检索结果-南通市图书馆

雷火灸结合益肾通淋方对社区老年女性复发性尿路感染的效果

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

上海医药 2024年第10期45卷 35-38页

作者：顾君王婷何立群上海市普陀区宜川街道社区卫生服务中心中医科上海200065 上海中医药大学附属曙光医院肾病科上海200021

目的:观察雷火灸结合益肾通淋治疗社区老年女性复发性尿路感染患者的效果。方法:选取2021年8月至2023年3月就诊的老年女性复发性尿路感染患者120例,随机分为两组,最终获得有效干预组57例,对照组59例数据信息。两组均根据中段尿培养结果... 详细信息

目的:观察雷火灸结合益肾通淋治疗社区老年女性复发性尿路感染患者的效果。方法:选取2021年8月至2023年3月就诊的老年女性复发性尿路感染患者120例,随机分为两组,最终获得有效干预组57例,对照组59例数据信息。两组均根据中段尿培养结果给予足量敏感抗生素治疗并缓解后,进行分组治疗和观察。对照组给予低剂量抑菌疗法,每日单剂量抗菌素1次,根据具体情况调整药物剂量。治疗组在对照组基础上每日服用益肾通淋方,同时加用雷火灸艾灸治疗,3次/周,共治疗12周。分析患者治疗前后中医证候积分评分疗效、尿常规(尿白细胞、尿红细胞水平)、焦虑(SAS)、抑郁(SDS)评分等各项指标的变化。结果:治疗组在改善中医证候方面疗效优于对照组(P0.05)。治疗后,干预组尿白细胞数明显低于对照组(P0.05)。治疗后,干预组SAS和SDS评分均低于对照组(P<0.05)。治疗3个月后,治疗组复发率低于对照组,差异具有统计学意义(P<0.05)。结论:雷火灸结合益肾通淋方的治疗方式在社区老年女性复发性尿路感染患者改善临床症状、心理健康及本病的复发率方面有积极作用。

关键词：复发性尿路感染雷火灸益肾通淋方老年女性

Investigation of mini-hydrocyclone performance in removing small-size microplastics

在线全文

学校读者我要写书评

暂无评论

Particuology 2022年第12期71卷 1-10页

作者： liqun he Li Ji Xun Sun Songying Chen Shibo Kuang Key Laboratory of High Efficiency and Clean Mechanical Manufacture Ministry of EducationSchool of Mechanical EngineeringShandong UniversityJinan 250061China National Demonstration Center for Experimental Mechanical Engineering Education Shandong UniversityJinan 250061China ARC Research Hub for Computational Particle Technology Department of Chemical EngineeringMonash UniversityClaytonVictoria 3800Australia

Large amounts of microplastics(MPs)have been found in rivers and oceans,bringing great harm to aquatic animals,plants,even human ***,the effective removal method of MPs,especially those with small sizes(5-20 μm)is still *** work presents mini-hydrocyclones to remove 10 μm(average size)diameter *** removal performance of nine mini-hydrocyclones with different diameters of spigot and vortex finder is examined experimentally and *** performance of the designed cyclones is evaluated in terms of recovery,water split,concentration ratio and pressure *** results show that mini-hydrocyclones are applicable to removing small-size MPs with the maximum concentra-tion ratio at 2.16 and the particle recovery at 51%.The flow characteristics inside the mini-hydrocyclones are analyzed in *** is shown that the distributions of water axial velocity and radial velocity could collectively affect the behaviors of small-size MPs in ***,a larger amount of water split could entrain more fine particles to ***,a less frequent alternation of radial velocity between the positive and negative directions on the same side of the cyclone should benefit the removal of small-size MPs.

关键词： Microplastics Mini-hydrocyclone Removal Experiment Simulation

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

肺隐球菌合并肺腺癌1例并文献复习

中国真菌学杂志 2024年第2期19卷 154-157页

作者：何立群王悦李洪波王建坤湖北省十堰市太和医院(湖北医药学院附属医院)肾病内科十堰442000 湖北省十堰市太和医院(湖北医药学院附属医院)检验科十堰442000 湖北省十堰市太和医院(湖北医药学院附属医院)呼吸与危重症医学科十堰442000

肺隐球菌病是由新生隐球菌或格特隐球菌引起的一种常见的机会性真菌感染,主要侵犯呼吸系统,同时以两个孤立肺结节为影像特征的肺隐球菌和肺癌共存的临床报道较为少见。该文报道1例肺隐球菌合并肺腺癌的临床诊断及治疗过程,包括5年随访,... 详细信息

肺隐球菌病是由新生隐球菌或格特隐球菌引起的一种常见的机会性真菌感染,主要侵犯呼吸系统,同时以两个孤立肺结节为影像特征的肺隐球菌和肺癌共存的临床报道较为少见。该文报道1例肺隐球菌合并肺腺癌的临床诊断及治疗过程,包括5年随访,为避免临床实践漏诊提供参考。

关键词：肺隐球菌肺腺癌电视辅助胸腔镜手术

On-Chip Fabrication of Carbon Nanoparticle–Chitosan Composite Membrane

在线全文

学校读者我要写书评

暂无评论

Journal of Materials Science & Technology 2015年第11期31卷 1087-1093页

作者： Weiping Ding Cheng Liang Sijie Sun liqun he Dayong Gao Center for Biomedical Engineering University of Science and Technology of China Department of Electronic Science and Technology University of Science and Technology of China Department of Laboratory Medicine University of Washington Department of Thermal Science and Energy Engineering University of Science and Technology of China Department of Mechanical Engineering University of Washington

The on-chip fabrication of a carbon nanoparticle-chitosan composite membrane （i.e. a sorbent membrane or a mixed matrix membrane） using laminar flow-based interfacial deprotonation technology was presented in this paper. In addition, the effects of carbon nanoparticles and reactant flow rates on membrane formation were investigated. Finally, the permeability and adsorption capacities of the membrane were discussed. During fabrication, an acidic chitosan solution and a basic buffer solution that contained carbon nanoparticles were introduced into a microchannel. At the flow interface, a freestanding composite membrane with embedded carbon nanoparticles was formed due to the deprotonation of the chitosan molecules. The membrane growth gradually stopped with time from upstream to downstream and the thickness of the membrane increased rapidly and then slowly along the reactant flow direction. The formation of the membrane was divided into two stages. The average growth rate in the first stage was significantly larger than the average growth rate in the second stage. Carbon nanoparticles in the basic solution acted as nucleating agents and made the membrane formation much easier. As the flow rate of the chitosan solution increased, the averaged membrane thickness and the membrane hydraulic permeability initially increased and then decreased. Because of the addition of carbon nanoparticles, the formed membrane had adsorption abilities. The carbon nanoparticle-chitosan composite membrane that was fabricated in this study could be employed for simultaneous adsorption and dialysis in microdevices in the future.

关键词： On-chip fabrication Composite membrane Carbon nanoparticle Chitosan Interracial deprotonation Mixed matrix membrane

中医四诊仪客观观测464例慢性肾脏病3~5期非替代治疗患者的中医证型分布规律

在线全文

学校读者我要写书评

暂无评论

国际中医中药杂志 2024年第4期46卷 439-443页

作者：张良何立群郑淇丹陈刚上海中医药大学附属曙光医院肾病科上海201203 上海市长宁区天山中医医院内科上海200051

目的探讨中医四诊仪客观观测慢性肾脏病(CKD)3~5期非替代治疗患者中医证型分布规律。方法运用中医四诊仪收集CKD 3~5期非替代治疗患者的四诊信息,进行证候判定,同时分析中医证候与患者基本病情特点的相关性。结果464例CKD3~5期非替代治... 详细信息

目的探讨中医四诊仪客观观测慢性肾脏病(CKD)3~5期非替代治疗患者中医证型分布规律。方法运用中医四诊仪收集CKD 3~5期非替代治疗患者的四诊信息,进行证候判定,同时分析中医证候与患者基本病情特点的相关性。结果464例CKD3~5期非替代治疗患者中医证型分布以虚证为本,兼有标实之证。本虚证中以脾气虚证最为多见,占24.6%(114/464),后依次为肾阳虚证、心气虚证、肾阴虚证、心血虚证、脾阳虚证、肺阴虚证;标实证按构成比由大到小依次为瘀血、湿热、水气、湿浊、浊毒。不同CKD分期患者性别、年龄分布比较,差异无统计学意义(P>0.05),但随年龄增长,虚证比例逐渐增高。不同CKD分期与中医本虚证分布存在差异(χ^(2)=57.48,P<0.001),与本虚标实证分布无差异(χ^(2)=2.59,P=0.957)。结论经中医四诊仪测定,CKD3~5期非替代治疗患者中医证型分布以虚证为本,兼有标实之证。CKD 3期中医证型以脾气虚证、肾气虚证为主,CKD4期以脾气虚证、肾阳虚证为主,CKD 5期以心气虚证、肾阳虚证为主。

关键词：肾功能不全,慢性中医四诊仪中医证型

HPV DNA、HPV E6/E7蛋白和TCT在宫颈上皮内瘤变及宫颈癌筛查中的价值

在线全文

学校读者我要写书评

暂无评论

中国现代医生 2024年第10期62卷 28-31页

作者：何立群张舒云袁婧吕艳婷诸暨市人民医院病理科浙江诸暨311800

目的探讨人乳头瘤病毒(human papilloma virus,HPV)DNA、HPV E6/E7蛋白和液基薄层细胞学检查(thin-prep cytology test,TCT)在宫颈上皮内瘤变(cervical intraepithelial neoplasia,CIN)及宫颈癌筛查中的价值。方法选取2021年7月至2022年6月于诸暨市人民医院妇科接受早期宫颈癌筛查的成年女性190例为研究对象,分别进行HPV DNA、HPVE6/E7蛋白及TCT检测,并进一步行阴道镜活检检查。比较不同病变患者的HPVDNA、HPVE6/E7蛋白和TCT对高级别病变的诊断效能。结果 CIN3及宫颈癌患者的HPV DNA、HPV E6/E7蛋白、TCT检查及三者联合检测的阳性率均显著高于宫颈炎患者(P<0.05),宫颈癌患者的HPV DNA、HPV E6/E7蛋白、TCT检查及三者联合检测的阳性率均显著高于CIN1患者(P<0.05)。CIN2+患者的HPV DNA、HPV E6/E7蛋白、TCT及三者联合检测的阳性率显著高于CIN1-患者。HPVDNA、HPVE6/E7蛋白、TCT三者联合诊断高级别病变的敏感度、特异性、阳性预测值和阴性预测值分别为90.80%、30.10%、52.32%、79.48%。结论 HPV DNA、HPV E6/E7蛋白及TCT可作为筛查宫颈癌和癌前病变的手段,且三者联合检测的敏感度最高。

关键词： HPV DNA HPV E6/E7蛋白液基薄层细胞学检查上皮内瘤变宫颈癌筛查

GW501516对低氧致肺动脉内皮细胞损伤的影响及机制

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

中国药房 2024年第2期35卷 179-185页

作者：陈昌贵易春峰余志华王栋李立为贺立群武汉市第一医院心血管内科武汉430022

目的探讨过氧化物酶体增殖物激活受体δ(PPARδ)激动剂GW501516对低氧诱导的肺动脉内皮细胞(PAECs)损伤的影响及机制。方法通过检测PAECs的相对存活率,观察GW501516的细胞毒性作用;采用Western blot法检测PPARδ蛋白的表达水平。建立低... 详细信息

目的探讨过氧化物酶体增殖物激活受体δ(PPARδ)激动剂GW501516对低氧诱导的肺动脉内皮细胞(PAECs)损伤的影响及机制。方法通过检测PAECs的相对存活率,观察GW501516的细胞毒性作用;采用Western blot法检测PPARδ蛋白的表达水平。建立低氧条件下PAECs损伤的细胞模型,以抗氧化剂N-乙酰半胱氨酸(NAC)为阳性对照,通过检测细胞凋亡率、细胞活力、乳酸脱氢酶(LDH)活性、活性氧(ROS)水平,考察GW501516对细胞损伤及ROS产生的影响。以核因子E2相关因子2(Nrf2)激活剂富马酸二甲酯(DMF)为阳性对照,在低氧条件下通过GW501516和(或)Nrf2抑制剂ML385孵育PAECs,以细胞损伤(细胞凋亡、细胞活力、LDH活性)及超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GPx)、过氧化氢酶(CAT)、丙二醛(MDA)、ROS水平及Nrf2、血红素加氧酶1(HO-1)、裂解型胱天蛋白酶3(C-caspase-3)蛋白的表达水平,探讨GW501516对低氧致PAECs损伤的作用机制。结果低氧刺激能够抑制PAECs内PPARδ蛋白的表达(P<0.05),而GW501516可在低氧条件下促进PPARδ蛋白的表达且无明显的细胞毒性作用。GW501516可抑制PAECs凋亡,提高细胞活力,降低LDH活性及ROS水平。GW501516可通过激活Nrf2通路,上调PAECs内HO-1蛋白表达水平及SOD、GPx、CAT水平,降低MDA、ROS水平(P<0.05),而Nrf2抑制剂ML385能够逆转GW501516的上述作用(P<0.05)。GW501516下调C-caspase-3蛋白表达,抑制低氧诱导的PAECs损伤的作用与Nrf2激活剂DMF相似(P<0.05),而Nrf2抑制剂ML385能够逆转GW501516抑制PAECs损伤的作用(P<0.05)。结论GW501516可通过抑制氧化应激来减轻低氧诱导的PAECs损伤,其机制与激活Nrf2有关。

关键词： GW501516 低氧肺动脉内皮细胞氧化应激损伤核因子E2相关因子2

Junction matters in hydraulic circuit bio-design of microfluidics

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

Bio-Design and Manufacturing 2023年第1期6卷 38-50页

作者： Yao Lin Dongliang he Zerui Wu Yurou Yao Zhanhao Zhang Yuheng Qiu Shan Wei Guangzhu Shang Xingyue Lei Ping Wu Weiping Ding liqun he Department of Thermal Science and Energy Engineering University of Science and Technology of ChinaHefei 230027China School of Chemistry and Materials Science University of Science and Technology of ChinaHefei 230027China GeneMind Biosciences Company Limited Shenzhen 518023China Department of Electronic Engineering and Information Science University of Science and Technology of ChinaHefei 230027China

Microfluidic channels are at micrometer scales;thus,their fluid flows are laminar,resulting in the linear dependence of pressure drop on flow rate in the length of the *** ratio of the pressure drop to flow rate,referred to as resistance,depends on channel size and dynamic ***,a microfluidic chip is analogous to an electric circuit in design,but the design is adjusted to optimize channel ***,whereas voltage loss is negligible at the nodes of an electric circuit,hydraulic pressure drops at the nodes of microfluidic chips by a magnitude are comparable to the pressure drops in the straight ***,we prove by experiment that one must fully consider the pressure drops at nodes so as to accurately design a precise microfluidic *** the process,we numerically calculated the pressure drops at hydraulic nodes and list their resistances in the range of flows as *** resorted to machine learning to fit the calculated results for complex ***,we obtained a library of node resistances for common junctions and used them to design three established chips that work for single-cell analysis and for precision allocation of solutes(in gradient and averaging concentration microfluidic networks).Endothelial cells were stimulated by generating concentrations of adriamycin hydrochloride from the last two microfluidic networks,and we analyzed the response of endothelial *** results indicate that consideration of junction resistances in design calculation brings experimental results closer to the design values than *** approach may therefore contribute to providing a platform for the precise design of organ chips.

关键词： Junctions Hydraulics Microfluidic chip design

Effect of Astragali and Angelica particle on proteinuria in Chinese patients with primary glomerulonephritis

在线全文

学校读者我要写书评

暂无评论

Journal of Traditional Chinese Medicine 2016年第3期36卷 299-306页

作者： Shen Peicheng Yang Xuejun he liqun Department of Nephrology Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine

OBJECTIVE: To investigate the effect of the traditional Chinese herbs Astragali and Angelicae Sinensis(A & As) particle [contains Huangqi(Radix Astragali Mongolica), Danggui(Radix Angelicae Sinensis),Huzhanggeng(Rhizoma Polygoni Cuspidati) and Danshen(Radix Salviae Miltiorrhizae)] on proteinuria in glomerulonephritis patients with stage 2 chronic kidney ***: A prospective, multi-center, and randomized controlled clinical trial was performed for 24 weeks. From March 2011 to April 2012, 158 patients from nine hospitals in China *** were randomized into the A&As group(79 cases, A&As particle 15.2 g/day) and losartan group(79 cases, losartan 50 mg/day). At each follow-up visit, clinical data including blood pressure, urinalysis, 24-h-urinary protein excretion, serum albumin and serum creatinine were ***: All 158 patients completed the follow-up. Proteinuria in the losartan group exhibited a biphasic time-dependent decline with a significant steady reduction from baseline to week 12(P = 0.0014), and a platform level during the remaining 12-week follow-up(P > 0.05). In contrast, there was a continual significant decrease of proteinuria in the A & As group(P hen compared with the losartan results, proteinuria in the A & As group from week 16 to week 24 was significantly reduced(P herapy with A & As particles may provide effective anti-proteinuria treatment.

关键词： Angelica sinensis Renal insufficiency chronic Glomerulonephritis Proteinuria Medicine Chinese Traditional