite de Picardie Jules Verne Amiens Cedex France FRE CNRS 3498 EDYSAN (Ecologie et Dynamique des Systemes Anthropises) University de Picardie Jules Verne Amiens Cedex France

We investigated whether plant ecotype might affect aphid performance and behavioi. The probing behaviors of the polyphagous aphid Myzus persicae and the oligophagous aphid Brevicoryne brassicae on two ecotypes of Arabidopsis thaliana, WS and Col-0 were recorded using the direct current electrical penetration graph method (DC-EPG). Myzus persicae displayed a significant preference for the WS ecotype but was not greatly disturbed on Col-0, while B. brassicae discriminated between the two A. thaliana ecotypes, feeding less on WS than on Col-0. A Principal Component Analysis of aphid probing behavior data recorded on Col-0 and WS ecotypes showed that the one of M. persicae was positively correlated with the phloem ingestion phases while the one of B. brassicae was more related to nonfeeding phase. The survival of the aphid species was followed during early larval stages on the two ecotypes and a significantly higher mortality was observed of B. brassicae neonates compared to M. persicae. Both reared on WS. Moreover, transcriptomic analysis of non infested plant leaves from both ecotypes was monitored and underlined constitutive differences between Col-0 and WS gene expression that might explain the different aphid behaviors. Among a unigene set comprising 39 042 sequences for A. thaliana, 6% were differently expressed affecting, for example, the secondary metabolites and cell wall pathways: two third upregulated in WS and one third upregulated in Col-0. Thus, the "ecotype” variable should be taken into account when setting up a plant-insect experimental research.

关键词： Arabidopsis thaliana Brevicoryne brassicae ecotypes EPG microarray Myzus persicae

Nursing education in China:Meeting the global demand for quality healthcare

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International Journal of Nursing Sciences 2016年第1期3卷 131-136页

作者： Carol Chunfeng Wang lisa Whitehead Sara Bayes School of Nursing and Midwifery Edith Cowan UniversityPerth WA 6027Australia

With a predicted global nursing shortage,ensuring the provision of quality healthcare has become a pressing *** China,these concerns include the need to produce nurses trained to a level to support advancing nursing practice and a healthcare system that supports the growth and retention of nurses in *** paper argues that the standard of nursing education in China plays a crucial role in preparing graduates to meet the health demands of China's growing population and the role that China can play into the future in the global progression of *** between nursing authorities,educators,and legislators is required to support the progression of nursing worldwide.

关键词： China Nursing education Globalisation Global healthcare Transcultural nursing

Patients Involved in Funding Research.A Look Back at the Unique Experience of the ECLAIR Working Group of Canceropole CLARA

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Psycho-Oncologie 2024年第1期18卷 17-22页

作者： Julien Biaudet lisa Laroussi-Libeault Mauricette Michallet Laurie Panse Raymond Merle Cancéropôle Lyon Auvergne-Rhône-Alpes(CLARA) Lyon69007France GroupeÉCLAIR du Cancéropôle Lyon Auvergne-Rhône-Alpes(CLARA) Lyon69007France Conseil Scientifique de la Ligue Contre le Cancer région Auvergne Rhône-Alpes Saône et Loire Lyon69008France Département Universitaire des Patients Grenoble Alpes La Tronche38400France

This article aims to share an innovative experience of organizing and funding research involving those most directly affected:***“ECLAIR”working group of the Canceropole Lyon Auvergne-Rhone-Alpes(CLARA)was created at the end of 2020 with the goal of contributing to the development of a call for projects on the patient experience in oncology,which was launched in January *** composed of 8 members,including 7 patients,coordinated by a project manager from CLARA,the ECLAIR working group actively participated in drafting the specifications of the call for projects,developing the eligibility criteria for applications,revising the evaluation and selection criteria for projects,and monitoring the selected *** experience was repeated *** significant freedom of action,the working group made two decisions that strongly demonstrate the commitment to supporting research partnerships and the active involvement of those affected:firstly,by making partnership a mandatory requirement for the eligibility of applications,and secondly,by conducting the selection of projects themselves,after an independent scientific evaluation *** to shed light on the“black box”of partnership,the article also presents the concrete modalities of interaction among the working group members,the adjustments made between different editions of the call for projects,and the relationships maintained with CLARA.

关键词： Cancer research public and patient involvement research funding participatory research healthcare democracy

Update on Hepatitis C Virus and HIV Coinfection

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Journal of Clinical and Translational Hepatology 2013年第2期1卷 109-115页

作者： Tilahun Amdissa Gemtessa lisa M.Chirch Division of Infectious Diseases University of Connecticut Health Center Farmington CT USA

Chronic hepatitis C virus (HCV) infection has historically been difficult to treat in the HIV-infected population,owing to generally poor responses to interferon-based *** recent rapid development of directly acting antiviral agents (DAAs) against HCV has the potential to revolutionize treatment of this infection in the HIV population by improving tolerability and outcome,and,ultimately,reducing the significant burden of liver-related morbidity and mortality in this *** trials to address the safety and efficacy of novel DAAs in the HCV/HIV coinfected population are ongoing,and show much *** rapidity of current drug discovery in the field of HCV is both impressive and daunting for clinicians who will have to master these *** forward,the inclusion of individuals from this large and growing patient population in clinical trials will be of paramount importance.

关键词： Hepatitis C HCV HIV Coinfection Antiretroviral therapy ART Drug interaction

Hybrid remote quantum dot/powder phosphor designs for display backlights

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Light(Science & Applications) 2016年第1期5卷 11-19页

作者： Sofie Abe Jonas J Joos lisa IDJ Martin Zeger Hens Philippe F Smet Department of Inorganic and Physical Chemistry Ghent UniversityGentBelgium Department of Solid State Sciences LumiLabGhent UniversityGentBelgium Center for Nano and Biophotonics Ghent UniversityGentBelgium

Quantum dots are ideally suited for color conversion in light emitting diodes owing to their spectral tunability,high conversion efficiency and narrow emission *** properties are particularly important for display backlights;the highly saturated colors generated by quantum dots justify their higher production ***,we demonstrate the benefits of a hybrid remote phosphor approach that combines a green-emitting europium-doped phosphor with red-emitting CdSe/CdS core/shell quantum *** stacking geometries,including mixed and separate layers of both materials,are studied at the macroscopic and microscopic levels to identify the configuration that achieves maximum device efficiency while minimizing material *** influence of reabsorption,optical outcoupling and refractive index-matching between the layers is evaluated in detail with respect to device efficiency and *** the findings of this study,general guidelines are derived to optimize both the cost and efficiency of CdSe/CdS and other(potentially cadmium-free)quantum dot *** reabsorption of the green and/or red emission is significant compared to the absorption strength for the blue emission of the pumping light emitting diode,the hybrid remote phosphor approach becomes beneficial.

关键词： cost-efficiency lanthanide light emitting diode nanocrystal remote phosphor

Non-glide effects and dislocation core fields in BCC metals

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npj Computational Materials 2019年第1期5卷 178-185页

作者： Antoine Kraych Emmanuel Clouet Lucile Dezerald lisa Ventelon François Willaime David Rodney Institut Lumière Matière UniversitéLyon 1-CNRSVilleurbanne F-69622France DEN-Service de Recherches de Métallurgie Physique CEAUniversitéParis-SaclayGif-sur-Yvette F-91191France Institut Jean Lamour CNRS UMR 7198Universitéde LorraineF-54000 NancyFrance DEN-Département des Matériaux pour le Nucléaire CEAUniversitéParis-SaclayGif-sur-Yvette F-91191France

A hallmark of low-temperature plasticity in body-centered cubic(BCC)metals is its departure from Schmid’s *** aspect is that non-glide stresses,which do not produce any driving force on the dislocations,may affect the yield *** show here that this effect is due to a variation of the relaxation volume of the 1/2screw dislocations during *** predict quantitatively nonglide effects by modeling the dislocation core as an Eshelby inclusion,which couples elastically to the applied *** model explains the physical origin of the generalized yield criterion classically used to include non-Schmid effects in constitutive models of BCC *** use first-principles calculations to properly account for dislocation cores and use tungsten as a reference BCC ***,the methodology developed here applies to other BCC metals,other energy models and other solids showing nonglide effects.

关键词： dislocation metals plasticity

Assessing bioactivity of environmental water samples filtered using nanomembrane technology and mammalian cell lines

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Eco-Environment & Health 2024年第3期3卷 347-354页

作者： Sarah E.Morgan lisa A.DeLouise Department of Environmental Medicine University of Rochester Medical CenterRochesterNY 14642USA Department of Biomedical Engineering University of RochesterRochesterNY 14627USA Department of Dermatology University of Rochester Medical CenterRochesterNY 14642USA Lake Ontario Center for Microplastics and Human Health in a Changing Environment University of Rochester Medical CenterRochesterNY 14642USA

This project reports on the use of a novel nanomembrane filtering technology to isolate and analyze the bioactivity of microplastic(MP)-containing debris from Lake Ontario water *** MPs are a complex mixture of polymers and sorbed chemicals that are persistent and can exhibit a wide range of toxic *** human exposure to MPs is unavoidable,it is necessary to characterize their bioactivity to assess potential health *** work seeks to quantify MP presence in the nearshore waters of Lake Ontario and begin to characterize the bioactivity of the filtrate containing *** utilized silicon nitride(SiN)nanomembrane technology to isolate debris sized between 8 and 20μm from lake water samples collected at various times and *** were identified with Nile red ***-based assays were conducted directly on the filtered debris to test for cell viability,aryl hydrocarbon receptor(AhR)activity,and interleukin 6(IL-6)levels as a measure of proinflammatory *** samples contained *** of the isolated debris impacted cell ***,AhR activity and IL-6 levels varied over ***,no associations were observed between the amount of plastic and *** differences in activity are likely due to variations in the physiochemical properties of debris between *** results highlight the need for increased sampling to fully characterize the bioactivity of MPs in human cells and to elucidate the role that sample physiochemical and spatiotemporal properties play in this activity.

关键词： Microplastics SiN nanomembranes Lake Ontario Aryl hydrocarbon receptor(AhR)activity IL-6 levels Bioactivity

FAIR： A Call to Make Published Data More Findable, Accessible, Interoperable, and Reusable

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Molecular Plant 2018年第9期11卷 1105-1108页

作者： Leonore Reiser lisa Harper Michael Freeling Bin Han Sheng Luan The Arabidopsis Information Resource/Phoenix Bioinformatics Fremont CA 94538 USA Maize Genome Database/United States Department of Agriculture Albany CA 94710 USA Department of Plant Biology University of California Berkeley CA 94720 USA National Center for Gene Research CAS Center for Excellence in Molecular Plant Sciences Institute of Plant Physiology and Ecology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 200233 China These authors contributed equally to this article

Biology has become an information-dense, data-intensive enterprise that requires the ability to access, integrate, and compute on large amounts of data. To enable better use of data, stakeholders （scientists, curators, librarians, and journal publishers） have established standards to ensure that data are findable, accessible, interoperable.

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Intensive care drug therapy and its potential adverse effects on blood pressure and heart rate in critically ill children

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World Journal of Pediatrics 2023年第9期19卷 902-911页

作者： lisa Marie Kiesel Astrid Bertsche Wieland Kiess Manuela Siekmeyer Thilo Bertsche Martina Patrizia Neininger Drug Safety Center and Clinical Pharmacy Institute of PharmacyMedical FacultyLeipzig UniversityBruederstr.3204103 LeipzigGermany Division of Neuropediatrics University Hospital for Children and AdolescentsFleischmannstr.817475 GreifswaldGermany Department of Women and Child Health Hospital for Children and Adolescents and Center for Pediatric ResearchUniversity Hospital of LeipzigLiebigstr.20a04103 LeipzigGermany

Background Owing to complex treatment,critically ill children may experience alterations in their vital *** investigated whether such hemodynamic alterations were temporally and causally related to drug *** In a university pediatric intensive care unit,we retrospectively analyzed hemodynamic alterations defined as values exceeding the limits set for heart rate(HR)and blood pressure(BP).For causality assessment,we used the World Health Organization–Uppsala Monitoring Center(WHO–UMC)system,which categorizes the probability of causality as“certain,”“probable,”“possible,”and“unlikely.”Results Of 315 analyzed patients with 43,200 drug prescriptions,59.7%experienced at least one hemodynamic alteration;39.0%were affected by increased HR,19.0%by decreased HR,18.1%by increased BP,and 16.2%by decreased *** to drug information databases,83.9%of administered drugs potentially lead to hemodynamic ***,88.3%of the observed hemodynamic alterations had a temporal relation to the administration of drugs;in 80.2%,more than one drug was *** on the WHO–UMC system,a drug was rated as a“probable”causing factor for only 1.4%of hemodynamic *** the remaining alterations,the probability ratings were lower because of multiple potential causes,e.g.,several *** Critically ill children were frequently affected by hemodynamic *** administration of drugs with potentially adverse effects on hemodynamic parameters is often temporally related to hemodynamic *** alterations are often multifactorial,e.g.,due to administering multiple drugs in rapid succession;thus,the influence of individual drugs cannot easily be captured with the WHO–UMC system.

关键词： Adverse drug reaction Drug therapy Hemodynamic monitoring Multifactorial causality Pediatric intensive care unit