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Acta Pharmaceutica Sinica B 2024年第4期14卷 1814-1826页

作者： Xiaoshan Tang Miaozhe Huo Yuting chen Hai Huang Shugang Qin Jiaqi Luo Zeyi Qin Xin Jiang Yongmei Liu Xing Duan Ruohan Wang lingxi chen Hao Li Na Fan Zhongshan He Xi He Bairong Shen Shuai cheng Li Xiangrong Song Institute of Systems Genetics Department of Critical Care MedicineFrontiers Science Center for Disease-related Molecular NetworkState Key Laboratory of Biotherapy and Cancer CenterWest China HospitalSichuan UniversityChengdu 610000China Department of Computer Science City University of Hong KongHong Kong 99907China Department of Biology Brandeis UniversityBostonMA 02453USA

Efficient translation mediated by the 5'untranslated region(5'UTR)is essential for the robust efficacy of mRNA ***,the N1-methyl-pseudouridine(m1)modification of mRNA can impact the translation efficiency of the 5'*** discovered that the optimal 5'UTR for m1y-modified mRNA(m1y-5'UTR)differs significantly from its unmodified counterpart,high-lighting the need for a specialized tool for designing mly-5'UTRs rather than directly utilizing high-expression endogenous gene 5'*** response,we developed a novel machine learning-based tool,Smart5UTR,which employs a deep generative model to identify superior m1y-5'UTRs in *** tailored loss function and network architecture enable Smart5UTR to overcome limitations inherent in existing *** a result,Smart5UTR can successfully design superior 5'UTRs,greatly benefiting mRNA vaccine ***,Smart5UTR-designed superior 5'UTRs significantly enhanced antibody titers induced by COVID-19 mRNA vaccines against the Delta and Omicron variants of SARS-CoV-2,surpassing the performance of vaccines using high-expression endogenous gene 5'UTRs.

关键词： mRNA vaccine Machine learning 5'UTR mRNA design Sequence design N1-Methyl-pseudouridine COVID-19 SARS-CoV-2

基于公益传播视域下的志愿服务APP设计——以“益帮”APP为例

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湖南包装 2024年第1期39卷 151-154,221页

作者：韩彪陈聆希长沙理工大学设计艺术学院湖南长沙410014

传统的公益慈善事业面临着大量的问题和痛点。数字化公益和服务越来越受到关注,为公益行为和社会问题的解决提供了平台。文章以“益帮”志愿服务类APP为例,提出引入传播学四维理论框架和用户体验ASIS理论的创新方法,对网络公益平台用户... 详细信息

传统的公益慈善事业面临着大量的问题和痛点。数字化公益和服务越来越受到关注,为公益行为和社会问题的解决提供了平台。文章以“益帮”志愿服务类APP为例,提出引入传播学四维理论框架和用户体验ASIS理论的创新方法,对网络公益平台用户的认知、选择和偏好等维度进行研究,设计出符合用户需求的产品。研究结果表明:让网络慈善平台的用户更好地参与到数字化的社会协同中来,通过网络慈善平台的协调来创造社会价值,对数字公益和服务的发展具有重要意义。

关键词：公益传播用户体验数字公益 APP设计

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网络游戏中传统文化的传播及其优化策略研究

艺术科技 2024年第9期37卷 176-178页

作者：杨子乙陈聆希长沙理工大学设计艺术学院湖南长沙410114

目的:文章深入研究中华传统文化在网络游戏领域的传播现状,并针对现状提出系列优化策略。当前国风复兴,网络游戏作为传播媒介得到广泛应用,因此研究网络游戏在传递中华传统文化方面的效果具有重要意义。方法:文章采用定量与定性相结合... 详细信息

目的:文章深入研究中华传统文化在网络游戏领域的传播现状,并针对现状提出系列优化策略。当前国风复兴,网络游戏作为传播媒介得到广泛应用,因此研究网络游戏在传递中华传统文化方面的效果具有重要意义。方法:文章采用定量与定性相结合的研究方法,分析当前网络游戏中中华传统文化的表现形式,包括其独特的艺术风格、深邃的哲学思想。着重探讨文化传达的准确性、对文化深度的挖掘及其与游戏元素的融合等方面面临的挑战。结果:尽管网络游戏作为一种新兴媒介在传播中华传统文化方面具有显著潜力,但仍需优化其文化表达的准确性与深度,在文化价值与经济利益之间找到平衡。结论:将中华优秀传统文化融入游戏产品设计,构建游戏社交增强文化体验,可以有效提升网络游戏在传播中华传统文化方面的影响力。这不仅能够更真实、更深刻地反映中华传统文化精髓,还能促进中华传统文化的创新传承和广泛传播,为文化的国际化作出贡献。

关键词：传统文化网络游戏文化传播融合

元宇宙视域下湘西苗族银饰文化活态传承的机遇及路径分析

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纺织报告 2024年第8期43卷 126-128页

作者：陈聆希李婉婷长沙理工大学湖南长沙410114

湖南湘西苗族银饰文化受工业生产和外来文化的冲击,面临着文化没落、传承体系即将断层、部分传统手工艺环节消失、银饰市场萎缩等生存及传播困境。当前,数字技术广泛应用于各行各业,元宇宙将深刻影响和重塑非遗文化活态传承的各个维度,... 详细信息

湖南湘西苗族银饰文化受工业生产和外来文化的冲击,面临着文化没落、传承体系即将断层、部分传统手工艺环节消失、银饰市场萎缩等生存及传播困境。当前,数字技术广泛应用于各行各业,元宇宙将深刻影响和重塑非遗文化活态传承的各个维度,从内容、空间、形式直至表现方式。文章在梳理湘西苗族银饰生存现状的基础上以元宇宙为切入点,探讨有效提升非遗文化竞争力的多元路径,并就湘西苗族银饰文化与元宇宙技术结合的前瞻性和可能性展开思考。

关键词：元宇宙湘西苗族银饰活态传承

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基于风险管理的高校网络舆情引导策略研究

新闻研究导刊 2024年第4期15卷 66-68页

作者：陈聆希邓锦文喻志雪长沙理工大学设计艺术学院湖南长沙410114

网络舆情是指网民以互联网的传播平台为媒介,通过留言、评论及转发,对自己关心、涉及自身利益或者影响力较大的社会事件发表自己的态度和看法形成的倾向集合。区块链、5G、人工智能、大数据等核心技术的快速发展,促进了新媒体、自媒体... 详细信息

网络舆情是指网民以互联网的传播平台为媒介,通过留言、评论及转发,对自己关心、涉及自身利益或者影响力较大的社会事件发表自己的态度和看法形成的倾向集合。区块链、5G、人工智能、大数据等核心技术的快速发展,促进了新媒体、自媒体等的快速发展,高校网络舆情已经不仅仅是大学生通过互联网对各种校园、社会事件产生的态度、认知和行为倾向的集合,其吸引了更多社会人员的关注和参与,同时也引发了高校网络舆情环境的变化。文章主要针对高校舆情环境,了解现阶段高校舆情应对措施,从中发现问题,并结合风险管理机制提出解决办法,形成新的应对机制。风险管理实现了从应对到管理的观念转变,从风险管理视角观察高校网络舆情治理,对于做好高校网络舆情引导乃至整个网络舆论场治理工作具有重要意义。文章针对现有案例和调查进行分析研究,从风险管理的角度对高校网络舆情引导策略进行筹划和完善,将风险管理相关理论应用到高校舆情工作中,通过对高校舆情风险内容进行识别、评价和分析,探究高校舆情特点,从舆情预警、舆情研判、舆情引导到舆情总结,针对性地建立一套行之有效的舆情风险规避预案,进而有效提升高校舆情应对能力。

关键词：风险管理网络舆情高校舆情引导舆论场

Alterations in nutrient digestion and utilization associated with different residual feed intake in Hu sheep

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Animal Nutrition 2023年第2期13卷 334-341页

作者： Hongbo Zeng Yuyang Yin lingxi chen Zhuoxin Xu Yang Luo Qian Wang Bin Yang Jiakun Wang Institute of Dairy Science College of Animal SciencesZhejiang UniversityHangzhou310058China b MoE Key Laboratory of Molecular Animal Nutrition Zhejiang UniversityHangzhou310058China School of Biological and Chemical Engineering Zhejiang University of Science and TechnologyHangzhou310023ZhejiangChina Huzhou Academy of Agricultural Sciences Huzhou313000China Hunan Institute of Animal and Veterinary Science Changsha410131China

Improving feed efficiency is crucial to the animal *** feed intake(RFI)is now regarded as an index of feed efficiency evaluation and is independent of growth *** study aims to explore the alterations in growth performance and nutrient digestion in Hu sheep with different RFI ***-four male Hu sheep(body weight=24.39±1.12 kg;postnatal days=90±7.9)were selected for the *** an evaluation period of 56 days and power analysis,samples were collected from 14 low RFI(L-RFI group,power=0.95)and 14 high RFI sheep(H-RFI group,power=0.95).The L-RFI sheep yielded a lower(P0.05).The acid detergent fiber,neutral detergent fiber,organic matter,and crude protein apparent digestibility were higher(P0.05)was found in urine N output(%of N intake)between the 2 ***,L-RFI sheep gave lower(P<0.05)serum glucose concentrations and higher(P<0.05)non-esterified fatty acid ***,a lower ruminal acetate molar proportion(P<0.05)and higher propionate molar proportion(P<0.05)were observed in L-RFI *** summary,these results revealed that despite having lower dry matter intake,L-RFI sheep possess higher nutrient digestibility,N retention,ruminal propionate production and serum glucose utilization,in order to meet energy *** for low RFI sheep could reduce feed costs,which in turn provides economic benefits to the sheep industry.

关键词： Residual feed intake Growth performance Apparent digestibility Nitrogen metabolism Rumen fermentation Sheep

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慢性创面诊疗管理策略的新契机:新兴技术

中华烧伤杂志 2019年第2期35卷 86-89页

作者：贾赤宇陈泠西厦门大学附属翔安医院烧伤整形科 361102

随着社会的进步和疾病谱的变化,慢性创面逐渐成为烧伤整形领域的主要部分。虽然在诊疗技术方面也取得了一些进步,但整体而言,慢性创面诊疗管理策略仍处于传统模式阶段。物联网、云计算、大数据、人工智能等新兴技术的发展日新月异,已快... 详细信息

随着社会的进步和疾病谱的变化,慢性创面逐渐成为烧伤整形领域的主要部分。虽然在诊疗技术方面也取得了一些进步,但整体而言,慢性创面诊疗管理策略仍处于传统模式阶段。物联网、云计算、大数据、人工智能等新兴技术的发展日新月异,已快速渗透至健康医疗领域。探索新兴技术在慢性创面诊疗管理中的应用前景,规划其在慢性创面诊治中的策略和模式,可进一步推动烧伤外科学发展。

关键词：诊疗工作管理医学慢性创面新兴技术

Geographical origin identification of winter jujube(Ziziphus jujuba Dongzao')by using multi-element fingerprinting with chemometrics

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Journal of Integrative Agriculture 2024年第5期23卷 1749-1762页

作者： Xiabing Kong Qiusheng chen Min Xu Yihui Liu Xiaoming Li lingxi Han Qiang Zhang Haoliang Wan Lu Liu Xubo Zhao Jiyun Nie College of Horticulture Qingdao Agricultural University/Laboratory of Quality&Safety Risk Assessment for Fruit(Qingdao)Ministry of Agriculture and Rural Affairs/National Technology Centre for Whole Process Quality Control of FSEN Horticultural Products(Qingdao)/Qingdao Key Lab of Modern Agriculture Quality and Safety EngineeringQingdao 266109China Institute of Agricultural Product Quality Safety and NutritionTianjin Academy of Agricultural SciencesTianjin 300381China College of Food Science and Engineering Northwest A&F UniversityYangling 712100China

Winter jujube(Ziziphus jujuba'Dongzao')is greatly appreciated by consumers for its excellent quality,but brand infringement frequently occurs in the ***,we first determined a total of 38 elements in 167 winter jujube samples from the main winter jujube producing areas of China by inductively coupled plasma mass spectrometer(ICP-MS).As a result,16 elements(Mg,K,Mn,Cu,Zn,Mo,Ba,Be,As,Se,Cd,Sb,Ce,Er,Tl,and Pb)exhibited significant differences in samples from different producing *** linear discriminant analysis(LDA)and orthogonal projection to latent structures discriminant analysis(OPLS-DA)showed better performance in identifying the origin of samples than unsupervised principal component analysis(PCA).LDA and OPLS-DA had a mean identification accuracy of 87.84 and 94.64%in the testing set,*** using the multilayer perceptron(MLP)and C5.0,the prediction accuracy of the models could reach 96.36 and 91.06%,*** on the above four chemometric methods,Cd,Tl,Mo and Se were selected as the main variables and principal markers for the origin identification of winter ***,this study demonstrates that it is practical and precise to identify the origin of winter jujube through multi-element fingerprint analysis with chemometrics,and may also provide reference for establishing the origin traceability system of other fruits.

关键词： winter jujube multi-element fingerprint analysis chemometrics origin traceability

Automation 5.0: The Key to Systems Intelligence and Industry 5.0

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IEEE/CAA Journal of Automatica Sinica 2024年第8期11卷 1723-1727页

作者： Ljubo Vlacic Hailong Huang Mariagrazia Dotoli Yutong Wang Petros A.Ioannou Lili Fan Xingxia Wang Raffaele Carli chen Lv lingxi Li Xiaoxiang Na Qing-Long Han Fei-Yue Wang Institute of Intelligent and Integrated Systems and the School of Engineering and Built Environment Griffith UniversityNathanQLD 4111Australia Department of Aeronautical and Aviation Engineering The Hong Kong Polytechnic UniversityHong KongChina Department of Electrical and Information Engineering Polytechnic of Bari70126 BariItaly State Key Laboratory of Multimodal Artificial Intelligence Systems Institute of AutomationChinese Academy of SciencesBeijing 100190and also with the Qingdao Academy of Intelligent IndustriesQingdao 266114China Department of Electrical Engineering-Systems University of Southern CaliforniaLos AngelesCA 90007 USA School of Automation Beijing Institute of TechnologyBeijing 100081China State Key Laboratory of Multimodal Artificial Intelligence Systems Institute of AutomationChinese Academy of SciencesBeijing 100190 School of Artificial Intelligence University of Chinese Academy of SciencesBeijing 100049 Beijing Huairou Academy of Parallel Sensing Beijing 101499China School of Mechanical and Aerospace Engineering Nanyang Technological UniversitySingapore 639798Singapore Department of Electrical and Computer Engineering Purdue School of Engineering and TechnologyIndiana University-Purdue University IndianapolisIndianapolisIN 46202 USA Department of Engineering University of CambridgeCB21TN CambridgeU.K. School of Science Computing and Engineering TechnologiesSwinburne University of TechnologyMelbourne VIC 3122Australia State Key Laboratory for Management and Control of Complex Systems Chinese Academy of SciencesBeijing 100190 School of Artificial Intelligence University of Chinese Academy of SciencesBeijing 100049China Dazhou Artificial Intelligence Institute Dazhouand the Faculty of Innovation EngineeringMacao University of Science and TechnologyMacao 999078China

AUTOMATION has come a long way since the early days of mechanization,i.e.,the process of working exclusively by hand or using animals to work with *** rise of steam engines and water wheels represented the first generation of industry,which is now called Industry Citation:***,***,***,***,***,***,***,***,***,***,***,Q.-***,and F.-***,“Automation 5.0:The key to systems intelligence and Industry 5.0,”IEEE/CAA ***,vol.11,no.8,pp.1723-1727,Aug.2024.

关键词： Automation machinery intelligence

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瘢痕疙瘩的肿瘤特征

中华烧伤杂志 2021年第4期37卷 301-305页

作者：贾赤宇陈泠西厦门大学附属翔安医院烧伤整形与创面修复外科 361102

临床工作中观察到瘢痕疙瘩存在与增生性瘢痕等其他类型瘢痕显著不同的特性,瘢痕疙瘩的生长通常超出原始伤口边界,向周围皮肤不断入侵,瘢痕疙瘩经手术、糖皮质激素注射等治疗后存在一定的复发率,提示瘢痕疙瘩具有一定的肿瘤特征,因此不... 详细信息

临床工作中观察到瘢痕疙瘩存在与增生性瘢痕等其他类型瘢痕显著不同的特性,瘢痕疙瘩的生长通常超出原始伤口边界,向周围皮肤不断入侵,瘢痕疙瘩经手术、糖皮质激素注射等治疗后存在一定的复发率,提示瘢痕疙瘩具有一定的肿瘤特征,因此不能仅仅站在瘢痕的角度看待瘢痕疙瘩。本文试图以肿瘤的视角重新描述瘢痕疙瘩的发病机制,从生长信号的自给自足、避免凋亡、异常血管生成等方面总结瘢痕疙瘩的肿瘤特征。

关键词：瘢痕疙瘩细胞凋亡肿瘤特征生长因子血管生成