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Plenary Lecture:Introduction to Eli Lilly and Company Research and Development

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Plenary Lecture:Introduction to Eli Lilly and Company Resear...

药物非临床安全性研究学术研讨会

作者： lisa a．shipley Drug Disposition/Global Pharmacokinetics/Pharmacodynamics/Trial Simulations Lilly Research Laboratories Division of Eli Lilly and Company Ph.D Vice President

Eli Lilly and Company:A Brief History

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The Role of ADME in Drug Safety Evaluation

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The Role of ADME in Drug Safety Evaluation

药物非临床安全性研究学术研讨会

作者： Michelle M He lisa a.shipley Carl L.McMillian Ph.D.Research Advisor Drug Disposition Lilly Research LaboratorieDivision of Eli Lilly and Comp Ph.D.Vice President Drug Disposition Lilly Research LaboratorieDivision of Eli Lilly and Comp Ph.D.Director Pathology and Investigative Toxicology Lilly Research LaboratorieDivision of Eli Lilly and Comp

Role of ADME in Safety Assessment ·Delineates the Absorption,Distribution, Metabolism and Excretion of drug candidates in animals and humans ·Determines exposure in Toxicology Studies to establish Margins of Safety

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大会报告：美国礼来公司研发工作介绍

大会报告：美国礼来公司研发工作介绍

药物非临床安全性研究学术研讨会

作者： lisa a．shipley 药物行为全球药代动力学/药效学/临床模拟分部礼来实验研究室美国礼来公司

130多年来,礼来致力于满足美国及全球范围内的人们卫生保健方面的需要。我们通过开发创新药物的方式来解决这个问题一将比其它大制药公司更高比例的销售额投入到药物研发之中。

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ADME在药品毒理学评价中的作用

ADME在药品毒理学评价中的作用

药物非临床安全性研究学术研讨会

作者： Michelle M．He lisa a．shipley Carl L．McMillian 礼来公司礼来研究实验室礼来公司礼来研究实验室礼来公司礼来研究实验室病理及毒理学研究室

ADME 在安全性评价中的作用·描述候选药物在动物和人体内的吸收、分布、代谢和扫泄(ADME) ·在毒理学研究中测定暴露量以确定安全范围(MOS)

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Going only half the way:cell cycle exit after the G1 restriction point

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Signal Transduction and Targeted Therapy 2024年第1期9卷 1-2页

作者： lisa Muller Tony Gutschner Mechthild Hatzfeld Department of Pathobiochemistry Institute of Molecular MedicineMartin Luther University Halle-WittenbergCharles Tanford Protein Research CenterHalleGermany Department of RNA Biology and Pathogenesis Institute of Molecular MedicineMartin Luther University Halle-WittenbergCharles Tanford Protein Research CenterHalleGermany

In a recent article published in Nature,James *** et *** that cyclin A2 levels determine whether cells will make an entrance into mitosis or whether cells will leave the cell cycle after having passed the G1/restriction(R)-point implicating that the decision is fully reversible(Fig.1).This ground-breaking study could impact future approaches for cancer treatment by targeting the mitotic clock.

关键词： point cycle

Exploring innovative synthetic solutions for advanced polymer-based electrochromic energy storage devices:Phenoxazine as a promising chromophore

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Journal of Energy Chemistry 2024年第4期91卷 433-452页

作者： Catalin-Paul Constantin Mihaela Balan-Porcarasu Gabriela lisa “Petru Poni”Institute of Macromolecular Chemistry Electroactive Polymers&Plasmochemistry Laboratory41A Grigore Ghica Voda AlleyIasi 700487Romania “Gh.Asachi”Technical University Iasi Faculty of Chemical EngineeringBd.Mangeron 71Iasi 700050Romania

The current investigation offers an innovative synthetic solution regarding electrochromic(EC)and energy storage applications by exploring phenoxazine(POZ)***,three POZ-based polymers(polyimide,polyazomethine,and polyamide)were synthesized to ascertain the superior *** polyamide exhibited remarkable attributes,including high redox stability during 500 repetitive CVs,optical contrast of 61.98%,rapid response times of 1.02 and 1.38 s for coloring and bleaching,EC efficiency of 280 cm^(2)C^(-1).and decays of the optical density and EC efficiency of only 12.18%and 6.23%after 1000 ***,the energy storage performance of polyamide PA was tested,for which the following parameters were obtained:74.7 F g^(-1)(CV,scan rate of 10 mV s^(-1))and 118 F g^(-1)(GCD,charging current of 0.1 A g^(-1)).Then,the polyamide was tested in EES devices,which yielded the following EC parameters:an optical contrast of 62.15%,response times of 9.24 and 5.01 s for coloring and bleaching,EC efficiency of 178 cm^(2)C^(-1),and moderate decays of 20.25%and 23.24%for the optical density and EC efficiency after 500 *** energy storage performance included a capacitance of 106 F g^(-1)(CV,scan rate of 0.1 mV s^(-1))and 9.23 F g^(-1)(GCD,charging current of 0.1 A g^(-1)),capacitance decay of 11.9%after500 cycles,and 1.7 V retention after 2 ***,two EES devices connected in series powered a 3 V LED for almost 30 s.

关键词： Polymers Phenoxazine Electrochromic Energy storage Electrochromi cenergy storage devices

Does ash dieback affect the reproductive ecology of Fraxinus excelsior L.?

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Journal of Forestry Research 2024年第2期35卷 54-69页

作者： Anna‑Katharina Eisen lisa Buchner Barbara Fussi Susanne Jochner‑Oette Physical Geography/Landscape Ecology and Sustainable Ecosystem Development Catholic University of Eichstätt-Ingolstadt85072 EichstättGermany Bavarian Office for Forest Genetics(AWG) 83317 TeisendorfGermany

Forest tree species reproduction is a key factor in maintaining the genetic diversity of future generations and the stability of forest *** ongoing ash dieback disease could affect the reproductive ecology of Fraxinus excelsior *** have a major impact on the quantity and quality of pollen and *** this study,we investigated pollen production and viability of pollen and seeds of ash trees with different health status from 2018 to *** were collected from 105 trees(pollen production),pollen from 125 trees(pollen viability),and seeds from 53 trees(seed quality)in two seed orchards and in one floodplain forest in southern *** all parameters were examined at every site every *** average pollen production per tree was estimated at 471.2±647.9 billion pollen *** addition,we found that a high number of inflorescences did not equate to high pollen production per *** production of healthy and diseased trees did not differ significantly,although only 47%of severely diseased male trees(vs.72%for healthy trees)produced *** regards to pollen viability,the TTC test showed an average viability of 73%±17%.Overall,there was a slight tendency for diseased trees to have less viable ***,a significant difference could only be calculated for trees in the floodplain *** percentage of germinable seeds in 2018 was 38%in the floodplain forest and 57%in one of the seed *** percentage of viable seeds(TTC test)ranged from 17 to 22%in the orchards in ***-viable seeds were usually heavily infested by *** general,seed quality was not significantly different between healthy and diseased *** results indicate that ash dieback affects flower formation and pollen viability but not pollen production or seed ***,the fact that hardly any flowering was observed,especially for trees that were seriously affected,suggests a negative effect of ash dieback on reproductive per

关键词： Common ash Seed orchard Floodplain forest Pollen production Viability TTC test Seed stratification Phenology

An updated inventory of marine opisthobranch(Mollusca,Gastropoda)from the territorial waters of the Republic of Mauritius

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Journal of Oceanology and Limnology 2024年第1期42卷 226-243页

作者： lisa AH SHEE TEE Chandani APPADOO Daneshwar PUCHOOA Vishwakalyan BHOYROO Department of Agricultural&Food Science Faculty of AgricultureUniversity of MauritiusRéduit 80837Mauritius Department of Biosciences&Ocean Studies Pole of Research Excellence Sustainable Marine BiodiversityFaculty of ScienceUniversity of MauritiusRéduit 80837Mauritius

Island ecosystems support diverse aquatic invertebrate communities comprising endemic *** of existing species is important for *** this study,a checklist of marine opisthobranch from the Republic of Mauritius is presented.A combination of benthic surveys(50 m×5 m in triplicates),rover diving techniques and photo documentation were used over two years(2018–2020)within 35 sheltered and unsheltered *** and molecular analysis were used for *** composition within sheltered and unsheltered areas in Mauritius was estimated using the Bray-Curtis *** checklist featured 117 species belonging to 61 genera and 28families,of which 13 are new *** findings increased the knowledge of opisthobranch diversity from the Mauritius by 15.4%.Among the listed species,the distribution range of Cyerce nigra,Actinocyclus papillatus,and Phyllidia picta extended from the Western Pacific to the South Western Indian *** analysis of the undescribed Gymnodoris *** it resembled Gymnodoris *** Hawaii and were different by a genetic distance value of 10.6%.The species richness and evenness were higher within the sheltered regions of Mauritius which harboured the food resource of *** areas as compared to unsheltered regions were heavily populated,suggesting the probable influence of wave actions on opisthobranch diversity and *** order Nudibranchia was reported as most speciose,with 86 *** Sacoglossa and Nudibranchia were observed only on macroalgae and sponges *** abundance was also recorded on shipwrecks which are the most common form of artificial *** the inclusion of observations from previous studies,201species belonging to 94 genera and 36 families are now known from the Mauritius.

关键词： marine opisthobranch inventory new record occurrence Republic of Mauritius Indian Ocean

Crafting chirality in three dimensions via a novel fabrication technique for bound states in the continuum metasurfaces

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Light(Science & Applications) 2024年第3期13卷 390-392页

作者： Zaid Haddadin Anna My Nguyen lisa V.Poulikakos Department of Electrical&Computer Engineering University of California San DiegoLa JollaCAUSA Department of Mechanical&Aerospace Engineering University of California San DiegoLa JollaCAUSA Program of Materials Science&Engineering University of California San DiegoLa JollaCAUSA

An additional deposition step was added to a multi-step electron beam lithographic fabrication process to unlock the height dimension as an accessible parameter for resonators comprising unit cells of quasi-bound stat... 详细信息

关键词： dimensions dimension intrinsic