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Elucidating regulatory processes of intense physical activity by m.lti-om.cs analysis

m.litary m.dical Research 2024年第4期11卷 479-499页

作者： Ernesto S.Nakayasu m.rina A.Gritsenko Young-m. Kim.Jennifer E.Kyle Kelly G.Stratton Carrie D.Nicora Nathalie m.noz Kathleen m.Navarro Daniel Claborne Yuqian Gao Karl K.Weitz Vanessa L.Paurus Kent J.Bloodsworth Kelsey A.Allen lisa m.bramer Fernando m.ntes Kathleen A.Clark Grant Tietje Justin Teeguarden Kristin E.Burnum.Johnson Biological Sciences Division Pacific Northwest National LaboratoryRichlandWA 99352USA Environm.ntal and m.lecular Sciences Division Pacific Northwest National LaboratoryRichlandWA 99352USA Centers for Disease Control and Prevention National Institute for Occupational Safety and HealthWestern States DivisionDenverCO 80204USA Com.utational Analytics Division Pacific Northwest National LaboratoryRichlandWA 99352USA National Security Directorate Pacific Northwest National LaboratoryRichlandWA 99352USA Los Angeles County Fire Departm.nt Los AngelesCA 90063USA Centers for Disease Control and Prevention National Institute for Occupational Safety and HealthRespiratory Health DivisionMorgantownWV 26505USA Environm.ntal and m.lecular Toxicology Oregon State UniversityCorvallisOR 97331USA

Background:Physiological and biochem.cal processes across tissues of the body are regulated in response to the high dem.nds of intense physical activity in several occupations,such as firefighting,law enforcem.nt,m.litary,and sports.A better understanding of such processes can ultim.tely help im.rove hum.n perform.nce and prevent illnesses in the work ***:To study regulatory processes in intense physical activity sim.lating real-life conditions,we perform.d a m.lti-om.cs analysis of 3 biofluids(blood plasm.,urine,and saliva)collected from.11 wildland firefighters before and after a 45 m.n,intense exercise *** profiles ***-exercise were com.ared by Student’s t-test followed by pathway analysis and com.arison between the different om.cs ***:Our m.lti-om.cs analysis identified and quantified 3835 proteins,730 lipids and 182 m.tabolites com.ining the 3 different types of *** blood plasm. analysis revealed signatures of tissue dam.ge and acute repair response accom.anied by enhanced carbon m.tabolism.to m.et energy *** urine analysis showed a strong,concom.tant regulation of 6 out of 8 identified proteins from.the renin-angiotensin system.supporting increased excretion of catabolites,reabsorption of nutrients and m.intenance of fluid *** saliva,we observed a decrease in 3 pro-inflam.atory cytokines and an increase in 8 antim.crobial peptides.A system.tic literature review identified 6 papers that support an altered susceptibility to respiratory ***:This study shows sim.ltaneous regulatory signatures in biofluids indicative of hom.ostatic m.intenance during intense physical activity with possible effects on increased infection susceptibility,suggesting that caution against respiratory diseases could benefit workers on highly physical dem.nding jobs.

关键词： m.lti-om.cs analysis Intense exercise Hum.n perform.nce Biofluids m.tabolism Im.unity

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Characterizing the Relative Im.ortance Assigned to Physical Variables by Clim.te Scientists when Assessing Atm.spheric Clim.te m.del Fidelity

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Advances in Atm.spheric Sciences 2018年第9期35卷 1101-1113页

作者： Susannah m.BURROWS Aritra DASGUPTA Sarah REEHL lisa bramer Po-Lun m. Philip J.RASCH Yun QIAN Pacific Northwest National Laboratory RichlandWashington 99354USA

Evaluating a clim.te m.del＇s fidelity（ability to sim.late observed clim.te） is a critical step in establishing confidence in the m.del＇s suitability for future clim.te projections, and in tuning clim.te m.del param.ters. m.del developers use their judgem.nt in determ.ning which trade-offs between different aspects of m.del fidelity are acceptable. However, little is known about the degree of consensus in these evaluations, and whether experts use the sam. criteria when different scientific objectives are defined. Here, we report on results from.a broad com.unity survey studying expert assessm.nts of the relative im.ortance of different output variables when evaluating a global atm.spheric m.del＇s m.an clim.te. We find that experts adjust their ratings of variable im.ortance in response to the scientific objective, for instance, scientists rate surface wind stress as significantly m.re im.ortant for Southern Ocean clim.te than for the water cycle in the Asian watershed. There is greater consensus on the im.ortance of certain variables（e.g., shortwave cloud forcing） than others（e.g., aerosol optical depth）. We find few differences in expert consensus between respondents with greater or less clim.te m.deling experience,and no statistically significant differences between the responses of clim.te m.del developers and users. The concise variable lists and com.unity ratings reported here provide baseline descriptive data on current expert understanding of certain aspects of m.del evaluation, and can serve as a starting point for further investigation, as well as developing m.re sophisticated evaluation and scoring criteria with respect to specific scientific objectives.

关键词： clim.te clim.te m.del m.del evaluation num.rical m.del skill expert elicitation

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