检索结果-南通市图书馆

ACEI attenuates the progression of CCl_4-induced rat hepatic fibrogenesis by inhibiting TGF-β1, PDGF-BB, NF-κB and MMP-2,9

引用

World Journal of Gastroenterology 2005年第31期11卷 4807-4811页

作者： Xu Li Ying Meng Xi-Shan Yang ling-fei mi Shao-Xi Cai Department of Emergency Nanfang Hospital Southern Medical University Guangzhou 510515 Guangdong ProvinceChina Department of Respiratory Diseases Nanfang HospitalSouthern Medical University Guangzhou 510515 Guangdong Province China Department of Digestive Disease Nanfang HospitalSouthern Medical University Guangzhou 510515 Guangdong Province China Department of Emergency the First People's Hospital of Huaihua 418000 Hunan Province China Department of Respiratory Diseases Nanfang Hospital Southern Medical University Guangzhou 510515Guangdong Province China

AIM： Angiotensin II has pro-fibrotic function in the liver. Blockade of the renin-angiotensin-aldosterone-system （RAAS） attenuates hepatic fibrosis. The aim of the present study was to determine the mechanism of angiotensin-converting enzyme inhibitor （ACEI） on the progression of rat hepatic fibrosis. METHODS： Forty male Wistar rats were divided into three groups. Model group （Mo）： The rats were injected subcutaneously with 40% of CCl4 0.25 mL/100 g. Perindopril group （Pe）： The rats were injected subcutaneously with 40% of CCl4. Perindopril, equivalent to 2 mg/（kg·d）, was administrated. Control group （Nc）： the rats were treated with olive oil only. After 4 and 6 wk, the rats were killed. The liver sections were stained with Masson. The protein expressions of ATIR, TGF-β1 and PDGF-BB were examined by Western blot. Nuclear factor κB （NF-κB） DNA binding activity was examined by EMSA （Electrophoretic gel mobility shift assay）. Matrix metalloproteinase-2,9 （MMP-2,9） activity was assessed by zymography. Serum laminin （LN） and hyaluronic acid （HA） were measured using radioimmunoassays. RESULTS： Using Western blot, we clearly provided direct evidence for the expression of ATIR in liver. The expression was up-regulated when fibrogenesis occurred. Perindopril treatment significantly reduced mean fibrosis score, protein levels of ATIR, TGF-β1 and PDGF-BB, serum levels of HA and LN, and the activity of MMP-2,9. NF-κB DNA bindingactivity markedly increased in model group, perindopril treatment considerably reduced NF-κB DNA binding ***： Perindopril attenuates CCl4-induced hepatic fibrogenesis of rat by inhibiting TGF-β1, PDGF-BB, NF-BB and MMP-2,9.

关键词： Renin-angiotensin-aldosterone system Angiotensin-converting enzyme inhibitor Hepatic fibrosis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Tailoring Cathode-Electrolyte Interface for High-Power and Stable Lithium-Sulfur Batteries

引用

Nano-micro Letters 2025年第4期17卷 181-211页

作者： Mengting Liu ling-Jiao Hu Zhao-Kun Guan Tian-ling Chen Xin-Yu Zhang Shuai Sun Ruoli Shi Panpan Jing Peng-fei Wang Center of Nanomaterials for Renewable Energy State Key Laboratory of Electrical Insulation and Power EquipmentSchool of Electrical EngineeringXi’an Jiaotong UniversityXi’an 710049People’s Republic of China Low-Dimensional Materials and Photo/Electrochemical Technology Lab School of Materials Science and EngineeringShaanxi Key Laboratory of Green Preparation and Functionalization for Inorganic MaterialsShaanxi University of Science&TechnologyXi’an 710021People’s Republic of China

Global interest in lithium-sulfur batteries as one of the most promising energy storage technologies has been sparked by their low sulfur cathode cost,high gravimetric,volumetric energy densities,abundant resources,and environmental ***,their practical application is significantly impeded by several serious issues that arise at the cathode-electrolyte interface,such as interface structure degradation including the uneven deposition of Li_(2)S,unstable cathode-electrolyte interphase(CEI)layer and intermediate polysulfide shuttle ***,an optimized cathode-electrolyte interface along with optimized electrodes is required for overall ***,we comprehensively outline the challenges and corresponding strategies,including electrolyte optimization to create a dense CEI layer,regulating the Li_(2)S deposition pattern,and inhibiting the shuttle effect with regard to the solid-liquid-solid pathway,the transformation from solid-liquid-solid to solid-solid pathway,and solid-solid pathway at the cathode-electrolyte *** order to spur more perceptive research and hasten the widespread use of lithium-sulfur batteries,viewpoints on designing a stable interface with a deep comprehension are also put forth.

关键词： Lithium-sulfur batteries Shuttle effect Cathode-electrolyte interface Structural enhancement Reaction pathway

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Parallel Seeds:From Foundation Models to Foundation Intelligence for Agricultural Sustainability

引用

IEEE/CAA Journal of Automatica Sinica 2025年第3期12卷 481-484页

作者： Laiyi Fu Shunkang ling Danyang Wu Mengzhen Kang fei-Yue Wang Hequan Sun the Shool of Automation Science and Engineering Faculty of Electronic and Information Engineering Xi'an Jiaotong University the College of Information Engineering Northwest A&F University IEEE the State Key Laboratory of Management and Control for Complex Systems Chinese Academy of Sciences

THE development of agriculture faces significant challenges due to population growth, climate change, land depletion, and environmental pollution, threatening global food security [1]. This necessitates the development of sustainable agriculture, where a fundamental step is crop breeding to improve agronomic or economic traits, e.g., increasing yields of crops while decreasing resource usage and minimizing pollution to the environment [2].

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Improved rate and cycling performances of Na_(3)V_(2)(PO_(4))_(2)F_(2)O by Ti^(3+/4+)doping with two oxidation states for sodium cathodes

引用

中国有色金属学报 2025年第1期35卷 243-256页

作者： Xiao-fei SUN Anastase NDAHIMANA ling-zhi WANG Zi-kang WANG Quan-sheng LI Wei TANG min-xing YANG Xue-song MEI State Key Laboratory for Manufacturing System Engineering Xi’an Jiaotong UniversityXi’an 710049China School of Mechanical Engineering Xi’an Jiaotong UniversityXi’an 710049China Shaanxi Key Laboratory of Intelligent Robots Xi’an Jiaotong UniversityXi’an 710049China School of Chemical Engineering and Technology Xi’an Jiaotong UniversityXi’an 710049China

Ti at the oxidation states of Ti^(3+)and Ti^(4+),was used to enhance the performance of Na_(3)V_(2)(PO_(4))_(2)F_(2)O by partially substituting *** doping Ti,the crystallographic volume is decreased due to the less radii of Ti^(3+/4+),and the valence of Ti is demonstrated identical to *** sodium insertion in Ti-doped Na_(3)V_(2)(PO_(4))_(2)F_(2)O,the two discharge plateaus split into three because of the rearrangement of local redox ***,the optimized Na_(3)V_(0.96)Ti_(0.04)(PO_(4))_(2)F_(2)O shows a specific capacity of 123 and 63 mA·h/g at 0.1C and 20C,*** 350 cycles at 0.5C,the capacity is gradually reduced corresponding to a retention of 71.05%.The significantly improved performance is attributed to the rapid electrochemical kinetics,and showcases the strategy of replacing V^(3+/4+)with Ti^(3+/4+)for high-performance vanadium-based oxyfluorophosphates.

关键词： sodium vanadium oxyfluorophosphate titanium doping cathode sodium battery energy storage

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Failure mechanisms of AlGaN/GaN HEMTs irradiated by high-energy heavy ions with and without bias

引用

Nuclear Science and Techniques 2025年第1期36卷 49-58页

作者： Pei-Pei Hu Li-Jun Xu Sheng-Xia Zhang Peng-fei Zhai ling Lv Xiao-Yu Yan Zong-Zhen Li Yan-Rong Cao Xue-Feng Zheng Jian Zeng Yuan He Jie Liu Institute of Modern Physics Chinese Academy of Sciences(CAS)Lanzhou 730000China Key Laboratory of Wide Band‑gap Semiconductor Materials Ministry of EducationXidian UniversityXi’an 710071China University of Chinese Academy of Sciences(UCAS) Beijing 100049China

Gallium nitride(GaN)-based devices have significant potential for space ***,the mechanisms of radiation damage to the device,particularly from strong ionizing radiation,remains *** study investigates the effects of radiation on p-gate AlGaN/GaN high-electron-mobility transistors(HEMTs).Under a high voltage,the HEMT leakage current increased sharply and was accompanied by a rapid increase in power density that caused"thermal burnout"of the *** addition,a burnout signature appeared on the surface of the burned devices,proving that a single-event burnout effect ***,degradation,including an increase in the on-resistance and a decrease in the breakdown voltage,was observed in devices irradiated with high-energy heavy ions and without *** latent tracks induced by heavy ions penetrated the heterojunction interface and extended into the GaN ***,a new type of N_(2)bubble defect was discovered inside the tracks using Fresnel *** accumulation of N_(2)bubbles in the heterojunction and buffer layers is more likely to cause leakage and *** study indicates that electrical stress accelerates the failure rate and that improving heat dissipation is an effective reinforcement method for GaN-based devices.

关键词： GaN HEMTs Heavy ions Single-event burnout Latent tracks Degradation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Genome-wide CRISPR screens identify CLC-2 as a drug target for anti-herpesvirus therapy:tackling herpesvirus drug resistance

引用

Science China(Life Sciences) 2025年第2期68卷 515-526页

作者： Fayu Yang Nan Wei Shuo Cai Jing Liu Qingping Lan Hao Zhang Lu Shang Bo Zheng mi Wang Yingchun Liu Lifang Zhang Chenzhong fei Wu Tong Changlong Liu Ersheng Kuang Guangzhi Tong Feng Gu Shanghai Veterinary Research Institute Chinese Academy of Agricultural SciencesShanghai 200241China Key Laboratory of Veterinary Chemical Drugs and Pharmaceutics Ministry of Agriculture and Rural AffairsShanghai 200241China State Key Laboratory for Animal Disease Control and Prevention College of Veterinary MedicineLanzhou UniversityLanzhou Veterinary Research InstituteChinese Academy of Agricultural SciencesLanzhou 730000China Institute of Human Virology Zhongshan School of MedicineSun Yat-Sen UniversityGuangzhou 510080China School of Medicine Tsinghua UniversityBeijing 100084China

The emergence of drug resistance to virus(i.e.,acyclovir(ACV)to herpesviruses)has been termed one of the common clinical issues,emphasizing the discovery of new antiviral *** address it,a genome-wide clustered regularly interspaced short palindromic repeats(CRISPR)screening was performed in mouse haploid embryonic stem cells infected with pseudorabies virus(PRV),anα-herpesvirus causing human and pig *** results demonstrated that type 2 voltage-gated chloride channels(CLC-2)encoded by one of the identified genes,CLCN2,is a potential drug target for anti-herpesvirus ***-2 inhibitors,omeprazole(OME)and 4,4'-diisothiocyanostilbene-2,2'-disulfonic acid(DIDS),can efficiently inhibit infection of multiple herpesviruses in cellulo(i.e.,PRV,HSV and EBV),and effectively treat murine herpes simplex encephalitis(HSE).Additionally,DIDS was found to inhibit HSV-1 replication by blocking the PI3K/Akt *** importantly,both DIDS and OME were able to inhibit ACV-resistant HSV-1 strain *** study's findings suggest that targeting host-cell factors such as CLC-2 may be a promising approach to tackling herpesvirus drug *** discovery of CLC-2 as a potential drug target for anti-herpesvirus therapy provides a new direction for the development of novel antiviral agents.

关键词： herpesviruses CRISPR host-directed therapy CLC-2 DIDS

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

miRNA-21-5p is an important contributor to the promotion of injured peripheral nerve regeneration using hypoxia-pretreated bone marrow-derived neural crest cells

引用

Neural Regeneration Research 2025年第1期20卷 277-290页

作者： Meng Cong Jing-Jing Hu Yan Yu Xiao-Li Li Xiao-Ting Sun Li-Ting Wang Xia Wu ling-Jie Zhu Xiao-Jia Yang Qian-Ru He fei Ding Hai-Yan Shi School of Medicine Nantong UniversityNantongJiangsu ProvinceChina Key Laboratory of Neuroregeneration of Jiangsu and ministry of Education and Coinnovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Department of Physiology Jiangsu Health Vocational CollegeNanjingJiangsu ProvinceChina Department of Pathology Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina

Our previous study found that rat bone marrow–derived neural crest cells(acting as Schwann cell progenitors)have the potential to promote long-distance nerve ***-based therapy can enhance peripheral nerve repair and regeneration through paracrine bioactive factors and intercellular ***,the complex contributions of various types of soluble cytokines and extracellular vesicle cargos to the secretome remain *** investigate the role of the secretome and extracellular vesicles in repairing damaged peripheral nerves,we collected conditioned culture medium from hypoxia-pretreated neural crest cells,and found that it significantly promoted the repair of sensory neurons damaged by oxygen-glucose *** mRNA expression of trophic factors was highly expressed in hypoxia-pretreated neural crest *** performed RNA sequencing and bioinformatics analysis and found that miR-21-5p was enriched in hypoxia-pretreated extracellular vesicles of neural crest ***,to further clarify the role of hypoxia-pretreated neural crest cell extracellular vesicles rich in miR-21-5p in axonal growth and regeneration of sensory neurons,we used a microfluidic axonal dissociation model of sensory neurons in vitro,and found that hypoxia-pretreated neural crest cell extracellular vesicles promoted axonal growth and regeneration of sensory neurons,which was greatly dependent on loaded ***,we constructed a miR-21-5p-loaded neural conduit to repair the sciatic nerve defect in rats and found that the motor and sensory functions of injured rat hind limb,as well as muscle tissue morphology of the hind limbs,were obviously *** findings suggest that hypoxia-pretreated neural crest extracellular vesicles are natural nanoparticles rich in ***-21-5p is one of the main contributors to promoting nerve regeneration by the neural crest cell *** helps to explain the mechanism of action of the secretome and e

关键词： axotomy cell-free therapy conditioned medium extracellular vesicles hypoxic preconditioning microRNA oxygen-glucose deprivation peripheral nerve injury Schwann cell precursors

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Subgenome asymmetry of gibberellins-related genes plays important roles in regulating rapid growth of bamboos

引用

Plant Diversity 2025年第1期47卷 68-81页

作者： ling Mao Cen Guo Liang-Zhong Niu Yu-Jiao Wang Guihua Jin Yi-Zhou Yang Ke-Cheng Qian Yang Yang Xuemei Zhang Peng-fei Ma De-Zhu Li Zhen-Hua Guo Germplasm Bank of Wild Species&Yunnan Key Laboratory of Crop Wild Relatives Omics Kunming Institute of BotanyChinese Academy of SciencesKunmingYunnan 650201China University of Chinese Academy of Sciences Beijing 100049China State Key Laboratory of Plant Diversity and Specialty Crops Kunming Institute of BotanyChinese Academy of SciencesKunmingYunnan 650201China Center for Integrative Conservation&Yunnan Key Laboratory for the Conservation of Tropical Rainforests and Asian Elephants Xishuangbanna Tropical Botanical GardenChinese Academy of SciencesMenglunMenglaYunnan 666303China Yunnan Key Laboratory of Dai and Yi Medicines Yunnan University of Chinese MedicineKunmingYunnan 650500China

Rapid growth is an innovative trait of woody bamboos that has been widely ***,the genetic basis and evolution of this trait are poorly *** advantage of genomic resources of 11 representative bamboos at different ploidal levels,we integrated morphological,physiological,and transcriptomic datasets to investigate rapid *** particular,these bamboos include two large-sized and a small-sized woody species,compared with a diploid herbaceous *** results showed that gibberellin A1 was important for the rapid shoot growth of the world's largest bamboo,Dendrocalamus sinicus,and indicated that two gibberellins(GAs)-related genes,KAO and SLRL1,were key to the rapid shoot growth and culm size in woody *** expression of GAs-related genes exhibited significant subgenome asymmetry with subgenomes A and C demonstrating expression dominance in the large-sized woody bamboos while the generally submissive subgenomes B and D dominating in the small-sized *** subgenome asymmetry was found to be correlated with the subgenome-specific gene structure,particularly UTRs and core *** study provides novel insights into the molecular mechanism and evolution of rapid shoot growth following allopolyploidization in woody bamboos,particularly via subgenome *** findings are helpful for understanding of how polyploidization in general and subgenome asymmetry in particular contributed to the origin of innovative traits in plants.

关键词： Allopolyploids GAs DEGs Culm sizes Rapid shoot growth Woody bamboos

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

女性友好型城市的经济增长效应

引用

经济问题 2025年第2期 21-30页

作者：姚永玲茹丽霏中国人民大学应用经济学院北京100872

在从工业社会向后工业社会转型的过程中,世界上越是繁荣的城市,女性友好度就越高,女性对城市生活的重塑具有决定性的作用。在经济和人口转型的新阶段,女性友好度对中国的可持续发展至关重要。在联合国倡议的框架下测量女性友好程度,并... 详细信息

在从工业社会向后工业社会转型的过程中,世界上越是繁荣的城市,女性友好度就越高,女性对城市生活的重塑具有决定性的作用。在经济和人口转型的新阶段,女性友好度对中国的可持续发展至关重要。在联合国倡议的框架下测量女性友好程度,并通过实证分析探讨女性友好度对城市经济增长的影响,结果表明,女性友好度的提升显著提高了城市人均地区生产总值,并呈现出倒“U”型效应。此外,这一效应在大城市逐渐减缓,中小城市建设女性友好城市对经济增长的效果更明显,中小城市要发展经济,必须注重建设女性友好城市,充分利用女性带来的性别红利;女性友好对城市发展服务经济效果比制造业更加明显。此外,家庭和社会维度的女性友好程度在短期和长期分别具有相反的影响。结合实证和理论分析,研究在中国国情的背景下从性别视角丰富了城市经济增长的相关研究,对新时代城市高质量发展提供了新的经验。

关键词：女性友好型城市性别平等城市经济增长

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Difference of the gut microbiota of premature ovarian insufficiency in two traditional Chinese syndromes

引用

Journal of Traditional Chinese Medicine 2025年第1期45卷 132-139页

作者： WU Jiaman NING Yan TAN Liya MA fei LIN Yanting ZHUO Yuanyuan Department of Traditional Chinese Medicine Shenzhen Maternity and Child Healthcare Hospital Guangzhou University of Traditional Chinese Medicine Department of Acupuncture and Moxibustion Shenzhen Traditional Chinese Medicine Hospital

PURPOSE: To investigate the differences in gut microbial characteristics between two traditional Chinese syndromes of premature ovarian insufficiency(POI). METHODS: Forty women with POI were recruited from the Department of Traditional Chinese Medicine at Shenzhen Maternity and Child Healthcare Hospital between June and December 2020. Women with POI were divided into the kidney deficiency and blood stasis syndrome(SDBS) and Qi and blood deficiency syndrome(QBDS) groups. Gut microbial community profiles were analyzed by 16S rRNA gene sequencing using an Illumina mi Seq system. A retrospective study comparing hormone levels and gut microbiota information was performed between the SDBS and QBDS groups. RESULTS: Compared with the QBDS group, the serum levels of estradiol(E2) and anti-Müllerian hormone(AMH) were significantly decreased in the SDBS group. The quantities of Adlercreutzia, Eggerthella, Klebsiella, and Paraprevotella significantly increased in the SDBS group, whereas Lactobacillus decreased significantly. Moreover, alterations in the microbiome in the SDBS and QBDS groups were closely related to the levels of E2 and AMH. The area under the receiver operating characteristic curve for the classification of the two syndromes by the gut microbiome was 0.71. CONCLUSIONS: There were significant differences in the dominant microbiota between the SDBS and QBDS groups, and the change in Proteobacteria in the QBDS group was more significant. The characteristics of gut microbiota help us differentiate between the SDBS and QBDS groups, which may provide a basis for the objectification of TCM syndrome types.

关键词： RNA, ribosomal, 16S gastrointestinal microbiome gonadal steroid hormones primary ovarian insufficiency traditional Chinese syndromes

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：