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Integration of gut microbiota and metabolomics analysis to unravel the neuroprotective effects of Hydroxy-α-sanshool on Alzheimer's Disease

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Food Science and Human Wellness 2024年

作者： Ruo-Lan Li Wen-Wen Chen Hong Zhang Qi Liang ling-yu wang Wei Peng Chun-Jie Wu State Key Laboratory of Southwestern Chinese Medicine Resources， School of Pharmacy， Chengdu University of Traditional Chinese Medicine Institute of Innovation， Chengdu University of Traditional Chinese Medicine Sichuan Cancer Hospital and Institute， School of Medicine， University of Electronic Science and Technology of China Chengdu Women's and Children's Central Hospital， School of Medicine， University of Electronic Science and Technology of China Meishan Hospital of TCM， Meishan Hospital Affiliated to Chengdu University of Traditional Chinese Medicine

Alzheimer's disease （AD） is a common neurodegenerative disease， and oxidative stress induced by Aβ deposition is the key cause of neuronal apoptosis in AD patient. Hydroxy-α-sanshool （HAS） is the predominant flavour substances in the pericarp of Zanthoxylum bungeanum Maxim. （Rutaceae family）， which is a known condiment food and herbal medicine in China. We attempt to comprehensively elucidate the pathway and related mechanisms of HAS therapy on AD through in vivo and in vitro experiments. The results showed that HAS could inhibit cell apoptosis， suppress the reactive oxygen species （ROS）， and increase the antioxidative enzymes in Aβ1-42induced HT22 cells. In vivo， HAS attenuated the learning and memory impairment in senescence-accelerated mouse prone 8 （SAMP8） mice， and protected neuronal cells in hippocampus. Interestingly， the 16S rRNA gene sequencing results showed HAS could restore the richness and diversity of the intestinal microbiota， reduce the abundance of Lactobacillus， and increase the abundance of Bateroides and Parabacteroides. Moreover， the contents of 10 metabolites were significantly changed after HAS treatment， which was beneficial to treat AD. In conclusion， HAS could inhibit apoptosis in nerve cells by attenuating Aβ induced oxidative stress level， while it can also influence the metabolic pathways and affect the gut microbiota composition of AD mice.

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Effect of low-temperature ausforming on bainitic transformation and mechanical properties in ultrahigh-strength bainitic steel

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Journal of Iron and Steel Research International 2023年第9期30卷 1843-1853页

作者： Tian-yu Zhang ling-yu wang yu wang Jun Hu Hong-shuang Di Wei Xu State Key Laboratory of Rolling and Automation Northeastern UniversityShenyang 110819LiaoningChina

Low-temperature ausforming(LT-AF)prior to bainitic transformation leads to a noticeable acceleration of bainitic transformation kinetics;however,the effect of LT-AF on the retained austenite(RA)features and the resulting mechanical properties is still ***-AF was applied to ultrahigh-strength bainitic steel before *** deformation behavior and the resulting dislocation substructures were investigated by thermomechanical simulator and transmission electron microscopy(TEM).The planar dislocation structures produced during deformation at 350℃ accelerate the bainitic transformation kinetics during isothermal *** effect of LT-AF on the bainitic transformation kinetics and the features of RA was elucidated via dilatometer measurement,TEM,scanning electron microscopy,and X-ray *** is observed that LT-AF not only retains more RA content but also facilitates improved RA *** trend is mainly due to the large amounts of planar dislocations in RA and bainitic laths inherited from undercooled austenite caused by LT-AF,the decrease in bainitic sheaves size,and the increase in filmy RA content compared to the sample without ausforming.A large fraction of filmy RA with high stability and the refinement of bainitic sheaves obtained by LT-AF remarkably enhance the strain hardening capacity and achieve significantly better ductility compared to the directly austempered sample.

关键词： Ultrahigh-strength bainitic steel Bainitic transformation Low-temperature ausforming Retained austenite Strain hardening rate

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NaV3O8/poly(3,4-ethylenedioxythiophene) composites as high-rate and long-lifespan cathode materials for reversible sodium storage

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Rare Metals 2020年第8期39卷 865-873页

作者： Guo-Chun Ding Li-Min Zhu Qi Yang ling-ling Xie Xiao-yu Cao yu-ling wang Jian-Ping Liu Xin-Li Yang School of Chemistry and Chemical Engineering Key Laboratory of High Specific Energy Materials for Electrochemical Power Sources of Zhengzhou CityHenan University of TechnologyZhengzhou 450001China School of Environmental Engineering Key Laboratory of High Specific Energy Materials for Electrochemical Power Sources of Zhengzhou CityHenan University of TechnologyZhengzhou 450001China Department of Molecular Sciences Australian Research Council Centre of Excellence for Nanoscale BioPhotonicsFaculty of Science and EngineeringMacquarie UniversitySydneyNSW 2109Australia

Sodium-ion batteries have received a surge of interests for the alternatives to lithium-ion batteries due to their abundant reserves and low *** quest of reliable and high-performance cathode materials is crucial to future Na storage ***,poly(3,4-ethylenedioxythiophene)(PEDOT)was successfully introduced to NaV3O8 via in situ oxidation polymerization,which can effectively enhance electron conductivity and ionic diffusion of NaV3O8 *** a result,these NaV3O8@-PEDOT composites exhibit a significantly improved electrochemical performance including cycle stability and rate *** particular,NaV3O8@20 wt%PEDOT composite demonstrates better dispersibility and lower charge transfer resistance compared with bare NaV3O8,which delivers the first discharge capacity of 142 mAh-g-1and holds about 128.7 mAh·g-1 after 300 cycles at a current density of 120 mA·*** at a high current density of 300 mA·g-1,a high reversible capacity of 99.6 mAh·g-1 is *** these consequences suggest that NaV3O8@20 wt%PEDOT composite may be a promising candidate to serve as a high-rate and long-lifespan cathode material for sodium-ion batteries.

关键词： Sodium-ion batteries NaV3O8@PEDOT cathode composites In situ oxidation polymerization High-rate Long-lifespan

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Minimal role mining method for Web service composition

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Journal of Zhejiang University-Science C(Computers and Electronics) 2010年第5期11卷 328-339页

作者： Chao HUANG Jian-ling SUN Xin-yu wang yuan-jie SI Department of Computer Science and Technology Zhejiang University Hangzhou 310027 China

Web service composition is a low cost and efficient way to leverage the existing resource and *** current Web service composition implementations,the issue of how to define the role for a new composite Web service has been little *** the access control policy for a new composite Web service always causes substantial administration overhead from the security ***,the distributed nature of Web service based applications makes traditional role mining methods *** this paper,we analyze the minimal role mining problem for Web service composition,and prove that this problem is *** propose a sub-optimal greedy algorithm based on the analysis of necessary role mapping for interoperation across multiple *** shows the effectiveness of our algorithm,and compared to the existing methods,our algorithm has significant performance *** also demonstrate the practical application of our method in a real agent based Web service *** results show that our method could find the minimal role mapping efficiently.

关键词： Web service composition Role base access control(RBAC) Role mining Access control policy Role mapping Web service security

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Yiqi Tongluo capsule has protective effects against non-alcoholic fatty liver disease via regulating PI3K/AKT signaling

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Integrative Medicine Discovery 2024年第1期8卷 1-9页

作者： Mei-Yan Li Cheng-Xun He ling-yu wang Die Qian Si-Rong Zhang yu Chen Run-Chun Xu School of Pharmacy Chengdu University of Traditional Chinese MedicineChengdu 611137China Department of Cardiovascular Medicine Guangyuan Hospital of Traditional Chinese MedicineGuangyuan 628000China

Background:Oxidative stress is one of the key elements in the progression of non-alcoholic fatty liver disease(NAFLD),and Yiqi Tongluo capsule(YTC)have a variety of physiological activities which include *** purpose of this investigation was to discover the potential mechanisms of YTC ameliorates ***:In this investigation,a high-fat diet(HFD)was adopted to establish a NAFLD mouse *** samples were stained for oil red O and hematoxylin and eosin *** levels of total cholesterol(TC),triglyceride(TG),malondialdehyde(MDA),and superoxide dismutase(SOD)in the tissues were also *** pharmacology was analyzed to filter out the key ingredients and targets of effect of YTC for the therapy of ***,free fatty acids(FFA)was applied to induce Aml12 cells for in vitro experiments,and the cell samples were stained with oil red O and assayed for TC,TG,MDA,and SOD *** last,the Western blot technique was used to illuminate the pathway by which YTC plays a protective role against ***:Histopathological results demonstrated that YTC ameliorated tissue damage in the HFD-induced mouse *** the same time,it also reduced the contents of TC,TG,MDA and increased the expression of SOD in the liver tissue of NAFLD mouse *** of these findings demonstrate that YTC can play a role in the treatment of NAFLD by ameliorating oxidative *** analysis of YTC ameliorates NAFLD mainly by modulating the PI3K-Akt signaling ***-up in vitro experiments revealed that FFA caused lipid accumulation in Aml12 cells,which was dramatically reduced by ***,YTC could remarkably reduce the FFA-induced elevation of TC,TG,and MDA contents,and reverse the FFA-induced reduction of SOD *** blot was verified for the PI3K-Akt signaling *** was found that FFA could remarkably decrease the expression of p-PI3K,p-Akt,and p-GSK-3βproteins,which could be significantly increased after YTC treat

关键词： Yiqi Tongluo capsule non-alcoholic fatty liver disease oxidative stress PI3K-Akt-GSK-3β Aml12 cells

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Synthesis and antibacterial activity of C-2(S)-substituted pleuromutilin derivatives

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Chinese Chemical Letters 2010年第5期21卷 507-510页

作者： Li Qiang Fu Xing Sheng Guo Xin Liu Hui Li He yu ling wang yu She Yang Shanghai Institute of Materia Medica Chinese Academy of SciencesShanghai 201203China School of Pharmaceutical Engineering Shenyang Pharmaceutical UniversityShenyang 110016China

In order to probe the effect of C-2(S)-substituted groups in the antibacterial activity,a series of novel C-2(S)-substituted pleuromutilin analogues of SB-225586 were synthesized and evaluated for their in vitro antibacterial *** results of antibacterial activities indicated that C-2(S)-substituted pleuromutilin derivatives retained appreciable antibacterial activity,and the 2-fluorination compounds 6a and 6b are more potent than the corresponding 2-hydroxylation analogues 7a and 7b.

关键词： Synthesis Pleuromutilin C-2(S)-substituted Antimicrobial activity

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A nonlocal dispersal and time delayed HIV infection model with general incidences

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Applied Mathematics(A Journal of Chinese Universities) 2024年第3期39卷 448-457页

作者： WU Peng ZHANG yu-huai wang ling School of Sciences Hangzhou Dianzi UniversityHangzhou 310018China School of Humanities and Management Zhejiang Chinese Medical UniversityHangzhou 311402China Public Foundational Courses Department Nanjing Vocational University of Industry TechnologyNanjing 210023China

Biologically,because of the impact of reproduction period and nonlocal dispersal of HIV-infected cells,time delay and spatial heterogeneity should be *** this paper,we establish an HIV infection model with nonlocal dispersal and infection ***,applying the theory of Fourier transformation and von Foerster rule,we transform the model to an integrodifferential equation with nonlocal time delay and *** well-posedness,positivity,and boundedness of the solution for the model are studied.

关键词： HIV model nonlocal dispersal time delay general incidences

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Fluorinated metal-organic framework for methane purification from a ternary CH_(4)/C_(2)H_(6)/C_(3)H_(8)mixture

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Chinese Journal of Structural Chemistry 2023年第11期42卷 50-54页

作者： Ke-Ai Zhou Lian Huang Xing-Ping Fu Li-ling Zhang yu-ling wang Qing-Yan Liu College of Chemistry and Chemical Engineering Jiangxi Normal UniversityNanchang330022PR China Department of Ecological and Resources Engineering Fujian Key Laboratory of Eco-industrial Green TechnologyWuyi UniversityWuyishanFujian354300PR China

Herein we present a fluorinated metal-organic framework of{(Me_(2)NH_(2))[Ni_(3)(μ_(3)-OH)(CF_(3)-BPDC-CF_(3))_(3)(tpt)]}_(n)(1)constructed from 2,2'-bis(trifluoromethyl)biphenyl-4,4'-dicarboxylic(CF_(3)-BPDC-CF_(3)^(2-))and 2,4,6-tri(4-pyridyl)-1,3,5-triazine(tpt)ligands,which is developed for separating propane(C_(3)H_(8))and ethane(C_(2)H_(6))from natural *** 1 preferentially adsorbs C_(3)H_(8)and C_(2)H_(6)over CH_(4)demonstrated by gas adsorption *** presence of trifluoromethyl groups on the biphenyl-4,4'-dicarboxylic ligands facilitates the highly polarized micropore environments for compound 1,thus providing suitable micorpores for capturing the C_(3)H_(8)and C_(2)H_(6)molecules with larger polarizabilities and sizes compared to CH_(4)*** dynamic mixture breakthrough experiments showed that compound 1 can separate C_(3)H_(8)and C_(2)H_(6)from the ternary CH_(4)/C_(2)H_(6)/C_(3)H_(8)mixtures efficiently,endowing compound 1 with excellent methane purification ability.

关键词： Gases separation Propane and ethane adsorption Fluorinated MOF Crystal structure Natural gas purification

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The risk model construction of the genes regulated by H3K36me3 and H3K79me2 in breast cancer

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Biophysics Reports 2023年第1期9卷 45-56页

作者： ling-yu wang Lu-Qiang Zhang Qian-Zhong Li Hui Bai Laboratory of Theoretical Biophysics School of Physical Science and Technology Inner Mongolia University The State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock Inner Mongolia University

Abnormal histone modifications(HMs) can promote the occurrence of breast cancer. To elucidate the relationship between HMs and gene expression, we analyzed HM binding patterns and calculated their signal changes between breast tumor cells and normal cells. On this basis, the influences of HM signal changes on the expression changes of breast cancer-related genes were estimated by three different methods. The results showed that H3K79me2 and H3K36me3 may contribute more to gene expression changes. Subsequently, 2109 genes with differential H3K79me2 or H3K36me3 levels during cancerogenesis were identified by the Shannon entropy and submitted to perform functional enrichment analyses. Enrichment analyses displayed that these genes were involved in pathways in cancer, human papillomavirus infection, and viral carcinogenesis. Univariate Cox, LASSO, and multivariate Cox regression analyses were then adopted, and nine potential breast cancer-related driver genes were extracted from the genes with differential H3K79me2/H3K36me3 levels in the TCGA cohort. To facilitate the application, the expression levels of nine driver genes were transformed into a risk score model, and its robustness was tested via time-dependent receiver operating characteristic curves in the TCGA dataset and an independent GEO dataset. At last, the distribution levels of H3K79me2 and H3K36me3 in the nine driver genes were reanalyzed in the two cell lines and the regions with significant signal changes were located.

关键词： Breast cancer Gene expression H3K79me2 H3K36me3 Driver genes

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Enhancing Evolutionary Algorithms With Pattern Mining for Sparse Large-Scale Multi-Objective Optimization Problems

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IEEE/CAA Journal of Automatica Sinica 2024年第8期11卷 1786-1801页

作者： Sheng Qi Rui wang Tao Zhang Weixiong Huang Fan yu ling wang College of Systems Engineering National University of Defense TechnologyChangsha 410073China College of Systems Engineering National University of Defense TechnologyChangsha 410073and also with the Xiangjiang LaboratoryChangsha 410205China College of Transportation and Engineering Central South UniversityChangsha 410073China Department of Automation Tsinghua UniversityBeijing 100084China

Sparse large-scale multi-objective optimization problems(SLMOPs)are common in science and ***,the large-scale problem represents the high dimensionality of the decision space,requiring algorithms to traverse vast expanse with limited computational ***,in the context of sparse,most variables in Pareto optimal solutions are zero,making it difficult for algorithms to identify non-zero variables *** paper is dedicated to addressing the challenges posed by *** start,we introduce innovative objective functions customized to mine maximum and minimum candidate *** substantial enhancement dramatically improves the efficacy of frequent pattern *** this way,selecting candidate sets is no longer based on the quantity of nonzero variables they contain but on a higher proportion of nonzero variables within specific ***,we unveil a novel approach to association rule mining,which delves into the intricate relationships between non-zero *** novel methodology aids in identifying sparse distributions that can potentially expedite reductions in the objective function *** extensively tested our algorithm across eight benchmark problems and four real-world *** results demonstrate that our approach achieves competitive solutions across various challenges.

关键词： Evolutionary algorithms pattern mining sparse large-scale multi-objective problems(SLMOPs) sparse large-scale optimization.

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