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The corrosion characteristic and mechanism of Mg-5Y-1.5Nd-xZn-0.5Zr(x=0,2,4,6 wt.%)alloys in marine atmospheric environment

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Journal of Magnesium and Alloys 2024年第1期12卷 139-158页

作者： Quantong Jiang Dongzhu Lu liren Cheng Nazhen Liu Baorong Hou CAS Key Laboratory of Marine Environmental Corrosion and Bio-fouling Institute of OceanologyChinese Academy of SciencesNo.7 Nanhai RoadQingdao 266071PR China State Key laboratory of Rare Earth Resource Utilization Changchun Institute of Applied ChemistryChinese Academy of SciencesNo.5625 Renmin StreetChangchun 130022PR China Open Studio for Marine Corrosion and Protection Pilot National Laboratory for Marine Science and Technology(Qingdao)No.1 Wenhai RoadQingdao 266071PR China Sanya Institute of Oceanology South China Sea Institute of OceanologyChinese Academy of SciencesZhenzhou RoadSanya 572000PR China

The microstructure and precipitated phases of as-cast Mg-5Y-1.5Nd-x Zn-0.5Zr(x=0,2,4,6 wt.%)alloys were investigated by optical microscopy,scanning electron microscopy,energy-dispersive spectrometry and X-ray *** exposure corrosion experiment of these magnesium alloys was tested in South China Sea and KEXUE vessel atmospheric *** corrosion characteristic and mechanism of magnesium alloys of Mg-5Y-1.5Nd-x Zn-0.5Zr(x=0,2,4,6 wt.%)alloys were analyzed by weight loss rate,corrosion depth,corrosion products and corrosion *** electrochemical corrosion tests were also measured in the natural *** comprehensive results showed that Mg-5Y-1.5Nd-4Zn-0.5Zr magnesium alloy existed the best corrosion resistance whether in the marine atmospheric environment and natural seawater *** depended on the microstructure,type and distribution of precipitated phases in Mg-5Y-1.5Nd-4Zn-0.5Zr magnesium *** quantity anodic precipitated phases in the microstructure of Mg-5Y-1.5Nd-4Zn-0.5Zr alloy played the key role in the corrosion resistance.

关键词： Marine atmospheric environment Exposure corrosion Magnesium alloy Corrosion rate Corrosion mechanism

Fabrication of Silane and Desulfurization Ash Composite Modified Polyurethane and Its Interfacial Binding Mechanism

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Journal of Wuhan University of Technology(Materials Science) 2024年第2期39卷 288-297页

作者：吴旺华 CHEN Shuichang YE Haodong 李世迁 LIN Yuanzhi 陈庆华 XIAO liren College of Chemistry and Materials Science Fujian Normal UniversityFuzhou 350117China College of Materials and Package Engineering Fujian Provincial Key Lab of Coastal Basin EnvironmentFujian Polytechnic Normal UniversityFuqing 350300China College of Agriculture Guangxi UniversityGuangxi 530004China

Polyurethane/desulfurization ash(PU/DA)composites were synthesized using"one-pot method",with the incorporation of a silane coupling agent(KH550)as a"molecular bridge"to facilitate the integration of DA as hard segments into the PU molecular *** effects of DA content(φ)on the mechanical properties,thermal stability,and hydrophobicity of PU,both before and after the addition of KH550,were thoroughly *** results of microscopic mechanism analysis confirmed that KH550 chemically modified the surface of DA,facilitating its incorporation into the polyurethane molecular chain,thereby significantly enhancing the compatibility and dispersion of DA within the PU *** the mass fraction of modified DA(MDA)reached 1.%,the mechanical properties,thermal stability,and hydrophobicity of the composites were substantially improved,with the tensile strength reaching 1..9 MPa,and the contact angle measuring 1.0.6°.

关键词： polyurethane silane coupling agent desulfurization ash modification mechanical property hydrophobicity thermal stability

Engineered extracellular vesicles efficiently deliver CRISPR-Cas9 ribonucleoprotein(RNP)to inhibit herpes simplex virus1.infection in vitro and in vivo

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Acta Pharmaceutica Sinica B 2024年第3期14卷 1362-1379页

作者： Yuanda Wan liren Li Ruilin Chen Jiajia Han Qiyun Lei Zhipeng Chen Xiaodong Tang Wenyu Wu Shuwen Liu Xingang Yao NMPA Key Laboratory for Research and Evaluation of Drug Metabolism Guangdong Provincial Key Laboratory of New Drug ScreeningSchool of Pharmaceutical SciencesSouthern Medical UniversityGuangzhou 510515China Center of Clinical Pharmacy Nanfang HospitalSouthern Medical UniversityGuangzhou 510515China State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen UniversityGuangzhou 510060China Key Laboratory of Infectious Diseases Research in South China(Southern Medical University) Ministry of EducationGuangzhou 510515China

Extracellular vesicles(EVs)have recently emerged as a promising delivery platform for CRISPR/Cas9 ribonucleoproteins(RNPs),owing to their ability to minimize off-target effects and immune ***,enhancements are required to boost the efficiency and safety of Cas9 RNP enrichment within *** response,we employed the Fc/Spa interaction system,in which the human Fc domain was fused to the intracellular domain of PTGFRN-Δ687 and anchored to the EV ***,the B domain of the Spa protein was fused to the C domain of cargos such as Cre or *** to the robust interaction between Fc and Spa,this method enriched nearly twice the amount of cargo within the *** loaded with spCas9 RNP targeting the HSV1.genome exhibited significant inhibition of viral replication in vitro and in ***,following neuron-targeting peptide RVG modification,the in vivo dosage in neural tissues substantially increased,contributing to the clearance of the HSV1.virus in neural tissues and exhibiting a lower off-target *** findings establish a robust platform for efficient EV-based SpCas9 delivery,offering potential therapeutic advantages for HSV1.infections and other neurological disorders.

关键词： Extracellular vesicles CRISPR/Cas9 Ribonucleoproteins PTGFRN Fc/Spa HSV1 Neuron-targeting Delivery

Advancing CRISPR base editing technology through innovative strategies and ideas

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Science China Life Sciences 2024年

作者： Xiongwei Fan Yang Lei liren Wang Xiushan Wu Dali Li The Center for Heart Development College of Life Science Hunan Normal University Shanghai Frontiers Science Research Base of Genome Editing and Cell Therapy Shanghai Key Laboratory of Regulatory Biology Institute of Biomedical Sciences and School of Life Sciences East China Normal University Guangdong Provincial Key Laboratory of Pathogenesis Targeted Prevention and Treatment of Heart Disease

The innovation of CRISPR/Cas gene editing technology has developed rapidly in recent years. It is widely used in the fields of disease animal model construction, biological breeding, disease diagnosis and screening, gene therapy, cell localization, cell lineage tracking, synthetic biology, information storage, etc. However, developing idealized editors in various fields is still a goal for future development. This article focuses on the development and innovation of non-DSB editors BE and PE in the platform-based CRISPR system. It first explains the application of ideas for improvement such as “substitution”, “combination”, “adaptation”, and “adjustment” in BE and PE development and then catalogues the ingenious inversions and leaps of thought reflected in the innovations made to CRISPR technology. It will then elaborate on the efforts currently being made to develop small editors to solve the problem of AAV overload and summarize the current application status of editors for in vivo gene modification using AAV as a delivery system. Finally, it summarizes the inspiration brought by CRISPR/Cas innovation and assesses future prospects for development of an idealized editor.

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迭代式创新、双元机会开发对消费升级的影响机制研究

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工程管理科技前沿 2024年第2期43卷 62-68页

作者：马蓝安立仁西北大学经济管理学院陕西西安710127

数字经济不仅打破了传统的企业生产模式也改变了消费模式。在数字技术更新换代的环境下,企业要更加重视选代式创新的重要作用,挖掘消费升级的机会。本文运用226家企业的研究样本数据进行实证分析,结果:选代式创新对消费升级具有显著正... 详细信息

数字经济不仅打破了传统的企业生产模式也改变了消费模式。在数字技术更新换代的环境下,企业要更加重视选代式创新的重要作用,挖掘消费升级的机会。本文运用226家企业的研究样本数据进行实证分析,结果:选代式创新对消费升级具有显著正向影响;选代式创新分别对均衡型机会开发和创新型机会开发具有显著正向影响;均衡型机会开发和创新型机会开发分别对消费升级具有显著正向影响;均衡型机会开发和创新型机会开发在选代式创新与消费升级关系间具有中介作用。企业在寻找符合自身发展的商业模式和新市场的开辟中,要更加重视选代式创新的重要作用,借助双元机会开发视角去探索不同的商业路径,提升消费的渠道和规模,实现价值创造。

关键词：迭代式创新双元机会开发消费升级

Lipid nanoparticle-mediated base-editing of the Hao1.gene achieves sustainable primary hyperoxaluria type 1.therapy in rats

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Science China Life Sciences 2024年

作者： Dexin Zhang Rui Zheng Zhoutong Chen liren Wang Xi Chen Lei Yang Yanan Huo Shuming Yin Dan Zhang Jiaxin Huang Xingang Cui Dali Li Hongquan Geng Department of Urology Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Department of Urology Children's Hospital of Fudan University Shanghai Frontiers Science Center of Genome Editing and Cell Therapy Shanghai Key Laboratory of Regulatory Biology Institute of Biomedical Sciences and School of Life Sciences East China Normal University

Primary hyperoxaluria type 1.PH1. is a severe hereditary disease, leading to the accumulation of oxalate in multiple organs, particularly the kidney. Hydroxyacid oxidase 1.HAO1., a pivotal gene involved in oxalate production, is an approved target for the treatment of PH1. In this study, we demonstrated the discovery of several novel therapeutic sites of the Hao1.gene and the efficient editing of Hao1.c.290-2 A in vivo with lipid nanoparticles(LNP) delivered adenine base editing(ABE) mR NA. A single infusion of LNP-ABE resulted in a near-complete knockout of Hao1.in the liver, leading to the sustainable normalization of urinary oxalate(for at least 6 months) and complete rescue of the pathophysiology in PH1.rats. Additionally, a significant correlation between Hao1.editing efficiency and urinary oxalate levels was observed and over60% Hao1.editing efficiency was required to achieve the normalization of urinary oxalate in PH1.rats. These findings suggest that the LNPmediated base-editing of Hao1.c.290-2 A is an efficient and safe approach to PH1.therapy, highlighting its potential utility in clinical settings.

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Exosome-loaded biomaterials for tendon/ligament repair

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Biomaterials Translational 2024年第2期5卷 129-143页

作者： Haohan Wang Yonglin Guo Yiwen Jiang Yingyu Ge Hanyi Wang Dingyi Shi Guoyang Zhang Jinzhong Zhao Yuhao Kang liren Wang Shanghai Jiao Tong University School of Medicine ShanghaiChina Department of Orthopaedics Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghaiChina School of Materials Science and Engineering East China University of Science and TechnologyShanghaiChina

Exosomes,a specialised type of extracellular vesicle,have attracted significant attention in the realm of tendon/ligament repair as a potential biologic therapeutic *** the competence of key substances responsible for the delivery function was gradually elucidated,series of shortcomings exemplified by the limited stability still need to be ***,how to take maximum advantage of the biological characteristics of exosomes is of great ***,the comprehensive exploration and application of biomedical engineering has improved the availability of exosomes and revealed the future direction of exosomes combined with *** review delves into the present application of biomaterials such as nanomaterials,hydrogels,and electrospun scaffolds,serving as the carriers of exosomes in tendon/ligament *** pinpointing and exploring their strengths and limitations,it offers valuable insights,paving the way the future direction of biomaterials in the application of exosomes in tendon/ligament repair in this field.

关键词： biomaterials electrospinning exosomes hydrogel microspheres hydrogels nanoparticles

考虑实际接触三维粗糙度退化的软岩节理剪胀规律预测模型

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岩土工程学报 2024年第5期46卷 1008-1017页

作者：班力壬杜伟升候宇航戚承志陶志刚北京建筑大学土木与交通工程学院北京100044 煤炭科学研究总院有限公司深地科学院北京100013 中国矿业大学(北京)力学与建筑工程学院北京100083

为预测岩石节理的剪胀变形行为,分析了恒法向荷载作用下实际接触微凸体三维粗糙度在剪切过程中的退化规律,提出了一个适用于软岩节理的剪胀曲线预测模型。在剪切荷载作用下节理法向位移的变化是节理在三角形微凸体侧面爬坡上升行为与爬... 详细信息

为预测岩石节理的剪胀变形行为,分析了恒法向荷载作用下实际接触微凸体三维粗糙度在剪切过程中的退化规律,提出了一个适用于软岩节理的剪胀曲线预测模型。在剪切荷载作用下节理法向位移的变化是节理在三角形微凸体侧面爬坡上升行为与爬越一些微凸体顶点后闭合行为的叠加,爬坡行为与闭合行为引起的位移都正比于节理最大可能剪胀角。最大可能剪胀角退化的实质是实际接触节理微凸体平均等效倾角的退化。通过分析初始剪切与残余应力阶段的节理形貌特征,提出了计算初始最大可能剪胀角与残余应力阶段剪胀角的模型。基于软岩节理不发生突然脆性破坏的假设,进一步通过研究剪切过程中节理微凸体退化规律,量化了最大可能剪胀角的变化规律。定量了节理爬坡行为、闭合行为与最大可能剪胀角之间的关系,进而提出了节理剪胀规律预测模型,通过试验验证了模型的有效性。模型可较准确预测软岩节理的剪胀规律,并可合理描述节理初始阶段剪切压密行为。

关键词：节理剪胀形貌退化微凸体三维粗糙度节理形貌

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水力耦合作用下煤岩渗流动态演化规律

采矿与岩层控制工程学报 2024年第2期6卷 36-47页

作者：吕明杰刘立仁张小涛陈博陕西德源府谷能源有限公司三道沟煤矿陕西府谷719400 中煤科工集团重庆研究院有限公司重庆400037

为探究煤层注水时水在煤体中的渗流演化规律,采用实验室试验与数值模拟结合的方法,开展了地应力及孔隙水压力耦合作用下煤体结构变形及渗透率演化规律试验,并建立了水力耦合下体积变形演化数学模型,基于UDF二次开发进行了煤岩注水渗流... 详细信息

为探究煤层注水时水在煤体中的渗流演化规律,采用实验室试验与数值模拟结合的方法,开展了地应力及孔隙水压力耦合作用下煤体结构变形及渗透率演化规律试验,并建立了水力耦合下体积变形演化数学模型,基于UDF二次开发进行了煤岩注水渗流动态演化数值模拟。研究结果表明:煤岩孔隙率变化受应力与水压共同作用的影响;煤岩轴向变形量与水压分布由上至下呈递减式传递,体积变形与轴向力、孔隙水压大小成正相关;孔隙水压为赋存于孔裂隙的自由水提供渗透动力,并对煤岩基质骨架产生力学作用,水压越大,煤岩基质骨架越容易破坏;采用UDF程序加载渗透性试验结果对孔隙率随孔隙水压变化进行拟合的结果更接近试验结果,误差较小,对于研究煤岩渗流规律可以提供一定的参考。

关键词：煤层注水渗流 UDF 孔隙率流固耦合数值模拟

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