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An updated inventory of marine opisthobranch(mollusca,Gastropoda)from the territorial waters of the Republic of mauritius

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Journal of Oceanology and Limnology 2024年第1期42卷 226-243页

作者： lisa AH SHEE TEE Chandani APPADOO Daneshwar PUCHOOA Vishwakalyan BHOYROO Department of Agricultural&Food Science Faculty of AgricultureUniversity of MauritiusRéduit 80837Mauritius Department of Biosciences&Ocean Studies Pole of Research Excellence Sustainable Marine BiodiversityFaculty of ScienceUniversity of MauritiusRéduit 80837Mauritius

Island ecosystems support diverse aquatic invertebrate communities comprising endemic *** of existing species is important for *** this study,a checklist of marine opisthobranch from the Republic of mauritius is presented.A combination of benthic surveys(50 m×5 m in triplicates),rover diving techniques and photo documentation were used over two years(2018–2020)within 35 sheltered and unsheltered *** and molecular analysis were used for *** composition within sheltered and unsheltered areas in mauritius was estimated using the Bray-Curtis *** checklist featured 117 species belonging to 61 genera and 28families,of which 13 are new *** findings increased the knowledge of opisthobranch diversity from the mauritius by 15.4%.Among the listed species,the distribution range of Cyerce nigra,Actinocyclus papillatus,and Phyllidia picta extended from the Western Pacific to the South Western Indian *** analysis of the undescribed Gymnodoris *** it resembled Gymnodoris *** Hawaii and were different by a genetic distance value of 10.6%.The species richness and evenness were higher within the sheltered regions of mauritius which harboured the food resource of *** areas as compared to unsheltered regions were heavily populated,suggesting the probable influence of wave actions on opisthobranch diversity and *** order Nudibranchia was reported as most speciose,with 86 *** Sacoglossa and Nudibranchia were observed only on macroalgae and sponges *** abundance was also recorded on shipwrecks which are the most common form of artificial *** the inclusion of observations from previous studies,201species belonging to 94 genera and 36 families are now known from the mauritius.

关键词： marine opisthobranch inventory new record occurrence Republic of mauritius Indian Ocean

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Efficacy and Safety of NVX-CoV2373 in Adults in the United States and mexico

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四川生理科学杂志 2021年第10期43卷 1796-1796页

作者： lisa m Dunkle From Novavax Gaithersburg (L.M.D. G.A. K.S. W.W. I.C. G.M.G. F.D.) the University of Maryland School of Medicine Baltimore (K.L.K. M.A.M. K.M.N.) the National Institute of Allergy and Infectious Diseases Bethesda (J.H.) and Walter Reed Army Institute of Research Silver Spring (J.A.A.) — all in Maryland FAICIC Clinical Research Veracruz (A.Q.B.H.) and Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán Mexico City (G.M.R.-P.) — both in Mexico Research Your Health Plano (J.M.A.) and the Texas Center for Drug Development Houston (V.G.-F.) — both in Texas m3-Wake Research Raleigh (W.L.H.) M3-Emerging Medical Research Durham (D.B.M.) and the University of North Carolina School of Medicine Chapel Hill (C.L.G.) — all in North Carolina SImEDHealth Gainesville (D.M.D.) and Velocity Clinical Research Hallandale Beach (B.E.S.) — both in Florida the University of Nebraska medical Center Omaha (D.F.F.) the University of Washington medical Center (R.S.m. R.W.C. A.L.G.) and Fred Hutchinson Cancer Research Center (L.C.) Seattle and Lummi Indian Health Center Bellingham (D.C.L.) — all in Washington the Atlanta Center for medical Research Atlanta (R.A.R.) and IACT Health Columbus (J.K.K.) — both in Georgia Velocity Clinical Research–Providence Warwick RI (D.L.F.) WR ClinSearch Chattanooga TN (M.M.) medPharmics Metairie LA (R.J.J.) and Black Hills Center for American Indian Health Rapid City SD (J.A.H.).Dr. Dunkle can be contacted at [email protected] or at Novavax 21 Firstfield Rd. Gaithersburg MD 20878. The members of the 2019nCoV-301 Study Group are listed in the Supplementary Appendix available at ***.

Background:NVX-CoV2373 is an adjuvanted,recombinant spike protein nanoparticle vaccine that was shown to have clinical efficacy for the prevention of coronavirus disease 2019(Covid-19)in phase 2b-3 trials in the United Kingdom and South Africa,but its efficacy had not yet been tested in North ***:We conducted a phase 3,randomized,observer-blinded,placebo-controlled trial in the United States and mexico during the first half of 2021 to evaluate the efficacy and safety of NVX-CoV2373 in adults(≥18 years of age)who had not had severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)*** were randomly assigned in a 2:1 ratio to receive two doses of NVX-CoV2373 or placebo 21 days *** primary objective was to determine vaccine efficacy against reverse-transcriptase-polymerase-chain-reaction-confirmed Covid-19 occurring at least 7 days after the second *** efficacy against moderate-to-severe disease and against different variants was also assessed.

关键词： vaccine doses prevention

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Targeted protein delivery:carbodiimide crosslinking influences protein release from microparticles incorporated within collagen scaffolds

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Regenerative Biomaterials 2019年第5期6卷 279-287页

作者： Constantin Edi Tanase Omar Qutachi lisa J.White Kevin m.Shakesheff Andrew W.mcCaskie Serena m.Best Ruth E.Cameron Department of materials Science and metallurgy University of CambridgeCambridge Centre for Medical MaterialsCambridge27Charles Babbage RoadCB30FSUK Centre for Biomolecular Sciences School of PharmacyUniversity of NottinghamUniversity ParkNottingham NG72RDUK Division of Trauma&Orthopaedic Surgery Department of SurgeryUniversity of CambridgeBox 180Addenbrooke’s HospitalHills RoadCambridge CB20QQUK Present address:School of Pharmacy De Montforte UniversityLeicester LE19BHUK

Tissue engineering response may be tailored via controlled,sustained release of active agents from protein-loaded degradable microparticles incorporated directly within three-dimensional(3D)ice-templated collagen ***,the effects of covalent crosslinking during scaffold preparation on the availability and release of protein from the incorporated microparticles have not been ***,we load 3D ice-templated collagen scaffolds with controlled additions of poly-(DL-lactide-co-glycolide)*** probe the effects of subsequent N-(3-dimethylaminopropyl)-N0-ethylcarbodiimide hydrochloride crosslinking on protein release,using microparticles with different internal protein *** isothiocyanate labelled bovine serum albumin is used as a model protein *** scaffolds display a homogeneous microparticle distribution,and a reduction in pore size and percolation diameter with increased microparticle addition,although these values did not fall below those reported as necessary for cell *** protein distribution within the microparticles,near the surface or more deeply located within the microparticles,was important in determining the release profile and effect of crosslinking,as the surface was affected by the carbodiimide crosslinking reaction applied to the *** of microparticles with a high proportion of protein at the surface caused both a reduction and delay in protein *** located within the bulk of the microparticles,was protected from the crosslinking reaction and no delay in the overall release profile was seen.

关键词： collagen scaffolds PLGA microparticles FITC-BSA EDC crosslinking pore size percolation diameter

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Regulator of G protein signaling 6 mediates exercise-induced recovery of hippocampal neurogenesis,learning,and memory in a mouse model of Alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2969-2981页

作者： mackenzie m.Spicer Jianqi Yang Daniel Fu Alison N.DeVore marisol Lauffer Nilufer S.Atasoy Deniz Atasoy Rory A.Fisher Department of Neuroscience and Pharmacology University of Iowa Carver College of MedicineIowa CityIAUSA Iowa Neuroscience Institute University of Iowa Carver College of MedicineIowa CityIAUSA Interdisciplinary Graduate Program in molecular medicine University of Iowa Carver College of MedicineIowa CityIAUSA Neural Circuits and Behavior Core University of Iowa Carver College of MedicineIowa CityIAUSA

Hippocampal neuronal loss causes cognitive dysfunction in Alzheimer’s *** hippocampal neurogenesis is reduced in patients with Alzheimer’s *** stimulates adult hippocampal neurogenesis in rodents and improves memory and slows cognitive decline in patients with Alzheimer’s ***,the molecular pathways for exercise-induced adult hippocampal neurogenesis and improved cognition in Alzheimer’s disease are poorly ***,regulator of G protein signaling 6(RGS6)was identified as the mediator of voluntary running-induced adult hippocampal neurogenesis in ***,we generated novel RGS6fl/fl;APP_(SWE) mice and used retroviral approaches to examine the impact of RGS6 deletion from dentate gyrus neuronal progenitor cells on voluntary running-induced adult hippocampal neurogenesis and cognition in an amyloid-based Alzheimer’s disease mouse *** found that voluntary running in APP_(SWE) mice restored their hippocampal cognitive impairments to that of control *** cognitive rescue was abolished by RGS6 deletion in dentate gyrus neuronal progenitor cells,which also abolished running-mediated increases in adult hippocampal *** hippocampal neurogenesis was reduced in sedentary APP_(SWE) mice versus control mice,with basal adult hippocampal neurogenesis reduced by RGS6 deletion in dentate gyrus neural precursor ***6 was expressed in neurons within the dentate gyrus of patients with Alzheimer’s disease with significant loss of these RGS6-expressing ***,RGS6 mediated voluntary running-induced rescue of impaired cognition and adult hippocampal neurogenesis in APP_(SWE) mice,identifying RGS6 in dentate gyrus neural precursor cells as a possible therapeutic target in Alzheimer’s disease.

关键词： adult hippocampal neurogenesis Alzheimer’s disease dentate gyrus exercise learning/memory neural precursor cells regulator of G protein signaling 6(RGS6)

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Is tenofovir disoproxil fumarate superior to entecavir for prevention of hepatocellular carcinoma in patients with chronic hepatitis B?

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Hepatobiliary Surgery and Nutrition 2023年第6期12卷 919-922页

作者： lisa m.van Velsen milan J.Sonneveld Karel J.van Erpecum Department of Gastroenterology and Hepatology Erasmus University Medical CenterRotterdamThe Netherlands Department of Gastroenterology and Hepatology University Medical Center UtrechtUtrechtThe Netherlands

Chronic hepatitis B(CHB)remains a major global health problem with approximately 258 million infected individuals(1).Hepatocellular carcinoma(HCC)is one of the major and most deadly consequences of *** cirrhotic patients are at risk of *** previous studies have also revealed a consistent association between higher hepatitis B virus(HBV)DNA levels and increased HCC risk.

关键词： Hepatocellular carcinoma(HCC) entecavir tenofovir chronic hepatitis B(CHB)

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Healthcare staff well-being and use of support services during COVID-19:a UK perspective

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General Psychiatry 2021年第3期34卷 143-153页

作者： Anika R Petrella Luke Hughes Lorna A Fern lisa monaghan Benjamin Hannon Adam Waters Rachel m Taylor Cancer Division University College London Hospitals NHS Foundation TrustLondonUK Staff Psychological and Welfare Service University College London Hospitals NHS Foundation TrustLondonUK Centre for Nurse Midwife and AHP Led Research(CNMAR)University College London Hospitals NHS Foundation TrustLondonUK

Background The COVID-19 pandemic has drastically increased demands on healthcare workers(HCWs)leaving them vulnerable to acute psychological distress,burnout and post-traumatic *** response,supportive services in a central London hospital mobilised mental health support specifically for *** This rapid evaluation assessed HCW psychological welfare during the acute phase of the COVID-19 pandemic and their use of supportive services made *** During the acute phase of COVID-19(April to may 2020)all staff working for the hospital were invited to complete an online survey assessing well-being(self-rated health,moral distress exposure,symptoms of burnout and psychological distress)and use of available supportive services(awareness of,use and perceived helpfulness).Associations among personal characteristics and psychological well-being were explored using correlations and linear *** A total of 1127 staff participated in the rapid *** average,psychological distress was high(mean(SD):22(7.57))regardless of role,with 84%of this sample scoring above the general population mean(14.5).Nearly half of the sample reported feeling emotionally drained and a profile emerged displaying higher levels of psychological distress and burnout in those who were younger and exposed to morally distressing situations,with this group also exhibiting greater support service *** levels of burnout were associated with increased psychological distress when controlling for personal *** this acute phase of the pandemic,majority of staff used at least one service and rated it as *** HCWs experienced high levels of psychological distress requiring continued support as the COVID-19 pandemic *** HCWs were aware of supportive services,uptake *** order to mitigate the risk of burnout and post-traumatic stress,long-term,effective strategies that facilitate staff accessing support are urgently required.

关键词： distress younger staff

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The impact of alpha-fetoprotein (AFP), child-turcotte-pugh (CTP) score and disease staging on the survival of hepatocellular carcinoma (HCC) patients: a retrospective cohort from single oncology center

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Oncology research 2025年第1期33卷 149-160页

作者： Nasser mulla Yousef Katib Asim m Almughamsi Duaa S Alkhayat mohamed mosaad Samir T Alfotih Rawan Alaofi Department of Internal medicine Faculty of Medicine Taibah University Madinah 42278 Saudi Arabia. Department of Radiology Faculty of Medicine Taibah University Madinah 42278 Saudi Arabia. Department of Surgery Faculty of Medicine Taibah University Madinah 42278 Saudi Arabia. Department of Endemic and Infectious Diseases Suez Canal University Ismailia 41522 Egypt. King Salman bin Abdulaziz medical City Madinah 42311 Saudi Arabia. Prince mohammed Bin Abdulaziz Hospital Madinah 41511 Saudi Arabia.

Background:Hepatocellular carcinoma (HCC) is the most common cause of cancer-related death in Saudi Arabia. Our study aimed to investigate the patterns of HCC and the effect of TNm staging, Alfa-fetoprotein (AFP), and Child-Turcotte Pugh (CTP) on patients' overall survival (OS).methods:A retrospective analysis was conducted on 43 HCC patients at a single oncology center in Saudi Arabia from 2015 to 2020. All patients had to fulfill one of the following criteria: (a) a liver lesion reported as definitive HCC on dynamic imaging and/or (b) a biopsy-confirmed diagnosis.Results:The mean patient age of all HCC cases was 66.8 with a male-to-female ratio of 3.3:1. All patients were stratified into two groups: viral HCC (n = 22, 51%) and non-viral HCC (n = 21, 49%). Among viral-HCC patients, 55% were due to HBV and 45% due to HCV. Cirrhosis was diagnosed in 79% of cases. Age and sex did not significantly statistically differ in OS among viral and non-viral HCC patients (-value > 0.05). About 65% of patients had tumor size >5 cm during the diagnosis, with a significant statistical difference in OS (-value = 0.027). AFP was >400 ng/ml in 45% of the patients. There was a statistically significant difference in the OS in terms of AFP levels (-value = 0.021). A statistically significant difference was also observed between the CTP score and OS (-value = 0.02). CTP class B had the longest survival. BSC was the most common treatment provided to HCC patients followed by sorafenib therapy. There was a significant statistical difference in OS among viral and non-viral HCC patients (-value = 0.008).Conclusions:The most common predictors for OS were the underlying cause of HCC, AFP, and tumor size. Being having non-viral etiology, a tumor size >5 cm, an AFP > 400 ng/mL, and a CTP score class C were all negatively associated with OS.

关键词： Alpha-fetoprotein (AFP) Child-turcotte-pugh Hepatocellular carcinoma Pattern Progression free survival

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Heterogeneity of mature oligodendrocytes in the central nervous system

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Neural Regeneration Research 2025年第5期20卷 1336-1349页

作者： Chao Weng Adam m.R.Groh moein Yaqubi Qiao-Ling Cui Jo Anne Stratton G.R.Wayne moore Jack P.Antel Neuroimmunology Unit Montreal Neurological Institute-HospitalDepartment of Neurology and NeurosurgeryMcGill UniversityMontrealQCCanada Department of Neurology Renmin Hospital of Wuhan UniversityWuhanHubei ProvinceChina

mature oligodendrocytes form myelin sheaths that are crucial for the insulation of axons and efficient signal transmission in the central nervous *** evidence has challenged the classical view of the functionally static mature oligodendrocyte and revealed a gamut of dynamic functions such as the ability to modulate neuronal circuitry and provide metabolic support to *** the recognition of potential heterogeneity in mature oligodendrocyte function,a comprehensive summary of mature oligodendrocyte diversity is *** delve into early 20th-century studies by Robertson and Río-Hortega that laid the foundation for the modern identification of regional and morphological heterogeneity in mature ***,recent morphologic and functional studies call into question the long-assumed homogeneity of mature oligodendrocyte function through the identification of distinct subtypes with varying myelination ***,modern molecular investigations,employing techniques such as single cell/nucleus RNA sequencing,consistently unveil at least six mature oligodendrocyte subpopulations in the human central nervous system that are highly transcriptomically diverse and vary with central nervous system *** and disease related mature oligodendrocyte variation denotes the impact of pathological conditions such as multiple sclerosis,Alzheimer's disease,and psychiatric ***,caution is warranted when subclassifying mature oligodendrocytes because of the simplification needed to make conclusions about cell identity from temporally confined *** studies leveraging advanced techniques like spatial transcriptomics and single-cell proteomics promise a more nuanced understanding of mature oligodendrocyte *** research avenues that precisely evaluate mature oligodendrocyte heterogeneity with care to understand the mitigating influence of species,sex,central nervous system region,age,and disease,

关键词： aging central nervous system diseases electron microscopy heterogeneity immunohistochemistry myelin sheath natural history neuroglia oligodendroglia single-cell gene expression analysis

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Helping the Blind to See How bionic eyes are offering better sight to the blind

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空中英语教室（高级版．彭蒙惠英语） 2015年第7期 19-19,42页

作者： lisa m. Krieger

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Phylogeny and taxonomy of Ophiognomonia(Gnomoniaceae,Diaporthales),including twenty-five new species in this highly diverse genus

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Fungal Diversity 2012年第6期57卷 84-146页

作者： Donald m.Walker lisa A.Castlebury Amy Y.Rossman Luis C.mejía James F.White Department of Natural Sciences The University of FindlayFindlayOH 45840USA Systematic mycology&microbiology Laboratory USDA Agricultural Research ServiceBeltsvilleMD 20705USA Smithsonian Tropical Research Institute Apartado0843-03092BalboaAnconRepublic of Panama Department of Plant Biology and Pathology Rutgers UniversityNew BrunswickNJ 08901USA

Species of Ophiognomonia are leaf-inhabiting endophytes,pathogens,and saprobes that infect plants in the families Betulaceae,Fagaceae,Juglandaceae,Lauraceae,malvaceae,Platanaceae,Rosaceae,Salicaceae,and *** on extensive collecting,this speciesrich genus is now known to have a world wide distribution in primarily temperate areas,although some species are known from the *** of DNA sequences from three markers including guanine nucleotide-binding protein subunit beta-like protein(mS204),translation elongation factor 1α(tef-1α),and the ITS region including ITS1,5.8 S rDNA and ITS2 regions(ITS)were used to define phylogenetic species in *** plant association correlated with these ***-five new species of Ophiognomonia and two new combinations are proposed with descriptions and *** addition,descriptions and illustrations are provided for 12 other species of Ophiognomonia.A key is provided to the 45 currently accepted species of *** disposition of additional names in Ophiognomonia is also discussed.

关键词： Birch foliar pathogen Butternut canker GCPSR Genealogical sorting index Host associations mS204 multilocus phylogeny Walnut anthracnose and leaf blotch

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