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Low Speed Axial Compressor Stall Margin Improvement by Unsteady Plasma Actuation

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Journal of Thermal Science 2014年第2期23卷 114-119页

作者： LI Gang XU Yanji yang lingyuan DU Wei ZHU Junqiang NIE Chaoqun Institute of Engineering Thermophysics Chinese Academy of Sciences

This research investigates the use of single dielectric barrier discharge(SDBD) actuators for energizing the tip leakage flow to suppress rotating stall inception and extend the stable operating range of a low speed axial compressor with a single *** jet induced by the plasma actuator adds momentum to the flow in the tip region and has a significant impact on the tip-gap *** are carried out on a low speed axial compressor with a single *** static pressure is measured at both the rotor inlet and *** flow coefficient and pressure rise coefficient are *** the characteristic line is acquired to show the overall performance of the *** unsteady plasma actuation of 18kV and 60W the compressor stability range improvement is realized at rotor speed of 1500 r/min – 2400 r/min.

关键词： axial compressor plasma actuation stall margin improvement

孤独症谱系障碍儿童外周血CNR1基因甲基化修饰水平的研究

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中国儿童保健杂志 2024年第3期32卷 237-241页

作者：王峰刘泽慧张艺霖田文茹杨凌渊邹明扬孙彩虹哈尔滨医科大学公共卫生学院儿少卫生与妇幼保健学教研室黑龙江哈尔滨150081

目的探讨CNR1基因甲基化水平与孤独症谱系障碍(ASD)间的关联,为ASD的病因学研究提供理论依据。方法采用病例对照研究方法,选取2017年6月—2018年12月就诊于哈尔滨医科大学儿童发育行为研究中心及康复机构的30名ASD儿童及年龄性别与之相... 详细信息

目的探讨CNR1基因甲基化水平与孤独症谱系障碍(ASD)间的关联,为ASD的病因学研究提供理论依据。方法采用病例对照研究方法,选取2017年6月—2018年12月就诊于哈尔滨医科大学儿童发育行为研究中心及康复机构的30名ASD儿童及年龄性别与之相匹配的30名正常儿童作为研究对象,应用Agena MassArray®飞行质谱分析系统检测两组儿童CNR1基因的甲基化水平,并与ASD发病风险及社交反应量表(SRS)得分进行关联分析。结果ASD儿童CNR1基因启动子区平均甲基化水平(t=2.224)、CpG_3.4(Z=2.187)、CpG_9.10.11(t=2.308)和CpG_28.29(t=2.943)位点甲基化水平均高于正常对照儿童,差异有统计学意义(P<0.05);其中CNR1基因启动子区平均甲基化水平(OR=1.117,95%CI:1.003~1.245)、CpG_9.10.11(OR=1.072,95%CI:1.006~1.142)和CpG_28.29(OR=1.078,95%CI:1.018~1.141)位点甲基化水平与ASD发病风险呈正相关(P<0.05);并且CpG_28.29位点甲基化水平与SRS量表社会动机领域评分呈正相关(r=0.421,P<0.05)。结论ASD儿童外周血中存在CNR1基因甲基化水平异常,并且可能与ASD发病风险及社交功能具有相关性,其作用机制值得进一步探讨。

关键词：孤独症谱系障碍 CNR1基因甲基化社交障碍

Impacts of land use changes on groundwater resources in the Heihe River Basin

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Journal of Geographical Sciences 2005年第4期15卷 405-414页

作者： WANG Genxu yang lingyuan CHEN Ling Jumpei Kubota Cold and Arid Regions Environmental and Engineering Research Institute CAS Lanzhou730000 China College of Earth and Environment Sciences Lanzhou University Lanzhou730000 China Research Institute for Humanity and Nature Kyoto 602-0878 Japan

Land use and land cover changes have a great impact on the regional hydrological process. Based on three periods of remote sensing data from the 1960s and the long-term observed data of groundwater from the 1980s, the impacts of land use changes on the groundwater system in the middle reach of Heihe River Basin in recent three decades are analyzed by the perspective of groundwater recharge and discharge system. The results indicate that with the different intensities of land use changes, the impacts on the groundwater recharge were 2.602 × 10^8 m^3/a in the former 15 years （1969-1985） and 0.218 × 10^8 m^3/a in the latter 15 years （1986-2000）, and the impacts on the groundwater discharge were 2.035 × 10^8 m^3/a and 4.91 × 10^8 m^3/a respectively. When the groundwater exploitation was in a reasonable range less than 3.0 × 10^8 m^3/a, the land use changes could control the changes of regional groundwater resources. Influenced by the land use changes and the large-scale exploitation in the recent decade, the groundwater resources present apparently regional differences in Zhangye region. Realizing the impact of land use changes on groundwater system and the characteristics of spatial-temporal variations of regional groundwater resources would be very important for reasonably utilizing and managing water and soil resources.

关键词： land use change inland fiver groundwater system Heihe River Basin

Alterations in nutrient digestibility and performance of heat-stressed dairy cows by dietary L-theanine supplementation

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Animal Nutrition 2022年第4期11卷 350-358页

作者： lingyuan yang Lingmei Zhang Peihua Zhang Yuli Zhou Xingguo Huang Qiongxian Yan Zhiliang Tan Shaoxun Tang Fachun Wan College of Animal Science and Technology Hunan Agricultural UniversityChangshaHunan 410128China CAS Key Laboratory of Agro-Ecological Processes in Subtropical Region National Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry ProductionHunan Provincial Key Laboratory of Animal Nutrition&Physiology and MetabolismInstitute of Subtropical AgricultureChinese Academy of SciencesChangshaHunan 410125China Shandong Provincial Key Laboratory of Livestock and Poultry Disease Prevention and Breeding JinanShandong 250000China

The purpose of this study was to investigate the effects of dietary L-theanine supplementation on apparent nutrient digestibility,milk yield,milk composition,and blood biochemical indices of dairy cows under heat *** Chinese Holstein cows(19.84±2.42 kg milk/d,192.36±40.77 d in milk and2±0.93 parities)were divided into 3 groups of 10 animals *** control group was fed a basal total mixed ration(TMR)diet,while treatment 1(LTA16)and treatment 2(LTA32)groups were fed a basal TMR diet supplemented with L-theanine at 16 and 32 g/cow per day,*** results showed that feeding the dairy cows with LTA16 treatment decreased(P0.05)on the dry matter intake,nutrient digestibility,total volatile fatty acid(TVFA)concentration and molar proportion of volatile fatty acid,milk yield,milk composition,feed efficiency and antioxidant capacity of the dairy *** triglyceride(TG)content of the LTA32 group was significantly greater(P=0.014)than that of the control *** the increase in L-theanine dosage,the serum cholesterol(CHOL)content significantly increased(P=0.013).The serum albumin(ALB;P=0.067),low-density lipoprotein cholesterol(LDL-C;P=0.053),and high-density lipoprotein cholesterol(HDL-C;P=0.067)contents showed an upward trend as L-theanine dosage ***,the results of this study show that supplementing dairy cow diet with L-theanine could decrease dairy cow rectal temperature,affect lipid metabolism,and potentially relieve the heat stress of dairy cows to some extent.

关键词： Cow Heat stress L-Theanine Nutrient digestibility Production performance Rumen fermentation

羊奶体细胞数与奶山羊瘤胃微生物区系的相关性

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湖南农业大学学报（自然科学版） 2024年第3期50卷 76-82页

作者：范斯琴周宇桥李虹佳龚新宇雍丛燕屈金涛简耀威杨玲媛湖南农业大学动物科学技术学院湖南长沙410128 湖南羴牧牧业有限公司湖南城步422500

选择120只(2.5±0.2)胎次、体质量(54.84±4.21)kg、泌乳日龄(72.0±3.5)d的健康西农萨能奶山羊,饲养42 d后收集奶样,测定羊奶中体细胞数(SCC),按照SCC将奶山羊分为3组,L–SCC组(SCC<5.0×10^(5)个/mL),M–SCC组(5.0×10^(5)个/mL≤SCC<1.0×10^(6)个/mL),H–SCC组(SCC≥1.0×10^(6)个/mL),从每组随机选取15只奶山羊,收集瘤胃液,测定瘤胃的微生物多样性,分析羊奶体细胞数与瘤胃微生物的相关性。结果表明:1)不同SCC水平奶山羊瘤胃微生物的α多样性、β多样性和优势菌群的差异不显著;L–SCC组放线菌门(Actinobacteriota)相对丰度显著高于M–SCC组和H–SCC组的,主要的差异菌属有解琥珀酸菌属(Succiniclasticum)、普氏菌UCG–003属(Prevotellaceae_UCG–003)、厌氧弧菌属(Anaerovibrio)、Gastranaerophilales_unclassified、双歧杆菌属(Bifidobacterium)、p–251–o5_unclassified、大肠杆菌–志贺菌属(Escherichia–Shigella)、夏普氏菌属(Sharpea)、乳杆菌属(Lactobacillus)、肠球菌属(Enterococcus);2)羊奶SCC与瘤胃解琥珀酸菌属的相对丰度呈显著正相关(P<0.05),与普氏菌UCG–003属的相对丰度呈极显著正相关(P<0.01)。

关键词：奶山羊羊奶体细胞数瘤胃微生物区系相关性

Alterations of endotoxin distribution across different biofluids and relevant inflammatory responses by supplementing L-theanine in dairy cows during heat stress

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Animal Nutrition 2021年第4期7卷 1253-1257页

作者： Zuo Wang Lingmei Zhang Zhicai Li Yuannian Yu lingyuan yang Peihua Zhang Weijun Shen Fachun Wan Jianhua He Wenjun Xiao Dasheng yang Zhiliang Tan Shaoxun Tang College of Animal Science and Technology Hunan Agricultural UniversityChangshaHunan410128China Key Laboratory of Agro-Ecological Processes in Subtropical Region National Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry ProductionHunan Provincial Key Laboratory of Animal Nutritional Physiology and Metabolic ProcessInstitute of Subtropical AgricultureChinese Academy of SciencesChangshaHunan410125China College of Horticulture Hunan Agricultural UniversityChangshaHunan410128China Deren Dairy Co.Ltd. ChangdeHunan415921China

The present trial was performed to reveal the regulatory effects of L-theanine on the levels of lipopolysaccharide(LPS)endotoxin within different biofluids,as well as relevant inflammatory responses of dairy cattle under heat stress *** lactating Chinese Holstein dairy cattle(189±47 d in milk,and 2±1 parities)were allocated in a completely randomized design to each of 3 dietary treatments:the control(CON,0 g/d per cow L-theanine),the low L-theanine dosage treatment(LL,16 g/d per cow L-theanine),and the high L-theanine dosage treatment(HL,32 g/d per cow L-theanine).This trial consisted of 38 d(7 d for adaption and 31 d for data and sample collection),and sample collection for rumen liquid,blood plasma or serum,and milk were conducted on the d 27 and 38,*** cattle were constantly exposed to environmental heat stress during this experiment according to the recorded temperature-humidity index(THI).In the LL treatment,LPS concentration in rumen liquid was higher(P<0.05),whilst LPS densities in plasma and milk were lower(P<0.05)than those of the *** L-theanine at 2 dosages both significantly lowered(P<0.05)the level of interleukin(IL)-1βin the *** of the present study suggested that L-theanine could be a promising additive in reducing the detrimental effects of heat stress on dairy cows,and L-theanine supplementation at 16 g/d per cow is preferred because it reduced the LPS translocation into the peripheral blood and LPS accumulation in the milk,as well as mitigated LPS-induced inflammatory reactions in dairy cows during heat *** studies are necessitated to investigate the underlying mechanisms of L-theanine in LPS alteration and inflammation alleviation.

关键词： Heat stress Endotoxin L-theanine Inflammation

AKT2^(S128)/CCTα^(S315/319/323)-positive cancer-associated fibroblasts (CAFs) mediate focal adhesion kinase (FAK) inhibitors resistance via secreting phosphatidylcholines (PCs)

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Signal Transduction and Targeted Therapy 2024年第2期9卷 782-796页

作者： Jie Chen lingyuan Zhang Yuheng Zhu Di Zhao Jing Zhang Yanmeng Zhu Jingyuan Pang Yuanfan Xiao Qingnan Wu Yan Wang Qimin Zhan Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Laboratory of Molecular OncologyPeking University Cancer Hospital&Institute100142 BeijingChina Peking University International Cancer Institute Peking University100191 BeijingChina Research Unit of Molecular Cancer Research Chinese Academy of Medical SciencesBeijingChina Soochow University Cancer Institute Suzhou 215000China Institute of Cancer Research Shenzhen Bay LaboratoryShenzhen 518107China

Abnormal metabolism is regarded as an oncogenic hallmark related to tumor progression and therapeutic *** study employed multi-omics,including phosphoproteomics,untargeted metabolomics and lipidomics,to demonstrate that the pAKT2 Ser128 and pCCTαSer315/319/323-positive cancer-associated fibroblasts(CAFs)substantially release phosphatidylcholines(PCs),contributing to the resistance of focal adhesion kinase(FAK)inhibitors in esophageal squamous cell carcinoma(ESCC)***,we observed extremely low levels of FAK Tyr397 expression in CAFs,potentially offering no available target for FAK inhibitors playing their anti-growth role in ***,FAK inhibitor increased the intracellular concentration of Ca2+in CAFs,promoting the formation of AKT2/CCTαcomplex,leading to phosphorylation of CCTαSer315/319/323 sites and eventually enhancing stromal PC *** activation could stimulate the intratumoral Janus kinase 2(JAK2)/Signal transducer and activator of transcription 3(STAT3)pathway,triggering resistance to FAK *** of clinical samples demonstrated that stromal pAKT2 Ser128 and pCCTαSer315/319/323 are related to the tumor malignancy and reduced patient ***-targeted lipidomics and further validation cohort quantitatively showed that plasma PCs enable to distinguish the malignant extent of ESCC *** conclusion,inhibition of stroma-derived PCs and related pathway could be possible therapeutic strategies for tumor therapy.

关键词： CAFs metabolism resistance

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粪菌移植改善猪肠道屏障功能的研究进展

动物营养学报 2023年第4期35卷 2072-2080页

作者：田玉杨玲媛黄兴国尹杰湖南农业大学动物科学技术学院长沙410128

肠道菌群是动物肠道系统组成的重要部分,对动物肠道发育和免疫功能成熟起着重要的作用,而且肠道菌群失衡与多种肠道疾病有关。粪菌移植(FMT)是一种将健康供体粪便菌群移植到患病受体肠道内,通过改善肠道菌群治疗肠道疾病的方法,是改善... 详细信息

肠道菌群是动物肠道系统组成的重要部分,对动物肠道发育和免疫功能成熟起着重要的作用,而且肠道菌群失衡与多种肠道疾病有关。粪菌移植(FMT)是一种将健康供体粪便菌群移植到患病受体肠道内,通过改善肠道菌群治疗肠道疾病的方法,是改善肠道菌群最直接、快速、有效的方法之一。近期的研究表明,FMT对畜禽肠道健康和生长性能有积极作用,可调节肠道菌群、维护肠道机械屏障、改善肠道黏液环境、提高肠道免疫力,对于维护肠道健康有很好的效果。本文综述了FMT对猪肠道屏障的影响,探讨了FMT的安全性和注意事项,以期为FMT技术在猪生产上更加安全规范的应用提供参考。

关键词：粪菌移植肠道屏障肠道免疫猪

Efficient and stable organic solar cells enabled by a poly(carbazole phosphonic acid)hole transporter

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Science China Chemistry 2024年第6期67卷 1941-1945页

作者： Zhijun Ren Siwei Luo Xiaoyu Shi Yunjie Dou Tianxiao Liu lingyuan Wang Kwok Kiu Tsang Feifei Wang Yu Zhao yangyang Liu Xiaodong Hu Xiaoxiao Peng Wei Liu He Yan Shangshang Chen State Key Laboratory of Coordination Chemistry MOE Key Laboratory of High Performance Polymer Materials&TechnologySchool of Chemistry and Chemical EngineeringNanjing UniversityNanjing210023China Department of Chemistry Guangdong-Hong Kong-Macao Joint Laboratory of Optoelectronic and Magnetic Functional MaterialsEnergy Institute and Hong Kong Branch of Chinese NationalEngineering Research Center for Tissue Restoration and ReconstructionHong Kong University of Science and TechnologyHong Kong999077China

Conventional self-assembled monolayer(SAM)hole transporters in organic solar cells(OSCs)generally suffer from poor uniformity and limited thickness tolerance,hindering their large-scale *** overcome these limitations,we introduce a novel polymeric hole transporter synthesized by polymerizing carbazole phosphonic acid(PACz).The resultant Poly-2PACz material exhibits exceptional conductivity,high tolerance for variations in layer thickness,and improved film uniformity compared with conventional ***,the OSCs utilizing Poly-2PACz achieve a remarkable power conversion efficiency of 19.1%and a high fill factor of 81.2%,surpassing the devices based on ***,Poly-2PACz-based OSCs demonstrate excellent operational stability,retaining over 80%of their initial efficiency after 1,400 h of continuous light exposure in ambient *** work presents a novel strategy for designing hole transporters,paving the way for more efficient and stable OSCs.

关键词： organic solar cells hole transporters poly(carbazole phosphonic acid) stability