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Silver-coated elevated bowtie nanoantenna arrays： Improving the near-field enhancement of gap cavities for highly active surface-enhanced Raman scattering

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Nano Research 2015年第11期8卷 3715-3724页

作者： Lei Feng Renping Ma Yandong Wang Daren Xu Dongyang Xiao lingxiao liu Nan Lu State Key Laboratory of Supramolecular Structure and Materials Jilin University Changchun 130012 China

Improving hot-spot intensity is a key issue in surface-enhanced Raman scattering （SERS）. The bowtie nanoantenna （BNA） is an effective device used to concentrate light energy into a nanoscale volume and produce strong hot spots. Nanosphere lithography （NSL） is a large-area and low-cost technique to produce BNA arrays; however, the SERS activity of NSL-fabricated BNAs is limited. In this paper, we present a simple method to improve the SERS activity of conventional NSL-fabricated BNAs by modifying their geometry. The new configuration is termed ＂silver-coated elevated bowtie nanoantenna＂（SCEBNA）. SCEBNAs perform intensive near-field enhancement in the gap cavities owing to the integrated contribution of the ＂lightning rod＂ effect, resonance coupling, and the formation of the plasmonic Fabry-Perot cavity. Experimental measurements and finite-difference time-domain simulations revealed that the hot-spot intensity and the substrate enhancement factor can be optimized by adjusting the silver thickness. The optimal sample has the capability of trace-amount detection with fine reproducibility.

关键词： surface-enhanced Raman scattering (SERS) surface plasmon resonance bowtie nanoantenna nanosphere lithography gap cavity

Highly effective and reproducible surface-enhanced Raman scattering substrates based on Ag pyramidal arrays

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Nano Research 2013年第3期6卷 159-166页

作者： Yandong Wang Nan Lu Wentao Wang lingxiao liu Lei Feng Zhoufang Zeng Haibo Li Weiqing Xu Zijian Wu Wei Hu Yanqing Lu Lifeng Chi State Key Laboratory of Supramolecular Structure and Materials Jilin University Changchun 130012 China National Laboratory of Solid State Microstructures Nanjing University Nanjing 210093 China Physikalisches Institut and Center for Nanotechnology (CeNTech) Westfalische Wilhelms-Universitat D-48149 Munster Germany

Close-packed Ag pyramidal arrays have been fabricated by using inverted pyramidal pits on Si as a template and used to generate plentiful and homogeneous surface-enhanced Raman scattering （SERS） hot sites. The sharp nanotip and the four edges of the Ag pyramid result in strong electromagnetic field enhancement with an average enhancement factor （EF） of 2.84 × 10^7. Moreover, the features of the close-packed Ag pyramidal array can be well controlled, which allows SERS substrates with good reproducibility to be obtained. The relative standard deviation （RSD） was lower than 8.78% both across a single substrate and different batches of substrates.

关键词： SERS Ag pyramidal array reproducibility etching nanosphere lithography

Microwave ablation combined with transarterial chemoembolization containing doxorubicin hydrochloride liposome for treating primary and metastatic liver cancers

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Journal of Interventional Medicine 2023年第3期6卷 121-125页

作者： Qin Shi Zihan Zhang Wen Zhang Jingqin Ma Minjie Yang Jianjun Luo lingxiao liu Zhiping Yan Department of Interventional Radiology Zhongshan HospitalFudan UniversityShanghai200032China Shanghai Institution of Medical Imaging Shanghai200032China National Clinical Research Center for Interventional Medicine Zhongshan HospitalFudan UniversityShanghai200032China

Aims:To determine the safety and efficacy of microwave ablation(MWA)and transarterial chemoembolization(TACE)with doxorubicin hydrochloride liposome(DHL)in patients with primary liver cancer(PLC)and metastatic liver cancer(MLC).Materials and methods:The medical records of patients with primary or metastatic liver cancer who underwent MWA combined with TACE containing DHL from March 2019 to March 2022 were collected and ***-related adverse events(AEs)were *** tumor response was evaluated according to the modified RECIST *** tumor progression-free survival(LTPFS)and overall survival(OS)were calculated using the Kaplan-Meier ***:Altogether,96 patients with liver cancer were included(PLC,n=45;MLC,n=51).Forty(41.7%)patients experienced AEs during treatment,and eight(8.3%)patients developed grade 3 *** to before treatment,the serum total bilirubin level and neutrophil to lymphocyte ratio significantly increased after *** median LTPFS was 14.5 months in patients with PLC and 10.7 months in patients with *** median OS was not reached in patients with PLC or *** 1-month and 3-month disease control rates reached more than 80%in both ***:MWA combined with TACE with DHL may be a safe and effective method for the treatment of liver cancer.

关键词： Liver cancer Doxorubicin hydrochloride liposome Transarterial chemoembolization Microwave ablation

Application of contrast-enhanced ultrasound in minimally invasive ablation of benign thyroid nodules

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Journal of Interventional Medicine 2022年第1期5卷 32-36页

作者： Jiaying Cao Peili Fan Feihang Wang Shuainan Shi lingxiao liu Zhiping Yan Yi Dong Wenping Wang Department of Ultrasound Zhongshan HospitalFudan UniversityShanghaiChina Department of Interventional Radiology Zhongshan HospitalFudan UniversityShanghaiChina Shanghai Institute of Medical Imaging ShanghaiChina

Objective:This study aimed to investigate the application value of contrast-enhanced ultrasound(CEUS)before and after minimally invasive ablation procedures for benign thyroid nodule(s)(BTN).Methods:This prospective study included patients with BTNs scheduled to undergo ultrasound-guided minimally invasive ablation *** was performed before and after ablation(at 1 day,and 1,6,and 12 months after ablation).Changes in microvascular perfusion and the volume of BTNs were noted and ***:Sixty-two patients(62 BTNs),who underwent ablation procedures between June 2016 and August 2020,were *** lesions were confirmed by biopsy,and histopathological results were obtained before ablation *** preoperative CEUS,the lesions exhibited hyperenhancement(53.23%)or iso-enhancement(46.77%)during the arterial phase,and all lesions exhibited iso-enhancement in the venous and late *** day after ablation,none of the BTNs exhibited obvious enhancement on ***(1.61%)lesion was retreated due to a nodule-like enhancement area detected by CEUS at the 6-month *** mean nodular volume reduction rate(VRR)at 1,6,and 12 months follow-up demonstrated no significant difference between the two ablation groups(microwave ablation versus radiofrequency ablation).Twelve months after ablation,the mean(±SD)VRR of all BTNs was 60.3±10.3%.Conclusion:CEUS helped guide treatment decisions for BTNs before ablation ***,it could also be used to accurately and noninvasively evaluate treatment efficacy.

关键词： Ultrasound Contrast agent Thyroid Microwave ablation Radiofrequency ablation

Percutaneous microwave ablation combined with simultaneous transarterial chemoembolization for hepatocellular carcinoma with macrovascular invasion or extrahepatic metastases

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Journal of Interventional Medicine 2019年第2期2卷 55-59页

作者： Mengfei Wu Shanshan Gao Huadan Song Zihan Zhang Zhiyuan Zheng Zhiping Yan Xiaolin Wang Jianhua Wang lingxiao liu Department of Interventional Radiology Zhongshan HospitalFudan UniversityShanghai200032China Shanghai Institute of Medical Imaging Shanghai200032China

Objective:To evaluate the safety and efficacy of percutaneous microwave ablation(MWA)combined with simultaneous transarterial chemoembolization(TACE)in patients with hepatocellular carcinoma(HCC)patients with microvascular invasion(MVI)or extrahepatic metastases(EHM).Methods:Between August 2012 and April 2017,101 patients with MVI/EHM of HCC underwent percutaneous MWA combined with simultaneous TACE at our *** clinical data were collected and analyzed for survival and prognostic ***:The mean follow-up time was 23.6±14.7 *** patient had grade 3 complications,and the median overall survival was 12.0 months(95%confidence interval 9.7-14.3).Multivariate analysis showed that ChildPugh class,serum alpha-fetoprotein level,and Eastern Cooperative Oncology Group performance status were independent factors of ***:Our results suggest that percutaneous MWA combined with simultaneous TACE is a safe and effective treatment for HCC with MVI/EHM.

关键词： Hepatocellular carcinoma Combination therapy Microwave ablation Survival

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农产品逆向物流的博弈分析

物流技术 2013年第3期32卷 271-273页

作者：刘凌霄北京交通大学交通运输学院北京100044

农产品逆向物流特有的动态复杂性、效益性及效益背反等特征,要求逆向物流构成的闭环供应链上众节点协同进行合理化管理。在寻求社会效益和企业自身效益的平衡中,政府和企业的博弈是关键,以政府和企业作为决策主体构建了农产品逆向物流... 详细信息

农产品逆向物流特有的动态复杂性、效益性及效益背反等特征,要求逆向物流构成的闭环供应链上众节点协同进行合理化管理。在寻求社会效益和企业自身效益的平衡中,政府和企业的博弈是关键,以政府和企业作为决策主体构建了农产品逆向物流博弈模型,并求出博弈的策略纳什均衡解,通过对所得结果的分析,指出政府及企业在农产品逆向物流体系建设中的相应策略。

关键词：农产品逆向物流闭环供应链博弈分析

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电缆测试车高压冲击信号发生装置的研制

高电压技术 2016年第2期42卷 528-534页

作者：李峰樊庆华徐丙垠刘领校合肥工业大学仪器科学与光电工程学院合肥230009 山东科汇电力自动化股份有限公司淄博255087 山东理工大学电气与电子工程学院淄博255049

传统的高压(HV)冲击信号发生装置放电能量低、结构分散,限制了电缆故障探测能力和系统可靠性。为此,研制了一种用于电缆测试车的高冲击能量、一体化高压冲击信号发生装置。采用组合电容容量转换和输出电压联动控制电路与开关,提高了装... 详细信息

传统的高压(HV)冲击信号发生装置放电能量低、结构分散,限制了电缆故障探测能力和系统可靠性。为此,研制了一种用于电缆测试车的高冲击能量、一体化高压冲击信号发生装置。采用组合电容容量转换和输出电压联动控制电路与开关,提高了装置的放电能量和一体化水平;采用由牵引电磁铁和连杆组件构成的专用放电开关,以控制可调高压冲击信号放电;采用放电方式控制电路,实现了装置单次手动放电和自动周期放电功能;此外,还提出了一种高压设备接地保护检测方法,可保护测试人员和设备的安全。结果表明,该装置一体化程度高,最大放电电压为-32 k V,最大冲击放电能量可达2 560 J,满足现场使用要求。

关键词：高压冲击信号发生装置电力电缆电缆测试车电缆故障定位电容转换开关放电开关

人工智能技术在甲状腺结节诊断及预测淋巴结转移中的应用

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介入放射学杂志 2021年第4期30卷 323-326页

作者：刘凌晓董怡复旦大学附属中山医院超声科上海200032

甲状腺结节是临床常见的疾病之一,早期精准诊断甲状腺结节性质对患者治疗及预后具有重要意义。人工智能(artificial intelligence,AI)辅助技术被日益广泛应用于甲状腺结节临床诊疗中,AI技术术前精准诊断甲状腺结节良恶性并预测颈部淋巴... 详细信息

甲状腺结节是临床常见的疾病之一,早期精准诊断甲状腺结节性质对患者治疗及预后具有重要意义。人工智能(artificial intelligence,AI)辅助技术被日益广泛应用于甲状腺结节临床诊疗中,AI技术术前精准诊断甲状腺结节良恶性并预测颈部淋巴结转移,是目前的研究热点。影像组学利用深度学习和卷积神经网络技术构建预测模型,为甲状腺结节术前决策提供重要信息。本文就AI技术在甲状腺结节诊断及预测淋巴结转移中的应用进展进行述评。

关键词：甲状腺结节淋巴结转移人工智能影像组学

Chondroitinase ABC combined with Schwann cell transplantation enhances restoration of neural connection and functional recovery following acute and chronic spinal cord injury

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Neural Regeneration Research 2025年第5期20卷 1467-1482页

作者： Wenrui Qu Xiangbing Wu Wei Wu Ying Wang Yan Sun lingxiao Deng Melissa Walker Chen Chen Heqiao Dai Qi Han Ying Ding Yongzhi Xia George Smith Rui Li Nai-Kui liu Xiao-Ming Xu Spinal Cord and Brain Injury Research Group Stark Neurosciences Research InstituteDepartment of Neurological SurgeryIndiana University School of MedicineIndianapolisINUSA Department of Hand Surgery the Second Hospital of Jilin UniversityChangchunJilin ProvinceChina Shriners Hospitals Pediatric Research Center Temple University School of MedicinePhiladelphiaPAUSA Department of Anatomy&Cell Biology Indiana University School of MedicineIndianapolisINUSA

Schwann cell transplantation is considered one of the most promising cell-based therapy to repair injured spinal cord due to its unique growth-promoting and myelin-forming properties.A the Food and Drug Administration-approved Phase I clinical trial has been conducted to evaluate the safety of transplanted human autologous Schwann cells to treat patients with spinal cord injury.A major challenge for Schwann cell transplantation is that grafted Schwann cells are confined within the lesion cavity,and they do not migrate into the host environment due to the inhibitory barrier formed by injury-induced glial scar,thus limiting axonal reentry into the host spinal *** we introduce a combinatorial strategy by suppressing the inhibitory extracellular environment with injection of lentivirus-mediated transfection of chondroitinase ABC gene at the rostral and caudal borders of the lesion site and simultaneously leveraging the repair capacity of transplanted Schwann cells in adult rats following a mid-thoracic contusive spinal cord *** report that when the glial scar was degraded by chondroitinase ABC at the rostral and caudal lesion borders,Schwann cells migrated for considerable distances in both rostral and caudal *** Schwann cell migration led to enhanced axonal regrowth,including the serotonergic and dopaminergic axons originating from supraspinal regions,and promoted recovery of locomotor and urinary bladder ***,the Schwann cell survival and axonal regrowth persisted up to 6 months after the injury,even when treatment was delayed for 3 months to mimic chronic spinal cord *** findings collectively show promising evidence for a combinatorial strategy with chondroitinase ABC and Schwann cells in promoting remodeling and recovery of function following spinal cord injury.

关键词： axonal regrowth bladder function chondroitinase ABC functional recovery glial scar lentivirus migration Schwann cell spinal cord injury transplantation