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Identification of micro RNAs in six solanaceous plants and their potential link with phosphate and mycorrhizal signalings

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Journal of Integrative Plant Biology 2014年第12期56卷 1164-1178页

作者： Mian gu Wei Liu Qi Meng Wenqi Zhang Aiqun Chen Shubin Sun guohua Xu State Key Laboratory of Crop Genetics and Germplasm Enhancement MOA Key Laboratory of Plant Nutrition and Fertilization in Lower-Middle Reaches of the Yangtze River Nanjing Agricultural University Jiangsu Collaborative Innovation Center for Solid Organic Waste Resource Utilization

To date, only a limited number of solanaceous miRNAs have been deposited in the miRNA database. Here,Rgenome-wide bioinformatic identification of miRNAs was performed in six solanaceous plants（potato, tomato, tobacco,eggplant, pepper, and petunia）. A total of 2,239 miRNAs were identified following a range of criteria, of which 982 were from potato, 496 from tomato, 655 from tobacco, 46 from eggplant,45 were from pepper, and 15 from petunia. The sizes of miRNA families and miRNA precursor length differ in all the ***, 620 targets were predicted, which could be functionally classified as transcription factors, metabolic enzymes, RNA and protein processing proteins, and other proteins for plant growth and development. We also showed evidence for miRNA clusters and sense and antisense miR ***, five Pi starvation- and one arbuscular mycorrhiza（AM）-related cis-elements were found widely distributed in the putative promoter regions of the miRNA genes. Selected miRNAs were classified into three groups based on the presence or absence of P1BS and MYCScis-elements, and their expression in response to Pi starvation and AM symbiosis was validated by quantitative reverse transcription-polymerase chain reaction（qRT-PCR）. These results show that conserved miRNAs exist in solanaceous species and they might play pivotal roles in plant growth, development, and stress responses.

关键词： Arbuscular mycorrhiza bioinformatic micro RNA phosphate starvation solanaceous

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TSNAdb: A Database for Tumor-specific Neoantigens from Immunogenomics Data Analysis

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Genomics, Proteomics & Bioinformatics 2018年第4期16卷 276-282页

作者： Jingcheng Wu Wenyi Zhao Binbin Zhou Zhixi Su Xun gu Zhan Zhou Shuqing Chen Institute of Drug Metabolism and Pharmaceutical Analysis and Zhejiang Provincial Key Laboratory of Anti-Cancer Drug Research College of Pharmaceutical Sciences Zhejiang University Hangzhou Institute of Innovative Medicine College of Pharmaceutical Sciences Zhejiang University College of Computer Science and Technology Zhejiang University MOE Key Laboratory of Contemporary Anthropology School of Life Sciences Fudan University Department of Genetics Development and Cell Biology Iowa State University

Tumor-specific neoantigens have attracted much attention since they can be used as biomarkers to predict therapeutic effects of immune checkpoint blockade therapy and as potential targets for cancer immunotherapy. In this study, we developed a comprehensive tumor-specific neoantigen database （TSNAdb v1.0）, based on pan-cancer immunogenomic analyses of somatic mutation data and human leukocyte antigen （HLA） allele information for 16 tumor types with 7748 tumor samples from The Cancer Genome Atlas （TCGA） and The Cancer Immunome Atlas （TCIA）. We predicted binding affinities between mutant/wild-type peptides and HLA class I molecules by NetMHCpan v2.8/v4.0, and presented detailed information of 3,707,562/1,146,961 potential neoantigens generated by somatic mutations of all tumor samples. Moreover, we employed recurrent mutations in combination with highly frequent HLA alleles to predict potential shared neoantigens across tumor patients,which would facilitate the discovery of putative targets for neoantigen-based cancer *** is freely available at http：//***/tsnadb.

关键词： Neoantigen Cancer immunotherapy Somatic mutation Human leukocyte antigen Database

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A New Tetrasubstituted Imidazole Based Difunctional Probe for UV-spectrophotometric and Fluorometric Detecting of Fe^3+Ion in Aqueous Solution

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Chemical Research in Chinese Universities 2019年第2期35卷 200-208页

作者： SHI yanpeng CHEN Xiaodong MI Zhiming ZHENG Ran FAN Jie gu Qiang ZHANG Yuinin College of Chemistry Jilin UniversityChangchun 130012P.R.China

Two new compounds,4-(2-bromophenxl-4,5-diphenyl-imidazol-1-yl)ani 1 ine(probe 1)and 4-[2,4,5-tris(4-bromopheny1)-1H-imidazol-1-y1]aniline(probe 2),were synthesized via a soft and high-efficiency one-pot microwave-assisted method under solvent-free *** sensing to different metal ions was detected by UV spectrophotometry and fluorescence *** 2 revealed highly selective and sensitive UV and fluorescence response to Fe^3+*** the addition of Fe^3+ion,probe 2 showed obvious color change of the solution,conspicuous absorbance enhancement and relatively quick fluorescence *** detection limit for Fe^3+ion was respectively calculated to be 0.72μmol/L(fluorescent detection)and 0.48μmol/L(UV-spectnim detection).Also,probe 2 was bound by Fe^3+ion to tonn a 1:1 ***,preliminary application of probe 2 tor detecting Fe^3+ion in aqueous solution was attempted,and satisfying results were obtained.

关键词： Fe^3+ion probe Imidazole Fluorescence quenching Absorbance enhancement Microwave synthesis

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基于SNA的基础设施建设PPP项目残值风险因素研究

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建筑经济 2020年第S2期41卷 126-131页

作者：顾湘傅之子颜妍重庆大学管理科学与房地产学院重庆400030

从全生命周期的视角,通过文献研究识别影响我国基础设施建设PPP项目残值风险的风险因素,在此基础上,引入社会网络分析法(SNA)分析风险因素之间的相互关系并判断风险因素在风险网络中的重要程度。最后筛选出重要风险因素,并提出相应的风... 详细信息

从全生命周期的视角,通过文献研究识别影响我国基础设施建设PPP项目残值风险的风险因素,在此基础上,引入社会网络分析法(SNA)分析风险因素之间的相互关系并判断风险因素在风险网络中的重要程度。最后筛选出重要风险因素,并提出相应的风险防范策略。

关键词：基础设施建设 PPP 残值风险社会网络分析

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Influence of Headland Breakwaters on Morphological Processes at Longfengtou Beach in Haitan Bay,Facing the Taiwan Strait

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Journal of Ocean University of China 2018年第6期17卷 1290-1300页

作者： KUANG Cuiping MA Yue WANG Binyu SUI Jueyi gu Jie LIU Jianhui LEI Gang College of Civil Engineering Tongji UniversityShanghai 200092China guangxi Vocational and Technical College of Communications Nanning 530216China Environmental Engineering Program University of Northern British ColumbiaPrince GeorgeBC V2N4Z9Canada College of Marine Ecology and Environment Shanghai Ocean UniversityShanghai 201306China Island Research Center PingtanFujian 350400China Third Institute of Oceanography State Oceanic AdministrationFujian 361005China

Breakwaters can be used as artificial headlands in beach nourishment to mitigate coastal erosion. Longfengtou Beach, located on the southwest coast of Haitan Bay facing the Taiwan Strait on the northeast, suffers severe erosion, where the monsoon causes significant season hydrodynamic variations. Headland breakwaters are intended to be employed to mitigate coastal erosion. A 2D sediment transport model is established using MIKE21 based on current-wave coupling and calibrated by measured data. Summer and winter wave conditions are chosen as characteristic weak and strong waves respectively. The numerical results of suspended sediment concentration and seasonal morphological evolution are compared under the conditions with and without the headland breakwaters. Sediment transport in summer can be regarded as mainly determined by current field, while in winter wave effect is strong enough to change current field. The northern breakwater, nearly perpendicular to the ebb current direction, obstructs the currents and decreases velocity of the ebb currents, and confines the water carrying sediments within the protection area during the flood period. The southern breakwater also breaks the waves in advance and significantly reduces the hydrodynamic effects during the flood period and maintains high suspended sediment concentration in the protection area. In general, two headland breakwaters decrease the erosion near the beach and enlarge the deposition area, which play a significant role in prevention of sediment loss in nearshore area and mitigate coastal erosion.

关键词： headland breakwater Haitan Bay sediment transport morphological evolution

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Improving uniform scattering device for straw-smashing,back-throwing,no-tillage planter under complete straw mulching condition

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International Journal of Agricultural and Biological Engineering 2018年第6期11卷 49-57页

作者： Fengwei gu Xuemei Gao Feng Wu Zhichao Hu Youqing Chen Chong Zhang Nanjing Research Institute for Agricultural Mechanization of National Ministry of Agriculture and Rural Affairs Nanjing 210014China

With the objective of obtaining a completely straw-mulched field,when no-tillage mechanical sowing is implemented with straw smashing,delivering,and back-throwing approaches,it may be difficult to scatter the smashed straw uniformly during a succeeding wheat sowing *** is because the previous rice straw is substantial in quantity and has a high humidity and toughness,which may easily result in non-uniform straw mulching and thus sparse and weak seedlings of *** a force-dispersing and uniform-scattering device was *** the number of scattering impellers,impeller angle,and impeller rotation speed as the main factors and the percentage of pass for the scattering width and non-uniformity of the straw mulching as the assessment indices,single-factor experiments and orthogonal regressive tests were performed,and a dual-index(percentage of pass for the scattering width and non-uniformity of the straw mulching)fitted regression equation was *** test results suggested that the main factors(from primary to secondary)that influence the indices were the impeller rotation speed,number of scattering impellers,and impeller *** optimal parameter combination for the uniform scattering device was four rows of impellers with an angle of 15°,rotation speed of 1015 r/min,percentage of pass of 72.65%for the scattering width,and a non-uniformity of 13.8%in the straw *** combination can be used to realize a uniform scattering of the smashed straw along the seedling rows on the after-sowing *** to the field investigation of the wheat growth,the wheat emergence rate was 90.7%.The research results can provide a reference for improving the uniform scattering device for a straw-smashing,back-throwing,no-tillage planter for obtaining a completely straw-mulched field,enhancing the quality of the machinery operation,and ensuring good and strong seedlings after sowing.

关键词： complete straw mulching no-tillage planter uniform scattering of straw

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Modification Method of Longitudinal Bow Structure for Ice-Strengthened Merchant Ship

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Journal of Shanghai Jiaotong university(Science) 2022年第3期27卷 298-306页

作者： DING Shifeng ZHOU Li gu Yingjie ZHOU Yajun School of Naval Architecture and Ocean Engineering Jiangsu University of Science and TechnologyZhenjiang 212003JiangsuChina Shanghai Rules and Research Institute China Classification SocietyShanghai 200135China

:Merchant ships,which are quite different from icebreakers,usually require the light ice-strengthened bow under the floe-ice *** to ice-class B,requirements of China Classification Society(CCS),intermediate frames and thick hull plates are necessary for the ice belt area to resist floe-ice ***,due to the limited space,it is not practical to set so many intermediate longitudinals from manufacture point of *** this paper,a modification method is proposed to solve the problem by maintaining the frame spacing and increasing the plate *** aim is to make sure that the bow owns the equivalent ice-bearing capacity with the original frame *** first,a bulk carrier with ice-class B is used for case *** to the requirements of the ice class rule,a designed ice thickness is used to calculate the ice load acting on the bow area due to the impact of ice *** structural models are presented to perform the strength analysis under ice load,including the out-shell plate model and the longitudinal *** results show that increasing the plate thickness is helpful to remove the negative effect induced by enlarging the spacing of the longitudinal.A reasonable curve is presented to modify the bow for the ice-strengthened merchant ship,which shows the relationship between the increase of plate thickness and the spacing of ***,a model test of floe-ice–ship interaction is conducted to measure the dynamic ice load,based on which nonlinear dynamic FE analysis is used to verify the presented plate-thickness–longitudinal spacing *** results show that the proposed method can be used to improve the ice-strengthened bow structure effectively,which provides theoretical foundation to modify the requirement of CCS’s ice class rule.

关键词： ice-strengthening ice load ice model test nonlinear FE method ice class rule

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肠道菌群对肺癌影响的研究进展

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中国肿瘤临床 2021年第17期48卷 910-913页

作者：王娅楠(综述) 顾岩(审校) 内蒙古医科大学呼呼浩特市010110 内蒙古医科大学附属医院呼吸与危重症医学科

人体肠道内寄生着约十万亿个由500~1000不同种类组成的细菌,影响着人体消化和吸收功能、抵御感染和自身免疫疾病的患病风险,还参与药物代谢过程。肺癌的发病率和死亡率快速增长,是对人类生命威胁较大的恶性肿瘤。肠道菌群可能通过代谢... 详细信息

人体肠道内寄生着约十万亿个由500~1000不同种类组成的细菌,影响着人体消化和吸收功能、抵御感染和自身免疫疾病的患病风险,还参与药物代谢过程。肺癌的发病率和死亡率快速增长,是对人类生命威胁较大的恶性肿瘤。肠道菌群可能通过代谢或免疫等途径影响肺癌的发生,同时影响肺癌对放化疗、免疫治疗等治疗方法的疗效,但不同患者获益不一。肠道菌群在恶性肿瘤的发生、发展、诊断、治疗中的作用已成为近年来的研究热点,本研究对肠道菌群和肺癌的相关性研究进展进行综述。

关键词：肠道菌群肺癌诊断治疗免疫

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早期依恋干预研究综述

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学前教育研究 2008年第7期 37-41页

作者：刘艳谷传华华中师范大学心理学院武汉430079

早期依恋干预的目的在于提高早期儿童依恋的安全性。近年来,研究者从影响依恋安全性的因素入手,进行了行为层面、依恋表征层面及综合两者的干预研究,取得了某些令人振奋的成就,但今后仍须加强适用一般儿童与特殊儿童干预方案理论与实践... 详细信息

早期依恋干预的目的在于提高早期儿童依恋的安全性。近年来,研究者从影响依恋安全性的因素入手,进行了行为层面、依恋表征层面及综合两者的干预研究,取得了某些令人振奋的成就,但今后仍须加强适用一般儿童与特殊儿童干预方案理论与实践的研究。

关键词：早期依恋干预研究依恋表征

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Performance analysis of amplify-and-forward relaying with hybrid-ARQ in Rayleigh fading channels

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The Journal of China Universities of Posts and Telecommunications 2009年第6期16卷 32-37页

作者： ZHENG Kan HU Li-jie gu Da-qing WANG Hai-la WANG Wen-bo Wireless Signal Processing and Network Lab Key Laboratory of Universal Wireless Communication Ministry of Education Beijing University of Posts and Telecommunications Beijing 100876 China Orange R&D (Beijing) Beijing 100080 China

Hybrid automatic repeat request（HARQ） is a well-known technique for improving system throughput and link performance of wireless communication systems,including cooperative communication *** amplify-and-forward（AF） relaying method is one of the most attractive cooperative diversity schemes because of its low *** this article,the end-to-end performance in terms of block error rate（BLER） and normalized throughput of AF relaying with HARQ transmission under the Rayleigh fading channel is *** results validate the proposed analysis and demonstrate the gain of HARQ schemes in AF relaying *** analytical method can be extended to the systems with other HARQ protocols and other cooperative relaying schemes.

关键词： cooperative diversity AF HARQ BLER

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