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地铁列车曲线运行振动源强特性分析

铁道学报 2019年第7期41卷 26-33页

作者：刘维宁杜林林刘卫丰北京交通大学土木建筑工程学院北京100044 中国中元国际工程有限公司技术研究院北京100089

城市轨道交通线路的一个重要特征是曲线占比高,当列车通过曲线轨道时,其特殊的振动源强特性产生了与直线轨道不同的环境振动影响,以往计算与评估并未对此做出严谨的考虑,从而带来了较大的评估误差。作为轨道交通环境振动与二次噪声评估... 详细信息

城市轨道交通线路的一个重要特征是曲线占比高,当列车通过曲线轨道时,其特殊的振动源强特性产生了与直线轨道不同的环境振动影响,以往计算与评估并未对此做出严谨的考虑,从而带来了较大的评估误差。作为轨道交通环境振动与二次噪声评估的一个重要因素,地铁列车曲线运行产生的振动源强,至今为止尚未研究清楚。为了填补这一空白,本文基于轮轨跟随模式,采用频域解析方法,建立了曲线轨道-车辆动力耦合解析模型,系统深入地研究了地铁曲线轨道源强支反力的振动强度、方向以及频域响应特性,研究了曲线行车时车-轨关键参数与振动源强的因果关系。这将提高曲线轨道振动影响预测的准确性,满足城市轨道交通环境振动影响预测与评估的实际需要。

关键词：地铁曲线轨道振动源强车轨耦合模型

Characterization of Nutrients,Heavy Metals,Petroleum and Their Impact on Phytoplankton in Laizhou Bay:Implications for Environmental Management and Monitoring

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Journal of Ocean University of China 2024年第3期23卷 822-834页

作者： WANG Kai ZHAO linlin ZHU Yugui YANG Liqiang WANG Yunfeng HONG Xuguang College of Marine Life Science Ocean University of ChinaQingdao 266003China First Institute of Oceanography Ministry of Natural ResourcesQingdao 266061China College of Fisheries Ocean University of ChinaQingdao 266003China Institute of Oceanology Chinese Academy of SciencesQingdao 266071China Southern Marine Science and Engineering Guangdong Laboratory Guangzhou 511458China

The Laizhou Bay(LB)represents a substantial ecological area that is vulnerable to human activities and confronts diverse environmental *** study provides a comprehensive characterization of nutrients,petroleum,heavy metals,and phytoplankton community structure across seven distinct areas in *** results indicate relatively high concentrations of NO_(2)-N,SiO_(4)-Si,and NO_(3)-N in the Southwest Laizhou Bay(SWLB)and Huanghe River Estuary(HRE).In contrast,the East Laizhou bay(ELB)and the North of Huanghe River Estuary(NHRE)exhibit the highest concentrations of heavy metals(As,Cr and Hg).The areas with high phytoplankton density and community diversity are mainly located in the *** adjusting for basic environmental factors,phytoplankton density and Margalef richness index D are significantly associated with nutrients(NO_(3)-N,NO_(2)-N,NH_(4)-N,SiO_(4)-Si),and heavy metal(Cr)*** highlight that,in addition to Xiaoqinghe River,nutrients brought by the Mihe River in the SWLB and heavy metal(Cr)pollution in the ELB resulting from industrial and mining activities along the coast significantly influence phytoplankton growth and community ***,it is recommended that more monitoring and management efforts be focused on these regions in the future.

关键词： Huanghe River Estuary Laizhou Bay nutrients heavy metals phytoplankton biodiversity

Therapeutic strategies of targeting nonapoptotic regulated cell death (RCD) with smallmolecule compounds in cancer

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Acta Pharmaceutica Sinica B 2024年第7期14卷 2815-2853页

作者： Xin Jin Wenke Jin linlin Tong Jia Zhao Lan Zhang Na Lin Department of Ultrasound Department of Medical Oncology and Department of Hematologythe First Hospital of China Medical UniversityChina Medical UniversityShenyang 110001China Sichuan Engineering Research Center for Biomimetic Synthesis of Natural Drugs School of Life Science and EngineeringSouthwest Jiaotong UniversityChengdu 610031China

Regulated cell death(RCD)is a controlled form of cell death orchestrated by one or more cascading signaling pathways,making it amenable to pharmacological *** subroutines can be categorized as apoptotic or non-apoptotic and play essential roles in maintaining homeostasis,facilitating development,and modulating *** evidence has recently revealed that RCD evasion is frequently the primary cause of tumor *** non-apoptotic RCD subroutines have garnered attention as promising cancer therapies due to their ability to induce tumor regression and prevent relapse,comparable to ***,they offer potential solutions for overcoming the acquired resistance of tumors toward apoptotic *** an increasing understanding of the underlying mechanisms governing these non-apoptotic RCD subroutines,a growing number of small-molecule compounds targeting single or multiple pathways have been discovered,providing novel strategies for current cancer *** this review,we comprehensively summarized the current regulatory mechanisms of the emerging non-apoptotic RCD subroutines,mainly including autophagy-dependent cell death,ferroptosis,cuproptosis,disulfidptosis,necroptosis,pyroptosis,alkaliptosis,oxeiptosis,parthanatos,mitochondrial permeability transition(MPT)-driven necrosis,entotic cell death,NETotic cell death,lysosome-dependent cell death,and immunogenic cell death(ICD).Furthermore,we focused on discussing the pharmacological regulatory mechanisms of related small-molecule *** brief,these insightful findings may provide valuable guidance for investigating individual or collaborative targeting approaches towards different RCD subroutines,ultimately driving the discovery of novel small-molecule compounds that target RCD and significantly enhance future cancer therapeutics.

关键词： Regulated cell death(RCD) Non-apoptotic RCD subroutine Autophagy Ferroptosis Necroptosis Regulatory mechanism Small-molecule compound Cancer therapy

The Influence of Internet Use on Women’s Depression and Its Countermeasures—Empirical Analysis Based on Data from CFPS

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International Journal of Mental Health Promotion 2024年第3期26卷 229-238页

作者： Dengke Xu linlin Shen Fangzhong Xu School of Economics Hangzhou Dianzi UniversityHangzhou310018China School of Mathematics and Computer Science Zhejiang A&F UniversityHangzhou311300China

Based on China Family Panel Studies(CFPS)2018 data,the multiple linear regression model is used to analyze the effects of Internet use on women’s depression,and to test the robustness of the regression *** the same time,the effects of Internet use on mental health of women with different residence,age,marital status and physical health status are ***,we can obtain that Internet use has a significant promoting effect on women’s mental health,while the degree of Internet use has a significant inhibitory effect on women’s mental *** addition,the study found that women’s age,education,place of residence,marital status,length of sleep,working status and physical health status are the main factors affecting the mental health of Chinese *** the heterogeneity investigation of residence,age,marital status and physical health status,Internet use has a greater negative impact on the Center for Epidemiological Studies Depression Scale(CES-D8)scores of women in rural areas,has a significant positive impact on the mental health of middle-aged and elderly women or women with spouses,and has a positive impact on the mental health of physically unhealthy ***,in view of women’s mental health needs and the problems existing in the use of the Internet,this paper puts forward some suggestions to further improve the overall mental health level of women.

关键词： Internet use depression multiple linear regression heterogeneity

Investigation of a falling film tube bank heat exchanger with baffle design for water recovery applications

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Energy and Built Environment 2024年第5期5卷 817-828页

作者： Liang Tang Xiaoling Cao Wei Zhong Long Yu linlin Yin Shandong Electric Power Engineering Consulting Institute Corp. LTD.Jinan 250013PR China School of Mechanical Engineering Southwest Jiaotong UniversityChengdu 610031PR China

Shell and tube heat exchangers(STHE)are essential thermal equipment and widely used in daily life.A novel thermosyphon system called falling-film thermosyphon(FFTS)is introduced and integrated into STHE system,resulting in a better thermal *** this study,a rectangular solid tube bank of FFTS bundles with a baffle design is *** numerical simulation for heat and mass transfer of the FFTS heat exchanger is developed to predict the condensation rate of the vapor in the flue gas,and a lab-scale prototype is also built up in *** prediction is validated with the experimental data from references,and the model’s accuracy is verified within 10%-12%***,the Non-dominated Sorting Genetic Algorithm,version 2(NSGA-II)is implemented to improve the thermal performance of rectangular tube banks in this *** parameters,e.g.,baffle number,tube number,and tube space,are *** a result,compact configurations with more baffles are preferred to enhance the performance associated with a high-pressure drop *** optimized layout for the lab-scale prototype can increase by 18 to 32%condensation with a pressure loss of less than 200 Pa.

关键词： Falling film Heat transfer Condensation NSGA-II algorithm Heat exchanger

Joint Biomedical Entity and Relation Extraction Based on Multi-Granularity Convolutional Tokens Pairs of Labeling

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Computers, Materials & Continua 2024年第9期80卷 4325-4340页

作者： Zhaojie Sun linlin Xing Longbo Zhang Hongzhen Cai Maozu Guo Department of Computer Science and Technology Shandong University of TechnologyZibo255000China Department of Agricultural Engineering and Food Science Shandong University of TechnologyZibo255000China Department of Electrical and Information Engineering Beijing University of Civil Engineering and ArchitectureBeijing100044China

Extracting valuable information frombiomedical texts is one of the current research hotspots of concern to a wide range of *** biomedical corpus contains numerous complex long sentences and overlapping relational triples,making most generalized domain joint modeling methods difficult to apply effectively in this *** a complex semantic environment in biomedical texts,in this paper,we propose a novel perspective to perform joint entity and relation extraction;existing studies divide the relation triples into several steps or ***,the three elements in the relation triples are interdependent and inseparable,so we regard joint extraction as a tripartite classification *** the same time,fromthe perspective of triple classification,we design amulti-granularity 2D convolution to refine the word pair table and better utilize the dependencies between biomedical word ***,we use a biaffine predictor to assist in predicting the labels of word pairs for relation *** model(MCTPL)Multi-granularity Convolutional Tokens Pairs of Labeling better utilizes the elements of triples and improves the ability to extract overlapping triples compared to previous ***,we evaluated our model on two publicly accessible *** experimental results show that our model’s ability to extract relation triples on the CPI dataset improves the F1 score by 2.34%compared to the current optimal *** the DDI dataset,the F1 value improves the F1 value by 1.68%compared to the current optimal *** model achieved state-of-the-art performance compared to other baseline models in biomedical text entity relation extraction.

关键词： Deep learning biomedical joint extraction triple classification multi-granularity 2D convolution

Hypoxia activates autophagy by Akt/FoxO1 pathway in fish cells

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Aquaculture and Fisheries 2024年第4期9卷 557-565页

作者： Kang Chen linlin Shi Hong Liu Huanling Wang Key Lab of Freshwater Animal Breeding Key Laboratory of Agricultural Animal GeneticsBreeding and ReproductionMinistry of EducationCollege of FisheriesHuazhong Agricultural UniversityWuhan430070China Engineering Research Center of Green Development for Conventional Aquatic Biological Industry in the Yangtze River Economic Belt Ministry of EducationWuhan430070China

Hypoxia,a common environmental condition,can affect cell survival and physiological function by triggering oxidative ***/FoxO pathway has been proven to play a non-negligible role in the regulation of ***,the role of Akt/FoxO pathway in hypoxia-induced autophagy is unclear in ***,in this study,grass carp hepatocyte cells(L8824)were treated by CoCl2 to simulate hypoxia,and the results showed that CoCl2 can increase the expression of Hif-1αprotein at different concentrations or different treatment *** study found that hypoxia increased intracellular reactive oxygen species(ROS)level,and the expression of autophagy-related genes(LC3-II,pink1,beclin-1 and p62)and foxO1a/*** mitochondrial membrane potential(Δψm)was also depolarized,and autophagosomes were intriguingly detected by transmission electron microscope(TEM)after the treatment of ***,hypoxia inhibited Akt phosphorylation,while PI3K/Akt pathway inhibitor,LY294002 significantly up-regulated the expression of foxO1a/1b and autophagy-related ***,silencing foxo1b also resulted in down-regulation of autophagy-related *** was demonstrated that hypoxia induced autophagy via Akt/FoxO1 *** results will provide a new light on further understanding the role of Akt/FoxO pathway in the response to hypoxia in fish.

关键词： Hypoxia Autophagy Fish cells Akt FoxO

Myosin Va‑dependent Transport of NMDA Receptors in Hippocampal Neurons

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Neuroscience Bulletin 2024年第8期40卷 1053-1075页

作者： Ru Gong Linwei Qin linlin Chen Ning Wang Yifei Bao Wei Lu Ministry of Education(MOE)Key Laboratory of Developmental Genes and Human Disease School of Life Science and TechnologySoutheast UniversityNanjing 210096China Department of Neurosurgery State Key Laboratory of Medical NeurobiologyMOE Frontiers Center for Brain ScienceHuashan HospitalInstitute for Translational Brain ResearchFudan UniversityShanghai 200032China Department of Neurobiology Nanjing Medical UniversityNanjing 210096China Co‑innovation Center of Neuroregeneration Nantong UniversityNantong 226001China

N-methyl-D-aspartate receptor(NMDAR)trafficking is a key process in the regulation of synaptic efficacy and brain ***,the molecular mechanism underlying the surface transport of NMDARs is largely *** we identified myosin Va(MyoVa)as the specific motor protein that traffics NMDARs in hippocampal *** found that MyoVa associates with NMDARs through its cargo binding *** association was increased during NMDAR surface *** of MyoVa suppressed NMDAR *** further demonstrated that Ca^(2+)/calmodulin-dependent protein kinase Ⅱ(CaMKⅡ)regulates NMDAR transport through its direct interaction with ***,MyoVa employed Rab11 family-interacting protein 3(Rab11/FIP3)as the adaptor proteins to couple themselves with NMDARs during their ***,the knockdown of FIP3 impairs hippocampal ***,we conclude that in hippocampal neurons,MyoVa conducts active transport of NMDARs in a CaMKII-dependent manner.

关键词： Myosin Va NMDA receptor CaMKⅡ Transport Memory

Research progress on electronic and active site engineering of cobalt‐based electrocatalysts for oxygen evolution reaction

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Carbon Energy 2024年第8期6卷 134-165页

作者： Chuansheng He linlin Yang Jia Wang Tingting Wang Jian Ju Yizhong Lu Wei Chen School of Materials Science and Engineering University of JinanJinanChina Catalonia Energy Research Institute—IREC Sant Adriàde BesòsBarcelonaSpain Department of Electronic and Biomedical Engineering University of BarcelonaBarcelonaSpain Graduate School of Integrated Sciences for Life Hiroshima UniversityHigashi‐HiroshimaHiroshimaJapan Wenzhou Institute University of Chinese Academy of SciencesWenzhouChina Oujiang Lab WenzhouChina School of Chemistry and Pharmaceutical Science Guangxi Normal UniversityGuilinChina

Electrocatalytic water splitting has been identified as a potential candidate for producing clean hydrogen energy with zero carbon ***,the sluggish kinetics of oxygen evolution reaction on the anode side of the watersplitting device significantly hinders its practical ***,the efficiency of oxygen evolution processes depends greatly on the availability of cost‐effective catalysts with high activity and *** recent years,extensive theoretical and experimental studies have demonstrated that cobalt(Co)‐based nanomaterials,especially low‐dimensional Co‐based nanomaterials with a huge specific surface area and abundant unsaturated active sites,have emerged as versatile electrocatalysts for oxygen evolution reactions,and thus,great progress has been made in the rational design and synthesis of Co‐based nanomaterials for electrocatalytic oxygen evolution *** the remarkable progress in this area,in this timely review,we highlight the most recent developments in Co‐based nanomaterials relating to their dimensional control,defect regulation(conductivity),electronic structure regulation,and so ***,a brief conclusion about recent progress achieved in oxygen evolution on Co‐based nanomaterials,as well as an outlook on future research challenges,is given.

关键词： Co‐based nanomaterial dimension regulation electronic structure and active site oxygen evolution reaction