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The quantitative proteome atlas of a model cyanobacterium

Journal of Genetics and Genomics 2022年第2期49卷 96-108页

作者： Jinlong Wang Xiahe Huang Haitao Ge Yan Wang Weiyang Chen limin Zheng Chengcheng Huang Haomeng Yang lingyu li Na Sui Yu Wang Yuanya Zhang Dandan Lu Longfa Fang Wu Xu Yuqiang Jiang Fang Huang Yingchun Wang State Key Laboratory of Molecular Developmental Biology The Innovative Academy of Seed DesignInstitute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China School of life Science Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhouZhejiang 310024China University of Chinese Academy of Sciences Beijing 100049China Key Laboratory of Photobiology Institute of BotanyChinese Academy of SciencesBejing 100093China Shandong Provincial Key Laboratory of Plant Stress College of Life ScienceShandong Normal UniversityJinanShandong 250014China State Key Laboratory of Crop Stress Adaptation and Improvement School of Life SciencesHenan UniversityKaifengHenan 475004China Department of Chemistry University of Louisiana at LafayetteLafayetteLA 70504USA

Cyanobacteria are a group of oxygenic photosynthetic bacteria with great potentials in biotechnological applications and advantages as models for photosynthesis research. The subcellular localizations of the majority of proteins in any cyanobacteria remain undetermined, representing a major challenge in using cyanobacteria for both basic and industrial researches. Here, using label-free quantitative proteomics, we map 2027 proteins of Synechocystis sp. PCC6803, a model cyanobacterium, to different subcellular compartments and generate a proteome atlas with such information. The atlas leads to numerous unexpected but important findings, including the predominant localization of the histidine kinases Hik33 and Hik27 on the thylakoid but not the plasma membrane. Such information completely changes the concept regarding how the two kinases are activated. Together, the atlas provides subcellular localization information for nearly 60% proteome of a model cyanobacterium, and will serve as an important resource for the cyanobacterial research community.

关键词： Proteome atlas Cyanobacteria Proteomics Membranes Synechocystis

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Analyzing the cellular and molecular atlas of ovarian mesenchymal cells provides a strategy against female reproductive aging

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Science China(life Sciences) 2023年第12期66卷 2818-2836页

作者： Longzhong Jia Wenji Wang Jing liang Shudong Niu Yibo Wang Jian Yang lingyu li Ge Wang Xueqiang Xu Lu Mu Kaixin Cheng Xuebing Yang Yijing Wang Haoshu Luo Guoliang Xia Yuwen Ke Yan Zhang Hua Zhang State Key Laboratory of Animal Biotech Breeding College of Biological SciencesChina Agricultural UniversityBeijing 100193China School of life Sciences Taizhou UniversityTaizhou 318000China National Institute of Biological Sciences Beijing 102206China Key Laboratory of Ministry of Education for Conservation and Utilization of Special Biological Resources in Western China College of Life ScienceNingxia UniversityYinchuan 750021China

Ovarian mesenchymal cells(oMCs)constitute a distinct microenvironment that supports folliculogenesis under physiological *** of exogenous non-ovarian mesenchymal-related cells has been reported to be an efficient approach to improve ovarian ***,the development and cellular and molecular characteristics of endogenous oMCs remain largely *** this study,we surveyed the single-cell transcriptomic landscape to dissect the cellular and molecular changes associated with the aging of oMCs in *** results showed that the oMCs were composed of five ovarian differentiatedMC(odMC)populations and one ovarian mesenchymal progenitor(oMP)cell *** cells could differentiate into various odMCs via an oMP-derived route to construct the ovarian stroma *** analysis revealed that ovarian aging was associated with decreased quantity of oMP cells and reduced quality of *** on the findings of bioinformatics analysis,we designed different strategies involving supplementation with young oMCs to examine their effects on female fertility and *** functional investigations revealed that oMCs supplementation prior to ovarian senescence was the optimal method to improve female fertility and extend the reproductive lifespan of aged females in the longterm.

关键词： single-cell analysis ovary mesenchyma mesenchymal progenitor cells aging infertility

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中国八大综合经济区环境治理绩效测度与时空演变

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中国人口·资源与环境 2023年第9期33卷 86-97页

作者：颉茂华李玲玉内蒙古大学经济管理学院内蒙古呼和浩特010021

环境治理绩效对推动绿色发展,实现“双碳”目标具有重要作用。基于非期望产出的SBM模型测算近十年中国八大综合经济区的环境治理绩效;同时,采用核密度估计和Dagum基尼系数测度环境治理绩效的时空差异,探讨环境治理绩效的时空分布情况;... 详细信息

环境治理绩效对推动绿色发展,实现“双碳”目标具有重要作用。基于非期望产出的SBM模型测算近十年中国八大综合经济区的环境治理绩效;同时,采用核密度估计和Dagum基尼系数测度环境治理绩效的时空差异,探讨环境治理绩效的时空分布情况;在此基础上,运用Malmquist指数模型研究技术进步、规模效率及纯技术效率对环境治理绩效的影响作用。研究发现:①中国八大综合经济区环境治理绩效整体呈现波动上升态势,但不同区域间或内部的环境治理绩效水平存在较大差别。②中国八大综合经济区环境治理绩效具有明显梯度效应,且环境治理绩效“两极化”程度缩小,存在动态收敛性特征。③中国八大综合经济区环境治理绩效总体差异呈现出波动下降趋势,主要差异贡献率源自区域间差异和交叉重叠,区域内差异贡献率相对较低。④技术进步是各地区环境治理绩效提升的主要影响因素,规模效率对环境治理绩效提升产生一定程度的抑制作用,纯技术效率对环境治理绩效提升具有一定程度的促进作用。基于以上研究结论,提出适度调整环境治理投资规模、加强环境治理技术创新能力、因地制宜考虑区域治理规模效率的政策建议。

关键词：环境治理绩效八大综合经济区 SBM模型 Dagum基尼系数 Malmquist指数

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Chartrenoline, a novel alkaloid isolated from a marine Streptomyces chartreusis NA02069

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Chinese Chemical Letters 2019年第1期30卷 44-46页

作者： Chengli liu Chenglong Yang Yingjie Zeng Jing Shi lingyu li Wei li Ruihua Jiao Renxiang Tan Huiming Ge State Key Laboratory of Pharmaceutical Biotechnology Institute of Functional Biomolecues School of Life Sciences Nanjing University

A novel alkaloid, chartrenoline(1), featuring an unusual 6/6/5/5-tetracyclic nucleus, was isolated from a marine Streptomyces chartreusis NA02069. The structure of 1 including its absolute configurations was established by extensive analyses of its high resolution mass, NMR and single-crystal X-ray diffraction data. A plausible biosynthetic pathway for chartrenoline(1) is proposed.

关键词： Alkaloid Chartrenoline Streptomyces chartreusis 6/6/5/5-Tetracyclic nucleus Marine-derived microorganism

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Advances in novel molecular typing and precise treatment strategies for small cell lung cancer

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Chinese Journal of Cancer Research 2021年第4期33卷 522-534页

作者： Rilan Bai lingyu li Xiao Chen Yuguang Zhao Wei Song Huimin Tian Jiuwei Cui Cancer Center the First Hospital of Jilin UniversityChangchun 130021China

Small cell lung cancer(SCLC)is a high-grade neuroendocrine(NE)cancer characterized by high circulating tumor-cell burden and early extensive *** the complexity of SCLC genes and the immune microenvironment,their unique molecular heterogeneity profiles have been continuously *** understanding of SCLC subtypes has recently changed from traditional"classical"and"variant"types to"NE"and"non-NE"phenotypes and to the subtypes defined by major transcriptional regulators,which indicates the gradual revelation of high intratumoral heterogeneity and plasticity characteristics of *** in genomics as well as the development of single-cell sequencing analysis and new preclinical models have helped investigators gain many new insights into SCLCs and the development of targeted therapy and immunotherapy *** article provides an overview of changes in molecular typing,tumor heterogeneity,and plasticity and that of advances in the precise treatment of different subtypes of SCLC.

关键词： Small cell lung cancer transcription factors tumor heterogeneity plasticity immune

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带有随机初值的复值Ginzburg-Landau方程的弱平均动力学

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数学年刊（A辑） 2022年第4期43卷 415-430页

作者：陈章李玲玉山东大学数学学院济南250100

本文研究了无界域上的带有随机初值的复值Ginzburg-Landau方程.首先,基于解过程的全局适定性,建立了带有随机初值的Ginzburg-Landau方程的平均随机动力系统.然后,证明了弱拉回平均随机吸引子的存在唯一性以及随机吸引子的周期性,并将其... 详细信息

本文研究了无界域上的带有随机初值的复值Ginzburg-Landau方程.首先,基于解过程的全局适定性,建立了带有随机初值的Ginzburg-Landau方程的平均随机动力系统.然后,证明了弱拉回平均随机吸引子的存在唯一性以及随机吸引子的周期性,并将其进一步推广到加权空间L2(Ω,Lσ2(R)).

关键词：复值Ginzburg-Landau方程随机初值平均随机动力系统弱拉回平均吸引子加权空间

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基于生态学边缘效应的叙词表交叉概念多样性研究

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情报杂志 2022年第6期41卷 142-147,156页

作者：李凌宇常春中国科学技术信息研究所北京100038

[研究目的]针对各学科领域研究日益交叉融合的现象,分析文献环境中交叉概念的多样性水平,引入生态学视角为综合性叙词表中交叉概念的编制规则增添理论依据。[研究方法]基于生态学中群落交错区存在的边缘效应原理,将学科交叉文献类比群... 详细信息

[研究目的]针对各学科领域研究日益交叉融合的现象,分析文献环境中交叉概念的多样性水平,引入生态学视角为综合性叙词表中交叉概念的编制规则增添理论依据。[研究方法]基于生态学中群落交错区存在的边缘效应原理,将学科交叉文献类比群落交错区、叙词表交叉概念类比交错区物种,假设叙词表交叉概念具有多样性较高的属性,引入数量生态学,提出概念种类和概念相对密度指标,建立叙词表交叉概念多样性模型,以生物和农业学科背景为例,统计对比单学科和学科交叉文献环境中的概念多样性指数。[研究结论]相同大小文献环境中,生物-农业交叉概念的概念数量最多,概念多样性指数也最大,符合叙词表交叉概念多样性较高的假设。

关键词：交叉概念多样性叙词表边缘效应群落交错区概念多样性指数

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Analysis of characteristics and predictive factors of immune checkpoint inhibitor-related adverse events

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Cancer Biology & Medicine 2021年第4期18卷 1118-1133页

作者： Rilan Bai Naifei Chen Xiao Chen lingyu li Wei Song Wei li Yuguang Zhao Yongfei Zhang Fujun Han Zheng Lyu Jiuwei Cui Cancer Center the First Hospital of Jilin UniversityChangchun 130021China

Objective:We aimed to retrospectively analyze the toxicity profiles and predictors of immune-related adverse events(irAEs)as well as the correlation between irAEs and the clinical efficacy of multi-type immune checkpoint inhibitors(ICIs)in patients with advanced pan-cancer in a real-world ***:We retrospectively analyzed data from 105 patients with advanced pan-cancer treated with multi-type ICIs at the First Hospital of Jilin University between January 1,2016 and August 1,*** used logistic regression analyses to investigate the associations of irAEs with clinical baseline characteristics,blood count parameters,and biochemical indicators during *** operating characteristic curves were used to determine cutoff values for parameters and area under the curve ***–Meier and Cox multivariate regression analyses were performed to estimate the relationships of baseline characteristics and irAEs with progression-free survival(PFS)and overall survival(OS).Results:A lower relative lymphocyte count(cutoff=28.5%),higher albumin level(cutoff=39.05 g/L),and higher absolute eosinophil count(AEC)(cutoff=0.175×10^(9)/L)were significantly associated with the occurrence of irAEs,among which a higher AEC(cutoff=0.205×10^(9)/L)was strongly associated with skin-related irAEs[odds ratios(ORs)=0.163,P=0.004].Moreover,a higher lactate dehydrogenase level(cutoff=237.5 U/L)was an independent predictor of irAEs of grade≥3(OR=0.083,P=0.023).In immune cell subgroup analysis,a lower absolute count of CD8+CD28−suppressor T cells(OR=0.806;95%confidence interval:0.643–1.011;P=0.062),which are regulatory T lymphocytes,was associated with the occurrence of irAEs,although the difference was not statistically ***,a higher percentage of CD19+B cells was associated with the occurrence of irAEs of grade≥3(P=0.02)and grade≥2(P=0.051).In addition,patients with any grade of irAE had a significantly high PFS(8.37 vs.3.77 months,hazard ratios(HR)=2.02,P

关键词： Neoplasm immune checkpoint inhibitors immune-related adverse events predictor efficacy

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产业用纺织品跨领域技术融合演化分析

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丝绸 2023年第8期60卷 28-37页

作者：李凌宇虎陈霞徐茜中国计量大学经济与管理学院杭州310018

技术融合为产业技术升级提供了新思路,然而对于技术融合的研究往往忽略了产业用纺织品领域。文章基于“重点产业专利信息服务平台”的专利数据,结合社会网络与链路预测方法,对产业用纺织品领域的技术融合现状、未来发展热点与趋势进行... 详细信息

技术融合为产业技术升级提供了新思路,然而对于技术融合的研究往往忽略了产业用纺织品领域。文章基于“重点产业专利信息服务平台”的专利数据,结合社会网络与链路预测方法,对产业用纺织品领域的技术融合现状、未来发展热点与趋势进行深入研究。结果表明:跨领域技术融合在产业用纺织品领域内的应用日益广泛,并主要集中在作业与运输、纺织与造纸及固定建筑物三大领域,其中分离、制作化学长丝、线、纤维、鬃或带子的机械方法或设备等技术在技术融合过程中扮演重要角色;纤维材料在航空航天等领域的应用与高品质非织造布、土木建筑用纺织品的应用是未来值得关注的方向。

关键词：技术融合产业用纺织品社会网络链路预测重点产业专利信息服务平台结构洞

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In Vivo Study of a Natural Whitening Agent

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China Detergent & Cosmetics 2023年第4期8卷 55-58页

作者： li lingyu Zhu Le Chen Mo Zhao Ya Zhou Ying Yuan Dengfeng Ni Xiangmei Jia Haidong Shanghai Jahwa United Co. Ltd.China

A natural whitening agent to replace synthetic bioactives was *** Qi Bai(XQB)was composed of traditional Chinese medicine(TCM)and the whitening efficacy was tested in *** volunteers were selected and used cream with or without XQB for 8 weeks *** individual type angle(ITA°),melanin index(MI)and the stain area(%)were tested after 0,2,4 and 8 *** can increase ITA°value,decrease MI value and the stain area of *** showed that XQB has good whitening efficacy in vivo,and is a natural whitening agent.

关键词： Whitening in vivo traditional Chinese medicine

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