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No generality in biodiversity-productivity relationships along elevation in temperate and subtropical forest landscapes

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Forest Ecosystems 2024年第3期11卷 255-265页

作者： Jiayun Zou Yahuang Luo Rupert Seidl Dominik Thom Jie Liu Lisa Geres Tobias Richter linjiang Ye Wei Zheng Liangliang Ma Jie song Kun Xu Dezhu Li Lianming Gao Sebastian Seibold Ecosystem Dynamics and Forest Management Research Group School of Life SciencesTechnical University of MunichHans-Carl-von-Carlowitz-Platz 285354FreisingGermany State Key Laboratory of Plant Diversity and Specialty Crops Kunming Institute of BotanyChinese Academy of SciencesKunming650201YunnanChina Germplasm Bank of Wild Species Kunming Institute of BotanyChinese Academy of SciencesKunming650201YunnanChina Lijiang Forest Biodiversity National Observation and Research Station Kunming Institute of BotanyChinese Academy of SciencesLijiang674100China Berchtesgaden National Park Doktorberg 683471Germany Gund Institute for Environment University of Vermont617 Main StreetBurlingtonVT 1105405USA Faculty of Biological Sciences Institute for EcologyEvolution and DiversityConservation BiologyGoethe University FrankfurtFrankfurt am MainGermany University of Chinese Academy of Sciences Beijing10049China TUD Dresden University of Technology Forest ZoologyPienner Str.701737TharandtGermany

An improved understanding of biodiversity-productivity relationships(BPRs)along environmental gradients is crucial for effective ecosystem management and biodiversity *** stress-gradient hypothesis suggests that BPRs are stronger in stressful environments compared to more favorable ***,there is limited knowledge regarding the variation of BPRs along elevational gradients and their generality across different *** study how BPRs change with elevation,we harnessed inventory data on 6,431 trees from152 plots surveyed twice in eight to ten year intervals in mountain forests of temperate Europe and subtropical *** quantified the relationship between aboveground productivity and different biodiversity measures,including taxonomic,functional,and phylogenetic *** elucidate the processes underlying BPRs,we studied the variation of different functional traits along elevation across *** found no general pattern of BPRs across landscapes and *** were neutral for all biodiversity measures in temperate forests,and negative for taxonomic and functional diversity in subtropical *** were largely congruent between taxonomic,functional and phylogenetic *** found only weak support for the stress-gradient hypothesis,with BPRs turning from negative to positive(effect not significant)close to the tree line in subtropical *** temperate forests,however,elevation patterns were strongly modulated by species identity effects as influenced by specific *** effect of traits such as community-weighted mean of maximum plant height and wood density on productivity was congruent across *** study highlights the context-dependence of BPRs across elevation gradients and *** traits are key modulating factors of BPRs and should be considered more explicitly in studies of the functional role of ***,our findings highlight that potential trade-offs be

关键词： Biodiversity-ecosystem functioning Climate mitigation Elevation gradients Forest management Forest productivity Functional traits Nature conservation Phylogenetic diversity

基于NF-κB/NLRP3/Caspase-1信号通路探讨羚羊角抗高热惊厥的作用机制

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中药药理与临床 2023年第5期39卷 82-88页

作者：孙雪张礼林王成维李金虎叶洵宋林江吴纯洁成都中医药大学成都615000

目的:以热水浴结合脂多糖(LPS)诱导的SD幼鼠高热惊厥(Febrile seizure, FS)模型探究羚羊角抗高热惊厥的作用。方法:72只21 d龄雄性SD大鼠,随机分为正常对照组、模型对照组、羚羊角1、1.5、3 g/kg组和地西泮6.7 mg/kg组。各组大鼠预先灌... 详细信息

目的:以热水浴结合脂多糖(LPS)诱导的SD幼鼠高热惊厥(Febrile seizure, FS)模型探究羚羊角抗高热惊厥的作用。方法:72只21 d龄雄性SD大鼠,随机分为正常对照组、模型对照组、羚羊角1、1.5、3 g/kg组和地西泮6.7 mg/kg组。各组大鼠预先灌胃相应药物3 d,末次灌胃前1 h腹腔注射LPS。灌胃后1.5 h,造模幼鼠用热水浴(46±0.5)℃诱导惊厥。观察并记录惊厥延迟时间、惊厥评分、惊厥死亡率;尼氏染色观察大鼠脑组织病变情况;ELISA法检测大鼠脑组织中神经递质谷氨酸(Glu)、去甲肾上腺素(NE)、γ-氨基丁酸(GABA)含量、白介素1β(IL-1β)、IL-6、肿瘤坏死因子(TNF)-α、IL-18含量及大鼠海马中半胱氨酸天冬氨酸蛋白酶1(Caspase-1)蛋白含量;RT-PCR法检测大鼠海马组织中Caspase-1、核苷酸结合寡聚化结构域样受体蛋白3(Nlrp3)、凋亡相关微粒蛋白(Asc)、Il1b、Il18 mRNA表达;Western blot法检测海马组织中细胞核与细胞质中核转录因子-κB(NF-κB)蛋白表达。结果:与正常对照组相比,模型对照组惊厥评级、死亡率明显增加,惊厥延迟时间明显降低(P<0.05或P<0.01),脑组织中Glu、IL-1β、IL-18、IL-6和TNF-α含量明显增加,NE和GABA含量明显降低(P<0.05或P<0.01),脑组织中Caspase-1蛋白含量显著增加,海马中Caspase-1、Nlrp3、Asc、Il1β及Il18 mRNA表达显著上调,海马组织核NF-κB表达显著上调(P<0.01),胞NF-κB表达下调(P<0.01);与模型对照组相比,羚羊角3 g/kg组能显著延长FS大鼠惊厥延迟时间,降低惊厥评分和惊厥死亡率(P<0.01),且对高热惊厥造成的神经病理损伤均有明显改善;羚羊角各组脑组织中Glu、GABA含量显著降低,NE含量显著升高(P<0.01);IL-1β、IL-6、TNF-α和IL-18含量明显降低(P<0.05),海马Caspase-1、Nlrp3、Asc、Il1b及Il18 mRNA表达均明显下调(P<0.01或P<0.05)。羚羊角3 g/kg组明显下调FS幼鼠海马组织中NF-κB蛋白的核转位并降低脑中Caspase-1蛋白含量(P<0.01)。结论:羚羊角对高热惊厥幼鼠具有较好的治疗作用。能够显著降低惊厥死亡率,对惊厥引起的脑组织病理损伤具有保护作用,可能是通过调控NF-κB/NLRP3/Caspase-1通路进而调节神经递质和抑制神经炎症等机制发挥抗惊厥作用。

关键词：羚羊角高热惊厥神经递质神经炎症细胞焦亡

麝香对Aβ_(1-42)诱导PC12细胞氧化应激损伤的保护作用研究

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中药药理与临床 2024年第4期40卷 83-89页

作者：谢林江秦涛宋才友楚志力邓婷谢丹妮徐颖孙涛成都中医药大学中药材标准化教育部重点实验室西南特色中药资源国家重点实验室成都611137 金堂县第二人民医院成都610404

目的:探讨麝香对阿尔兹海默症(AD)细胞模型氧化应激损伤及凋亡的保护作用。方法:使用LC-MS/MS法分析麝香化学成分。通过β-淀粉样蛋白1-42(Aβ_(1-42))诱导PC12细胞建立体外AD细胞模型,采用CCK-8法测定PC12细胞存活率,考察Aβ_(1-42)对P... 详细信息

目的:探讨麝香对阿尔兹海默症(AD)细胞模型氧化应激损伤及凋亡的保护作用。方法:使用LC-MS/MS法分析麝香化学成分。通过β-淀粉样蛋白1-42(Aβ_(1-42))诱导PC12细胞建立体外AD细胞模型,采用CCK-8法测定PC12细胞存活率,考察Aβ_(1-42)对PC12的细胞毒性及麝香对Aβ_(1-42)诱导PC12细胞损伤的保护作用;采用Annexin V-FITC/PI双染色法检测麝香对Aβ_(1-42)致PC12细胞凋亡的影响,JC-1法检测麝香对Aβ_(1-42)致PC12细胞线粒体膜电位的影响;采用探针DCFH-DA检测麝香对Aβ_(1-42)致PC12细胞内活性氧(ROS)的影响;采用超氧化物歧化酶(SOD)和谷胱甘肽过氧化物酶(GSH-Px)试剂盒检测麝香对Aβ_(1-42)致PC12细胞内抗氧化酶活性水平的影响;采用Western blot法检测PC12细胞内相关凋亡蛋白BAX、BCL-2和Cleaved caspase-3的表达以及核因子红细胞2相关因子2(Nrf-2)、血红素加氧酶-1(HO-1)和Kelch样ECH相关蛋白1(Keap 1)的表达。结果:通过LC-MS/MS法鉴定出麝香的7种化学成分分别为:次黄嘌呤、雄烯二酮、表睾酮、十六碳酰胺、麝香酮、油酸酰胺、硬脂酰胺。与空白对照组比较,模型对照组PC12细胞存活率显著降低(P<0.01),细胞内ROS水平、细胞凋亡率显著升高(P<0.01),线粒体膜电位明显降低(P<0.05),SOD和GSH-Px活力明显降低(P<0.05或P<0.01),BAX、Cleaved caspase-3和Keap 1蛋白表达明显上调,BCL-2、Nrf-2和HO-1蛋白表达明显下调(P<0.05或P<0.01);与模型对照组相比,麝香0.025、0.05、0.1 mg/mL组细胞存活率明显升高(P<0.05或P<0.01),细胞内ROS水平、细胞凋亡显著减少(P<0.01),SOD活力明显升高(P<0.05或P<0.01);其中0.05和0.1 mg/mL组中线粒体膜电位显著升高(P<0.01),BAX、Cleaved caspase-3和Keap 1蛋白表达明显下调(P<0.05或P<0.01);麝香0.1 mg/mL组GSH-Px活力显著升高(P<0.01),BCL-2、Nrf-2和HO-1蛋白表达明显上调(P<0.05或P<0.01)。结论:麝香通过Nrf-2/HO-1通路显著改善Aβ_(1-42)诱导的AD细胞模型的氧化应激和凋亡。

关键词：麝香 β-淀粉样蛋白1-42 氧化应激细胞凋亡核因子红细胞2相关因子2/血红素加氧酶-1/Kelch样ECH相关蛋白1信号通路

干扰雄性小鼠睾丸Clock基因对胎鼠发育的影响及机制研究

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四川农业大学学报 2021年第3期39卷 378-384页

作者：梁鑫宋林江刘驰何煊江舟陈浩然成姝婷王正荣成都中医药大学医学与生命科学学院/附属生殖妇幼医院成都610041 四川大学华西基础医学与法医学院成都610041

【目的】研究干扰雄性小鼠睾丸Clock基因后,对小鼠胚胎着床及后期胎鼠发育的影响,并从甲基化的角度探讨引起胎鼠发育异常的原因。【方法】将成年雄性小鼠分为干扰组和对照组,分别于睾丸中注射干扰质粒和阴性质粒,与经过促排处理的雌鼠合... 详细信息

【目的】研究干扰雄性小鼠睾丸Clock基因后,对小鼠胚胎着床及后期胎鼠发育的影响,并从甲基化的角度探讨引起胎鼠发育异常的原因。【方法】将成年雄性小鼠分为干扰组和对照组,分别于睾丸中注射干扰质粒和阴性质粒,与经过促排处理的雌鼠合笼,研究比较两组胚胎着床情况,观察两组胎鼠的外形及体重等指标的差异;观察胎鼠组织结构,比较两组是否存在差异;分析胎鼠总甲基化水平,同时测定甲基转移酶(DNMTs)水平,比较两组是否存在差异。【结果】:①与对照组比较,干扰组胚胎着床数下降(14.5 vs.20.33),胎儿体重减轻,死胎和异常胎数增多(P<0.05)。②干扰组胎鼠的心脏和脊柱发育分节出现异常。③11.5~16.5 dpc阶段胎鼠总甲基化水平,干扰组较对照组显著降低(8.59 vs.18.25);干扰组甲基转移酶DNMT3B-4的相对IOD值低于对照组(0.124 vs.0.141),有统计学意义。【结论】干扰雄性小鼠睾丸Clock基因,可导致胚胎着床数下降,胎鼠发育异常增多,体重减轻。甲基转移酶DNMT3B-4水平下调及总甲基化水平下降,可能是影响胎鼠发育异常的原因。本研究表明Clock基因与胎鼠发育密切相关,初步探讨引起不育的机制,为揭示该类疾病发病机制提供依据。

关键词： Clock基因小鼠胚胎着床 DNA甲基转移酶(DNMTs) 近日节律 DNA甲基化

Bimodal plate structures induced by pulsed laser in duplex-phase Zr alloy

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Science China(Technological Sciences) 2017年第4期60卷 587-592页

作者： CHAI linjiang WANG ShuYan WU Hao YANG ZhiNan PAN HuCheng song Bo GUO Ning College of Materials Science and Engineering Chongqing University of Technology National Engineering Research Center for Equipment and Technology of Cold Strip Rolling Yanshan University Key Laboratory for Anisotropy and Texture of Materials (Ministry of Education) Northeastern University Faculty of Materials and Energy Southwest University

A duplex-phase Zr-2.5Nb alloy was treated by pulsed laser, followed by careful microstructural characterization using field emission gun scanning electron microscope and attached electron backscatter diffraction. Beneath the modification zones with common uniform α-plate structures(UPS), a layer of unreported bimodal α-plate structures(BPS) featured by coarse(submicron)plates forming multiple cores surrounded by dense fine(nanoscale) plates was found. Presence of such BPS is attributed to non-equilibrium thermodynamic conditions induced by the pulsed laser treatments. Limited diffusion of Nb due to the short pulse during laser heating allows β phases with distinctly different Nb contents to be presented: Nb-enriched prior β films and Nb-depleted β phases, transforming into the fine and the coarse plates during cooling, respectively. Orientation analyses show that both types of plates in the BPS are aroused essentially from a single β orientation, suggesting epitaxial growth of the Nb-depletedβ phases from the preexisting β films.

关键词：激光诱导板结构短脉冲双峰合金双相场发射扫描电子显微镜电子背散射衍射

Texture control by {10-12} twinning to improve the formability of Mg alloys: A review

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Journal of Materials Science & Technology 2019年第10期35卷 2269-2282页

作者： Bo song Qingshan Yang Tao Zhou linjiang Chai Ning Guo Tingting Liu Shengfeng Guo Renlong Xin School of Materials and Energy Southwest UniversityChongqing 400715China School of Metallurgy and Materials Engineering Chongqing University of Science and TechnologyChongqing 401331China College of Materials Science and Engineering Chongqing University of TechnologyChongqing 400054China College of Materials Science and Engineering Chongqing UniversityChongqing 400044China

Texture control of wrought Mg alloys, particularly in rolled Mg alloy sheets, has been an important research topic for the past several decades because it has significant influence on stretch formability at room temperature. For Mg alloys, {10-12} twinning can be easily activated and causes a 86.3° lattice rotation. Thus, pre-twinning deformation is considered as an effective and low-cost method for texture control in wrought Mg and its alloys. Furthermore, it has been verified that texture control via pre-twinning deformation can remarkably improve stretch formability of rolled Mg alloy sheets. In this review, recent researches on texture control via twinning deformation and its influence on stretch formability will be critically reviewed. The main contents include the micro-mechanism and impact factors of control in twin-orientation, plastic processing techniques of pre-inducing twins and the application of pre-induced twins in improvement of stretch formability. Finally, further research directions on this field were proposed.

关键词： Mg alloys Texture Twinning Recrystallization Formability

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科兴中维某框架-抗震墙结构隔震加固设计

工程抗震与加固改造 2024年第1期46卷 56-62页

作者：袁鹏宋刚曹许王巍中国建筑科学研究院有限公司工程抗震研究所北京100013 建研(北京)抗震工程结构设计事务所有限公司北京100013 南京临江老城改造建设投资有限公司江苏南京210005

科兴中维某框架-抗震墙结构因工艺调整,抗震设防类别提高,采取隔震的方式进行抗震加固。本文通过建立弹塑性模型进行大震弹塑性分析,结果表明本结构隔震加固后,隔震层以上楼层,两方向层间位移角、抗倾覆、剪重比等关键指标均满足大震要... 详细信息

科兴中维某框架-抗震墙结构因工艺调整,抗震设防类别提高,采取隔震的方式进行抗震加固。本文通过建立弹塑性模型进行大震弹塑性分析,结果表明本结构隔震加固后,隔震层以上楼层,两方向层间位移角、抗倾覆、剪重比等关键指标均满足大震要求;隔震支座消耗总能量接近地震输入能量的2/3;隔震支座抗拉、抗压和位移均满足大震下规范要求;隔震层以上构件并未出现较严重的损坏;隔震层以下支撑隔震支座的框架柱经加固后,满足大震承载力要求。

关键词：隔震加固生物安全三级实验室弹塑性模型

α→β Transformation characteristics revealed by pulsed laser-induced non-equilibrium microstructures in duplex-phase Zr alloy

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Science China(Technological Sciences) 2017年第8期60卷 1255-1262页

作者： CHAI linjiang WANG Shu Yan WU Hao GUO Ning PAN HuCheng CHEN Liang Yu MURTY K.L. song Bo College of Materials Science and Engineering Chongqing University of Technology Faculty of Materials and Energy Southwest University Key Laboratory for Anisotropy and Texture of Materials(Ministry of Education) Northeastern University School of Mathematics and Science Jiangsu University of Science and Technology Department of Nuclear Engineering North Carolina State University

Microstructures of a duplex-phase Zr-2.5Nb alloy treated by pulsed laser were characterized by electron backscatter diffraction(EBSD) and electron channeling contrast(ECC) imaging *** attention has been paid to non-equilibrium hybrid microstructure consisting of both prior a and β phases,and a plates transformed from new β phases to probe α→β transformation characteristics in the *** origin of the hybrid microstructure is attributed to the specific thermodynamic conditions induced by the pulsed laser *** observation shows that newly formed β phases during laser heating prefer to nucleate and grow at the expense of edges of prior a grains rather than their *** analyses further reveal that orientations of the new βphases are not determined by the prior a grains according to the Burgers relationship but maintain those of the prior β phases in an epitaxial growth way.

关键词：非平衡组织双相合金转化特征激光诱导脉冲电子背散射衍射显示 EBSD

Preclinical and early clinical studies of a novel compound SYHA1813 that efficiently crosses the blood-brain barrier and exhibits potent activity against glioblastoma

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Acta Pharmaceutica Sinica B 2023年第12期13卷 4748-4764页

作者： Yingqiang Liu Zhengsheng Zhan Zhuang Kang Mengyuan Li Yongcong Lv Shenglan Li linjiang Tong Fang Feng Yan Li Mengge Zhang Yaping Xue Yi Chen Tao Zhang Peiran song Yi Su Yanyan Shen Yiming Sun Xinying Yang Yi Chen Shanyan Yao Hanyu Yang Caixia Wang Meiyu Geng Wenbin Li Wenhu Duan Hua Xie Jian Ding Division of Antitumor Pharmacology State Key Laboratory of Drug ResearchShanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China Department of Medicinal Chemistry Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China Department of Neuro-oncology Cancer CenterBeijing Tiantan HospitalCapital Medical UniversityBeijing 100070China Shanghai Runshi Pharmaceutical Technology Co. Ltd.Shanghai 201218China Zhongshan Institute for Drug Discovery Shanghai Institute of Materia MedicaChinese Academy of SciencesZhongshan 528400China University of Chinese Academy of Sciences Beijing 100049China Hangzhou Institute for Advanced Study University of Chinese Academy of SciencesHangzhou 310024China

Glioblastoma(GBM)is the most common and aggressive malignant brain tumor in adults and is poorly *** studies have shown that both macrophages and angiogenesis play significant roles in GBM progression,and co-targeting of CSF1R and VEGFR is likely to be an effective strategy for GBM ***,this study developed a novel and selective inhibitor of CSFIR and VEGFR,SYHA1813,possessing potent antitumor activity against ***1813 inhibited VEGFR and CSFIR kinase activities with high potency and selectivity and thus blocked the cell viability of HUVECs and macrophages and exhibited anti-angiogenetic effects both in vitro and in ***1813 also displayed potent in vivo antitumor activity against GBM in immune-competent and immune-deficient mouse models,including temozolomide(TMZ)insensitive ***,SYHA1813 could penetrate the blood-brain barrier(BBB)and prolong the survival time of mice bearing intracranial GBM ***,SYHA1813 treatment resulted in a synergistic antitumor efficacy in combination with the PD-1 *** a clinical proof of concept,SYHA1813 achieved confirmed responses in patients with recurrent GBM in an ongoing first-in-human phase I *** data of this study support the rationale for an ongoing phase I clinical study(ChiCTR2100045380).

关键词： Small molecule inhibitor Glioblastoma VEGFR CSF1R Angiogenesis Macrophage Tumor microenvironment Immune-checkpoint inhibitor