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Increased Expression of Serum Monocyte Chemoattractant Protein-1,Chemokine(C-C motif)Ligand 3,and Interleukins in Patients With Vitiligo

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International Journal of Dermatology and Venereology 2024年第1期7卷 40-43页

作者： xiao-ling zhao Ya-Lan Li Zi-Han Li xiao-Chong Zhang Li-Hui An Yu-Jiao Sun Deng-Xiang Liu Fang Cheng Cancer Laboratory Xingtai People’s HospitalXingtaiHebei 054001China Endocrine Department Xingtai People’s HospitalXingtaiHebei 130500China Dermatological Department Xingtai People’s HospitalXingtaiHebei 054001China

Objective:Vitiligo is a chronic,acquired depigmentation of the skin,which can be divided into active and stable *** stable and active stages are not immutable and often *** of internal markers would help to diagnose the active stage of vitiligo,and the purpose of this study was to find potential active markers in the progression of ***:We compared 30 healthy controls to 60 patients with vitiligo(30 with active disease and 30 with stable disease)regarding the expression of serum monocyte chemoattractant protein(MCP)-1,chemokine(C-C motif)ligand(CCL)3,CCL5,CCL21,interleukin(IL)-6,and *** were collected from May 2017 to December *** detection was carried out by enzyme-linked immunosorbent *** difference between groups was compared by Kruskal-Wallis H test and Mann-Whitney U ***:We found that the serum levels of MCP-1,CCL3,IL-6,and IL-17 were significantly higher in patients with vitiligo than in healthy controls(P<0.01)and that IL-17 was higher in patients with active vitiligo than in those with stable vitiligo(P<0.01).After 3months of treatment,the serum IL-17 level of patients with active vitiligo was not significantly different from that before treatment(P=0.526);after 6months of treatment,however,the serum IL-17 level had significantly decreased(P<0.01).Conclusion:These findings suggest that the serum IL-17 level can be used as a marker of vitiligo disease activity giving it certain guiding significance for clinical treatment.

关键词： clinical marker serum cytokines vitiligo

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Beneficial effects of metformin on primary cardiomyocytes via activation of adenosine monophosphate-activated protein kinase

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Chinese Medical Journal 2011年第12期124卷 1876-1884页

作者： WANG xiao-fang ZHANG Jin-ying LI ling zhao xiao-yan Department of Cardiology First Affiliated Hospital College ofMedicine Zhengzhou University Zhengzhou Henan 450052China

Background Metformin has become a cornerstone in the treatment of patients with type-2 diabetes. Accumulated evidence suggests that metformin supports direct cardiovascular effects. The present study aimed to investigate if metformin has beneficial effects on primary cardiomyocytes damaged by H2O2, and reveal the potential mechanism of action of metformin. Methods Cardiomyocytes were incubated in the presence of 100μmol/L H2O2 for 12 hours. Cardiomyocytes were pretreated with metformin at different concentrations and time and with aminoimidazole carboxamide ribonucleotide （AICAR）（500μmol/L）, an adenosine monophophate （AMP）-activated protein kinase （AMPK） agonist for 60 minutes before the addition of H2O2. Other cells were preincubated with compound C （an AMPK antagonist, 20μmol/L） for 4 hours. The viability and apoptosis of cells were analyzed. AMPK, endothelial nitric oxide synthase （eNOS）, and transforming growth factor （TGF）-β1 were analyzed using immunblotting. Results Metformin had antagonistic effects on the influences of H2O2 on cell viability and attenuated oxidative stress-induced apoptosis. Metformin also increased phosphorylation of AMPK and eNOS, and reduced the expression of TGF-β1, basic fibroblast growth factor （bFGF）, and tumor necrosis factor （TNF）-α. Conclusions Metformin has beneficial effects on cardiomyocytes, and this effect involves activation of the AMPK-eNOS pathway. Metformin may be potentially beneficial for the treatment of heart disease.

关键词： adenosine monophosphate-activated protein kinase cardiomyocyte, endothelial nitric oxide synthase metformin transforming growth factor

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Dynamic material performance of cold-formed steel hollow sections： a state-of-the-art review

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Frontiers of Structural and Civil Engineering 2017年第2期11卷 209-227页

作者： Cameron B. RITCHIE Jeffrey A. PACKER xiao-ling zhao Amin HEIDARPOUR Yiyi CHEN Department of Civil Engineering University of Toronto Toronto Ontario MSS 1A4 Canada Department of Civil Engineering Monash University Victoria 3800 Australia College of Civil Engineering Tongji University Shanghai 200092 China

This paper presents a literature review focused on the material performance of cold-formed, carbon steel, hollow structural sections under impulsive （highly dynamic） loading. Impulsive loading, represented by impact and blast, is characterized by a very rapid, time-dependent loading regime in the affected members and materials. Thus, the effect of high-strain-rate loading is initially reviewed. Next the material toughness, an important energy-absorption property and one measure of a material＇s ability to arrest fracture, is considered by means of studying the Charpy V-notch behavior. The response of hollow sections under axial and lateral impact loading is then reviewed. Studies of blast on hollow sections, most of which fall under the categories of contact/near-field loading or far-field loading are presented. Under large-scale field blast experiments, cold-formed hollow sections have shown excellent behavior. Software for modeling blast loading and structural response, the latter including single degree of freedom analysis and explicit finite element analysis, is described and discussed.

关键词： cold-formed steel hollow structural sections composites impulsive loading impact blast experimentation analysis material properties

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A Denoiser for Correlated Noise Channel Decoding: Gated-Neural Network

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China Communications 2024年第2期21卷 122-128页

作者： xiao Li ling zhao Zhen Dai Yonggang Lei School of Electronic and Information Engineering Beihang UniversityBeijing 100191China Beijing Institute of Tracking and Telecommunications Technology BITTT

This letter proposes a sliced-gated-convolutional neural network with belief propagation(SGCNN-BP) architecture for decoding long codes under correlated noise. The basic idea of SGCNNBP is using Neural Networks(NN) to transform the correlated noise into white noise, setting up the optimal condition for a standard BP decoder that takes the output from the NN. A gate-controlled neuron is used to regulate information flow and an optional operation—slicing is adopted to reduce parameters and lower training complexity. Simulation results show that SGCNN-BP has much better performance(with the largest gap being 5dB improvement) than a single BP decoder and achieves a nearly 1dB improvement compared to Fully Convolutional Networks(FCN).

关键词： belief propagation channel decoding correlated noise neural network

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The Equivalence between Property (ω) and Weyl’s Theorem

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Journal of Mathematical Research and Exposition 2011年第4期31卷 705-712页

作者： ling ling zhao xiao Hong CAO He Jia ZHANG College of Mathematics and Information Science Shaanxi Normal University Shaanxi 710062 P. R. China

We call T C B（H） consistent in Fredholm and index （briefly a CFI operator） if for each B ∈ B（H）, TB and BT are Fredholm together and the same index of B, or not Fredholm together. Using a new spectrum defined in view of the CFI operator, we give the equivalence of Weyl＇s theorem and property （ω） for T and its conjugate operator T^＊. In addition, the property （ω） for operator matrices is considered.

关键词： Weyl's theorem property (ω) spectrum

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Effect of transient scrotal hyperthermia on sperm parameters, seminal plasma biochemical markers, and oxidative stress in men

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Asian Journal of Andrology 2015年第4期17卷 668-675页

作者： Meng Rao xiao-ling zhao Jing Yang Shi-Fu HU Hui Lei Wei Xia Chang-Hong Zhu Family Planning Research Institute Tengii Medical College Huazhong University of Science and Technology Wuhan China Reproductive Medicine Center TongjiMedical College Huazhong University of Science and Technology Wuhan China

In this experimental prospective study, we aimed to analyze the effect of transient scrotal hyperthermia on the male reproductive organs, from the perspective of sperm parameters, semen plasma biochemical markers, and oxidative stress, to evaluate whether different frequencies of heat exposure cause different degrees of damage to spermatogenesis. Two groups of volunteers （10 per group） received testicular warming in a 43~C water bath 10 times, for 30 min each time： group 1：10 consecutive days; group 2： once every 3 days. Sperm parameters, epididymis and accessory sex gland function, semen plasma oxidative stress and serum sex hormones were tested before treatment and in the 16-week recovery period after treatment. At last, we found an obvious reversible decrease in sperm concentration （P = 0.005 for Group 1 and P = 0.008 for Group 2 when the minimums were compared with baseline levels, the same below）, motility （P= 0.009 and 0.021, respectively）, the hypoosmotic swelling test score （P-- 0.007 and 0.008, respectively）, total acrosin activity （P = 0.018 and 0.009, respectively）, and an increase in the seminal plasma malondialdehyde concentration （P = 0.005 and 0.017, respectively）. The decrease of sperm concentration was greater for Group 2 than for Group 1 （P = 0.031）. We concluded that transient scrotal hyperthermia seriously, but reversibly, negatively affected the spermatogenesis, oxidative stress may be involved in this process. In addition, intermittent heat exposure more seriously suppresses the spermatogenesis compared to consecutive heat exposure. This may be indicative for clinical infertility etiology analysis and the design of contraceptive methods based on heat stress.

关键词： hyperthermia oxidative stress seminal plasma biochemical markers sperm parameters spermatogenesis

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A novel route to enhance high-temperature mechanical property and thermal shock resistance of low-carbon Mgo-C bricks by introducing ZrSiO_(4)

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Journal of Iron and Steel Research International 2024年第6期31卷 1436-1448页

作者： Chun-hui Sun ling-ling Zhu Hao Yan Wei zhao Jing-xuan Liu Lin Ren Xian-tang zhao xiao-song Tong Shu-wen Yu Beijing Lirr High-Temperature Materials Co. Ltd.Beijing 102211China School of Materials Science and Engineering Henan Province Industrial Technology Research Institute of Resources and MaterialsZhengzhou UniversityZhengzhou 450001HenanChina School of Chemistry and Chemical Engineering Suzhou UniversitySuzhou 234000AnhuiChina

Conventional MgO-C bricks(graphite content>14 wt.%)produce a great deal of greenhouse gas emission,while low-carbon MgO-C bricks have serious thermal shock resistance during high-temperature *** enhance the high-temperature mechanical property and thermal shock resistance of low-carbon MgO-C bricks,a novel route of introducing ZrSiO_(4) powder into low-carbon MgO-C bricks was reported in such refractories with 2 wt.% flaky *** results indicate that the low-carbon MgO-C brick with 0.5 wt.%ZrSiO_(4) addition has the maximum hot modulus of rupture at 1400℃ and the corresponding specimen fired in the carbon embedded atmosphere has the maximum residual strength ratio(98.6%)after three thermal shock *** is found that some needle-like AlON and plate-like Al_(2)O_(3)-ZrO_(2) composites were in situ formed in the matrices after the low-carbon MgO-C bricks were coked at 1400℃,which can enhance the high-temperature mechanical property and thermal shock resistance due to the effect of fiber toughening and particle ***,CO_(2) emission of the newly developed low-carbon MgO-C bricks is reduced by 58.3% per ton steel after using them as the working lining of a 90 t vacuum oxygen decarburization ladle.

关键词： Low-carbon MgO-C brick ZrsiO_(4) Synergistic toughening effect High-temperature mechanical property Thermal shock resistance Vacuum oxygen decarburization ladle

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Ginsenoside Rd Induces Differentiation of Myeloid Leukemia Cells via Regulating ERK/GSK-3βSignaling Pathway

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Chinese Journal of Integrative Medicine 2024年第7期30卷 588-599页

作者： JIANG Yu-xia zhao Yan-na YU xiao-ling YIN Li-ming Department of Hematology Tongde Hospital of Zhejiang ProvinceHangzhou310012China Institute of Hematology Research the First Affiliated Hospital of Zhejiang Chinese Medical University(Zhejiang Provincial Hospital of Chinese Medicine)Hangzhou310006China

Objective To investigate the role of ginsenoside Rd(GRd)in acute myeloid leukemia(AML)cell *** AML cells were treated with GRd(25,50,100 and 200µg/mL),retinoic acid(RA,0.1g/L)and PD98059(20 mg/mL)for 72 h,cell survival was detected by methylthiazolyldiphenyl-tetrazolium bromide and colony formation assays,and cell cycle was detected by flow *** morphology and differentiation were observed by Wright-Giemsa staining,peroxidase chemical staining and cellular immunochemistry assay,*** protein expression levels of GATA binding protein 1(GATA-1),purine rich Box-1(PU.1),phosphorylated-extracellular signal-related kinase(p-ERK),ERK,phosphorylated-glycogen synthase kinase-3β(p-GSK3β),GSK3βand signal transducer and activator of transcription 1(STAT1)were detected by Western ***-six mice were randomly divided into 3 groups using a random number table:model control group(non-treated),GRd group[treated with 200 mg/(kg·d)GRd]and homoharringtonine(HTT)group[treated with 1 mg/(kg·d)HTT].A tumor-bearing nude mouse model was established,and tumor weight and volume were *** of subcutaneous tumor tissue were observed after hematoxylin and eosin ***1 and GATA-1 expressions were detected by immunohistochemical *** The cell survival was inhibited by GRd in a dose-dependent manner and GRd caused G0/G1 cell arrest(p<0.05).GRd treatment induced leukemia cell differentiation,showing increased expressions of peroxidase and specific proteins concerning erythrogenic or granulocytic differentiation(p<0.05).GRd treatment elicited upregulation of p-ERK,p-GSK-3βand STAT1 expressions in cells,and reversed the effects of PD98059 on inhibiting the expressions of peroxidase,GATA-1 and PU.1(P<0.05).After GRd treatment,tumor weight and volume of mice were decreased,and tumor cells underwent massive apoptosis and necrosis(P<0.05).WT1 level was decreased,and GATA-1 level was significantly increased in subcutaneous tumor ti

关键词： ginsenoside Rd myeloid leukemia survival differentiation extracellular signal-related kinase signaling pathway

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DOING SOMETHING FOR THE ADVANCEMENT AND PRESERVATION OF ETHNIC CULTURES

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China's Tibet 2011年第3期22卷 40-43页

作者： xiao ling & zhao Yao

Kunkyap Dontse was born in 1950 in Xinlong ounty of Garze Tibetan Autonomous refecture in Sichuan *** 1975,he graduated from the Art Department of the Central College for *** was then sent to Bathang Normal School in Sichuan to *** years later, he was transferred to work in the Education Bureau of *** 1983,he was employed by the Tibetan School of Sichuan as deputy president,mainly in charge of educational *** 1988,he was working for the Editing and Translation Bureau in *** 2000,he was elected as the vice chairman of the CPPCC of the Garze *** founded several entities,including the Green Khampa Culture,Art Research Association,

关键词：民族文化甘孜藏族自治州保护文化艺术四川省民族学院人民政协教育局

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The acclimatization to extreme environments and its physiological mechanisms

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中国应用生理学杂志 2012年第6期28卷 494-503页

作者： Hai WANG Wei LIU Dan-feng YANG xiao-ling zhao Chao-liang LONG zhao-yun YIN Jia-ying LIU Institute of Health and Environmental Medicine Academy of Military Medical Sciences

Acclimatization is a process of biological adaptation when exposed to environmental factors such as hypoxia,cold and heat for prolonged periods of time,where non-genetical variations play a role in allowing subjects to tolerate hypoxic,cold or hot *** review focuses on the characteristics and mechanisms of acclimatization found through major research advances by our ***,the mechanisms underlying the acclimatization to extreme environments are *** our investigations,the physiological changes of multiple systems including the nervous,circulatory,respiratory,and hemopoietic system were demonstrated when the acclimatization to hypoxia was developed,and the underlying significance of hypoxia-inducible factor-1(HIF-1) was ***,it is suggested that the development of acclimatization to extreme environments is *** and cold coexist at high *** investigations revealed the characteristics of negative cross-relationship in the acclimatization to hypoxia and *** third,it is interesting for us to understand that acclimatization to extreme environments is transferable among individuals,and the characteristics of heat acclimatizationinducing factor(HAIF) were *** above findings will provide a theoretical guidance for protective operations and help to establish a solid foundation for future research related to acclimatization.

关键词：极端环境生理机制驯化缺氧诱导因子1 循环系统 HIF-1 环境因素遗传变异

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