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Gilbert’s syndrome coexisting with hereditary spherocytosis might not be rare: Six case reports

World Journal of Clinical Cases 2020年第10期8卷 2001-2008页

作者： ling-ling kang Ze-Lin Liu Hou-De Zhang Department of Gastroenterology Nanshan HospitalGuangdong Medical UniversityShenzhen 518052Guangdong ProvinceChina Department of Hematology Nanshan HospitalGuangdong Medical UniversityShenzhen 518052Guangdong ProvinceChina Guangdong Breath Test Engineering and Technology Research Center Shenzhen 518052Guangdong ProvinceChina

BACKGROUND Both Gilbert's syndrome(GS)and hereditary spherocytosis(HS)are common genetic ***,comorbidity of GS with HS has always been considered a rare phenomenon,and it can impede accurate diagnoses in the presence of isolated unconjugated *** SUMMARY In a study on Levitt’s carbon monoxide(CO)breath test for the differential diagnosis of isolated hyperbilirubinemia,we found six GS patients with HS in 6 *** patients,including five males and one female,aged 25-58 years,were from four families and generally in good *** chronic fluctuating jaundice and/or hyperbilirubinemia had been diagnosed as simple constitutional jaundice for 6-30 *** function tests showed isolated unconjugated hyperbilirubinemia with serum total bilirubin ranging from 20.7-75.4μmol/*** hemoglobin was normal in five cases,and slightly decreased in one(11.5 g/dL).Overt hemolytic signs were absent,while erythrocyte lifespan determined by the newly developed Levitt’s CO breath test was significantly short(15-50 d),definitely demonstrating the presence of *** that their unconjugated hyperbilirubinemia compared inappropriately with hemolytic severity,as indicated by the hemoglobin level,further combined genetic tests for both UGT1A1 and hereditary erythrocyte deficiencies were *** tests confirmed,at last,the coexistence of GS with *** Comorbidity of GS and HS might not be uncommon in isolated unconjugated *** CO breath test would sensitively detect the hemolysis,the discordance between the hyperbilirubinemia and hemoglobin level could strongly indicate the coexistence of GS and HS.

关键词： Gilbert’s syndrome Hereditary spherocytosis Unconjugated hyperbilirubinemia Erythrocyte lifespan Levitt’s CO breath test Case report

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Adjuvant Efficacy of Nutrition Support During Pulmonary Tuberculosis Treating Course： Systematic Review and Meta-analysis

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Chinese Medical Journal 2015年第23期128卷 3219-3230页

作者： Zhuang-Li Si ling-ling kang Xu-Bo Shen Yuan-Zhong Zhou Department of Hygiene Toxicology School of Public Health Zunyi Medical University Zunyi Guizhou 563099 China Business Department Chengdu Qingbaijiang District Center for Disease Control and Prevention Chengdu Sichuan 610300 China

Background： Malnutrition and tuberculosis （TB） tend to interact with each other. TB may lead to nutrition deficiencies that will conversely delay recovery by depressing immune functions. Nutrition support can promote recovery in the subject being treated for TB. The aim of this study was to evaluate the effectiveness of nutrition support on promoting the recovery of adult pulmonary TB patients with anti-TB drug therapy. Methods： English database of the Cocbrane Controlled Trials Register, PubMed, EMBASE, and Chinese database ofCBM, CNKI, VIE and WAN FANG were searched. Randomized controlled trials comparing nutrition support （given tbr more than 2 weeks） with no nutrition intervention, nutrition advice only, or placebo-control for TB patients being anti-TB treated were included. Two reviewers conducted data extraction, assessed the quality of the studies independently, and any discrepancies were solved by the third reviewer. Data were entered and analyzed by RevMan 5.2 software, and recta-analysis was done using risk ratios （RRs） for dichotomous variables and mean differences （MDs） for continuous variables with 95% confidence intervals （C/s）. Results： A total of 19 studies （3681 participants） were included. In nutritional support for TB patients, pooled RR and its 95% CI of sputum smears- or culture-negative conversion rate and chest X-ray （CXR） absorption rate were 1.10 （1.04, 1.17） and 1.22 （1.08, 1.39）, respectively, the pooled MD and its 95% CI of body mass index （BMI） and time of sputum smears or culture negativity were 0.59 （0.16, 1.2） and - 5.42 （-7.93, -2.92）, respectively, compared with the control group. The differences in outcomes of CXR zone affected, TB score, serum albumin, and hemoglobin were not statistically significant （P = 0.76, 0.24, 0.28, and 0.20, respectively） between the intervention group and the control group. No systemic adverse events were recorded. Conclusions： During anti-TB course, nutrition support may be helpful in treatment of TB pa

关键词： Intervention Nutrition Support Tuberculosis

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PowerBuilder开发环境下通用录入编辑控件的设计与开发

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江汉大学学报（自然科学版） 2004年第4期32卷 39-41页

作者：汪亚玲方康玲武汉科技大学计算机学院湖北武汉430081

采用面向对象的程序设计思想和数据窗口技术,并考虑到数据完整性和多种实际需要,提出了一个通用录入与编辑控件的设计方案,并在PowerBuilder(简称PB)环境下完成了实际控件的编程实现.

关键词： PowerBuilder 数据库用户对象

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超滤技术在颐寿酒过滤中的应用

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膜科学与技术 1985年第2期 48-58页

作者：吴玲玲康德宽刘淑秀戤黎明北京工业大学

本文主要讨论了聚砜、聚砜酰胺超滤膜提纯颐寿酒,截留直径为0.15—4μm的悬浮粒子和大分子有机物,超滤后的酒经理化分析和专家品尝,在色、香、味方面均优于未处理酒,放置半年后未见沉淀物产生。并对膜的耐化学稳定性及结构进行了观察。

关键词：超滤技术 PSA 酒类生物膜沉淀物

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含Fe3S3簇核的两个异构体化合物的合成和结构研究

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化学学报 1988年第10期46卷 972-977页

作者：刘平黄梁仁王玲玲康北笙卢嘉锡中国科学院福建物质结构研究所福州

用氯化亚铁、苯硫酚钠及溴化四乙基铵在乙腈溶液中,经一步反应,得到两个同分异构的化合物α-[Et4N]3[Fe3(PhS)3Cl3Br3]1和β-[Et4N]3[Fe3(PhS)3Cl3Br3]2.X射线晶体结构测定表明,1和2的阴离子骨架为3Fe、3S交叉排列的六元环.

关键词： Fe3S3 六元环原子构成化合物

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Optimal power and subcarrier allocation with partial side information for downlink OFDMA system

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The Journal of China Universities of Posts and Telecommunications 2010年第5期17卷 50-57页

作者： ZENG ling-kang LIU Yuan-an XIE Gang CHANG ling-jun Key Laboratory of Universal Wireless Communications Ministry of Education Beijing University of Posts and Telecommunications Beijing 100876 China

In this paper,we investigate the power and subcarrier allocation issue in the case of partial side information for downlink orthogonal frequency division multiple access （OFDMA） *** method is utilized to characterize the necessary conditions of the optimal solution and the uniqueness of the optimal solution is *** game theoretical concept,surplus function is also introduced to analyze the optimal *** on the theoretical analysis,we propose iterative surplus balancing algorithm （ISBA） that can jointly assign the power and subcarriers in multiple rounds,and then the optimality of ISBA is *** results are presented to show the characteristics of the theoretical analysis and ISBA.

关键词： resource allocation partial side information OFDMA surplus function game theory

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Mechanism of Fuzheng kang'ai Formula Regulating Tumor Microenvironment in Non-Small Cell Lung Cancer

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Chinese Journal of Integrative Medicine 2022年第5期28卷 425-433页

作者： TIAN Yun-ling FU Song-bo LI Bo YUAN ling-yan BING Zhi-tong Department of Endocrinology and Metabolism the First Hospital of Lanzhou UniversityLanzhou(730000)China Evidence Based Medicine Center School of Basic Medical Science of Lanzhou UniversityLanzhou(730000)China Department of Computational Physics Institute of Modern PhysicsChinese Academy of SciencesLanzhou(730000)China School of Nuclear Science and Technology University of Chinese Academy of SciencesBeijing(100049)China

Objective:To study the mechanism of Chinese herbal medicine Fuzheng kang’ai Formula(FZKA)on tumor microenvironment(TME).Methods:CIBERSORTx was used for analysis of *** Chinese Medicine Systems Pharmacology and Analysis Platform was applied to identify compounds-targets network and the Cancer Genome Atlas(TCGA)was employed to identify the differential expression genes(DEGs)between tumor and paracancerous tissues in lung adenocarcinoma(LUAD)from ***,DEGs with prognosis in LUAD was calculated by univariable and multivariate Cox *** core targets of FZKA were analyzed in lung adenocarcinoma ***-protein interaction database was employed to predict down-stream of *** reverse transcription polymerase chain reaction was employed for biological experiment in A549,H1299 and PC9 cell ***:The active and resting mast cells were significantly associated with prognosis of LUAD(P<0.05).Of the targets,CCNA2 as an important target of FZKA(hazard ratio=1.41,95%confidential interval:1.01-2.01,P<0.05)was a prognostic target and significantly associated with mast ***2 was positively correlated with mast cell activation and negatively correlated with mast cell resting ***1 L2,ACTL6 A and ITGAV were down-stream of CCNA2,which were validated by q RT-PCR in A549 ***:FZKA could directly bind to CCNA2 and inhibit tumor growth by regulating CCNA2 downstream genes and TME of NSCLC closely related to CCNA2.

关键词： network pharmacology prognosis tumor microenvironment Fuzheng kang’ai Formula Chinese medicine lung adenocarcinoma

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A new depth-integrated non-hydrostatic model for free surface flows

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Science China(Technological Sciences) 2013年第4期56卷 824-830页

作者： GUO XiaoMing kang ling JIANG TieBing School of Hydropower and Information Engineering Huazhong University of Science and Technology

A new depth-integrated model deploying a non-hydrostatic pressure distribution is *** the pressure divided into hydrostatic and dynamic components,the horizontal momentum equations were obtained by integrating the Navier-Stokes equations from the bottom to the free *** vertical momentum equation,in which the convective and viscosity terms were omitted,was approximated by the Keller-box *** model has two ***,the dynamic pressure gradient terms were discretized semi-implicitly and the other terms were in explicit ***,the velocities expressed as the unknown dynamic pressure were substituted into the continuity equation,resulting in a five-diagonal symmetric matrix linear system that was solved by the conjugate gradient *** model was validated with the propagation of a solitary wave and sinusoidal wave,indicating that it can predict free surface flows well.

关键词： depth-integrated free surface non-hydrostatic pressure waves

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Kinetics of hot metal desulfurization using CaO-SiO2-Al2O3-Na2O-TiO2 slag

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Journal of Iron and Steel Research International 2019年第10期26卷 1041-1051页

作者： kang-hui Zhang Yan-ling Zhang Tuo Wu State Key Laboratory of Advanced Metallurgy University of Science and Technology BeijingBeijing 100083China

Kinetics of hot metal desulfurization were studied using CaO-SiO2-Al2O3-Na2O-TiO2 slag in the range of 1400-1500℃on a laboratory *** results of kinetic experiments indicate that the desulfurization rate increases as the temperature,Al2O3 content,Na2O content,and TiO2 content increase and basicity increases from 1.01 to 1.75,but decreases when basicity increases from 1.75 to *** melting effect of slag is promoted as the temperature,Na2O content,and TiO2 content increase and Al2O3 content increases from 12.13 to 17.17 mass%,but worsened as basicity increases and Al2O3 content increases from 17.17 to 22.27 mass%.A kinetic model of hot metal desulfurization has been developed to calculate the mass transfer coefficient and the mass transfer resistance of sulfur in *** mass transfer coefficient of sulfur increases as the temperature,Al2O3 content,Na2O content,and TiO2 content increase and basicity *** mass transfer coefficients of sulfur were in the range of(5.02-23.78)×10^-7 m s^-*** activation energy was estimated to be 464.06 kJ mo1^-1 at the temperature from 1400 to 1450℃and 176.35 kJ mol-1 at the temperature from 1450 to 1500℃.The sulfur distribution at the slag-metal interface was observed using a mineral liberation *** result shows that the mass transfer of sulfur in slag is the controlling step at high temperature during the desulfurization process.

关键词： Hot metal desulfurization Kinetics Model Liquid area Kinetic parameter

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Design and Modeling on Stranded Wires Helical Springs

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Chinese Journal of Mechanical Engineering 2011年第4期24卷 626-637页

作者： ZHOU Jie WANG Shilong kang ling CHEN Tianyi State Key Laboratory of Mechanical Transmissions Chongqing University Chongqing 400044 China China Aerodynamics Research ＆ Development Center Mianyang 621000 China

A stranded wires helical spring is formed of a multilayer and coaxial strand of several wires twisted together with the same direction of spiral. Compared with the conventional single wire spring, the stranded wires helical spring has the notable predominance in strength, damping and vibration reduction, which is usually used in aircraft engines, automatic weapons, etc. However, due to its complicated structure, the precise computation of its strength and rigidity need be a correct mathematical model, which then will be imported to finite element analysis software for solutions. Equations on solving geometric parameters, such as external diameters of strands and screw pitches of wires, are put forward in the paper. It also proposes a novel methodology on solving geometric parameters and establishing entity models of the stranded wires helical spring, which provides foundation of computing mechanical parameters by FEA. Then mathematical models on the centre line of the strand and the surface curve of each wire, after closing two ends in a spring, are proposed. Finally, geometric parameters are solved in a case study, and a 3D entity model of a spring with 3 layers and 16 wires is established, which has validated the accuracy of the proposed methodology and the 3D entity mathematical model. The method provides a new way to design stranded wire helical spring.

关键词： stranded wires helical spring mathematical model finite element analysis closing ends

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