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光学学报 2009年第5期29卷 1408-1415页

作者：刘立人中国科学院上海光学精密机械研究所上海201800

基于合成孔径激光成像雷达(SAIL)二维数据收集方程和成像算法,研究了圆形孔径和矩形孔径光学望远镜天线的方位向成像分辨率,导出了点扩展函数的解析表达式,分析了理想成像点尺寸及其光学足迹中心偏离、相位二次项匹配滤波失匹、空间采... 详细信息

基于合成孔径激光成像雷达(SAIL)二维数据收集方程和成像算法,研究了圆形孔径和矩形孔径光学望远镜天线的方位向成像分辨率,导出了点扩展函数的解析表达式,分析了理想成像点尺寸及其光学足迹中心偏离、相位二次项匹配滤波失匹、空间采样宽度、采样周期等的影响;也研究了距离向成像分辨率并分析了非线性啁啾补偿等的影响。对于各种影响因素都给出了数学判据,特别是发现了矩形孔径的光学望远镜可以产生适合于SAIL扫描方式的矩形光学足趾并消除方位向分辨率不均匀降低,可以设计最佳的矩形孔径的尺度分别控制光学足趾在方位向及其垂直方向上的尺度,得到大扫捕宽度和高方位向分辨率;也发现了目标外差延时必须尽量小以克服非线性啁啾和初始光频不稳定性相位误差。

关键词：合成孔径激光成像雷达圆形孔径矩形孔径点目标激光雷达数据收集方程方位向分辨率距离向分辨率点扩展函数外差接收方向性函数光束发散度函数

双曲波前差自扫描直视合成孔径激光成像雷达原理

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光学学报 2015年第1期35卷 395-404页

作者：刘立人中国科学院上海光学精密机械研究所空间激光信息传输与探测技术重点实验室上海201800

提出了一种双曲波前差自扫描直视合成孔径激光成像雷达系统,结构上采用正交偏振同轴双光束发射和偏振干涉自差探测结构,原理上应用波面变换产生双曲波前差照射光斑,因此通过目标的相对运动在交轨向自动扫描产生目标面横向距离有关的线... 详细信息

提出了一种双曲波前差自扫描直视合成孔径激光成像雷达系统,结构上采用正交偏振同轴双光束发射和偏振干涉自差探测结构,原理上应用波面变换产生双曲波前差照射光斑,因此通过目标的相对运动在交轨向自动扫描产生目标面横向距离有关的线性相位调制,同时在顺轨向产生目标顺轨向距离有关的二次项相位历程,采用补偿二次多普勒频移的傅里叶变换和补偿交叉耦合的共轭二次项匹配滤波算法实现图像重构。本系统主要特点是结构简单,无需使用任何光调制器,没有交轨向信号的初始相位同步问题,不存在目标时间延时影响,同时也保留了直视合成孔径激光成像雷达的固有优点,如有效地降低了大气等相位干扰,照明光斑可以很大,接收口径可以很大。本雷达适用于航空航天的各种相对运动速度和作用距离的对地观察成像和基于逆合成孔径原理的激光成像雷达。

关键词：遥感合成孔径激光成像雷达直视合成孔径激光成像雷达波面变换双曲波面自动扫描线性相位调制

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自干涉合成孔径激光三维成像雷达原理

光学学报 2014年第5期34卷 253-260页

作者：刘立人中国科学院上海光学精密机械研究所中国科学院空间激光信息传输与探测技术重点实验室上海201800

在直视合成孔径激光成像雷达(SAL)的基础上,提出了一种自干涉的产生三维成像的原理方法。首先对于交轨向正扫描和反扫描的柱面镜进行位置偏置,造成交轨向成像频谱的平移并产生相对线性相延,然后逐一对一对交轨向正扫描和反扫描收集聚焦... 详细信息

在直视合成孔径激光成像雷达(SAL)的基础上,提出了一种自干涉的产生三维成像的原理方法。首先对于交轨向正扫描和反扫描的柱面镜进行位置偏置,造成交轨向成像频谱的平移并产生相对线性相延,然后逐一对一对交轨向正扫描和反扫描收集聚焦像进行相干叠加,并由此产生自干涉。自干涉产生的交轨向平展条纹对于目标面的倾斜投射即可产生包含目标高度信息的波痕干涉图,最后通过解包裹算法产生表征目标表面轮廓的等位线图。本方法采用一发一收的雷达结构通过单航过干涉法实现三维成像,结构简单,原理有效,同时具有抗大气、运动平台等相位干扰能力。

关键词：成像系统合成孔径激光成像雷达直视合成孔径激光成像雷达干涉合成孔径雷达三维地形浮雕成像扫描柱面镜位置偏置

合成孔径激光成像雷达(VI):时空散斑效应和外差探测信噪比

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光学学报 2009年第8期29卷 2326-2332页

作者：刘立人中国科学院上海光学精密机械研究所

研究了合成孔径激光成像雷达成像过程中激光散斑效应对于光学外差探测的影响,考虑了光学天线孔径对于散斑的空间平滑效应,特别是提出了时间变化的散斑统计特性并进行了数学分析,因为线性调频激光在一次激光曝光时间过程中激光散斑的花... 详细信息

研究了合成孔径激光成像雷达成像过程中激光散斑效应对于光学外差探测的影响,考虑了光学天线孔径对于散斑的空间平滑效应,特别是提出了时间变化的散斑统计特性并进行了数学分析,因为线性调频激光在一次激光曝光时间过程中激光散斑的花样是变化的。最终给出了考虑时空散斑效应的光子受限外差探测信噪比。

关键词：合成孔径激光成像雷达啁啾激光激光散斑散斑平滑光子受限外差探测载波噪音比信号噪音比

合成孔径激光成像雷达(Ⅲ):双向环路发射接收望远镜

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光学学报 2008年第7期28卷 1405-1410页

作者：刘立人中国科学院上海光学精密机械研究所上海201800

提出了一种用于合成孔径激光成像雷达的双向环路结构的发射接收望远镜,双向环路包括发射4-f转像系统、接收4-f转像系统和独立的望远镜。发射通道中设置离焦和相位调制平板偏置,接收通道中设置离焦和相位平板偏置。控制发射离焦量,发射... 详细信息

提出了一种用于合成孔径激光成像雷达的双向环路结构的发射接收望远镜,双向环路包括发射4-f转像系统、接收4-f转像系统和独立的望远镜。发射通道中设置离焦和相位调制平板偏置,接收通道中设置离焦和相位平板偏置。控制发射离焦量,发射相位调制函数,接收离焦量,接收相位调制函数,用同一个望远镜可以同时实现空间二次项相位附加偏置的激光发射和消除目标点散射回波接收波面像差的离焦光学接收,并产生雷达运动方向上合适的和可控制的相位二次项历程,从而实现孔径合成成像。详细介绍了系统设计,给出了从发射到光电外差接收的全过程传输方程。

关键词：合成孔径激光成像雷达望远镜双向环路 4-f转像系统离焦相位平板

Effect of electroacupuncture at Zuansanli(ST36) on dorsal random-pattern skin flap survival in a rat model

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Effect of electroacupuncture at Zuansanli(ST36) on dorsal ra...

One-operation image algebra for optical processing

201.年浙江省骨科学学术年会

作者： liren Wang Dingsheng Lin Wenzhou Medical University Department of Hand and Plastic Surgery Second Affiliated Hospital of Wenzhou Medical University

Specific aims & objectives:Electroacupuncture at Zusanli(ST36) could accelerate angiogenesis by upregulating HIF-1.protein,and enhance skin microcirculation blood *** paper aims to study the effects of electroacupuncture at Zuansanli(ST36) on random-pattern flap survival rate in a rat *** and methods:Thirty female Sprague-Dawley rats were randomly divided into three groups:(1.control group(no postoperative electro-acupuncture);(2) study A group(postoperative electroacupuncture at non-acupoint areas,1. Hz for 30 min per day) and(3) study B group(postoperative electroacupuncture at Zusanli,1. Hz for 30 min per day).The ’McFarlane flap’ rat models were established on the rat ***:After 7 days’ electroacupuncture,the flap survival area ratio was *** tissue samples were taken for histological *** vascular endothelial growth factor(VEGF),malondialdehyde(MDA)and Superoxide dismutase(SOD) expression were detected by ***:7 days after operation,the percentage of flap survival areas ratio in control group(51.06%±2.50%) and in study A group(52.4%±3.1.%) were significantly lower compared with that of the study B group(74.0%±3.33%)%(P 1..Histological analysis demonstrated angiogenesis with mean vessel density per mm2 be lower in control group(1..75%±1.93%) and in study A(1..71.±2.64%) than in study B group(32.28%±2.73%)(P 1..VEGF expression and SOD contents were significantly increased in study B Group compared with study A Group and control group(p 1.,whereas MDA level was reduced(p 1..Discussion:Electroacupuncture at Zuansanli(ST36) may increase the expression of VEGF,which can effectively increase angiogenesis to provide inadequate vascular perfusion and block the release of ischemia reperfusion injury associated free radical,as well as the production of the superoxide ***:Electroacupuncture at Zuansanli(ST36) can improve random flap survival rate effectively.

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Chinese Journal of Lasers 1993年第4期B2卷 67-73页

作者： liren Liu(Shanghai Institute of Optics and Fine Mechanics, Academia Sinica, P. O. Box 800-21.,Shanghai 201.00,China) Shanghai Inst of Optics and Fine Mechanics Shanghai China

A binary image algebra with one operation of a logic operation followed by a dilation and its modification with three additional operations for threshold processing of grey level images are developed in this paper. All the binary image processing functions and various grey level image processing functions related to morphological operations can be represented by the algebraic structure. The algebra is particularly suitable for parallel processing by optics in a cellular logic image processor architecture.

关键词： image algebra. mathematical morphology logic operations optical processing

HIF-1.-induced expression of m6A reader YTHDF1.drives hypoxia-induced autophagy and malignancy of hepatocellular carcinoma by promoting ATG2A and ATG1. translation

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Signal Transduction and Targeted Therapy 2021年第3期6卷 988-1000页

作者： Qing Li Yong Ni liren Zhang Runqiu Jiang Jing Xu Hong Yang Yuanchang Hu Jiannan Qiu Liyong Pu Jinhai Tang Xuehao Wang Hepatobiliary Center The First Affiliated Hospital of Nanjing Medical UniversityKey Laboratory of Liver TransplantationChinese Academy of Medical SciencesNHC Key Laboratory of Living Donor Liver Transplantation(Nanjing Medical University)NanjingJiangsu ProvinceChina School of Medicine Southeast UniversityNanjingChina department of Hepatopancreatobiliary Surgery Shenzhen Second People's HospitalThe First Affiliated Hospital of Shenzhen UniversityShenzhenGuangdongChina Department of Hepatobiliary Surgery The Affiliated Drum Tower Hospital of Nanjing University Medical SchoolNanjingJiangsu ProvincePeople's Republic of China Medical School of Nanjing University NanjingJiangsuChina Department of Oncology The First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsu ProvinceChina Department of Immunology Key Laboratory of Immune Microenvironment and DiseaseNanjing Medical UniversityNanjingJiangsu ProvinceChina Department of General Surgery The First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsu ProvinceChina

N6-methyladenosine(m6A),and its reader protein YTHDF1.play a pivotal role in human tumorigenesis by affecting nearly everystage of RNA *** activation is one of the ways by which cancer cells survive ***,the possibleinvolvement of m6A modification of mRNA in hypoxia-induced autophagy was unexplored in human hepatocellular carcinoma(HCO).In this study,specific variations in YTHDF1.expression were detected in YTHDF1.overexpressing,knockout,and-knockdownHCC cells,HCC organoids,and HCC patient-derived xenograft(PDX)murine ***1.expression and hypoxia inducedautophagy were significantly correlated in vitro;signifhcant overexpression of YTHDF1.in HCC tissues was associated with poorprognosis,Multivariate cox regression analysis identihed YTHDF1.expression as an independent prognostic factor in patients *** HC models conhrmed that YTHDF1.deficiency inhibited HCC autophagy,growth,and *** reporterassays and chromatin immunoprecipitation demonstrated that HlIF-1. regulated YTHDF1.transcription by directly binding to itspromoter region under *** results of methylated RNA immunoprecipitation sequencing,proteomics,and polysomeprofling indicated that YTHDF1.contibuted to the translation of autophagy-related genes ATG2A and ATG1. by binding to m6A-modifhed ATG2A and ATG1. mRNA,thus facilitating autophagy and autophagy-related malignancy of *** together,HlE-1.-induced YTHDF1.expression was associated with hypoxia-induced autophagy and autophagy-related HCC progression via promoting translation of autophagy-related genes ATG2A and ATG1. in a m6A-dependent *** fndings suggest thatYTHDF1.is a potential prognostic biomarker and therapeutic target for patients with HCC.

关键词： malignancy hepatocellular inhibited

Optical Mbius Cubes:Integrated Packaging Configurations

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Chinese Journal of Lasers 1997年第2期B6卷 131-140页

作者： WANG Ning LIU liren(Shanghai Institute of Optics & Fine Mechanics, Chinese Academy of SciencesP. O. Box 800-21., Shanghai 201.00) Shanghai Inst of Optics and Fine Mechanics Chinese Acad of Sciences Shanghai China

Two integrated packaging configurations of optical Mobius cubes are demonstrated. One is based on space division multiplex technique, the other is based on wavelength djvision multiplex technique. The physical constraints from the effect of diffraction on the optical Mdbius cubes are also discussed which defines the upper bound of the space-bandwidth product.

关键词： optical M■bius cubes packaging configurations physical constraints