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MicroRNA-365 Knockdown Prevents Ischemic Neuronal Injury by Activating Oxidation Resistance 1-Mediated Antioxidant Signals

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Neuroscience Bulletin 2019年第5期35卷 815-825页

作者： Jia-Lin Mo Zhi-Guang Pan Xiao Chen Yu Lei ling-ling lv Cheng Qian Feng-Yan Sun Department of Neurobiology and Institute for Basic Research on Aging and Medicine School of Basic Medical Sciences Fudan University Shanghai 200032 China Department of Neurosurgery National Clinical Research Center for Aging and Medicine Huashan Hospital Shanghai Medical College Fudan University Shanghai 200032 China State Key Laboratory of Medical Neurobiology School of Basic Medical Sciences Fudan University Shanghai 200032 China Shanghai Key Laboratory of Clinical Geriatric Medicine Research Center on Aging and Medicine Shanghai Medical College Fudan University Shanghai 200032 China

Micro RNA-365(mi R-365) is upregulated in the ischemic brain and is involved in oxidative damage in the diabetic rat. However, it is unclear whether mi R-365 regulates oxidative stress(OS)-mediated neuronal damage after ischemia. Here, we used a transient middle cerebral artery occlusion model in rats and the hydrogen peroxide-induced OS model in primary cultured neurons to assess the roles of mi R-365 in neuronal damage. We found that mi R-365 exacerbated ischemic brain injury and OS-induced neuronal damage and was associated with a reduced expression of OXR1(Oxidation Resistance 1). In contrast, mi R-365 antagomir alleviated both the brain injury and OXR1 reduction. Luciferase assays indicated that mi R-365 inhibited OXR1 expression by directly targeting the 30-untranslated region of Oxr1. Furthermore, knockdown of OXR1 abolished the neuroprotective and antioxidant effects of the mi R-365 antagomir. Our results suggest that mi R-365 upregulationincreases oxidative injury by inhibiting OXR1 expression,while its downregulation protects neurons from oxidative death by enhancing OXR1-mediated antioxidant signals.

关键词： MicroRNA Ischemic stroke Neuronal damage Oxidative stress Neuroprotection

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Frost deformation and microstructure evolution of porous rock under uniform and unidirectional freeze-thaw conditions

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Journal of Mountain Science 2024年第8期21卷 2855-2869页

作者： lv Zhitao LIU Jintao WAN ling LIU Weiping School of Infrastructure Engineering Nanchang UniversityNanchang 330031China College of Civil Engineering and Architecture Nanchang Hangkong UniversityNanchang 330063China

The frost deterioration and deformation of porous rock are commonly investigated under uniform freeze-thaw(FT)***,the unidirectional FT condition,which is also prevalent in engineering practice,has received limited ***,a comparative study on frost deformation and microstructure evolution of porous rock under both uniform and unidirectional FT conditions was ***,frost deformation experiments of rock were conducted under cyclic uniform and unidirectional FT action,*** illustrate that frost deformation of saturated rock exhibits isotropic characteristics under uniform FT cycles,while it shows anisotropic characteristics under unidirectional FT condition with both the frost heaving strain and residual strain along FT direction much higher than those perpendicular to FT ***,the peak value and residual value of cumulative frost strain vary as logarithmic functions with cycle number under both uniform and unidirectional FT ***,the microstructure evolution of rock suffered cyclic uniform and unidirectional FT action were *** uniform FT cycles,newly generated pores uniformly distribute in rock and pore structure of rock remains isotropic in micro scale,and thus the frost deformation shows isotropic characteristics in macro *** unidirectional FT cycles,micro-cracks or pore belts generate with their orientation nearly perpendicular to the FT direction,and rock structure gradually becomes anisotropic in micro scale,resulting in the anisotropic characteristics of frost deformation in macro scale.

关键词： Frost deformation Microstructure evolution Porous rock Unidirectional freeze-thaw cycles Uniform freeze-thaw cycles

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Widespread and active piezotolerant microorganisms mediate phenolic compound degradation under high hydrostatic pressure in hadal trenches

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Marine Life Science & Technology 2024年第2期6卷 331-348页

作者： Hao ling Yongxin lv Yu Zhang Ning‑Yi Zhou Ying Xu State Key Laboratory of Microbial Metabolism Joint International Research Laboratory of Metabolic and Developmental Sciences and School of Life Sciences and BiotechnologyShanghai Jiao Tong UniversityShanghai 200240China School of Oceanography Shanghai Jiao Tong UniversityShanghai 200240China State Key of Laboratory of Ocean Engineering Shanghai Jiao Tong UniversityShanghai 200240China

Phenolic compounds,as well as other aromatic compounds,have been reported to be abundant in hadal *** high-throughput sequencing studies have hinted at the potential of hadal microbes to degrade these compounds,direct microbiological,genetic and biochemical evidence under in situ pressures remain ***,a microbial consortium and a pure culture of Pseudomonas,newly isolated from Mariana Trench sediments,efficiently degraded phenol under pressures up to 70 and 60 MPa,respectively,with concomitant increase in *** analyzing a high-pressure(70 MPa)culture metatranscriptome,not only was the entire range of metabolic processes under high pressure generated,but also genes encod-ing complete phenol degradation via ortho-and meta-cleavage pathways were *** isolate of Pseudomonas also contained genes encoding the complete degradation *** transcribed genes(dmpKLMNOP_(sed))were functionally identified to encode a multicomponent hydroxylase catalyzing the hydroxylation of phenol and its methylated derivatives by heterogeneous *** addition,key catabolic genes identified in the metatranscriptome of the high-pressure cultures and genomes of bacterial isolates were found to be all widely distributed in 22 published hadal microbial *** microbiological,genetic,bioinformatics,and biochemical levels,this study found that microorganisms widely found in hadal trenches were able to effectively drive phenolic compound degradation under high hydrostatic *** information will bridge a knowledge gap concerning the microbial aromatics degradation within hadal trenches.

关键词： Hadal trench High hydrostatic pressure Phenolic compounds degradation Piezotolerant microorganisms Widespread distribution

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Cone-beam computed tomography noise reduction method based on U-Net with convolutional block attention module in proton therapy

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Nuclear Science and Techniques 2024年第7期35卷 89-100页

作者： Xing-Yue Ruan Xiu-Fang Li Meng-Ya Guo Mei Chen Ming lv Rui Li Zhi-ling Chen Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai201800China University of Chinese Academy of Sciences Beijing100049China Shanghai Advanced Research Institute Chinese Academy of SciencesShanghai201210China Department of Radiation Oncology Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghai200025China Shanghai Key Laboratory of Proton therapy Shanghai201801China

Cone-beam computed tomography(CBCT) is mostly used for position verification during the treatment process. However,severe image artifacts in CBCT hinder its direct use in dose calculation and adaptive radiation therapy re-planning for proton therapy. In this study, an improved U-Net neural network named CBAM-U-Net was proposed for CBCT noise reduction in proton therapy, which is a CBCT denoised U-Net network with convolutional block attention modules. The datasets contained 20 groups of head and neck images. The CT images were registered to CBCT images as ground truth. The original CBCT denoised U-Net network, sCTU-Net, was trained for model performance comparison. The synthetic CT(SCT) images generated by CBAM-U-Net and the original sCTU-Net are called CBAM-SCT and U-Net-SCT images, respectively. The HU accuracies of the CT, CBCT, and SCT images were compared using four metrics: mean absolute error(MAE), root mean square error(RMSE), peak signal-to-noise ratio(PSNR), and structure similarity index measure(SSIM). The mean values of the MAE, RMSE, PSNR, and SSIM of CBAM-SCT images were 23.80 HU, 64.63 HU, 52.27 dB, and 0.9919, respectively,which were superior to those of the U-Net-SCT images. To evaluate dosimetric accuracy, the range accuracy was compared for a single-energy proton beam. The γ-index pass rates of a 4 cm × 4 cm scanned field and simple plan were calculated to compare the effects of the noise reduction capabilities of the original U-Net and CBAM-U-Net on the dose calculation results. CBAM-U-Net reduced noise more effectively than sCTU-Net, particularly in high-density tissues. We proposed a CBAM-U-Net model for CBCT noise reduction in proton therapy. Owing to the excellent noise reduction capabilities of CBAM-U-Net, the proposed model provided relatively explicit information regarding patient tissues. Moreover, it maybe be used in dose calculation and adaptive treatment planning in the future.

关键词： Proton therapy Cone-beam CT CBAM-U-Net γ-index

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Regulating zinc ion transport behavior and solvated structure towards stable aqueous Zn metal batteries

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Journal of Energy Chemistry 2024年第6期93卷 609-626,I0015页

作者： Qiang Ma Aoen Ma Shanguang lv Bowen Qin Yali Xu Xianxiang Zeng Wei ling Yuan Liu Xiongwei Wu College of Materials Engineering Henan International Joint Laboratory of Rare Earth Composite MaterialsHenan University of EngineeringZhengzhou 451191HenanChina Nanozyme Medical Center School of Basic Medical SciencesZhengzhou UniversityZhengzhou 450001HenanChina School of Chemistry and Materials Science Hunan Agricultural UniversityChangsha 410125HunanChina College of Electrical and Information Engineering Hunan UniversityChangsha 410082HunanChina Hunan Province Yin Feng New Energy Co.Ltd. Changsha 410019HunanChina

Aqueous Zn metal batteries(AZMBs)with intrinsic safety,high energy density and low cost have been regarded as promising electrochemical energy storage ***,the parasitic reaction on metallic Zn anode and the incompatibility between electrode and electrolytes lead to the deterioration of electrochemical performance of AZMBs during the *** critical point to achieve the stable cycling of AZMBs is to properly regulate the zinc ion solvated structure and transfer behavior between metallic Zn anode and *** recent years,numerous achievements have been made to resolve the formation of Zn dendrite and interface incompatible issues faced by AZMBs via optimizing the sheath structure and transport capability of zinc ions at electrode-electrolyte *** this review,the challenges for metallic Zn anode and electrode-electrolyte interface in AZMBs including dendrite formation and interface characteristics are *** the influences of different strategies involving designing advanced electrode structu re,artificial solid electrolyte interphase(SEI)on Zn anode and electrolyte engineering to regulate zinc ion solvated sheath structure and transport behavior are summarized and ***,the perspectives for the future development of design strategies for dendrite-free Zn metal anode and long lifespan AZMBs are also given.

关键词： aqueous Zn metal batteries Zn metal anode Transport behavior Solvated structure Dendrite-free

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Boosting solar hydrogen production via electrostatic interaction mediated ***-TiO_(2−x)biohybrid system

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Nano Research 2024年第6期17卷 5390-5398页

作者： Xingxing lv Weicheng Huang Ya Gao Rui Chen Xiaowei Chen Danqing Liu ling Weng Liangcan He Shaoqin Liu School of Material Science and Chemical Engineering Harbin University of Science and TechnologyHarbin 150040China School of Medicine and Health and Key Laboratory of Micro-systems and Micro-structures Manufacturing of Ministry of EducationHarbin Institute of TechnologyHarbin 150001China Department of Physics School of ScienceJimei UniversityXiamen 361021China Zhengzhou Research Institute Harbin Institute of TechnologyZhengzhou 450046China

Hydrogen is garnering growing attention as a green energy source with zero carbon ***,most hydrogen production technologies still rely on the consumption of fossil fuels and are therefore *** has driven the search for more environmentally friendly methods of hydrogen *** this work,we present an innovative approach to enhance hydrogen generation via electrostatic interaction in the Escherichia coli and defective titanium dioxide(TiO_(2−x))*** method involves narrowing the forbidden bandwidth of TiO2 while introducing defect bands into its conduction band to facilitate visible light absorption and efficient charge *** biohybrid system,consisting of *** and TiO_(2−x),demonstrates a remarkable capability to produce 1.25 mmol of hydrogen within a 3-h timeframe under visible light *** accomplishment signifies a 3.31-fold rise in hydrogen production in comparison to ***,signifying a substantial enhancement in hydrogen production ***,we delve into the alterations in biological metabolites associated with hydrogen production and the changes in electron transfer in different biohybrid *** provides valuable insights into the understanding of the intrinsic mechanisms that drive the *** work introduces a novel and promising avenue for achieving this exciting goal.

关键词： Escherichia coli TiO_(2−x)nanoparticles biohybrid system hydrogen production

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Insight study of rare earth elements in PM_(2.5)during five years in a Chinese inland city:Composition

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Journal of Environmental Sciences 2024年第4期138卷 439-449页

作者： Yi-Wen Shen Chang-Xian Zhao Hao Zhao Shuo-Fei Dong Qi Guo Jiao-Jiao Xie Mei-ling lv Chun-Gang Yuan Hebei Key Lab of Power Plant Flue Gas Multi-Pollutants Control Department ofEnvironmental Science&EngineeringNorth China Electric Power UniversityBaoding 071000China MOE Key Laboratory of Resources and Environmental Systems Optimization College of Environmental Science and EngineeringNorth China Electric Power UniversityBeijing 102206China Agilent Technologies Co.Ltd.(China) Beijing 100102China

The booming development of rare earth industry and the extensive utilization of its products accompanied by urban development have led to the accelerated accumulation of rare earth elements(REEs)as emerging pollutants in atmospheric *** this study,the variation of REEs in PM_(2.5)with urban(a non-mining city)transformation was investigated through five consecutive years of sample *** compositional variability and provenance contribution of REEs in PM_(2.5)were characterized,and the REEs exposure risks of children and adults via inhalation,ingestion and dermal absorption were also *** results showed an increase in the total REEs concentration from 46.46±35.16 mg/kg(2017)to 81.22±38.98 mg/kg(2021)over the five-year period,with Ce and La making the largest *** actual increment of industrial and traffic emission source among the three pollution sources was 1.34 ng/m^(3).Coal combustion source displayed a downward *** was the main exposure pathway for REEs in PM_(2.5)for both children and *** contributed the most to the total intake of REEs in PM_(2.5)among the population,followed by La and *** exposure risks of REEs in PM_(2.5)in the region were relatively low,but the trend of change was of great *** was strongly recommended to strengthen the concern about traffic-related non-exhaust emissions of particulate matter.

关键词： Rare earth elements Exposure risks Pollution sources Traffic-related non-exhaust emissions

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Prognostic significance and relationship of SMAD3 phosphoisoforms and VEGFR-1 in gastric cancer:A clinicopathological study

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World Journal of Gastrointestinal Oncology 2024年第1期16卷 118-132页

作者： Shi-Lin lv Pei Guo Jun-Rong Zou Ren-Sheng Chen ling-Yu Luo De-Qiang Huang Hospital of Gastroenterology Institute of Digestive DiseasesThe First Affiliated Hospital of Nanchang UniversityNanchang 330006Jiangxi ProvinceChina Department of Pathology Shenzhen Hospital of Southern Medical UniversityShenzhen 518000Guangdong ProvinceChina Institute of Urology The First Affiliated Hospital of Gannan Medical UniversityGanzhou 341000Jiangxi ProvinceChina Department of Pathology The First Affiliated Hospital of Nanchang UniversityNanchang 330006Jiangxi ProvinceChina

BACKGROUND The TGF-β/SMAD3 and VEGFR-1 signaling pathways play important roles in gastric cancer ***3 phosphorylation is a crucial prognostic marker in gastric *** To determine the prognostic value and relationship of SMAD3 phospho-isoforms and VEGFR-1 in gastric *** This was a single-center observational study which enrolled 98 gastric cancer patients and 82 adjacent normal gastric tissues from patients aged 32-84 years(median age 65)between July 2006 and April *** were followed up until death or the study ended(median follow-up duration of 28.5 mo).The samples were used to generate tissue microarrays(TMAs)for immunohistochemical(IHC)*** expressions of TGF-β1,pSMAD3C(S423/425),pSMAD3L(S204),and VEGFR-1 in gastric cancer(GC)tumor tissue and normal tissue were measured by IHC staining using TMAs obtained from 98 GC *** and survival information of the patients was recorded by Outdo Biotech from May 2007 to July *** relationship between TGF-β1,pSMAD3C(S423/425),pSMAD3L(S204),and VEGFR-1 protein expression levels was analyzed using Pearson's correlation *** relationship between protein expression levels and clinicopathological parameters was analyzed using the Chi-squared test.A survival curve was generated using the Kaplan-Meier survival *** TGFβ-1 and VEGFR-1 expression was significantly upregulated in gastric cancer tissue compared to adjacent noncancerous *** positive expression of phosphorylated isoforms of Smad3 varied depending on the phosphorylation site[pSMAD3C(S423/425):51.0%and pSMAD3L(S204):31.6%].High expression of pSMAD-3L(S204)was significantly correlated with larger tumors(P=0.038)and later N stages(P=0.035).Additionally,high expression of VEGFR-1 was closely correlated with tumor size(P=0.015)and pathological grading(P=0.013).High expression of both pSMAD3L(S204)and VEGFR-1 was associated with unfavorable outcomes in terms of overall survival(OS).Multiva

关键词： Gastric cancer pSMAD3L(S204) pSMAD3C(S423/425) Survival Transforming growth factor-β1 VEGFR-1

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Deamidation enables pathogenic SMAD6 variants to activate the BMP signaling pathway

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Science China(Life Sciences) 2024年第9期67卷 1915-1927页

作者： ling Li Lei Lu Ziqi Xiao Jingyi lv Hefeng Huang Bo Wu Tongjin Zhao Chengtao Li Weimin Wang Hongyan Wang Obstetrics and Gynecology Hospital State Key Laboratory of Genetic EngineeringInstitute of Reproduction and Developmentand Children’s HospitalFudan UniversityShanghai 200090China Shanghai Key Laboratory of Metabolic Remodeling and Health Institute of Metabolism and Integrative BiologyFudan UniversityShanghai 200438China Prenatal Diagnosis Center of Shenzhen Maternity&Child Healthcare Hospital Shenzhen 518028China Shanghai Medical College Fudan UniversityShanghai 200032China Department of Pharmacy College of Life SciencesChina Jiliang UniversityHangzhou 310018China

The BMP signaling pathway plays a crucial role in regulating early embryonic development and tissue ***6 encodes a negative regulator of BMP,and rare variants of SMAD6 are recurrently found in individuals with birth ***,we observed that a subset of rare pathogenic variants of SMAD6 consistently exhibited positive regulatory effects instead of the initial negative effects on the BMP signaling *** sought to determine whether these SMAD6 variants have common pathogenic ***,we showed that pathogenic SMAD6 variants accompanying this functional reversal exhibit similar increases in ***,increased deamidation of SMAD6 variants promotes the accumulation of the BMP receptor BMPR1A and the formation of new complexes,both of which lead to BMP signaling pathway ***,two residues,N262 and N404,in SMAD6 were identified as the crucial sites of deamidation,which was catalyzed primarily by glutamine-fructose-6-phosphate transaminase 2(GFPT2).Additionally,treatment of cells harboring SMAD6 variants with a deamidase inhibitor restored the inhibitory effect of SMAD6 on the BMP signaling ***,when wild-type SMAD6 was manually simulated to mimic the deamidated state,the reversed function of activating BMP signaling was *** together,these findings show that deamidation of SMAD6 plays a crucial role in the functional reversal of BMP signaling activity,which can be induced by a subset of various SMAD6 *** study reveals a common pathogenic mechanism shared by these variants and provides a potential strategy for preventing birth defects through deamidation regulation,which might prevent the off-target effects of gene editing.

关键词： SMAD6 deamidation BMP signaling pathway GFPT2

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Advancing Energy Systems with In-Situ and Operando Surface-Enhanced Raman Scattering Spectroscopy

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CCS Chemistry 2024年第6期6卷 1403-1421页

作者： Haoming Bao Shi Xuan Leong Jaslyn Ru Ting Chen Zhenhai Shi Suli Chen Yan lv Tianxi Liu In Yee Phang Xing Yi ling Key Laboratory of Synthetic and Biological Colloids Ministry of EducationInternational Joint Research Laboratory for Nano Energy CompositesSchool of Chemical and Material EngineeringJiangnan UniversityWuxi 214122 School of Chemistry Chemical Engineering and BiotechnologyNanyang Technological UniversitySingapore 637371

Surface-enhanced Raman scattering spectroscopy(SERS)has emerged as a powerful analytical technique to enable nanoscale investigations of energy *** mini-review focuses on the applications of in-situ and operando SERS in energy-related research,highlighting its unique capabilities and significant contributions to understanding energy storage and conversion *** first introduce the fundamental principles of SERS,key SERS-derived techniques,and commonly employed ***,we delve into the diverse applications of in-situ and operando SERS across various energy systems,encompassing photocatalytic and electrocatalytic systems,fuel cells,solar cells,and ***,we conclude with our perspective on the current challenges and prospects in this *** hope thismini-review serves as an essential overview to guide the design and implementation of in-situ and operando SERS studies of energy systems.

关键词： surface-enhanced Raman scattering spectroscopy in-situ operando energy systems photocatalysis electrocatalysis fuel cells solar cells batteries

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