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Ternary Ni-Co-Fe oxyhydroxide oxygen evolution catalysts:Intrinsic activity trends,electrical conductivity,and electronic band structure

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Nano Research 2019年第9期12卷 2288-2295页

作者： michaela Burke Stevens lisa J. Enman Ester Hamal Korkus Jeremie Zaffran Christina D. m. Trang James Asbury matthew G. Kast maytal Caspary Toroker Shannon W. Boettcher Department of Chemistry & Biochemistry and the materials Science Institute University of OregonEugeneOR 97403USA Department of materials Science & Engineering and The Nancy & Stephen Grand Technion Energy Program Technion Israel Institute of TechnologyHaifa 3200003Israel

Nickel-,cobalt-,and iron-based(oxy)hydroxides comprise the most-commonly studied electrocatalysts for the oxygen-evolution reaction(OER)in alkaline solution.A fundamental understanding of composition-structure-activity relationships for mixed-metal Ni-Co and Ni-Co-Fe(oxy)hydroxides is important to guide the design of advanced OER *** we use cyclic voltammetry,chronopotentiometry,inductively-coupled plasma-optical emission spectroscopy,and in situ electrical conductivity measurements to characterize the properties and activity of various compositions of Ni-Co-Fe(oxy)hydroxides prepared by cathodic *** with previous studies,we find Fe is essential for the mixed-metal(oxy)hydroxides to achieve high OER *** the rigorous absence of Fe(achieved by using specially cleaned electrolytes),the most-active Ni-Co(oxy)hydroxide composition has an OER turn-over frequency only twice that ofpure Co(oxy)hydroxide,suggesting minimal synergism between the two *** addition of Co to Ni-Fe(oxy)hydroxides shifts the onset of electrical conductivity to lower potentials,but has little effect on the intrinsic OER activity,with the most-active Ni-Co-Fe(oxy)hydroxide having an OER turn-over frequency only -1.5 times that of the Ni-Fe(oxy)*** magnitudes of the electrical conductivities are similar for all the compositions ***-functional-theory-calculated projected density of states show a significant contribution of all chemical elements at the valence band edge of the mixed-metal oxyhydroxide electronic structure,demonstrating significant electronic hybridization between the *** calculations suggest the involvement of all the elements in modulating the electronic structure at putative Fe-based active sites that are probably located at edges or defects in the two-dimensional oxyhydroxide sheets.

关键词： electrocatalysis heterogeneous catalysis water electrolysis oxygen evolution density functional theory

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Familial Alzheimer's disease modelling using induced pluripotent stem cell technology

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World Journal of Stem Cells 2014年第2期6卷 239-247页

作者： lisa mohamet Natalie J miazga Christopher m Ward Stem Cell Biology Group Core Technology FacilityFaculty of Human and Medical SciencesThe University of Manchester

Alzheimer’s disease(AD)is a progressive neurodegenerative disease in which patients exhibit gradual loss of memory that impairs their ability to learn or carry out daily *** of AD is difficult,particularly in early stages of the disease,and largely consists of cognitive assessments,with only one in four patients being correctly *** of novel therapeutics for the treatment of AD has proved to be a lengthy,costly and relatively unproductive process with attrition rates of>90%.As a result,there are no cures for AD and few treatment options available for ***,there is a pressing need for drug discovery platforms that can accurately and reproducibly mimic the AD phenotype and be amenable to high content screening ***,we discuss the use of induced pluripotent stem cells(iPSCs),which can be derived from adult cells,as a method of recapitulation of AD phenotype in *** assess their potential use in high content screening assays and the barriers that exist to realising their full potential in predictive efficacy,toxicology and disease *** present,a number of limitations need to be addressed before the use of iPSC technology can be fully realised in AD therapeutic ***,whilst the use of AD-derived iPSCs in drug discovery remains a fledgling field,it is one with immense potential that is likely to reach fruition within the next few years.

关键词： Human induced pluripotent stem cells Alzheimer’ s disease Neurodegenerative diseases High-throughput screening assays Cholinergic neurons Drug discovery Stratified medicine

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Cloud One

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考试与评价（高中英语教师版） 2009年第4期 45-49页

作者： lisa m. Bradley Gabriel Lally Bodkin

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Polyphenol-Rich Olive mill Wastewater Extract and Its Potential Use in Hair Care Products

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Journal of Cosmetics, Dermatological Sciences and Applications 2021年第4期11卷 356-370页

作者： lisa-marie Sittek Thomas m. Schmidts Peggy Schlupp RSC Pharma GmbH & Co. KG Giessen Germany

In this work, the influence of phenol-enriched olive mill wastewater (OmWW) extract on hair growth was investigated in vitro on human follicle dermal papilla cells. OmWW has already shown great potential for use in sk... 详细信息

In this work, the influence of phenol-enriched olive mill wastewater (OmWW) extract on hair growth was investigated m>in vitrom> on human follicle dermal papilla cells. OmWW has already shown great potential for use in skincare products, and its high polyphenol content is predestined to have a positive effect on hair growth. The studies included caffeine, a positive modulator of hair growth, and dihydrotestosterone, which causes hair loss m>in vivom>, as controls. The impact of the investigated compounds on hair growth was evaluated by studies on cell viability and proliferation, the release of growth factors (insulin-like growth factor-1 and vascular endothelial growth factor), and the reduction of reactive oxygen species formation. OmWW showed a positive influence on the proliferation of the human follicle dermal papilla cells. moreover, the extract leads to a significantly increased secretion of insulin-like growth factor-1, and a considerable reduction in reactive oxygen species formation was observed. Overall, our results show that the investigated phenol-enriched OmWW extract is a promising ingredient for hair care to improve hair growth, prevent hair loss due to oxidative stress and maintain a healthy scalp.

关键词： Hair Growth Hair Loss Human Follicle Dermal Papilla Cells Caffeine Dihydrotestosterone IGF-1 VEGF Reactive Oxygen Species

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macular microvascular and structural changes on optical coherence tomography angiography in atypical optic neuritis

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World Journal of methodology 2025年第1期15卷 88-94页

作者： Chinmay mahatme madhurima Kaushik Veerappan Rathinasabapathy Saravanan Karthik Kumar Virna m Shah Department of General Ophthalmology Aravind Eye HospitalCoimbatore 641014Tamil NāduIndia Department of Neuro-ophthalmology Aravind Eye HospitalCoimbatore 641014Tamil NāduIndia Department of Vitreoretina Aravind Eye HospitalCoimbatore 641014Tamil NāduIndia

BACKGROUND Atypical optic neuritis,consisting of neuromyelitis optica spectrum disorders(NmOSD)or myelin oligodendrocyte glycoprotein antibody disease(mOGAD),has a very similar presentation but different prognostic implications and longterm management *** and metabolic factors are being thought to play a role in such autoimmune neuro-inflammatory disorders,apart from the obvious immune mediated *** the advent of optical coherence tomography angiography(OCTA),it is easy to pick up on these subclinical macular microvascular and structural *** To study the macular microvascular and structural changes on OCTA in atypical optic *** This observational cross-sectional study involved 8 NmOSD and 17 mOGAD patients,diagnosed serologically,as well as 10 healthy *** vascular density(mVD)and ganglion cell+inner plexiform layer thickness(GCIPL)were studied using *** There was a significant reduction in mVD in NmOSD and mOGAD affected as well as unaffected eyes when compared with healthy *** and mOGAD affected eyes had significant GCIPL thinning compared with healthy *** unaffected eyes did not show significant GCIPL thinning compared to healthy controls in contrast to mOGAD unaffected *** comparing NmOSD with mOGAD,there was no significant difference in terms of mVD or GCIPL in the affected or unaffected *** Although significant microvascular and structural changes are present on OCTA between atypical optic neuritis and normal patients,they could not help in differentiating between NmOSD and mOGAD cases.

关键词： Optical coherence tomography angiography Atypical optic neuritis macular microvascular changes Neuromyelitis optica spectrum disorders myelin oligodendrocyte glycoprotein antibody disorder

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Getting physical with medical education:Exercise based virtual anatomy review classes for medical students

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World Journal of methodology 2025年第1期15卷 20-25页

作者： Nadeesha R Samarasinghe Taniya S Nagpal michele L Barbeau Charys m martin Division of General Surgery Faculty of MedicineUniversity of British ColumbiaVancouver V6T 1Z3BCCanada Faculty of Kinesiology Sport and RecreationUniversity of AlbertaEdmonton T6G 2R3ABCanada Anatomy and Cell Biology University of Western OntarioLondon N6A 3K7ONCanada Department of Anatomy and Cell Biology Schulich School of Medicine and DentistryThe University of Western OntarioLondon N6A 3K7ONCanada

The benefits of regular physical activity are well ***,few studies have examined the effectiveness of integrating physical activity(PA)into curricula within a post-secondary *** investigate the incorporation of PA into medical curriculum,we developed a series of optional exercise-based review sessions designed to reinforce musculoskeletal(mSK)anatomy course *** synchronous sessions were co-taught by a group fitness instructor and an anatomy *** fitness instructor would lead students through both strength and yoga style exercises,while the anatomy instructor asked questions about relevant anatomical structures related to course material previously *** the sessions,participants were asked to evaluate the classes on their self-reported exam preparedness in improving mSK anatomy knowledge,PA levels,and mental *** participants completed surveys;a majority agreed that the classes increased understanding of mSK concepts(90.0%)and activity levels(97.7%).many(70.0%)felt that the classes helped reduce *** majority of respondents(90.0%)agreed that the classes contributed to increased feelings of social ***,medical students saw benefit in PA based interventions to supplement mSK course *** with increasing activity levels and promoting health behaviours,integrating PA into medical curriculum may improve comprehension of learning material,alleviate stress and foster social connectivity among medical students.

关键词： medical education musculoskeletal Anatomy Exercise Online learning

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寻求安全

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作者： (美)lisa m. Najavits

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Trends in maternal body mass index in Northern Ireland:a cross-sectional and longitudinal study

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Family medicine and Community Health 2021年第4期9卷 20-30,I0003-I0012页

作者： lisa Kent Christopher Cardwell Ian Young Kelly-Ann Eastwood Administrative Data Research Centre Northern Ireland Centre for Public HealthQueen's University BelfastBelfastUK Institute of Clinical Science Block BCentre for Public HealthQueen's University BelfastBelfastUK Fetal medicine Unit University Hospitals Bristol and Weston NHS Foundation TrustBristolUK

Objectives Explore(1)associations between maternal body mass index(BmI),demographic and clinical characteristics,(2)longitudinal trends in BmI,(3)geographical distributions in prevalence of maternal overweight and *** Retrospective population-based *** Linked,anonymised,routinely collected healthcare data and official statistics from Northern *** All pregnancies in Northern Ireland(2011-2017)with BmI measured at≤16 weeks *** Analysis of variance andχ^(2)tests were used to explore *** linear regression was used to explore longitudinal trends and spatial visualisation illustrated geographical *** outcomes are prevalence of overweight(BmI≥25 kg/m^(2))and obesity(BmI≥30 kg/m^(2)).Results 152961 singleton and 2362 multiple pregnancies were included.A high prevalence of maternal overweight and obesity in Northern Ireland is apparent(singleton:52.4%;multiple:48.3%)and is *** was positively associated with older age,larger numbers of previous pregnancies and unplanned pregnancy(pmI category was also positively associated with unemployment(35%in obese class III vs 22%in normal BmI category)(pmI categories were associated with increased rate of comorbidities,including hypertension(normal BmI:1.8%vs obese III:12.4%),diabetes mellitus(normal BmI:0.04%vs obese III:1.29%)and mental ill-health(normal BmI:5.0%vs obese III:11.8%)(pmaternal obesity varied with deprivation(most deprived:22.8%vs least deprived:15.7%)(pmI was associated with agemployment and mental ill-health(pmaternal BmI>25 kg/m^(2)is increasing over time in Northern *** are entering pregnancy with additional comorbidities likely to impact their life course beyond *** highlights the need for prioritisation of preconception and inter-pregnancy support for management of weight and

关键词： routine index category

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ORGANIC CARBON STOCKS IN A SILTY TEXTURED SOIL FOLLOWING REINTEGRATION OF A 20 YEARS OLD mISCANTHUS×GIGANTEUS SITE INTO A CROP ROTATION

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Frontiers of Agricultural Science and Engineering 2023年第2期10卷 183-197页

作者： lisa ESSICH Reiner RUSER Jens HARTUNG Anne HANEmANN meike GASSNER Liam OBERDORFER Jörn BREUER Jürgen RECKNAGEL Helmut NUßBAUmER Torsten mÜLLER Institute of Crop Science Department Fertilization and Soil Matter DynamicsUniversity of Hohenheim70599 StuttgartGermany Institute of Crop Science Biostatistics UnitUniversity of Hohenheim70599 StuttgartGermany Center for Agricultural Technology Augustenberg(LTZ) 76227 KarlsruheGermany

miscanthus×giganteus may play an important role in replacing fossil energy resources by bio-based *** further advantage of miscanthus production is the generally high soil organic carbon(C_(org))enrichment in *** to declining yields,miscanthus stocks are commonly reintegrated into crop rotation after approximately 20 *** there is only few information,whether these high amounts of(C_(org))can be conserved while intensifying soil tillage and crop management after ***,we monitored(C_(org))stocks in a control with more than 20 years of continuous miscanthus and in a treatment with reintegration of a 20-years old miscanthus stock into an organic crop *** onδ^(13)C soil values,we calculated an annual(C_(org))enrichment of 0.98 mg·ha^(-1)·yr^(-1)C under *** than 95%of the miscanthus-C was determined in the upper 0.25 m of *** miscanthus cultivation did not affect yields during the first five extension years and(C_(org))stocks increased *** reintegration,(C_(org))stocks remained constant during five years,which was mainly attributed to the humification and/or stabilization of high amounts of destroyed roots and rhizomes.A significant decrease in(C_(org))(-5.7 mg·ha^(-1)C)compared to the continuing miscanthus cultivation was at first measured six years after reintegration into crop rotation,underlining the need of long-term *** data also show,that miscanthus production cycles can be extended in our region,and that sowing of the alfalfa grass mixture after rhizome/root destruction was efficient in preserving(C_(org))stocks for at least first five years after reintegration.

关键词： biobased energy crops C balance humus accumulation

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Validation and reproducibility of the Heidelberg Edge Perimeter in the detection of glaucomatous visual field defects

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International Journal of Ophthalmology(English edition) 2019年第4期12卷 577-581页

作者： Qi N.Cui Priyanka Gogt Jonathan m.Lam Safa Siraj lisa A.Hark Jonathan S.myers L.Jay Katz michael Waisbourd Glaucoma Research Center Wills Eye Hospital Scheie Eye Center University of Pennsylvania Department of Ophthalmology Tel Aviv Sourasky Medical Center affiliated to the Sackler Faculty of Medicine Tel Aviv University

AIm: To validate the ability of the Heidelberg Edge Perimeter(HEP) in detecting glaucomatous visual field(VF) defects compared to the Octopus Visual Field(OVF) Analyzer and to determine the test-retest repeatability of both ***: This prospective, cross-sectional study was conducted at Wills Eye Hospital, Philadelphia, PA. Glaucoma subjects and unaffected controls underwent VF testing using HEP standard automated perimetry(SAP) Ⅲ 30-2 Adaptive Staircase Thresholding Algorithm(ASTA) FAST protocol and OVF G-TOP white-on-white strategy. Testing order was randomized. Pearson's correlation coefficient was calculated for both mean deviation(mD) and pattern standard deviation/square root of loss of variance(PSD/s LV). Receiver operating characteristic(ROC) curves were used to determine the diagnostic abilities of both modalities. Glaucoma subjects returned for repeat testing and intraclass correlation coefficients(ICCs) were calculated to assess test-retest repeatability. RESULTS: Seventy-nine subjects with glaucoma and 36 unaffected controls were enrolled. HEP and OVF were significantly correlated for both mD(r=-0.84; Pmparable between HEP and OVF for both mD(0.74 and 0.79, respectively; P=0.26) and PSD/sL V(0.74 and 0.82; P=0.08). ICC was high for both HEP (0.96 for mD, 0.95 for PSD/s LV) and OVF(0.82 and 0.88, respectively). mean test duration(min) was significantly shorter for OVF(2.63) compared to HEP(5.15; PmD and PSD/s LV, and have similar validity for detecting glaucoma. The test-retest repeatability is high for both HEP and OVF, however the average testing duration of HEP is significantly longer than that of OVF.

关键词： glaucoma Heidelberg Edge Perimeter standard automated perimetry Octopus Visual Field Analyzer visual field

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