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内镜下可旋转重复开闭软组织夹止血联合奥曲肽、奥美拉唑治疗非静脉曲张性上消化道出血的效果及对凝血功能的影响

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临床医学研究与实践 2024年第23期9卷 66-69页

作者：苗涛周黎强张瑞峰城固县医院陕西汉中723200 汉中市中心医院陕西汉中723000

目的探讨内镜下可旋转重复开闭软组织夹止血联合奥曲肽、奥美拉唑治疗非静脉曲张性上消化道出血的效果。方法选取2021年1月至2022年12月收治的120例非静脉曲张性上消化道出血患者,以随机数字表法将其分为对照组与观察组,各60例。对照组... 详细信息

目的探讨内镜下可旋转重复开闭软组织夹止血联合奥曲肽、奥美拉唑治疗非静脉曲张性上消化道出血的效果。方法选取2021年1月至2022年12月收治的120例非静脉曲张性上消化道出血患者,以随机数字表法将其分为对照组与观察组,各60例。对照组采用奥曲肽、奥美拉唑治疗,观察组在对照组基础上行内镜下可旋转重复开闭软组织夹止血治疗。比较两组的治疗效果。结果观察组的即时止血率、止血有效率高于对照组,72 h再出血率低于对照组(P<0.05)。治疗后,观察组的凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)短于对照组,D-二聚体(D-D)水平低于对照组,纤维蛋白原(FIB)水平高于对照组(P<0.05)。治疗后,观察组的α-颗粒膜糖蛋白(CD62P)低于对照组,血小板计数(PLT)和血小板聚集率(PAR)高于对照组(P<0.05)。结论内镜下可旋转重复开闭软组织夹止血联合奥曲肽、奥美拉唑治疗非静脉曲张性上消化道出血患者可改善血小板活化功能及凝血功能,提高整体治疗效果。

关键词：可旋转重复开闭软组织夹奥曲肽奥美拉唑非静脉曲张性上消化道出血

Nanoengineered sonosensitive platelets for synergistically augmented sonodynamic tumor therapy by glutamine deprivation and cascading thrombosis

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Bioactive Materials 2023年第6期24卷 26-36页

作者： liqiang zhou Wei Feng Yuhang Mao Yu Chen Xuanjun Zhang MOE Frontiers Science Center for Precision Oncology Faculty of Health SciencesUniversity of MacaoMacaoSAR999078China Materdicine Lab School of Life SciencesShanghai UniversityShanghai200444China School of Medical Technology Xi’an Medical CollegeXi’an710021ShanxiChina

Ultrasound(US)-activated sonodynamic therapy(SDT)stands for a distinct antitumor modality because of its attractive characteristics including intriguing noninvasiveness,desirable safety,and high tissue penetration depth,which,unfortunately,suffers from compromised therapeutic efficacy due to cancer cell-inherent adaptive mechanisms,such as glutathione(GSH)neutralization response to reactive oxygen species(ROS),and glutamine addictive properties of *** this work,we developed a biological sonosensitive platelet(PLT)pharmacytes for favoring US/GSH-responsive combinational therapeutic of glutamine deprivation and augmented *** amino acid transporter SLC6A14 blockade agentα-methyl-DL-tryptophan(α-MT)-loaded and MnO_(2)-coated porphyrinic metal-organic framework(MOF)nanoparticles were encapsulated in the PLTs through the physical adsorption of electrostatic attraction and the intrinsic endocytosis of *** the sonosensitive PLT pharmacytes reached tumor sites through their natural tendencies to TME,US stimulated the PLTs-loaded porphyrinic MOF to generate ROS,resulting in morphological changes of the PLTs and the release of ***,intracellular high concentration of GSH and extracellular spatio-temporal controlled US irradiation programmatically triggered the release ofα-MT,which enabled the synergistically amplified SDT by inducing amino acid starvation,inhibiting mTOR,and mediating *** addition,US stimulation achieved the targeted activation of PLTs at tumor vascular site,which evolved from circulating PLTs to dendritic PLTs,effectively blocking the blood supply of tumors through thrombus formation,and revealing the encouraging potential to facilitate tumor therapeutics.

关键词： Sonosensitive platelets Glutamine deprivation Sonodynamic tumor therapy Amino acid starvation Drug delivery

MXene-Ti3C2Tx for watt-level high-efficiency pulse generation in a 2.8μm mid-infrared fiber laser

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Photonics Research 2020年第6期8卷 972-977页

作者： CHEN WEI liqiang zhou DONGSHENG WANG HAO CHI Hua HUANG HAN ZHANG YONG LIU State Key Laboratory of Electronic Thin Films and Integrated Devices School of Optoelectronic Science and EngineeringUniversity of Electronic Science and Technology of ChinaChengdu 610054China College of Electrical Engineering Sichuan UniversityChengdu 610065China

We report a watt-level passively Q switched 2.8μm mid-infrared multi-mode fiber laser by employing multi-layered two dimensional MXene-Ti3C2Tx as the saturable absorber(SA).The MXene-Ti3C2Tx is fabricated by selectively etching aluminum layers in *** non-saturable loss,modulation depth,and saturable inten-sity of the SA at 2866 nm were measured to be 25.0%,33.2%,and 0.043 GW/cm^2,*** maximum average output power of the Ti3C2Tx Q-switched fiber laser reached 1.09 W at 28.23%slope *** pulse repetition rate,shortest pulse width,pulse peak power,and single-pulse energy were 78.12 kHz,1.04μs,13.4 W,and 13.93μJ,*** is the frst demonstration of watt-level pulse gencration in a mid-infrared fiber laser using low dimensional materials,to the best of our *** results indicate that the Ti3C2Tx is a reliable and superior broadband SA for high power mid-infrared pulsed laser generation.

关键词： fiber pulse laser

Scalable Talbot effect of periodic array objects

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Chinese Optics Letters 2020年第3期18卷 6-10页

作者： Rui Yang Zhenfa Xue Zhiyong Shi liqiang zhou Linwei Zhu School of Physics and Optoelectronic Engineering Ludong UniversityYantai 264025China

A type of scalable self-imaging capable of variable magnification or minification of periodic objects is demonstrated in the focal plane of a lens illuminated by a point *** theory and the experimental results show that the self-imaging phenomenon can also be realized in the focal plane of a lens regardless of whether the distances satisfy the lens formula or *** particular property of this scalable self-imaging effect is that the images in the focal plane can be controlled with different scaling factors only when the distances between the point source and the periodic object satisfy a certain *** discovery should open a new field of diffraction imaging and new application opportunities in precision measurement.

关键词： Talbot effect periodic object diffraction theory lens

Chloride ion battery:A new emerged electrochemical system for next-generation energy storage

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Journal of Energy Chemistry 2024年第1期88卷 154-168,I0004页

作者： Shulin Chen Lu Wu Yu Liu Peng zhou Qinyou An liqiang Mai State Key Laboratory of Advanced Technology for Materials Synthesis and Processing School of Materials Science and EngineeringWuhan University of TechnologyWuhan 430070HubeiChina State Key Laboratory of Refractories and Metallurgy Institute of Advanced Materials and NanotechnologyWuhan University of Science and TechnologyWuhan 430081HubeiChina

In the scope of developing new electrochemical concepts to build batteries with high energy density,chloride ion batteries(CIBs)have emerged as a candidate for the next generation of novel electrochemical energy storage technologies,which show the potential in matching or even surpassing the current lithium metal batteries in terms of energy density,dendrite-free safety,and elimination of the dependence on the strained lithium and cobalt ***,the development of CIBs is still at the initial stage with unsatisfactory performance and several challenges have hindered them from reaching *** this review,we examine the current advances of CIBs by considering the electrode material design to the electrolyte,thus outlining the new opportunities of aqueous CIBs especially combined with desalination,chloride redox battery,*** respect to the developing road of lithium ion and fluoride ion batteries,the possibility of using solid-state chloride ion conductors to replace liquid electrolytes is tentatively *** beyond,perspectives and clear suggestions are concluded by highlighting the major obstacles and by prescribing specific research topics to inspire more efforts for CIBs in large-scale energy storage applications.

关键词： Chloride ion battery Anion shuttling Conversion reaction Chloride redox

Prognostic value of BCL2 and TP53 genetic alterations for diffuse large B-cell lymphoma patients treated with R-CHOP

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Cancer Biology & Medicine 2022年第6期19卷 893-909页

作者： Yan Qin Haizhu Chen Peng Liu Changgong Zhang Jianliang Yang Lin Gui Xiaohui He liqiang zhou Shengyu zhou Shiyu Jiang Hongxin Jiang Yuankai Shi Department of Medical Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing Key Laboratory of Clinical Study on Anticancer Molecular Targeted DrugsBeijing 100021China Department of Medical Oncology Suzhou Municipal HospitalAffiliated Suzhou Hospital of Nanjing Medical UniversitySuzhou 215001China

Objective:Limited data about the prognostic significance of BCL2 mutations and BCL2 copy number variations in diffuse large B-cell lymphoma(DLBCL)are *** study aimed to comprehensively describe BCL2 genetic alterations in DLBCL patients,and examine correlation of BCL2,TP53 and other genetic alterations with outcomes in patients treated with ***:Probe capture-based high-resolution sequencing was performed on 191 patients diagnosed with de novo ***,BCL2,and BCL6 protein expressions were detected by ***:The presence of BCL2 alterations significantly correlated with poor progression-free survival(PFS)(5-year PFS:13.7%vs.40.8%;P=0.003)and overall survival(OS)(5-year OS:34.0%vs.70.9%;P=0.036).Importantly,patients who harbored BCL2 gain/amplifications(BCL2GA/AMP)also had a remarkably inferior 5-year PFS(11.1%vs.38.3%;P<0.001)and OS(22.1%vs.69.6%;P=0.009).In contrast,neither BCL2 mutations nor BCL2 translocations were significantly prognostic for *** analyses showed that the presence of BCL2 alterations,especially BCL2GA/AMP,TP53 mutations,and International Prognostic Index(IPI)were significantly associated with inferior PFS and *** prognostic models for OS were constructed based on 3 risk factors,including BCL2 alterations(Model 1)or BCL2GA/AMP(Model 2),TP53 mutations,and IPI,to stratify patients into 4 risk groups with different survival ***:This study showed that DLBCL patients treated with R-CHOP,BCL2 alterations,especially BCL2GA/AMP and TP53 mutations were significantly associated with inferior outcomes,which were independent of the *** novel prognostic models we proposed predicted outcomes for DLBCL patients treated with R-CHOP,but further validation of the prognostic models is still warranted.

关键词： BCL2 TP53 genetic alterations diffuse large B-cell lymphoma prognosis

Study of the reaction mechanism for preparing powdered activated coke with SO_(2)adsorption capability via one-step rapid activation method under flue gas atmosphere

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Chinese Journal of Chemical Engineering 2024年第1期65卷 158-168页

作者： Binxuan zhou Jingcai Chang Jun Li Jinglan Hong Tao Wang liqiang Zhang Ping zhou Chunyuan Ma School of Environmental Science and Engineering Shandong UniversityQingdao 266237China School of Energy and Power Engineering Shandong UniversityJinan 250061China Weihai Research Institute of Industrial Technology of Shandong University Weihai 264209China

In this study,the impact of different reaction times on the preparation of powdered activated carbon(PAC)using a one-step rapid activation method under flue gas atmosphere is investigated,and the underlying reaction mechanism is *** indicate that the reaction process of this method can be divided into three stages:stage I is the rapid release of volatiles and the rapid consumption of O_(2),primarily occurring within a reaction time range of 0-0.5 s;stage II is mainly the continuous release and diffusion of volatiles,which is the carbonization and activation coupling reaction stage,and the carbonization process is the main in this *** stage mainly occurs at the reaction time range of 0.5 -2.0 s when SL-coal is used as material,and that is 0.5-3.0 s when JJ-coal is used as material;stage III is mainly the activation stage,during which activated components diffuse to both the surface and interior of *** stage mainly involves the reaction stage of CO_(2)and H2O(g)activation,and it mainly occurs at the reaction time range of 2.0-4.0 s when SL-coal is used as material,and that is 3.0-4.0 s when JJ-coal is used as ***,the main function of the first two stages is to provide more diffusion channels and contact surfaces/activation sites for the diffusion and activation of the activated components in the third *** the reaction mechanism would serve as a crucial reference and foundation for designing the structure,size of the reactor,and optimal positioning of the activator nozzle in PAC preparation.

关键词： Reaction mechanism Powdered activated coke preparation SO_(2)adsorption One-step rapid activation Flue gas atmosphere

Continuous Fe^(3+)releasing enabled complete reconstruction of Ni-based MOF for promoted water oxidation in industrial alkali

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Science China Chemistry 2024年第9期67卷 2949-2957页

作者： Zhaojian Wang Wei Zhang Wenzhong Huang Ruohan Yu Changliang Chen liqiang Mai Liang zhou State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070China Sanya Science and Education Innovation Park Wuhan University of TechnologySanya 572000China Hubei Longzhong Laboratory Wuhan University of Technology(Xiangyang Demonstration Zone)Xiangyang 441000China

Most oxygen evolution reaction(OER)electrocatalysts show poor stability under industrial alkaline conditions(20–30 wt.%KOH).Therefore,it is essential to develop stable,efficient,and low-cost OER catalysts for industrial water ***,we present a straightforward approach for the complete electrochemical reconstruction of Ni-BDC,a Ni-based metal-organic framework,for *** method involves the continuous release of Fe^(3+)from Fe foam counter electrode in a high-concentration(6.0 M,25 wt.%)KOH *** continuously Fe^(3+)releasing not only realizes in situ Fe^(3+)doping,but also introduces abundant defects in the obtained catalyst during cyclic voltammetry activation,thereby accelerating the electrochemical *** reconstructed OER catalyst(Fe-doped nickel hydroxide/oxyhydroxide nanosheets supported on Ni foam,Fe-NiO_(x)(OH)y/NF)manifests a low overpotential of 217 mV at 10 mA cm^(-2)and 263 m V at 100 m A cm^(-2)in 1.0 M ***,the Fe-NiO_(x)(OH)_(y)/NF also demonstrates high stability in 30 wt.%*** strategy of regulating the electrochemical reconstruction process sheds light on the construction of stable and efficient OER catalysts for industrial water electrolysis.

关键词： oxygen evolution reaction industrial alkaline conditions metal-organic framework complete reconstruction

Hierarchical crystalline-amorphous nanocomposites with high strength and large deformability enabled by elemental diffusion

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Journal of Materials Science & Technology 2024年第4期171卷 150-161页

作者： liqiang Wang Heyi Wang Xin zhou Huangliu Fu James Utama Surjadi Shuo Qu Xu Song Rong Fan Yang Lu Department of Mechanical Engineering City University of Hong KongHong KongChina Nano-Manufacturing Laboratory(NML) Shenzhen Research Institute of City University of Hong KongShenzhen 518057China Chengdu Research Institute City University of Hong KongChengdu 610200China Shenyang National Laboratory for Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China Department of Mechanical and Automation Engineering The Chinese University of Hong KongHong KongChina Department of Mechanical Engineering The University of Hong KongHong KongChina

Amorphous/nanocrystalline dual-phase structures have recently emerged as an effective way for over-coming the strength-ductility trade-offand breaking the limitation of the reverse Hall-Petch ***,we proposed a new strategy to develop a hierarchical and interconnected amorphous-crystalline nanocomposite arising from the nanoscale elemental interdiffusion and oxygen adsorption behavior dur-ing thermal treatment *** nanocomposite consisted of a three-dimensional(3D)hierarchical network structure where the crystalline phase(Cr-Co-Ni-Al)was embedded into the Al-O-based amor-phous phase network with critical feature sizes encompassing three orders of magnitude(from microm-eter to nanometer scale).It can achieve ultrahigh compression yield strength of-3.6 GPa with large homogeneous deformation of over 50%*** massive interstitial atoms induced lattice distortion and hierarchical amorphous phase boundary contributed to the strength *** situ Uniaxial compression inside a transmission electron microscope(TEM)revealed that the exceptional deformability of the nanocomposites resulted from the homogenous plastic flow of nano-sized amorphous phase and the plastic co-deformation behavior restricted by the nano-architected dual-phase *** proposed dual-phase synthesis approach can outperform conventional nanolaminates design strategies in terms of the mechanical properties achievable while providing a pathway to easily tune the microstructure of these nanolaminates.

关键词： Nanolaminates Dual-phase nanocomposites In situ transmission electron microscopy Multi-component alloy