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Magnetic labeling of natural lipid encapsulations wit ron-based nanoparticles

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Nano Research 2018年第6期11卷 2970-2991页

作者： Dewen Ye yan Li Ning gu State Key Laboratory of Bioelectronics Jiangsu Key Laboratory for Biomaterials and Devices School of Biological Sciences & Medical Engineering Southeast University Nanjing 210096 China Collaborative Innovation Center of Suzhou Nano Science and Technology Suzhou 215123 China

With superior biocompatibility and unique magnetic properties, iron-based nanoparticles （IBNP） are commonly encapsulated in cells and extracellular vesicles （EV） to allow for magnetic force controlled drug delivery and non-invasive tracking. Based on their natural source and similar morphologs; we classify both cells and EVs as being natural lipid encapsulations （NLEs）, distinguishing them from synthetic liposomes. Both their imaging contrast and drug effects are dominated by the amount of iron encapsulated in each NLE, demonstrating the importance of magnetic labeling efficiency. It is known that the membranes function as barriers to ensure that substances pass in and out in an orderly manner. The most important issue in increasing the cellular uptake of IBNPs is the interaction between the NLE membrane and IBNPs, which has been found to be affected by properties of the IBNPs as well as NLE heterogeneity. Two aspects are important for effective magnetic labelling： First, how to effectively drive membrane wrapping of the nanoparticles into the NLEs, and second, how to balance biosafety and nanoparticle uptake. In this review, we will provide a systematic overview of the magnetic labeling of NLEs with IBNPs. This article provides a summary of the applications of magnetically labeled NLEs and the labeling methods used for IBNPs. The review also analyzes the role of IBNPs physicochemical properties, especially their magnetic properties, and the of NLEs in the internalization pathway. At the same time, the future of magnetically labeled NLEs is also discussed. development

关键词： magnetic labeling iron-based nanopartide (IBNP) natural lipid encapsulation(NLE) IBNP-membrane interactions

AIMP1 promotes multiple myeloma malignancy through interacting with ANP32A to mediate histone H3 acetylation

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Cancer Communications 2022年第11期42卷 1185-1206页

作者： Rongfang Wei yan Zhu Yuanjiao Zhang Wene Zhao Xichao Yu ling Wang Chunyan gu Xiaosong gu Ye yang Nanjing Hospital of Chinese Medicine affiliated to Nanjing University of Chinese Medicine NanjingJiangsu 210001P.R.China School of Medicine&Holistic Integrative Medicine Nanjing University of Chinese MedicineNanjingJiangsu 210023P.R.China Department of Analytical and Testing Center Nanjing Medical UniversityNanjingJiangsu 211112P.R.China Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education Nantong UniversityNantongJiangsu 226019P.R.China

Background:Multiple myeloma(MM)is the second most common hematological *** overwhelming majority of patients with MM progress to serious osteolytic bone ***-tRNA synthetase-interacting multifunctional protein 1(AIMP1)participates in several steps during cancer development and osteoclast *** study aimed to explore its role in ***:The gene expression profiling cohorts of MM were applied to determine the expression of AIMP1 and its association with MM patient ***-linked immunosorbent assay,immunohistochemistry,and Western blotting were used to detect AIMP1 *** chip analysis,RNA-sequencing,and chromatin immunoprecipitation and next-generation sequencing were employed to screen the interacting proteins and key downstream targets of *** impact of AIMP1 on cellular proliferation was determined using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT)assay in vitro and a xenograft model in *** lesions were evaluated using tartrate-resistant acid phosphatase staining in vitro.A NOD/SCID-TIBIA mouse model was used to evaluate the effect of siAIMP1-loaded exosomes on bone lesion formation in ***:AIMP1 expression was increased in MM patients and strongly associated with unfavorable *** AIMP1 expression promoted MM cell proliferation in vitro and in vivo via activation of the mitogen-activated protein kinase(MAPK)signaling *** chip assays and subsequent experiments revealed that AIMP1 interacted with acidic leucine-rich nuclear phosphoprotein 32 family member A(ANP32A)to regulate histone H3 *** addition,AIMP1 increased histone H3 acetylation enrichment function of GRB2-associated and regulator of MAPK protein 2(GAREM2)to increase the phosphorylation of extracellular-regulated kinase 1/2(p-ERK1/2).Furthermore,AIMP1 promoted osteoclast differentiation by activating nuclear factor of activated T cells c1(NFATc1)in *** contrast,exo

关键词： multiple myeloma AIMP1 osteoclast differentiation MAPK signaling ANP32A histone H3 acetylation osteolytic lesions

Synthesis of TS-1 Films on Porous Supports for Epoxidation ofAllyl Chloride by Hydrogen Peroxide

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China Petroleum Processing & Petrochemical Technology 2013年第3期15卷 45-49页

作者： gu ling Wang Li School of Chemistry and Environmental Engineering Shanxi Datong University Key Laboratory for Green Chemical Technology of the Ministry of Education School of ChemicalEngineering and TechnologyTianjin University

Titanium silicalite-1(TS-1)films were synthesized on stainless steel plate,glass slide and monolith supports via an in-situ hydrothermal *** data showed that the formation of TS-1 films was easier on the porous flat support with rough surface such as monolith than on the smooth non-porous supports like glass slide and stainless steel *** film on the monolith had the highest uniformity and smallest size of *** catalytic property of monolithsupported film was tested for epoxidation of allyl chloride(ACH)by H2O2in a fixed bed *** the condition of a methanol(solvent)/ACH(90% )/H2O2(30% )ratio of 12:1:1,a LHSV of 1.35 h-1and a temperature of 318 K,the conversion of allyl chloride and the selectivity to epichlorohydrin reached 79% and 51% ,respectively.

关键词： TS-1 film epoxidation epichlorohydrin

Adaptive estimation and control for uncertain nonlinear systems and full actuation control

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Science China(Information Sciences) 2023年第11期66卷 169-184页

作者： Fei yan Mingyuan ZHANG guoxiang gu School of Information Science and Technology Southwest Jiaotong University School of Electrical Engineering and Computer Science Louisiana State University

We study adaptive control for a family of nonlinear systems, involving unknown and uncertain parameters. The proposed control law estimates the system parameters adaptively and stabilizes the closedloop system asymptotically for the initial state over any given bounded set of the state-space. Moreover,reconstruction filters are designed to obtain error residue signals and to enable the use of the least-squares algorithm for estimating the parameters, in order to achieve the convergence based on the persistent excitation condition and asymptotic linearization. The proposed methods are applicable to full actuation and under actuation control systems. Simulation studies are carried out for a pendulum system and for a third-order vehicle model, as well as control of vehicle platoons, validating the theoretical results presented in this paper.

关键词： adaptive control asymptotic stabilization full actuation and under actuation least-squares nonlinear systems

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Three-dimensional visualization and quantification of microporosity in aluminum castings by X-ray micro-computed tomography

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Journal of Materials Science & Technology 2021年第6期65卷 99-107页

作者： Cheng gu yan Lu Alan A.Luo Department of Materials Science and Engineering The Ohio State University2041 College Rd N.ColumbusOhio 43210USA Department of Integrated Systems Engineering The Ohio State University1971 NeilAve.ColumbusOhio 43210USA

Porosity is a major issue in solidification processing of metallic *** this work,wedge die casting experiments were designed to investigate the effect of cooling rate on microporosity in an aluminum alloy *** information including dendrites and porosity were measured and observed by optical microscopy and X-ray micro-computed tomography(XMCT).The effects of cooling rate on secondary dendrite arm spacing(SDAS)and porosity were *** relationship between SDAS and cooling rate was established and validated using a mathematical ***-dimensional(3-D)porosity information,including porosity percentage,pore volume,and pore number,was determined by *** the cooling rate decreasing from a lower to a higher position of the wedge die,the observed pore number decreases,the porosity percentage increases,and the equivalent pore radius *** of the pores was discussed as an empirical criterion to distinguish the types of *** different cooling rates,the larger the equivalent pore radius is,the lower the sphericity of the *** research suggests that XMCT is a useful tool to provide critical 3-D porosity information for integrated computational materials engineering(ICME)design and process optimization of solidification products.

关键词： X-ray computed tomography Casting micropore Quantitative evaluation Al alloy

Hypothalamic-Modified New Hippocampal Neurons for Alzheimer’s Disease

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Neuroscience Bulletin 2023年第11期39卷 1735-1737页

作者： yan gu Shaoyu Ge Center of Stem Cell and Regenerative Medicine and Department of Neurology of the Second Affiliated HospitalNHC and CAMS Key Laboratory of Medical NeurobiologyZhejiang University School of MedicineHangzhou310058China MOE Frontier Science Center for Brain Science and Brain-Machine Integration Zhejiang UniversityHangzhou310058China Department of Neurobiology and Behavior SUNY Stony BrookStony BrookNY11794USA

Alzheimer's disease(AD)is the leading cause of dementia *** its pathology has been extensively studied,treatment options for AD remain *** option to enhance the plasticity in the degenerating brain renders a potential... 详细信息

关键词： Alzheimer pathology treatment

Enhanced thermoelectric performance of Cu_(2)SnSe_(3) via synergistic effects of Cd-doping and CuGaTe_(2) alloying

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Rare Metals 2022年第10期41卷 3466-3474页

作者： Yi-Jing Fan Kun-ling Peng Yu-ling Huang Hui-Jun Liao Zheng-Yong Huang Jian Li yan-Ci yan Hao-Shuang gu Bin Zhang Yong-Ming Hu Xu Lu Xiao-Yuan Zhou Faculty of Physics and Electronic Sciences Hubei Key Laboratory of Ferro and Piezoelectric Materials and DevicesHubei UniversityWuhan430062China College of Physics Chongqing UniversityChongqing400044China State Key Laboratory of Power Transmission Equipment and System Security and New Technology Chongqing UniversityChongqing400044China School of Science Chongqing University of Posts and TelecommunicationsChongqing400065China Analytical and Testing Center Chongqing UniversityChongqing400044China

In this work,we show significantly enhanced thermoelectric performance in Cu_(2) SnSe_(3) via a synergistic effect of Cd-doping and CuGaTe_(2) alloying in the temperature range of 300-823 *** the electron and phonon transport properties can be simultaneously regulated by Cd doping at Sn site,leading to a higher quality ***,a maximum figure of merit(zT) value of ~0.68 was obtained for Cu_(2) Sn_(0.93)Cd_(0.07)Se_(3) sample at823 K,which is about four times higher than that of the pristine sample(zT=0.18 at 773 K).Furthermore,Cu_(2) Sn_(0.93)Cd_(0.07)Se_(3) was alloyed with CuGaTe_(2) to reduce the lattice thermal conductivity in the high-temperature ***,a further enhanced zT value(0.77,823 K) was achieved in the(Cu_(2) Sn_(0.93)Cd_(0.07)Se_(3))_(0.94)(CuGaTe_(2))_(0.06) sample,with a high average zT(zT_(ave)) value of0.30 between 300 and 823 *** results demonstrate that Cd-doping combined with CuGaTe2 alloying could be an effective method to enhance zT values of Cu_(2) SnSe_(3) based compounds.

关键词： Cu_(2)SnSe_(3) Synergistic optimization Alloying Quality factor Thermoelectric

Correlations between hippocampal functional connectivity,structural changes,and clinical data in patients with relapsing-remitting multiple sclerosis:a case-control study using multimodal magnetic resonance imaging

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Neural Regeneration Research 2022年第5期17卷 1115-1124页

作者： Xin-Quan gu Ying Liu Jie-Bing gu Lin-Fang Li ling-ling Fu Xue-Mei Han China-Japan Union Hospital of Jilin University ChangchunJilin ProvinceChina First Department of Neurology China-Japan Union Hospital of Jilin UniversityChangchunJilin ProvinceChina Cardre’s Ward Changchun Central hospitalChangchunJilin ProvinceChina

Multiple sclerosis is associated with structural and functional brain alterations leading to cognitive impairments across multiple domains including attention,memory,and the speed of information *** hippocampus,which is a brain important structure involved in memory,undergoes microstructural changes in the early stage of multiple *** this study,we analyzed hippocampal function and structure in patients with relapsing-remitting multiple sclerosis and explored correlations between the functional connectivity of the hippocampus to the whole brain,changes in local brain function and microstructure,and cognitive function at *** retrospectively analyzed data from 20 relapsing-remitting multiple sclerosis patients admitted to the Department of Neurology at the China-Japan Union Hospital of Jilin University,China,from April 2015 to November *** healthy volunteers were recruited as the healthy control *** participants were evaluated using a scale of extended disability status and the Montreal cognitive assessment within 1 week before and after head diffusion tensor imaging and functional magnetic resonance *** with the healthy control group,the patients with relapsing-remitting multiple sclerosis had lower Montreal cognitive assessment scores and regions of simultaneously enhanced and attenuated whole-brain functional connectivity and local functional connectivity in the bilateral *** diffusion tensor imaging data showed that,compared with the healthy control group,patients with relapsing-remitting multiple sclerosis had lower hippocampal fractional anisotropy values and higher mean diffusivity values,suggesting abnormal hippocampal *** left hippocampus whole-brain functional connectivity was negatively correlated with the Montreal cognitive assessment score(r=-0.698,P=0.025),and whole-brain functional connectivity of the right hippocampus was negatively correlated with extended disability stat

关键词： cognitive impairment diffusion tensor imaging fractional anisotropy functional connectivity functional magnetic resonance imaging hippocampus local consistency low frequency oscillation amplitude mean diffusivity multiple sclerosis neurodegeneration

Magnetic responsive scaffolds and magnetic fields in bone repair and regeneration

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Frontiers of Materials Science 2014年第1期8卷 20-31页

作者： Hai-yan XU Ning gu Department of Biomedical Engineering Institute of Basic Medical Sciences Chinese Academy of Medical Science & Peking Union Medical College Beijing 100005 China State Key Laboratory of Bioelectronics and Jiangsu Key Laboratory for Biomaterials and Devices School of Biological Science & Medical Engineering Southeast University Nanjing 210096 China

Increasing evidence shows that magnetic fields and magnetic responsive scaffolds can play unique roles in promoting bone repair and regeneration. This article addresses the synergistic effects of magnetic scaffolds in response to external magnetic fields on the bone regeneration in situ. Additionally, the exploration of using magnetic scaffolds as tools in the bone implant fixation, local drug delivery and mimicking microenvironment of stem cell differentiation are introduced. We also discussed possible underlying mechanisms and perspectives of magnetic responsive scaffolds in the bone repair and regeneration.

关键词： bone repair magnetic scaffold magnetic field physical stimulation