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Plume-lithosphere interaction in the Comei Large Igneous Province: Evidence from two types of mafic dykes in Gyangze, south Tibet, China

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China Geology 2024年第1期7卷 80-90页

作者： Ya-ying Wang ling-sen Zeng Li-e Gao Li-long Yan ling-hao zhao Jia-hao Gao Ying-long Di Guang-xu Li Yi-hong Tian Institute of Geology Chinese Academy of Geological SciencesBeijing 100037China National Research Center for Geoanalysis Chinese Academy of Geological SciencesBeijing 100037China China Nonferrous Metals(Guilin)Geology and Mining Co. LtdGuilin 541004China

Two suites of mafic dykes,T1193-A and T1194-A,outcrop in Gyangze area,southeast Tibet.They are in the area of Comei LIP and have indistinguishable field occurrences with two other dykes in Gyangze,T0902 dyke with 137.7±1.3 Ma zircon age and T0907 dyke with 142±1.4 Ma zircon age reported by Wang YY et al.(2016),indicating coeval formation time.Taking all the four diabase dykes into consideration,two different types,OIB-type and weak enriched-type,can be summarized.The“OIB-type”samples,including T1193-A and T0907 dykes,show OIB-like geochemical features and have initial Sr-Nd isotopic values similar with most mafic products in Comei Large Igneous Provinces(LIP),suggesting that they represent melts directly generated from the Kerguelen mantle plume.The“weak enriched-type”samples,including T1194-A and T0902 dykes,have REEs and trace element patterns showing withinplate affinity but have obvious Nb-Ta-Ti negative anomalies.They show uniform lowerεNd(t)values(−6‒−2)and higher 87Sr/86Sr(t)values(0.706‒0.709)independent of their MgO variation,indicating one enriched mantle source.Considering their closely spatial and temporal relationship with the widespread Comei LIP magmatic products in Tethyan Himalaya,these“weak enriched-type”samples are consistent with mixing of melts from mantle plume and the above ancient Tethyan Himalaya subcontinental lithospheric mantle(SCLM)in different proportions.These weak enriched mafic rocks in Comei LIP form one special rock group and most likely suggest large scale hot mantle plume-continental lithosphere interaction.This process may lead to strong modification of the Tethyan Himalaya lithosphere in the Early Cretaceous.

关键词： OIB type diabase Comei Large Igneous Province Weakly enriched diabase Plume-lithosphere interaction Nb-Ta-Ti negative anomaly Kerguelen plume Geological survey engineering Tibet Plateau

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Effective assignment of positional isomers in dimeric shikonin and its analogs by ^(1)H NMR spectroscopy

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Chinese Chemical Letters 2024年第5期35卷 223-226页

作者： ling-hao zhao Hai-Wei Yan Jian-Shuang Jiang Xu Zhang Xiang Yuan Ya-Nan Yang Pei-Cheng Zhang State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China

An approach for distinguishing two types of positional isomers of dimeric shikonin and its analogs was explored with ^(4)JC,H long-range correlation by prolonging the acquisition time at ^(2,3)JC,H values of 2.0 and 8.0Hz.Furthermore,the ^(1)H(proton)nuclear magnetic resonance(NMR)pattern of phenolic hydroxyl protons was developed as a“diagnosis signal”to ascertain the relative location of each side chain in DMSO-d_(6) at sample concentrations of 0.022-0.034 mol/L.The chemical shift differences of 0.6ppm between OH-5' and OH-1 and between OH-8'and OH-4 are assigned to Type A and Type B,respectively.All reported ambiguous structures were corrected by this pattern.Additionally,the steric structures of isolated compounds were elucidated by quantum chemical calculations of electronic circular dichroism(ECD)spectra.

关键词： Arnebia euchroma Dimeric hydroxyl naphthoquinones Positional isomers ^(1)H NMR spectroscopy Chemical shift difference

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One-versus two-stage partial hepatectomy for large resectable solitary hepatocellular carcinomas determined preoperatively to have a narrow resection margin:a propensity score matching analysis

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Hepatobiliary Surgery and Nutrition 2022年第5期11卷 662-674页

作者： Yao Li Peng-Peng Li Da-Peng Sun Jun-Sheng Ni Hui Liu Ze-Ya Pan Yuan Yang ling-hao zhao Wan Yee Lau Gang Huang Wei-Ping Zhou The Third Department of Hepatic Surgery Eastern Hepatobiliary Surgery HospitalShanghaiChina Faculty of Medicine The Chinese University of Hong KongPrince of Wales HospitalShatinHong KongChina Key Laboratory of Signaling Regulation and Targeting Therapy of Liver Cancer(SMMU) Ministry of EducationShanghaiChina Shanghai Key Laboratory of Hepatobiliary Tumor Biology(EHBH) ShanghaiChina

Background:For patients with a large but resectable solitary hepatocellular carcinoma(HCC)of>5 cm in diameter,it is often difficult to achieve a sufficient resection margin.There is still no study on whether a two-stage hepatectomy to increase a narrow resection margin would be beneficial.Methods:From August 2014 to February 2017,patients with a large but resectable solitary HCC of>5 cm and a preoperative estimated resection margin of5 cm,and resulted in significantly better long-term survival outcomes after partial hepatectomy.

关键词： One-stage hepatectomy two-stage hepatectomy large solitary hepatocellular carcinoma(HCC) resection margin

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Behavior of apatite in granitic melts derived from partial melting of muscovite in metasedimentary sources

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China Geology 2021年第1期4卷 44-55页

作者： Li-E Gao ling-sen Zeng ling-hao zhao Jia-hao Gao Zhen Shang Key Laboratory of Deep-Earth Dynamics of Ministry of Natural Resources Institute of GeologyChinese Academy of Geological SciencesBeijing 100037China National Research Center for Geoanalysis Chinese Academy of Geological ScienceBeijing 100037China

Fluid-absent and fluid-fluxed melting of muscovite in metasedimentary sources are two types of crustal anatexis to produce the Himalaya Cenozoic leucogranites.Apatite grains separated from melts derived from the two types of parting melting have different geochemical compositions.The leucogranites derived from fluid-fluxed melting have relict apatite grains and magmatic crystallized apatite grains,by contrast,there are only crystallized apatite grains in the leucogranites derived from fluid-absent melting.Moreover,apatite grains crystallized from fluid-fluxed melting of muscovite contain higher Sr,but lower Th and LREE than those from fluid-absent melting of muscovite,which could be controlled by the distribution of partitioning coefficient(D_(Ap/Melt))between apatite and leucogranite.D_(Ap/Melt) in granites derived from fluidabsent melting is higher than those from fluid-fluxed melting.So,not only SiO_(2) and A/CNK,but also types of crustal anatexis are sensitive to trace element partition coefficients for apatite.In addition,due to being not susceptible to alteration,apatite has a high potential to yield information about petrogenetic processes that are invisible at the whole-rock scale and thus is a useful tool as a petrogenetic indicator.

关键词： Apatite Partitioning coefficient Crustal anatexis Leucogranite Malashan Dome Tethyan Himalaya Geological survey engineering Tibet

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Baddeleyite and zircon U-Pb ages of the ultramafic rocks in Chigu Tso area,Southeastern Tibet and their constraints on the timing of Comei Large Igneous Province

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China Geology 2020年第2期3卷 262-268页

作者： Ya-ying Wang ling-sen Zeng ling-hao zhao Li-e Gao Jia-hao Gao zhao-ping Hu Hai-tao Wang Guang-xu Li Ying-long Di Yu Shen Qian Xu Institute of Geology Chinese Academy of Geological SciencesMinistry of Natural ResourcesBeijing 100037China National Research Center for Geoanalysis Chinese Academy of Geological SciencesMinistry of Natural ResourcesBeijing 100037China

A suite of ultramafic and mafic rocks developed in the Chigu Tso area,eastern Tethyan Himalaya.Baddeleyite and zircon U-Pb ages acquired by SIMS and LA-ICP-MS from olivine pyroxenite rocks in the Chigu Tso area are 138.9±3.0 Ma and 139.0±1.9 Ma,respectively.These two Early Cretaceous ages are similar with the ages of the more abundant mafic rocks in the eastern Tethyan Himalaya,indicating that this suite of ultramafic and mafic rocks in the Chigu Tso area should be included in the outcrop area of the Comei Large Igneous Province(LIP).These ultramafic rocks provide significant evidence that the involvement of mantle plume/hot spot activities in the formation of the Comei LIP.Baddeleyite U-Pb dating by SIMS is one reliable and convenient method to constrain the formation time of ultramafic rocks.The dating results of baddeleyite and zircon from the olivine pyroxenite samples in this paper are consistent with each other within analytical uncertainties,suggesting that baddeleyite and zircon were both formed during the same magmatic process.The consistency of baddeleyite U-Pb ages in the Chigu Tso area with zircon U-Pb ages for a large number of Early Cretaceous mafic rocks in the eastern Tethyan Himalaya further support that zircon grains from such mafic rocks yielding Early Cretaceous ages are also magmatic in origin.

关键词： U-Pb dating Baddeleyite Zircon Ultramafic rock Comei Large Igneous Province Kerguelen plume Tethyan Himalaya Geological survey engineering Tibet China

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Nomogram for prediction of fatal outcome in patients with severe COVID-19:a multicenter study

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Military Medical Research 2021年第4期8卷 535-545页

作者： Yun Yang Xiao-Fei Zhu Jian Huang Cui Chen Yang Zheng Wei He ling-hao zhao Qian Gao Xuan-Xuan Huang Li-Juan Fu Yu Zhang Yan-Qin Chang Huo-Jun Zhang Zhi-Jie Lu The Third Affiliated Hospital of Second Military Medical University Shanghai 200438China. The Guanggu Branch of the Women and Children’s Hospital of Hubei Province Wuhan 430070China. The First Affiliated Hospital of Second Military Medical University Shanghai 200438China. 4904 Hospital of PLA Joint Logistic Support Force Wuxi 215000JiangsuChina. Tongji Taikang Hospital Wuhan 430050China. 6924 Hospital of PLA Joint Logistic Support Force Guilin 541002GuangxiChina. Huoshen Mountain Hospital Wuhan 430113China.

Background:To develop an effective model of predicting fatal outcomes in the severe coronavirus disease 2019(COVID-19)patients.Methods:Between February 20,2020 and April 4,2020,consecutive confirmed 2541 COVID-19 patients from three designated hospitals were enrolled in this study.All patients received chest computed tomography(CT)and serological examinations at admission.Laboratory tests included routine blood tests,liver function,renal function,coagulation profile,C-reactive protein(CRP),procalcitonin(PCT),interleukin-6(IL-6),and arterial blood gas.The SaO2 was measured using pulse oxygen saturation in room air at resting status.Independent high-risk factors associated with death were analyzed using Cox proportional hazard model.A prognostic nomogram was constructed to predict the survival of severe COVID-19 patients.Results:There were 124 severe patients in the training cohort,and there were 71 and 76 severe patients in the two independent validation cohorts,respectively.Multivariate Cox analysis indicated that age≥70 years(HR=1.184,95%CI 1.061–1.321),panting(breathing rate≥30/min)(HR=3.300,95%CI 2.509–6.286),lymphocyte count10pg/ml(HR=3.029,95%CI 1.567–7.116)were independent high-risk factors associated with fatal outcome.We developed the nomogram for identifying survival of severe COVID-19 patients in the training cohort(AUC=0.900,95%CI 0.841–0.960,sensitivity 95.5%,specificity 77.5%);in validation cohort 1(AUC=0.811,95%CI 0.763–0.961,sensitivity 77.3%,specificity 73.5%);in validation cohort 2(AUC=0.862,95%CI 0.698–0.924,sensitivity 92.9%,specificity 64.5%).The calibration curve for probability of death indicated a good consistence between prediction by the nomogram and the actual observation.The prognosis of severe COVID-19 patients with high levels of IL-6 receiving tocilizumab were better than that of those patients without tocilizumab both in the training and validation cohorts,but without difference(P=0.105 for training cohort,P=0.133 for va

关键词： Severe COVID-19 Nomogram Prediction Survival

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Differential expression of miRNAs and mRNAs in the livers of largemouth bass Micropterus salmoides under heat stress

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Journal of Oceanology and Limnology 2024年第2期42卷 594-608页

作者： Xuqian zhao Zijie LIN Caijuan LI hao ZHU lingling LI Wenjia MAO Qufei ling School of Biology and Basic Medical Sciences Suzhou Medical College of Soochow UniversitySuzhou 215000China

Global warming threatens freshwater ecosystems and compromises fish survival.To elucidate the role of miRNAs in the livers of heat stressed largemouth bass,juvenile fish was subject to heat stress under 37°C.Both mRNA-seq and miRNA-seq were conducted on the liver tissues under control and heat stress conditions.Differential gene expression analysis and enrichment analysis were performed on mRNA and miRNA expression profiles.A total of 406 differentially expressed genes(DEGs)were discovered,of which 212 were up-regulated and 194 were down-regulated.Most of the DEGs were significantly implicated in the regulation of“protein processing in endoplasmic reticulum”,“proteasome”,“steroid biosynthesis”,and“ornithine decarboxylase inhibitor activity”pathways.In addition,47 differentially expressed miRNAs(DEMs)were identified in largemouth bass livers under heat stress,including 21 up-regulated and 25 down-regulated miRNAs.A negatively regulated miRNA-mRNA network including 12 miRNAs and 19 mRNAs was constructed with DEMs involved in“protein degradation”,“calcium ion regulation”,“cell apoptosis”,and“lipid metabolism”.Moreover,this study indicated novel-miR-144 activated the IRE1 signaling pathway by targeting txndc5 to induce liver apoptosis in largemouth bass under heat stress.This study revealed the involvement of miRNA regulation in largemouth bass in response to heat stress.

关键词： heat stress largemouth bass miRNA-mRNA interaction

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Insight study of rare earth elements in PM_(2.5)during five years in a Chinese inland city:Composition

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Journal of Environmental Sciences 2024年第4期138卷 439-449页

作者： Yi-Wen Shen Chang-Xian zhao hao zhao Shuo-Fei Dong Qi Guo Jiao-Jiao Xie Mei-ling Lv Chun-Gang Yuan Hebei Key Lab of Power Plant Flue Gas Multi-Pollutants Control Department ofEnvironmental Science&EngineeringNorth China Electric Power UniversityBaoding 071000China MOE Key Laboratory of Resources and Environmental Systems Optimization College of Environmental Science and EngineeringNorth China Electric Power UniversityBeijing 102206China Agilent Technologies Co.Ltd.(China) Beijing 100102China

The booming development of rare earth industry and the extensive utilization of its products accompanied by urban development have led to the accelerated accumulation of rare earth elements(REEs)as emerging pollutants in atmospheric environment.In this study,the variation of REEs in PM_(2.5)with urban(a non-mining city)transformation was investigated through five consecutive years of sample collection.The compositional variability and provenance contribution of REEs in PM_(2.5)were characterized,and the REEs exposure risks of children and adults via inhalation,ingestion and dermal absorption were also evaluated.The results showed an increase in the total REEs concentration from 46.46±35.16 mg/kg(2017)to 81.22±38.98 mg/kg(2021)over the five-year period,with Ce and La making the largest contribution.The actual increment of industrial and traffic emission source among the three pollution sources was 1.34 ng/m^(3).Coal combustion source displayed a downward trend.Ingestion was the main exposure pathway for REEs in PM_(2.5)for both children and adults.Ce contributed the most to the total intake of REEs in PM_(2.5)among the population,followed by La and Nd.The exposure risks of REEs in PM_(2.5)in the region were relatively low,but the trend of change was of great concern.It was strongly recommended to strengthen the concern about traffic-related non-exhaust emissions of particulate matter.

关键词： Rare earth elements Exposure risks Pollution sources Traffic-related non-exhaust emissions

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Classification of anatomical morphology of cystic duct and its association with gallstone

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World Journal of Gastrointestinal Surgery 2024年第2期16卷 307-317页

作者： Jia-Hai Zhu Song-ling zhao Qiang Kang Ya Zhu Li-Xin Liu hao Zou Department of Hepatobiliary Pancreatic Surgery The Second Affiliated Hospital of Kunming Medical UniversityKunming 650106Yunnan ProvinceChina Department of Hepatobiliary Surgery The Second Affiliated HospitalKunming Medical UniversityKunming 650106Yunnan ProvinceChina

BACKGROUND Gallstones are common lesions that often require surgical intervention.Laparo-scopic cholecystectomy is the treatment of choice for symptomatic gallstones.Preoperatively,the anatomical morphology of the cystic duct(CD),needs to be accurately recognized,especially when anatomical variations occur in the CD,which is otherwise prone to bile duct injury.However,at present,there is no optimal classification system for CD morphology applicable in clinical practice,and the relationship between anatomical variations in CDs and gallstones remains to be explored.AIM To create a more comprehensive clinically applicable classification of the morphology of CD and to explore the correlations between anatomic variants of CD and gallstones.METHODS A total of 300 patients were retrospectively enrolled from October 2021 to January 2022.The patients were divided into two groups:The gallstone group and the nongallstone group.Relevant clinical data and anatomical data of the CD based on magnetic resonance cholangiopancreatography(MRCP)were collected and analyzed to propose a morphological classification system of the CD and to explore its relationship with gallstones.Multivariate analysis was performed using logistic regression analyses to identify the independent risk factors using variables that were significant in the univariate analysis.RESULTS Of the 300 patients enrolled in this study,200(66.7%)had gallstones.The mean age was 48.10±13.30 years,142(47.3%)were male,and 158(52.7%)were female.A total of 55.7%of the patients had a body mass index(BMI)≥24 kg/m2.Based on the MRCP,the CD anatomical typology is divided into four types:Type I:Linear,type II:n-shaped,type III:S-shaped,and type IV:W-shaped.Univariate analysis revealed differences between the gallstone and nongallstone groups in relation to sex,BMI,cholesterol,triglycerides,morphology of CD,site of CD insertion into the extrahepatic bile duct,length of CD,and angle between the common hepatic duct and CD.According to the multivariate analysis,female,BMI(≥24 kg/m2)

关键词： Cystic duct Gallstone Classification Anatomy Magnetic resonance cholangiopancreatography Risk factor

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Detection of Novel BEST1 Variations in Autosomal Recessive Bestrophinopathy Using Third-generation Sequencing

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Current Medical Science 2024年第2期44卷 419-425页

作者： Jia-xun LI ling-rui MENG Bao-ke HOU Xiao-lu hao Da-jiang WANG ling-hui QU zhao-hui LI Lei ZHANG Xin JIN Department of Senior Ophthalmology the Third Medical Center of PLA General HospitalBeijing 100853China Department of Ophthalmology the 74th Army Group HospitalGuangzhou 510318China

Objective:Autosomal recessive bestrophinopathy(ARB),a retinal degenerative disease,is characterized by central visual loss,yellowish multifocal diffuse subretinal deposits,and a dramatic decrease in the light peak on electrooculogram.The potential pathogenic mechanism involves mutations in the BEST1 gene,which encodes Ca2+-activated Cl−channels in the retinal pigment epithelium(RPE),resulting in degeneration of RPE and photoreceptor.In this study,the complete clinical characteristics of two Chinese ARB families were summarized.Methods:Pacific Biosciences(PacBio)single-molecule real-time(SMRT)sequencing was performed on the probands to screen for disease-causing gene mutations,and Sanger sequencing was applied to validate variants in the patients and their family members.Results:Two novel mutations,c.202T>C(chr11:61722628,p.Y68H)and c.867+97G>A,in the BEST1 gene were identified in the two Chinese ARB families.The novel missense mutation BEST1 c.202T>C(p.Y68H)resulted in the substitution of tyrosine with histidine in the N-terminal region of transmembrane domain 2 of bestrophin-1.Another novel variant,BEST1 c.867+97G>A(chr11:61725867),located in intron 7,might be considered a regulatory variant that changes allele-specific binding affinity based on motifs of important transcriptional regulators.Conclusion:Our findings represent the first use of third-generation sequencing(TGS)to identify novel BEST1 mutations in patients with ARB,indicating that TGS can be a more accurate and efficient tool for identifying mutations in specific genes.The novel variants identified further broaden the mutation spectrum of BEST1 in the Chinese population.

关键词： autosomal recessive bestrophinopathy BEST1 gene third-generation sequencing mutation

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