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World Journal of Engineering and Technology 2023年第2期11卷 246-251页

作者： lingyu li Tianjin Branch of CNOOC Ltd. Tianjin China

In today’s society, with the continuous growth of energy demand, Bohai Oilfield, as an important offshore oil resource base in China, is facing increasingly severe challenges while contributing to national energy security. In order to improve the quality of water injection in the oilfield and gradually achieve efficient and stable production, Bohai Oilfield has launched a water injection well pressure optimization project, focusing on improving the efficiency and quality of water injection in the water injection wells, in order to achieve the optimal water injection plan. In practical work, P Oilfield continues to promote the development of water injection well pressure optimization projects, emphasizing practical exploration and continuous optimization of work plans. However, during the project implementation process, there were some problems, one of which was that the statistics of cumulative injection volume were not scientific enough, resulting in a more comprehensive and accurate presentation of the actual results of pressure optimization work. In the context of continuous improvement work, after careful analysis and research, P Oilfield has decided to optimize the cumulative injection rate algorithm to guide the oilfield’s water injection work in a more refined way, ensuring sufficient and good water injection, and enhancing the oilfield’s production efficiency and comprehensive competitiveness.

关键词： Offshore Oil Fields Water Injection Wells Pressure Optimization Water Injection Volume Calculation Method

Advances in novel molecular typing and precise treatment strategies for small cell lung cancer

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Chinese Journal of Cancer Research 2021年第4期33卷 522-534页

作者： Rilan Bai lingyu li Xiao Chen Yuguang Zhao Wei Song Huimin Tian Jiuwei Cui Cancer Center the First Hospital of Jilin UniversityChangchun 130021China

Small cell lung cancer(SCLC)is a high-grade neuroendocrine(NE)cancer characterized by high circulating tumor-cell burden and early extensive *** the complexity of SCLC genes and the immune microenvironment,their unique molecular heterogeneity profiles have been continuously *** understanding of SCLC subtypes has recently changed from traditional"classical"and"variant"types to"NE"and"non-NE"phenotypes and to the subtypes defined by major transcriptional regulators,which indicates the gradual revelation of high intratumoral heterogeneity and plasticity characteristics of *** in genomics as well as the development of single-cell sequencing analysis and new preclinical models have helped investigators gain many new insights into SCLCs and the development of targeted therapy and immunotherapy *** article provides an overview of changes in molecular typing,tumor heterogeneity,and plasticity and that of advances in the precise treatment of different subtypes of SCLC.

关键词： Small cell lung cancer transcription factors tumor heterogeneity plasticity immune

Atramacronoids A-C,three eudesmanolide sesquiterpene-phenol hybrids with an unprecedented C-C linkage from the rhizomes of Atractylodes macrocephala

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Chinese Chemical Letters 2023年第1期34卷 284-288页

作者： Haixin Zhang Jingrong li Jinguang Si Chengya Dong Qi li Meng Yu lingling Qin lingyu li Chenxu Zhao Tao Zhang Zhongmei Zou Institute of Medicinal Plant Development Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100193China Medical Sciences Guizhou Medical UniversityGuiyang 550000China China National Clinical Research Center for Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijing 100193China School of Pharmacy Henan University of Chinese MedicineZhengzhou 450000China

Three eudesmanolide sesquiterpene-phenol hybrids,atramacronoids A-C(1-3),featuring an unusual6/6/5/5/6 skeleton furnished by forming an unexpected C-8-C-16 linkage,were obtained from the rhizomes of Atractylodes *** structures and absolute configurations were elucidated by spectroscopic data analysis,chemical calculations,combined with X-ray *** plausible biosynthetic pathways for compounds 1-3 are ***,compound 1 exhibited cytotoxicity against SGC-7901 cells by inducing cells apoptosis,which might relate to the promotion of synthesis of neutrophil elastase.

关键词： Atractylodes macrocephala Compositae Sesquiterpene-phenol hybrids Anti-cancer Neutrophil elastase

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煤层气井电潜螺杆泵故障识别与治理对策

中国煤层气 2024年第3期21卷 25-28页

作者：李玲玉刘昌平王岩刘斌雷兴龙李泽州中国石油华北油田山西煤层气勘探开发分公司山西046000

L型套管压裂水平井在低渗或深部煤层气田开发上具有很大的技术优势,电潜螺杆泵举升工艺为水平井排采的重要方式之一,具有排量大,设备占地面积小,调参方便,自动化程度高等技术优势。通过现场270余口井的排采实践,发现该类泵型存在卡泵、... 详细信息

L型套管压裂水平井在低渗或深部煤层气田开发上具有很大的技术优势,电潜螺杆泵举升工艺为水平井排采的重要方式之一,具有排量大,设备占地面积小,调参方便,自动化程度高等技术优势。通过现场270余口井的排采实践,发现该类泵型存在卡泵、烧泵等5类故障,分析总结了各类故障发生前后的生产特征及原因,提出4类针对性预防及后期治理对策,研究结果为电潜螺杆泵在沁水煤层气田的稳定排采奠定了基础,同时也为其他煤层气区块的开发提供了借鉴经验。

关键词：煤层气井电潜螺杆泵故障识别及诊断治理对策

Energy Consumption Analysis and Optimization of Electric Submersible Pump System

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Engineering（科研） 2023年第5期15卷 269-274页

作者： lingyu li Tianjin Branch of CNOOC Ltd. Tianjin China

Electric submersible pumps account for a considerable proportion in the development of the Bohai Oilfield. Improving the system efficiency of the electric submersible pump wells, ensuring that the units operate in the high-efficiency zone, is essential. Analysis shows that the efficiency of the electric submersible pump system depends on the wear and tear of each component of the submersible pump equipment, the setting of operational parameters, and more importantly, the production status and daily management level of the oil well. Therefore, improving the structural performance of the submersible pump product, optimizing the parameters setting of the oil well, strengthening daily management, establishing a scientific management system, and improving the production management process and system can effectively improve the production efficiency and economic benefits of the oil well, and further achieve the goal of energy saving and emission reduction. In addition, it is necessary to actively promote the concept and technology of energy saving and emission reduction, encourage oilfield enterprises to explore effective measures to reduce the energy consumption of the electric submersible pump system by strengthening the scientific management system, and achieve a green, low-carbon, and high-quality development of oilfield production to achieve the unity of economic benefits, social benefits, and environmental benefits. This article applies the above measures in the P oilfield to achieve energy optimization of submersible electric pump systems, reducing the daily power consumption of single well submersible electric pump systems by 371 kWh per day, increasing the submersible electric pump's lifespan by 200 days, generating considerable project benefits.

关键词： Offshore Oil Fields Electric Submersible Pumps System Energy Consump-tion System Efficiency Energy Conservation and Consumption Reduction

Analysis of characteristics and predictive factors of immune checkpoint inhibitor-related adverse events

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Cancer Biology & Medicine 2021年第4期18卷 1118-1133页

作者： Rilan Bai Naifei Chen Xiao Chen lingyu li Wei Song Wei li Yuguang Zhao Yongfei Zhang Fujun Han Zheng Lyu Jiuwei Cui Cancer Center the First Hospital of Jilin UniversityChangchun 130021China

Objective:We aimed to retrospectively analyze the toxicity profiles and predictors of immune-related adverse events(irAEs)as well as the correlation between irAEs and the clinical efficacy of multi-type immune checkpoint inhibitors(ICIs)in patients with advanced pan-cancer in a real-world ***:We retrospectively analyzed data from 105 patients with advanced pan-cancer treated with multi-type ICIs at the First Hospital of Jilin University between January 1,2016 and August 1,*** used logistic regression analyses to investigate the associations of irAEs with clinical baseline characteristics,blood count parameters,and biochemical indicators during *** operating characteristic curves were used to determine cutoff values for parameters and area under the curve ***–Meier and Cox multivariate regression analyses were performed to estimate the relationships of baseline characteristics and irAEs with progression-free survival(PFS)and overall survival(OS).Results:A lower relative lymphocyte count(cutoff=28.5%),higher albumin level(cutoff=39.05 g/L),and higher absolute eosinophil count(AEC)(cutoff=0.175×10^(9)/L)were significantly associated with the occurrence of irAEs,among which a higher AEC(cutoff=0.205×10^(9)/L)was strongly associated with skin-related irAEs[odds ratios(ORs)=0.163,P=0.004].Moreover,a higher lactate dehydrogenase level(cutoff=237.5 U/L)was an independent predictor of irAEs of grade≥3(OR=0.083,P=0.023).In immune cell subgroup analysis,a lower absolute count of CD8+CD28−suppressor T cells(OR=0.806;95%confidence interval:0.643–1.011;P=0.062),which are regulatory T lymphocytes,was associated with the occurrence of irAEs,although the difference was not statistically ***,a higher percentage of CD19+B cells was associated with the occurrence of irAEs of grade≥3(P=0.02)and grade≥2(P=0.051).In addition,patients with any grade of irAE had a significantly high PFS(8.37 vs.3.77 months,hazard ratios(HR)=2.02,P

关键词： Neoplasm immune checkpoint inhibitors immune-related adverse events predictor efficacy

地方高水平大学科教融合中药学创新人才培养模式研究

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现代医院 2024年第1期24卷 127-129页

作者：高澜文曹叶张荣华杨丽王欢李小云李玲玉蔡宇暨南大学药学院广东广州510432

中药学源远流长,在现代医学和药学领域中具有举足轻重的地位,是我国传统医学的重要组成部分。随着时代的发展,人们愈加重视中药学的创新传承与发展,但目前各大高校培养的中药学人才并不能满足社会的需求和要求,这与目前高校的人才培养... 详细信息

中药学源远流长,在现代医学和药学领域中具有举足轻重的地位,是我国传统医学的重要组成部分。随着时代的发展,人们愈加重视中药学的创新传承与发展,但目前各大高校培养的中药学人才并不能满足社会的需求和要求,这与目前高校的人才培养模式密切相关。地方高水平大学在培养中药学创新人才方面具有独特的优势和潜力,将具有地方特色的传统中医药文化纳入中药学人才培养的教学内容和实践环节中,构建具有创新型的科教融合中药学人才培养模式,更有助于培养适应社会和中药学传承发展需求的拔尖创新人才。本文以“地方高水平大学科教融合中药学创新人才培养模式研究”为题,分析和探讨了地方高水平大学如何通过结合地方特色和学科优势开发出适合中药学领域需求的创新人才培养模式,从而为地方高水平大学在中药学人才培养方面提供有益的借鉴和启示。

关键词：地方高水平大学中药学科教融合人才培养模式

Prediction of three-dimensional ocean temperature in the South China Sea based on time series gridded data and a dynamic spatiotemporal graph neural network

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Acta Oceanologica Sinica 2024年第7期43卷 26-39页

作者： Feng Nan Zhuolin li Jie Yu Suixiang Shi Xinrong Wu lingyu Xu Department of Computer Engineering and Science Shanghai UniversityShanghai 200444China Key Laboratory of Digital Ocean National Marine Data and Information ServiceTianjin 300171China

Ocean temperature is an important physical variable in marine ecosystems,and ocean temperature prediction is an important research objective in ocean-related ***,one of the commonly used methods for ocean temperature prediction is based on data-driven,but research on this method is mostly limited to the sea surface,with few studies on the prediction of internal ocean *** graph neural network-based methods usually use predefined graphs or learned static graphs,which cannot capture the dynamic associations among *** this study,we propose a novel dynamic spatiotemporal graph neural network(DSTGN)to predict threedimensional ocean temperature(3D-OT),which combines static graph learning and dynamic graph learning to automatically mine two unknown dependencies between sequences based on the original 3D-OT data without prior *** and spatial dependencies in the time series were then captured using temporal and graph *** also integrated dynamic graph learning,static graph learning,graph convolution,and temporal convolution into an end-to-end framework for 3D-OT prediction using time-series grid *** this study,we conducted prediction experiments using high-resolution 3D-OT from the Copernicus global ocean physical reanalysis,with data covering the vertical variation of temperature from the sea surface to 1000 m below the sea *** compared five mainstream models that are commonly used for ocean temperature prediction,and the results showed that the method achieved the best prediction results at all prediction scales.

关键词： dynamic associations three-dimensional ocean temperature prediction graph neural network time series gridded data

污水处理厂人工湿地不同时间总磷去除效率分析

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广东化工 2024年第2期51卷 97-98,96页

作者：蒲正宇李凌宇邹鹏雷朝洁陈庆仙杨志四川阳晨环境工程投资有限公司四川成都611130 成都生物城城市运营管理有限公司四川成都610200 云南民族大学化学与环境学院云南昆明650500

人工湿地具有较好的总磷去除效果,但总磷去除效率受季节性变化影响。通过对人工湿地为期一整年的总磷去除效率研究,结果表面:全年人工湿地平均总磷去除量和去除率分别为0.030 mg/L和22.70%,9月和10月总磷平均去除量最高,10月总磷平均去... 详细信息

人工湿地具有较好的总磷去除效果,但总磷去除效率受季节性变化影响。通过对人工湿地为期一整年的总磷去除效率研究,结果表面:全年人工湿地平均总磷去除量和去除率分别为0.030 mg/L和22.70%,9月和10月总磷平均去除量最高,10月总磷平均去除率最高;1月总磷平均去除量和去除率均为最低;秋季总磷平均去除率最高,冬季最低。该研究结果对污水处理厂设计、建设及运营具有指导意义。

关键词：污水处理人工湿地总磷去除效率

Ectodermal progenitors derived from epiblast stem cells by inhibition of Nodal signaling

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分子细胞生物学报:英文版 2015年第5期7卷 455-465页

作者： lingyu li Lu Song Chang liu Jun Chen Guangdun Peng Ran Wang Pingyu liu Ke Tang Janet Rossant Naihe Jing State Key Laboratory of Cell Biology Institute of Biochemistry and Cell BiologyShanghai Institutes for Biological SciencesChinese Academy of SciencesShanghai 200031China Institute of life Science Nanchang UniversityNanchang 330031JiangxiChina Program in Developmental and Stem Cell Biology Hospital for Sick Children Research InstituteTorontoON M5G 1X8Canada Department of Developmental Biology Stanford University School of MedicineStanfordCA 94305USA

The ectoderm has the capability to generate epidermis and neuroectoderm and plays imperative roles during the early embryonic *** recent study uncovered a region with ectodermal progenitor potential in mouse embryo at embryonic day 7.0 and revealed that Nodal inhibition is essential for its ***,we demonstrate that through brief inhibition of Nodal signaling in vitro,mouse embryonic stem cell(ESC)-derived epiblast stem cells(ESD-EpiSCs)could be committed to transient ectodermal progenitor populations,which possess the ability to give rise to neural or epidermal ectoderm in the absence or presence of BMP4,*** studies reveal that BMP4 recruits distinct transcriptional targets in ESD-EpiSCs and ectoderm-like ***,FGF–Erk signaling may also be alleviated during the generation of ectoderm-like ***,our data suggest that instructive interactions among several extracellular signals participate in the commitment of ectoderm from ESD-EpiSCs,which shed new light on the understanding of the formation of ectoderm during the gastrulation in early mouse embryo development.

关键词： EpiSCs ectoderm BMP4 Nodal FGF