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Expanding luminal epitheliums as cells of origin for prostate cancer

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Asian Journal of Urology 2021年第2期8卷 238-240页

作者： Yuexi gu Gong-Hong Wei Fudan University Shanghai Cancer Center Department of Biochemistry and Molecular BiologySchool of Basic Medical SciencesShanghai Medical College of Fudan UniversityShanghaiChina Fudan University Shanghai Cancer Center Department of Biochemistry and Molecular BiologySchool of Basic Medical SciencesShanghai Medical College of Fudan UniversityShanghaiChina Biocenter Oulu and Faculty of Biochemistry and Molecular MedicineUniversity of OuluOuluFinland

Despite tremendous progress made in human prostate biology over the past few decades,a full picture of prostate lineage hierarchy and its connection to cancer initiation remain to be *** recent studies published in Nat Genet.[1]and in Science[2]have profiled subpopulations of prostate cells at the single-cell *** analyses of data from the studies demonstrate self-renewal and differentiation capacities of different luminal epithelial cells,which can serve as cells of origin for prostate *** system of lineage hierarchy controls cell differentiation and tissue formation from stem and progenitor cells,which may initiate cancer development if the process goes awry[3].Therefore,it is of great interest to identify cells with stemness or progenitor properties and delineate their lineage hierarchy in order to pinpoint the cells of origin for cancer when cellular genetics are altered[4].

关键词： luminal epithelium cancer

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融合改进A*和蚁群算法的机器人路径规划

天津理工大学学报 2025年第2期41卷 73-80页

作者：倪建云吴杰薛晨阳谷海青天津理工大学电气工程与自动化学院

针对蚁群算法（ant colony optimization, ACO）在搜索前期导向性差、易陷入局部最优和路径不平滑等问题，提出了一种融合A*和改进蚁群的平滑路径规划算法。首先，通过A*算法对地图进行信息素浓度差异化处理，加快初期蚁群收敛速度；其... 详细信息

针对蚁群算法（ant colony optimization, ACO）在搜索前期导向性差、易陷入局部最优和路径不平滑等问题，提出了一种融合A*和改进蚁群的平滑路径规划算法。首先，通过A*算法对地图进行信息素浓度差异化处理，加快初期蚁群收敛速度；其次，通过将路径代价、转移角度和障碍物浓度3种影响因素引入传统启发函数，并将距离偏置函数融入转移概率以及动态调整启发因子权重，从多方面增强了目标点对蚂蚁的吸引力；并利用一种奖惩机制对信息素进行更新处理，解决算法易局部最优的问题；最后引入三次B样条对路径进行拐角优化，改善路径平滑性。仿真实验结果表明，该算法在复杂环境下，具有良好的全局规划能力和鲁棒性。

关键词：路径规划蚁群算法奖惩机制全局规划

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数据仓库中实体化视图的一致性维护问题的研究

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计算机应用与软件 2005年第5期22卷 43-45,56页

作者：谷岩郭庆广州大学广东广州510091

实现实体化视图是提高系统响应时间的一个关键技术和有效的解决方案,但在具体的实现过程中面临着实体化视图的一致性维护问题。由于源数据的不稳定性,其结构和数据的变化必须及时传播到实体化视图中,以保持实体化视图与源数据的变化一致... 详细信息

实现实体化视图是提高系统响应时间的一个关键技术和有效的解决方案,但在具体的实现过程中面临着实体化视图的一致性维护问题。由于源数据的不稳定性,其结构和数据的变化必须及时传播到实体化视图中,以保持实体化视图与源数据的变化一致性,否则会降低实体化视图中数据的新鲜度,并影响OLAP查询结果的真实性和有效性。为此本文针对视图的一致性维护问题,介绍了视图中数据的维护方法,同时还就实体化视图结构的维护,提出了使视图重计算代价最小化的解决方案和基本算法。

关键词：实体化视图一致性维护数据仓库 OLAP查询解决方案关键技术响应时间实现过程不稳定性维护方法视图结构计算代价源数据新鲜度真实性最小化算法

Autumn living coccolithophores in the Yellow Sea and the East China Sea

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Acta Oceanologica Sinica 2014年第8期33卷 83-94页

作者： BAI Jie gu Xiaoyao FENG Yuanyuan JIANG Wensheng JIN Haiyan CHEN Jianfang SUN Jun College of Environmental Science and Engineering Ocean University of China College of Marine Science and Engineering Tianjin University of Science and Technology Physical Oceanography Laboratory Ocean University of China Laboratory of State Oceanic Administration for Marine Ecosystem and Biogeochemistry Second Institute of OceanographyState Oceanic Administration

An investigation was carried out on living coccolithophores （LCs） distribution in the Yellow Sea and the East China Sea from October 17 to November 24, 2011. A total of 223 samples from different depths were col-lected at 48 stations. Totally 18 taxa belonging to coccolithophyceae were identified using a polarized micro-scope at the 1 000× magnification. The maximum species abundance was found at the outside of Transect P. The dominated species wereGephyrocapsa oceanica, Emiliania huxleyi,Helicosphaera carteri,andAlgiros-phaera *** abundance of coccoliths and cells ranged 0-2 965.73 coccoliths/mL, and 0-119.16 cells/mL, with the average values of 471.00 coccoliths/mL and 23.42 cells/mL, respectively. The LCs in surface layer were mainly observed on the coastal belt and middle part of the survey area. The comparison among Transects A, F, P and E indicated lower species diversity and less abundance in the Yellow Sea than those of the East China Sea. The highest abundance of LCs was found in transect F and P. The coccolith abundance increased slightly from surface to bottom in the water column, but the highest value of the cell abundance was observed in the depth of 10-30 m. Temperature, depth and nutrient concentration were suggested as the major environmental factors controlling the distribution and species composition of LCs in the studying area based on canonical correspondence analysis （CCA）.

关键词： living coccolithophore geographic distribution Yellow Sea East China Sea Transect P

纳米二氧化硅颗粒的制备及其在加压毛细管电色谱中的应用

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分析化学 2011年第4期39卷 455-460页

作者：张晓辉王彦谷雪瞿其曙阎超上海交通大学药学院扬州大学化学化工学院

为了考察小粒径固定相在色谱分析中的特性,以Stber法为基础,以86.5%乙醇(V/V)作为反应溶剂,加入0.2 mol/L四乙氧基硅烷、2.0 mol/L氨水制得517 nm无孔二氧化硅颗粒,并将其用高压匀浆法填充,制得毛细管色谱柱。以加压毛细管电色谱(pCEC... 详细信息

为了考察小粒径固定相在色谱分析中的特性,以Stber法为基础,以86.5%乙醇(V/V)作为反应溶剂,加入0.2 mol/L四乙氧基硅烷、2.0 mol/L氨水制得517 nm无孔二氧化硅颗粒,并将其用高压匀浆法填充,制得毛细管色谱柱。以加压毛细管电色谱(pCEC)为分析平台,采用乙腈-水为流动相,探讨该硅胶色谱柱的保留机理。为了考察制备的硅胶固定相对碱性化合物的分离能力,选用4-二甲氨基吡啶、阿米替林、咖啡因、2,4,6-三氯苯胺4种碱性化合物为分离对象,讨论了流动相比例、缓冲盐浓度、pH值及操作电压对于分离的影响。结果表明,当流动相中乙腈与5 mmol/L Tris-HCl缓冲液的体积比为30:70,pH=5.0,电压为-9 kV,检测波长为214 nm时,4种碱性物质能够获得很好的分离,对咖啡因的柱效达到90000理论塔板/m。实现了500 nm二氧化硅固定相用于pCEC分离,为亚微米固定相在色谱中的应用提供了可能。

关键词：加压毛细管电色谱硅胶固定相制备碱性化合物

Precipitation Behavior and Its Strengthening Effect of X100 Pipeline Steel

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Journal of Iron and Steel Research International 2010年第11期17卷 73-78页

作者： NIU Tao KANG Yong-lin gu Hong-wei YIN Yu-qun QIAO Ming-liang School of Materials Science and Engineering University of Science and Technology Beijing Beijing 100083 China State Key Laboratory for Advanced Metals and Materials University of Science and Technology Beijing Beijing 100083 China Nanjing Iron and Steel Co Ltd Nanjing 210035 Jiangsu China

Using TEM （transmisson electron microscopy）, electron diffraction, EDX （energy dispersive X-ray） analysis and physicochemical phase analysis, the morphology, crystal structure, size distribution and chemical composition of precipitates in the microstructure of high strength Nb-microalloyed Xl00 pipeline steel were investigated, and the strengthening effect of precipitation was quantitatively calculated with Ashhy-Orowan correction model. The precipitates obtained in X100 pipeline steel can be divided into two kinds：＂complex＂ and ＂single＂ particles by morphology. The EDX analysis of ＂single＂ precipitates reveals that the chemical composition matches well with particle dimensions, especially the Nb to Ti ratio regularly decreases with the increase of particle size. The yield strength increments in the way of precipitation strengthening of X100 pipeline steel reached about 52 MPa, suggesting that the precipitation strengthening is not the dominative strengthening mechanism for X100 pipeline steel.

关键词： X100 pipeline steel carbonitride precipitation behavior strengthening effect

Seismogenesis and occurrence of earthquakes as observed by temporally continuous gravity variations in China

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Chinese Science Bulletin 1998年第1期43卷 8-21页

作者： Gongxu gu John T. Kuo Keren Liu Jinhan Zheng Hongyan Lu Duanfa Liu State Seismol Bur Inst Geophys Beijing 100081 Peoples R China Columbia Univ Lamont Doherty Earth Observ New York NY 10027 USA Columbia Univ Aldridge Lab Appl Geophys New York NY 10027 USA

In the last decade and a half, a number of earthquakes of magnitude 4-5 have occurred in the Beijing_Tianjin_Tangshan_Zhangjiakou (BTTZ) region. On the basis of the analysis of the temporally continuous gravity variation data principally from the Baijiatuan (BJTN) semi_permanent gravity base station, a general picture of gravity variation related to the seismogenesis and occurrence of earthquakes has emerged.\;As gravity variation is generally observed on the earth’s surface, the predominant influence is that of the near_surface groundwater. The subsurface fluids are distributed throughout all depths in the crust and respond to the seismogenic processes of earthquakes as well. The influence of the subsurface fluid on gravity variation is, therefore, of equal importance. The fluids, which include the near_surface groundwater and the subsurface fluids distributed throughout all depths in the crust, play a more important role in the gravity variations in terms of the seismogenesis and occurrence of earthquakes than previously realized.\;The abundance of accumulated data shows that the dilatancy instability (IPE) model seems not applicable at least to the seismogenesis and occurrence of earthquakes in the BTTZ region. In order to reflect the physical reality, the earlier proposed combined dilatancy model requires modification. The seismogenic area in the BTTZ region may be modelled as a large pre_stressed volume of a fluid_filled poroelastic medium, including not only the pre_stressed volume surrounding the impending rupture zone but also the volume containing the rupture of the fault zone itself. The pre_stressed volume outside the impending rupture zone is under a state of relatively small change of the pre_existing regional tectonic stress, while the volume containing the impending rupture zone is an induced region of very high local stress concentration, and/or pore over_pressure.\;The calculated gravity variations based on the modified combined dilatancy model (MCD

关键词： gravity variations earthquake groundwater subsurface fluids.

Bionic peptide scaffold in situ polarization and recruitment of M2 macrophages to promote peripheral nerve regeneration

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Bioactive Materials 2023年第12期30卷 85-97页

作者： Pengxiang yang Yong Peng Xiu Dai Jing Jie Deling Kong Xiaosong gu Yumin yang Key Laboratory of Neuroregeneration of Jiangsu Province and Ministry of Education Co-Innovation Center of NeuroregenerationNMPA Key Laboratory for Researchand Evaluation of Tissue Engineering Technology ProductsNantong University226001NantongPR China Institute of Cancer Prevention and Treatment Heilongjiang Academy of Medical ScienceHarbin Medical University150081HarbinPR China Department of Clinical Laboratory The Second Affiliated Hospital of Nantong University226001NantongPR China State Key Laboratory of Medicinal Chemical Biology College of Life SciencesNankai UniversityTianjin300071PR China

Tissue regeneration requires exogenous and endogenous signals,and there is increasing evidence that the exogenous microenvironment may play an even more dominant role in the complex process of coordinated multiple *** short-distance peripheral nerve showed a spontaneous regenerative phenomenon,which was initiated by the guiding role of ***,it cannot sufficiently restore long-distance nerve injury by *** on this principle,we firstly constructed a proinflammatory model to prove that abnormal M2 expression reduce the guidance and repair effect of long-distance ***,a bionic peptide hydrogel scaffold based on self-assembly was developed to envelop M2-derived regenerative cytokines and extracellular vesicles(EVs).The cytokines and EVs were quantified to mimic the guidance and regenerative microenvironment in a direct and mild *** bionic scaffold promoted M2 transformation in situ and led to proliferation and migration of Schwann cells,neuron growth and motor function ***,the peptide scaffold combined with CX3CL1 recruited more blood-derived M2 macrophages to promote long-distance nerve recon***,we systematically confirmed the important role of M2 in regulating and restoring the injury peripheral *** bionic peptide hydrogel scaffold mimicked and remodeled the local environment for M2 transformation and recruitment,favoring long-distance peripheral nerve *** can help to explicate regulative effect of M2 may be a cause not just a consequence in nerve repair and tissue integration,which facilitating the development of pro-regenerative biomaterials.

关键词： Bionic peptide scaffolds Peripheral nerve regeneration Macrophages Conditional media Immune microenvironment

企业文化的激励功能及其对员工工作满意度影响研究

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管理学报 2009年第9期6卷 1274-1278页

作者：古继宝李妍中国科学技术大学管理学院

在文献回顾的基础上,将企业文化分成7个维度,然后研究这些维度对员工的激励作用,并建构相应的理论假设。在研究方法上,对企业员工采取问题调研,通过对所收集的数据进行回归分析,得出企业文化中的尊重员工、授权与奖励公平性3个维度对员... 详细信息

在文献回顾的基础上,将企业文化分成7个维度,然后研究这些维度对员工的激励作用,并建构相应的理论假设。在研究方法上,对企业员工采取问题调研,通过对所收集的数据进行回归分析,得出企业文化中的尊重员工、授权与奖励公平性3个维度对员工满意度有着显著的积极影响。研究还发现,人员的职级对这种关系有着一定的调节作用,授权维度对普通员工表现出显著性,而对管理人员无显著性;尊重维度对管理人员表现出显著性,而对员工则未表现出显著性。

关键词：企业文化工作满意度激励理论