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Role of submucosal injection in radiofrequency ablation of gastric low-grade dysplasia: Effects on symptoms and outcomes

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中华医学杂志(英文版) 2024年第17期137卷 2099-2110页

作者： Niu Xiaotong Wang Nanjun Wang Yan Feng Jia Li Longsong Han ke Chai Ningli linghu Enqiang Medical School of Chinese PLA General Hospital Beijing China Department of Gastroenterology and Hepatology The First Medical Center Chinese PLA General Hospital Beijing China Nankai University School of Medicine Nankai University Tianjin China Department of Gastroenterology Bethune International Peace Hospital ShijiaZhuang Hebei China

Background: To date, there is still a lack of standardized management strategies for gastric low-grade dysplasia (LGD), which is a direct neoplastic precancerous lesion and requires specifically superficial destruction. Radiofrequency ablation (RFA) is expected to be an effective method for gastric LGD, but post-RFA pain may affect patients’ satisfaction and compliance. The current study aimed to evaluate the value of a submucosal injection prior to RFA (SI-RFA) for postoperative pain and treatment ***: Between October 2014 and July 2021, gastric LGDs without risk factors (size >2 cm, unclear boundary, and abnormal microsurface and microvascularity) undergoing regular RFA and SI-RFA were retrospectively analyzed. Postoperative pain scores, wound healing, and clinical efficacy were compared. Propensity score matching, stratified analysis, and multivariable logistic regression were performed to control the confounding ***: One hundred and ninety-seven gastric LGDs in 151 patients received regular RFA. Forty-nine gastric LGDs in 36 patients received SI-RFA. Thirty-six pairs of patients were selected for the assessment of postoperative pain by propensity score matching. Compared to regular RFA, SI-RFA significantly decreased the degree and duration of postoperative pain (OR, 0.32; 95% CI, 0.13-0.84;P = 0.020), improved wound healing rate (80.0% [36/45]vs. 58.9% [89/151],P = 0.012), increased the complete ablation rate (91.8% [45/49]vs. 86.3% [170/197],χ2 = 1.094,P = 0.295), but correlated with higher rates of local recurrence and progression (25.6% [10/39]vs. 13.2% [18/136],χ2 = 3.471,P = 0.062; 8.3% [3/36]vs. 0.9% [1/116],P = 0.042). The multivariable logistic regression model confirmed that submucosal injection was associated with local recurrence (OR, 2.93; 95% CI, 1.13-7.58;P = 0.027).Conclusions: Submucosal injections prior to RFA may reduce postoperative pain and scar formation while ensuring complete ablation of gastric LGD. However, lo

关键词： Gastric low-grade dysplasia Radiofrequency ablation Submucosal injection Postoperative pain Treatment outcome

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带钢拉伸横向屈曲及拉伸极限载荷的研究

钢铁研究学报 2010年第7期22卷 6-9页

作者：令狐克志闻达蔡阿云首钢技术研究院薄板所北京100043 北京首钢冷轧薄板有限公司北京101304

研究了对于在4个边进行了简单支持约束的带钢的临界拉伸横向屈曲应力,并通过修正拉伸横向屈曲应力系数K,得到了不同支撑条件下的临界拉伸应力计算公式,继而对带钢的拉伸横向后屈曲进行了研究,最后引入了"有效宽度"概念来计算带钢不致发... 详细信息

研究了对于在4个边进行了简单支持约束的带钢的临界拉伸横向屈曲应力,并通过修正拉伸横向屈曲应力系数K,得到了不同支撑条件下的临界拉伸应力计算公式,继而对带钢的拉伸横向后屈曲进行了研究,最后引入了"有效宽度"概念来计算带钢不致发生屈服失效的极限载荷。

关键词：带钢拉伸横向瓢曲临界应力极限载荷

Transcriptome analysis suggests broad jejunal alterations in linghu’s obesity-diarrhea syndrome:A pilot study

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World Journal of Gastroenterology 2024年第21期30卷 2777-2792页

作者： Xiao-Tong Niu Xiang-Yao Wang Yan Wang ke Han Nan Ru Jing-Yuan Xiang En-Qiang linghu Medical School of Chinese PLA Chinese PLA General HospitalBeijing 100853China Department of Gastroenterology The First Medical Center of Chinese PLA General HospitalBeijing 100853China School of Medicine Nankai UniversityTianjin 300071China

BACKGROUND Obesity is associated with a significantly increased risk for chronic diarrhea,which has been proposed as linghu’s obesity-diarrhea syndrome(ODS);however,its molecular mechanisms are largely *** To reveal the transcriptomic changes in the jejunum involved in *** In a cohort of 6 ODS patients(JOD group),6 obese people without diarrhea(JO group),and 6 healthy controls(JC group),high-throughput sequencing and bioinformatics analyses were performed to identify jejunal mucosal mRNA expression alterations and dysfunctional biological *** another cohort of 16 ODS patients(SOD group),16 obese people without diarrhea(SO group),and 16 healthy controls(SC group),serum diamine oxidase(DAO)and D-lactate(DLA)concentrations were detected to assess changes in intestinal barrier *** The gene expression profiles of jejunal mucosa in the JO and JC groups were similar,with only 1 differentially expressed gene(DEG).The gene expression profile of the JOD group was significantly changed,with 411 DEGs compared with the JO group and 211 DEGs compared with the JC group,129 of which *** enrichment analysis of these DEGs showed that the biological processes such as digestion,absorption,and transport of nutrients(especially lipids)tended to be up-regulated in the JOD group,while the biological processes such as rRNA processing,mitochondrial translation,antimicrobial humoral response,DNA replication,and DNA repair tended to be down-regulated in the JOD *** DEGs(CDT1,NHP2,EXOSC5,EPN3,NME1,REG3A,PLA2G2A,and PRSS2)may play a key regulatory role in the pathological process of ODS,and their expression levels were significantly decreased in ODS patients(Pkers(DAO and D-LA)were significantly increased in all obese individuals(P<0.01),but were higher in the SOD group than in the SO group(P<0.001).CONCLUSION Compared with health

关键词： Obesity Chronic diarrhea Jejunum Transcriptome Intestinal barrier

Magnetic emission intensity enhancement for amorphous alloys by constructing a multi-phase structure withα-Fe nanocrystals

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Nano Research 2024年第7期17卷 6630-6637页

作者： ke Liu zhi Qin Jie Shen zhi Cheng Shiyue You Liang Ma Jing Zhou Wen Chen State key Laboratory of Advanced Technology for Materials Synthesis and Processing School of Materials Science and EngineeringWuhan University of TechnologyWuhan 430070China Sanya Science and Education Innovation Park Wuhan University of TechnologySanya 572024China Hubei Longzhong Laboratory Wuhan University of Technology Xiangyang Demonstration ZoneXiangyang 441000China

The perturbation in the magnetic field generated by the rotation or oscillation of magnetic domains in magnetic materials can emit low-frequency electromagnetic waves,which are expected to be used in low-frequency ***,the magnetic emission intensity,defined by the perturbation ability,of current commercially applied amorphous alloys,such as Metglas,cannot meet the application requirements for low-frequency antennas due to the domain motion energy ***,a multi-phase Metglas amorphous alloy was constructed by incorporatingα-Fe nanocrystals using rapid annealing to manipulate the domain *** was found that 3.89 times higher magnetic emission intensity is obtained compared to the pristine due to the synergism of the deformation and displacement ***,the low-frequency magnetic emission performance verification was carried out by preparing magnetoelectric composites as the antenna vibrator by assembling the alloy and macro piezoelectric fiber composites(MFC).Enhancements of magnetic emission intensity are found at 93.3%and 49.2%at the first and second harmonic frequencies compared with the unmodified alloy ***,the approach leads to the development of high-performance communication with a novel standard for evaluation.

关键词： multi-phase amorphous alloys magnetic emission intensity enhancing mechanism magnetic domain pinning theory Jiles-Atherton model analysis

Concurrent hetero-/homo-geneous electrocatalysts to bi-phasically mediate sulfur species for lithium-sulfur batteries

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Journal of Energy Chemistry 2024年第6期93卷 663-668,I0016页

作者： Rui-Bo linghu Jin-Xiu Chen Jin-Hao Zhang Bo-Quan Li Qing-Shan Fu Gulnur Kalimuldina Geng-zhi Sun Yunhu Han Long Kong Xi’an Institute of Flexible Electronics(IFE) Northwestern Polytechnical UniversityXi’an 710129ShaanxiChina Institute of Advanced Materials Nanjing Tech UniversityNanjing 211816JiangsuChina Advanced Research Institute of Multidisciplinary Science Beijing Institute of TechnologyBeijing 100081China Department of Mechanical and Aerospace Engineering School of Engineering and Digital SciencesNazarbayev UniversityKabanbay Batyr Ave.53Astana 010000Kazakhstan

Expediting redox kinetics of sulfur species on conductive scaffolds with limited charge accessible surface is considered as an imperative approach to realize energy-dense and power-intensive lithium-sulfur(Li-S)*** this work,the concept of concurrent hetero-/homo-geneous electrocatalysts is proposed to simultaneously mediate liquid-solid conversion of lithium polysulfides(LiPSs)and solid lithium disulfide/sulfide(Li_(2)S_(2)/Li_(2)S)propagation,the latter of which suffers from sluggish reduction kinetics due to buried conductive scaffold surface by extensive deposition of Li_(2)S_(2)/Li_(2)*** selected model material to verify this concept is a two-in-one catalyst:carbon nanotube(CNT)scaffold supported iron-cobalt(Fe-Co)alloy nanoparticles and partially carbonized selenium(C-Se)*** Fe-Co alloy serves as a heterogeneous electrocatalyst to seed Li_(2)S_(2)/Li_(2)S through sulphifilic active sites,while the C-Se sustainably releases soluble lithium polyselenides and functions as a homogeneous electrocatalyst to propagate Li_(2)S_(2)/Li_(2)S via solution *** bi-phasic mediation of the sulfur species benefits reduction kinetics of LiPS conversion,especially for the massive Li_(2)S_(2)/Li_(2)S growth scenario by affording an additional solution directed route in case of conductive surface being largely *** strategy endows the Li-S batteries with improved cycling stability(836 mA h g^(-1)after 180 cycles),rate capability(547 mA h g^(-1)at 4 C)and high sulfur loading superiority(2.96 mA h cm^(-2)at 2.4 mg cm^(-2)).This work hopes to enlighten the employment of bi-phasic electrocatalysts to dictate liquid-solid transformation of intermediates for conversion chemistry batteries.

关键词： Lithium-sulfur batteries Electrocatalysis Lithium polysulfides Sulfur cathode Energy density

Observation of ballistic-diffusive thermal transport in GaN transistors using thermoreflectance thermal imaging

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Rare Metals 2024年第1期43卷 389-394页

作者： zhi-ke Liu Yang Shen Han-Ling Li Bing-Yang Cao key Laboratory for Thermal Science and Power Engineering of Ministry of Education Department of Engineering MechanicsTsinghua UniversityBeijing 100084China

To develop effective thermal management strategies for gallium-nitride (GaN) transistors, it is essential to accurately predict the device junction temperature. Since the width of the heat generation in the devices is comparable to phonon mean free paths (MFPs) of GaN, phonon ballistic transport exists and can significantly affect the heat transport process.

关键词： temperature. transistors GaN

Interface strengthening for thermal sprayed WC-10Co4Cr coating subjected to pulsed magnetic treatment

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Rare Metals 2024年第2期43卷 780-795页

作者： Cheng-Kai Qian Qu Liu Heng Wang ke-Jian Li zhi-Peng Cai Department of Mechanical Engineering Tsinghua UniversityBeijing100084China Tianjin Research Institute for Advanced Equipment Tsinghua UniversityTianjin300304China State key Laboratory of Tribology in Advanced Equipment Tsinghua UniversityBeijing100084China

The reliability of the coated industry components demands ideal fatigue properties of the coating,and it is mainly determined by the performance of the *** this study,pulsed magnetic treatment(PMT)was applied to the thermal sprayed WC-10Co4Cr coating,and the fatigue lifetime of the coated bolt increased by 219.82%under an imitation of the operating mode *** tests further proved that both the adhesion and cohesion strength were improved after PMT,and they benefit from the interface strengthening *** formation of coherent WC/Co interfaces was characterized by in-situ transmission electron microscopy(TEM),and the molecular dynamic simulations indicate that the work of separation of these interfaces is much higher than the original disordered *** stress was relaxed and distributed more homogeneously after PMT,and it mainly contributes to the coating/substrate *** work provides a new post-treatment method focusing on the interfaces in the WC-based coating and gives insight into its mechanism so that it is hopeful to be applied to other kinds of coatings.

关键词： Cemented carbide coating Pulsed magnetic treatment Interface strengthening Fatigue properties Adhesion strength

Lewis Base Catalyzed Selenofunctionalization of Alkynes with Acid-Controlled Divergent Chemoselectivity

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Chinese Journal of Chemistry 2024年第14期42卷 1623-1629页

作者： Ling-Ling Chen Ren-Fei Cao Hua ke zhi-Min Chen School of Chemistry and Chemical Engineering Shanghai Key Laboratory for Molecular Engineering of Chiral DrugsShanghai Jiao Tong UniversityShanghai200240 China Engineering Technology Research Center for Environmental Protection Materials Pingxiang UniversityPingxiangJiangxi337055 China

Lewis base catalyzed and Brønsted acid controlled chemodivergent electrophilic selenofunctionalizations of alkynes were developed for the first *** selenium-containing tetrasubstituted alkenes were readily obtained in moderate to excellent yields with complete E/Z *** the substrates were 1-ethynyl naphthol derivatives,linear selenium-containing tetrasubstituted alkenes were produced via intermolecular oxygen nucleophilic attack in the absence of acid additive;in contrast,cyclic selenium-containing tetrasubstituted alkenes were generated through intramolecular carbon nucleophilic capture with the addition of Brønsted acid.

关键词： Alkynes Electrophilic addition Chemoselectivity Lewis base catalysis Selenofunctionalization

State of the art in movement around a remote point:a review of remote center of motion in robotics

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Frontiers of Mechanical Engineering 2024年第2期19卷 1-28页

作者： Wuxiang ZHANG zhi WANG ke MA Fei LIU Pengzhi CHENG Xilun DING School of Mechanical Engineering and Automation Beihang UniversityBeijing 100191China Ningbo Institute of Technology Beihang UniversityNingbo 315832China Intelligent Aerospace Manufacturing Engineering Technology Co. Ltd.Beijing 100191China

The concept of remote center of motion(RCM)is pivotal in a myriad of robotic applications,encompa-ssing areas such as medical robotics,orientation devices,and exoskeletal *** efficacy of RCM technology is a determining factor in the success of these robotic *** paper offers an exhaustive review of RCM technologies,elaborating on their various methodologies and practical *** delves into the unique characteristics of RCM across different degrees of freedom(DOFs),aiming to distill their fundamental *** addition,this paper categorizes RCM approaches into two primary classifications:design based and control *** are further organized according to their respective DOFs,providing a concise summary of their core *** upon the understanding of RCM’s versatile capabilities,this paper then transitions to an in-depth exploration of its applications across diverse robotic *** this review,we critically analyze the existing research challenges and issues that are inherently present in both RCM methodologies and their *** discussion is intended to serve as a guiding framework for future research endeavors and practical deployments in related areas.

关键词： remote center of motion mechanism robotics medical robot orientation device exoskeleton