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LncRNA AFAP1-AS1 exhibits oncogenic characteristics and promotes gemcitabine-resistance of cervical cancer cells through miR-7-5p/EGFR axis

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Oncology Research 2024年第12期32卷 1867-1879页

作者： CHAOQUN WANG TING zhang CHAOHE zhang Department of Gynecology Aviation General HospitalBeijing100020China Department of Burn and Skin Surgery First Affiliated Hospital of Air Force Military Medical UniversityXi’an710032China Department of Oncology and Hematology Second Hospital of Jilin UniversityChangchun130000China

Background:Drug resistance is the main factor contributing to cancer recurrence and poor *** of drug resistance-related mechanisms and effective therapeutic targets are the aim of molecular targeted *** our study,the role of long non-coding RNA(lncRNA)AFAP1-AS1 in gemcitabine resistance and related mechanisms were explored in cervical cancer ***:Gemcitabine-resistant cervical cancer cell lines HT-3-Gem and SW756-Gem were constructed using the gemcitabine concentration gradient *** overall survival rates and recurrence-free survival rates were evaluated by Kaplan-Meier *** interaction was veriﬁed through a Dual-luciferase reporter gene assay and a Biotinylated RNA pull-down *** proliferation ability was assessed through methyl-thiazolyl-tetrazolium(MTT),soft agar,and colony formation *** cycle and apoptosis were detected byﬂow ***:Up-regulation of AFAP1-AS1 in cervical cancer predicted a poor ***,patients in the gemcitabine-resistance group had higher levels of AFAP1-AS1 than the gemcitabine-sensitive ***1-AS1 promoted tumor growth and induced gemcitabine tolerance of cervical cancer *** addition,AFAP1-AS1 mediated epidermal growth factor receptor(EGFR)expression by serving as a molecular sponge for microRNA-7a-5p(miR-7-5p).This present study also proved that the knockdown of EGFR or overexpression of miR-7a-5p abolished the accelerative role of AFAP1-AS1 overexpression in cancer progression and gemcitabine ***:In general,the AFAP1-AS1/miR-7-5p/EGFR axis was tightly related to the progression and gemcitabine tolerance of cervical cancer,providing potential targets for the management of cervical cancer.

关键词： Long non-coding RNA(lncRNA)AFAP1-AS1 miR-7-5p Epidermal growth factor receptor(EGFR) Gemcitabine-resistance Cervical cancer

Photocatalytic and photochemical processes of AgCl/TiO_(2) studied with a fully integrated X-ray photoelectron spectrometer

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Rare Metals 2021年第4期40卷 799-807页

作者： Kai Zhou Wen-Lu He Xiao zhang Bin zhang Xiang-Nan Gong Kai-Wen Wang Zhi-Chao zhang Xi-Lan zhang Zhi-Ning Xia Xiao-Yuan Zhou Analytical and Testing Center Chongqing UniversityChongqing 401331China College of Physics Chongqing UniversityChongqing 401331China Beijing Key Laboratory and Institute of Microstructure and Property of Advanced Materials Beijing University of TechnologyBeijing 100124China School of Materials Science and Engineering Chongqing UniversityChongqing 400045China

A fully integrated X-ray photoelectron spectrometer(XPS) was employed for the investigation of the separation processes and recombination behaviors of photogenerated electrons and holes on the surface of AgCl and ultra-small nano-titanium oxide cluster composite photocatalyst(AgCl/TiO_(2)).A facile route,by direct colloidal synthesis,for preparing AgCl/TiO_(2)with high stability and enhanced visible light(Vis) driven catalytic activity was *** photocatalytic activity of AgCl/TiO_(2),which revealed that the photo-degradation rate of the as-prepared AgCl/TiO_(2)was nearly 10.5 times higher than that of bare AgCl,was evaluated by applying it to the photo-degradation of methyl orange(MO) in water ***,AgCl/TiO_(2)exhibited an outstanding long-term stability during ten cycles of *** band gap of AgCl decreased from 3.25 to 2.85 eV because of the ultrasmall nano-TiO_(2)clusters that were pinned to its *** results indicate that the band gap narrowing and surface plasmon resonance(SPR) of Ag(0) were two major contributors to the enhancement of the photocatalytic activity of AgCl/TiO_(2)by improving the utilization of *** situ XPS analysis was,therefore,certified as a beneficial method to explore the catalytic mechanism of photocatalysts.

关键词： Photocatalysis AgCl/TiO_(2) Fully integrated XPS Band gap narrowing

Effect of Reaction Layers on the Residual Stress of the Brazed TiC Cermets/Steel Joints

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Journal of Materials Science & Technology 2009年第2期25卷 203-207页

作者： Lixia zhang Jicai Feng National Key Laboratory of Advanced Welding Production Technology Harbin Institute of Technology Harbin 150001 China

For the first time, considering the effect of reaction layers, numerical simulation calculation of residual stress on brazed TiC cermets/steel joint was studied by finite element method （FEIVl）. The calculation results show that, when the joint is brazed at 1123 K for 300 s （low brazing parameters）, the maximum shear stress value occurs on （Cu, Ni） layer near TiC cermets, which is 92.16 MPa as the temperature is 300 K. When the joint is brazed at 1273 K for g00 s （high brazing parameters）, the maximum shear stress value occurs on （Cu, Ni）＋（Fe, Ni） layer, which is 39.18 MPa as the temperature is 300 K. The fracture sites of the joints obtained from numerical simulation calculation accord with experimental results.

关键词： Numerical simulation Residual stress Reaction layer Brazing

Experimental Study of the Distribution of Au and Cu in Aqueous Vapor Phase at High Temperatures and Its Role on Ore-forming Transportation

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Acta Geologica Sinica(English Edition) 2008年第4期82卷 875-883页

作者： zhang Ronghua HU Shumin zhang Xuetong Open Research Laboratory of Geochemical Kinetics Institute of Mineral Resources Chinese Academy of Geological Sciences Beijing 100037

This study focuses on experiments of Au and Cu dissolved in vapor phase in hydrothermal fluids. Experiments prove that Au and Cu can re-distribute in vapor phase and liquid phase during separation of Au- and Cu-bearing supercritical fluids to vapor and liquid phases. These experimental results can illustrate some ore geneses, where boiling phenomena of ore fluids were found. Au- and Cubearing NaHCO3-HCl solutions were heated up to more than 350℃ in the main vessel, and then passed through a phase separator in a temperature range from 250℃ to 300℃, separated into vapor and liquid phases. We collected and analyzed the liquid and vapor samples separately, and found that Au and Cu dissolved and distributed in vapor phase. In some cases, the concentrations of Au and Cu in vapor are higher than those in liquid phase. Those experiments are used to interpret field observations of fluid inclusion data of some Au and Cu deposits, and demonstrate that some Au and Cu ore deposits are derived from metals transportation in vapor phase.

关键词： Au and Cu in vapor phase ore genesis boiling phenomena liquid and vapor phase separation metal transportation in gases

Representation type of local and two-vertex bocses

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Science China Mathematics 2009年第5期52卷 949-958页

作者： zhang XueYing zhang YingBo ZHAO ShuangMei School of Mathematical Sciences Beijing Normal UniversityBeijing 100875China

Let k be an algebraically closed field. It has been proved by zhang and Xu that if a bocs is of tame representation type, then the degree of the differential of the first solid arrow must be less than or equal to 3. We will prove in the present paper that: The bocs is still wild when the degree of the differential of the first arrow is equal to 3. Especially, the bocs with only one solid arrow is of tame type if and only if the degree of the differential of the arrow is less than or equal to 2. Moreover, we classify in this case the growth problems of the representation category of the bocs and layout the sufficient and necessary conditions when the bocs is of finite representation type, tame domestic and tame exponential growth respectively.

关键词： bocs reduction tame representation type wild representation type domestic 15A21 16G20 16G60 16G70

Adaptive robust simultaneous stabilization of multiple nn-degree-of-freedom robot systems

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Control Theory and Technology 2022年第1期20卷 80-94页

作者： Haiying zhang Renming Yang School of Information Science and Electrical Engineering Shandong Jiaotong UniversityJinan250357ShandongChina

In this paper,the adaptive robust simultaneous stabilization problem of uncertain multiple n-degree-of-freedom(n-DOF)robot systems is studied using the Hamiltonian function method,and the corresponding adaptive L2 controller is ***,we investigate the adaptive simultaneous stabilization problem of uncertain multiple n-DOF robot systems without external ***,the single uncertain n-DOF robot system is transformed into an equivalent Hamiltonian form using the unified partial derivative operator(UP-DO)and potential energy shaping method,and then a high dimensional Hamiltonian system for multiple uncertain robot systems is obtained by applying augmented dimension technology,and a single output feedback controller is designed to ensure the simultaneous stabilization for the higher dimensional Hamiltonian *** this basis,we further study the adaptive robust simultaneous stabilization control problem for the uncertain multiple n-DOF robot systems with external disturbances,and design an adaptive robust simultaneous stabilization ***,the simulation results show that the adaptive robust simultaneous stabilization controller designed in this paper is very effective in stabilizing multi-robot systems at the same time.

关键词： Multiple robot systems Adaptive robust control Simultaneous stabilization Hamiltonian function method

A Note on Curvature Estimate of the Hermitian–Yang–Mills Flow Dedicated to celebrate the Sixtieth anniversary of USTC

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Communications in Mathematics and Statistics 2018年第3期6卷 319-358页

作者： Jiayu Li Chuanjing zhang Xi zhang School of Mathematical Sciences University of Science and Technology of ChinaHefei 230026People’s Republic of China AMSS CASBeijing 100080People’s Republic of China

In this paper,we study the curvature estimate of the Hermitian–Yang–Mills flow on holomorphic vector *** one simple case,we show that the curvature of the evolved Hermitian metric is uniformly bounded away from the ... 详细信息

关键词： Holomorphic structure Harder-Narasimhan-Seshadri filtration Hermitian-Yang-Mills flow

γ-Fe_2O_3 nanoparticle-facilitated bisphenol A degradation by white rot fungus

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Science Bulletin 2016年第6期61卷 468-472页

作者： Mingzhu Li Chengdong zhang Ministry of Education Key Laboratory of Pollution Processes and Environmental Criteria Tianjin Key Laboratory of Environmental Remediation and Pollution Control and College of Environmental Science and Engineering Nankai University

The effect of γ-Fe_2O_3 nanoparticles on bisphenol A(BPA)biodegradation by white rot fungus(Pleurotus ostreatus)was ***,the addition of γ-Fe_2O_3 nanoparticles enhanced BPA degradation efficiency by as much as 32% after 3 d in the presence of an environmentally relevant concentration of H_2O_*** γ-Fe_2O_3-induced BPA degradation enhancement was not due to a commonly assumed Fenton-like reaction catalyzed by γ-Fe_2O_3 or dissolved Fe^(3+) ***,γ-Fe_2O_3was bioreduced to Fe_3O_4,which was more efficient at catalyzing the Fenton reaction,producing a highly active hydroxyl *** bioreduction of γ-Fe_2O_3 was confirmed by X-ray powder diffraction *** study elucidates the potential biotransformation of nanoparticles in the environment and broadens the application of iron oxide nanoparticles for improved pollutant control.

关键词： γ-Fe2O3 nanoparticles Bisphenol A Degradation White rot fungus

A New Equalization Method for Lithium-Ion Battery Packs Based on CUK

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Energy Engineering 2024年第6期121卷 1459-1472页

作者： Yu zhang Sheng Tian Yongkang zhang School of Electrical and Electronic Engineering Hubei University of TechnologyWuhan430000China

Aiming at the traditional CUK equalizer can only perform energy equalization between adjacent batteries,if the two single batteries that need to be equalized are far away from each other,there will be the problem of longer energy transmission path and lower equalization efficiency,this paper optimizes the CUK equalizer and optimizes its peripheral selection circuit,which can support the equalization of single batteries at any two *** control strategy adopts the open-circuit voltage(OVC)of the battery and the state of charge(SOC)of the battery as the equalization variables,and selects the corresponding equalization variables according to the energy conditions of the two batteries that need to be equalized,and generates the adaptive equalization current with an adaptive PID controller in order to improve the equalization *** modeling is performed in Matlab/Simulink 2021b,and the experimental results show that the optimized CUK equalizer in this paper improves the equalization time by 25.58%compared with the traditional CUK *** addition,compared with the mean value difference(MVD)method,the adaptive PID method reduces the equalization time by about 30%in the static and charging and discharging experimental environments,which verifies the superiority of this equalization scheme.

关键词： battery balancing CUK equalizer adaptive PID SOC