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Construction of MoP/MoS_(2) Core-shell Structure Electrocatalyst for Boosting Hydrogen Evolution Reaction

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Chemical Research in Chinese Universities 2024年第3期40卷 490-498页

作者： meng Dan RAN Shunjiang GAO ling ZHANG Yue SAN Xiaoguang ZHANG Lei LI Ruixiang JIN Quan College of Chemical Engineering Shenyang University of Chemical TechnologyShenyang 110142P.R.China Key Laboratory of Automobile Materials(Ministry of Education) School of Materials Science and EngineeringJilin UniversityChangchun 130022P.R.China

Hydrogen energy stands out as one of the most promising alternative energy sources due to its cleanliness and *** water splitting offers a sustainable pathway for hydrogen ***,the kinetic rate of the hydrogen evolution reaction(HER)is sluggish,emphasizing the critical need for stable and highly active electrocatalysts to facilitate HER and enhance reaction *** metal-based catalysts have garnered attention for their favorable catalytic activity in electrochemical hydrogen evolution in alkaline *** this investigation,flower-like nanorods of MoS_(2) were directly synthesized in situ on a nickel foam substrate,followed by the formation of MoP/MoS_(2)-nickel foam(NF)heterostructures through high-temperature phosphating in a tube furnace *** findings reveal that MoP/MoS_(2)-NF-450 exhibits outstanding electrocatalytic performance in an alkaline milieu,demonstrating a low overpotential(90 mV)and remarkable durability at a current density of 10 mA/cm^(2).Comprehensive analysis indicates that the introduction of phosphorus(P)atoms enhances the synergistic effect with MoS_(2),while the distinctive flower-like nanorod structure of MoS_(2) exposes more active ***,the interface between the MoP/MoS_(2) heterostructure and NF facilitates electron transfer during hydrogen evolution,thereby enhancing electrocatalytic *** design and synthesis of such catalysts offer a valuable approach for the development of high-performance hydrogen evolution electrocatalysts.

关键词： MoP/MoS_(2) Core-shell structure Heterostructure Synergistic effect Hydrogen evolution reaction

NLRP3-mediated autophagy dysfunction links gut microbiota dysbiosis to tau pathology in chronic sleep deprivation

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Zoological Research 2024年第4期45卷 857-874页

作者： Na Zhao Xiu Chen Qiu-Gu Chen Xue-Ting Liu Fan Geng meng-meng Zhu Fu-ling Yan Zhi-Jun Zhang Qing-Guo Ren Department of Neurology School of MedicineSoutheast UniversityNanjingJiangsu 210009China Department of Neurology Affiliated Zhongda HospitalSoutheast UniversityNanjingJiangsu 210009China

Emerging evidence indicates that sleep deprivation(SD)can lead to Alzheimer’s disease(AD)-related pathological changes and cognitive ***,the underlying mechanisms remain *** the present study,we identified the existence of a microbiota-gut-brain axis in cognitive deficits resulting from chronic SD and revealed a potential pathway by which gut microbiota affects cognitive functioning in chronic *** findings demonstrated that chronic SD in mice not only led to cognitive decline but also induced gut microbiota dysbiosis,elevated NLRP3 inflammasome expression,GSK-3βactivation,autophagy dysfunction,and tau hyperphosphorylation in the *** with the“SD microbiota”replicated the pathological and behavioral abnormalities observed in chronic sleep-deprived ***,both the deletion of NLRP3 in NLRP3-/-mice and specific knockdown of NLRP3 in the hippocampus restored autophagic flux,suppressed tau hyperphosphorylation,and ameliorated cognitive deficits induced by chronic SD,while GSK-3βactivity was not regulated by the NLRP3 inflammasome in chronic ***,deletion of NLRP3 reversed NLRP3 inflammasome activation,autophagy deficits,and tau hyperphosphorylation induced by GSK-3βactivation in primary hippocampal neurons,suggesting that GSK-3β,as a regulator of NLRP3-mediated autophagy dysfunction,plays a significant role in promoting tau ***,gut microbiota dysbiosis was identified as a contributor to chronic SD-induced tau pathology via NLRP3-mediated autophagy dysfunction,ultimately leading to cognitive ***,these findings highlight GSK-3βas a regulator of NLRP3-mediated autophagy dysfunction,playing a critical role in promoting tau hyperphosphorylation.

关键词： Chronic sleep deprivation Tau pathology NLRP3 inflammasome Autophagy GSK-3β Microbiota-gut-brain axis

Advanced 2D molybdenum disulfide for green hydrogen production: Recent progress and future perspectives

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Frontiers in Energy 2024年第3期18卷 308-329页

作者： meng FANG Yuqin PENG Puwei WU Huan WANG Lixin XING Ning WANG Chunmei TANG ling meng Yuekuan ZHOU Lei DU Siyu YE Huangpu Hydrogen Energy Innovation Centre School of Chemistry and Chemical EngineeringGuangzhou UniversityGuangzhou 510006China Sustainable Energy and Environment Thrust Function HubThe Hong Kong University of Science and Technology(Guangzhou)Guangzhou 511400China Department of Mechanical and Aerospace Engineering The Hong Kong University of Science and TechnologyHong KongChina SinoHykey Technology Company Ltd. Guangzhou 510760China

The development of renewable and affordable energy is crucial for building a sustainable society. In this context, establishing a sustainable infrastructure for renewable energy requires the integration of energy storage, specifically use of renewable hydrogen. The hydrogen evolution reaction (HER) of electrochemical water splitting is a promising method for producing green hydrogen. Recently, two-dimensional nanomaterials have shown great promise in promoting the HER in terms of both fundamental research and practical applications due to their high specific surface areas and tunable electronic properties. Among them, molybdenum disulfide (MoS2), a non-noble metal catalyst, has emerged as a promising alternative to replace expensive platinum-based catalysts for the HER because MoS_(2)has a high inherent activity, low cost, and abundant reserves. At present, greatly improved activity and stability are urgently needed for MoS_(2)to enable wide deployment of water electrolysis devices. In this regard, efficient strategies for precisely modifying MoS_(2)are of interest. Herein, the progress made with MoS_(2)as an HER catalyst is reviewed, with a focus on modification strategies, including phase engineering, morphology design, defect engineering, heteroatom doping, and heterostructure construction. It is believed that these strategies will be helpful in designing and developing high-performance and low-cost MoS2-based catalysts by lowering the charge transfer barrier, increasing the active site density, and optimizing the surface hydrophilicity. In addition, the challenges of MoS_(2)electrocatalysts and perspectives for future research and development of these catalysts are discussed.

关键词： molybdenum disulfide(MoS_(2)) hydrogen evolution reaction(HER) active site electrocatalyst modification strategie

Multifunctional Sodium Gluconate Electrolyte Additive Enabling Highly Reversible Zn Anodes

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Chemical Research in Chinese Universities 2024年第4期40卷 722-729页

作者： ZHAO Kang ZHAO Jianan YU meng LIU Fangming dong Yang WANG Shiwen CHENG Fangyi College of Chemistry Nankai UniversityTianjin300071P.R.China College of New Energy Zhengzhou University of Light IndustryZhengzhou450002P.R.China

Sodium gluconate(SG)is reported as an electrolyte additive for rechargeable aqueous zinc *** SG addition is proposed to modulate the nucleation overpotential and plating behaviors of Zn by forming a shielding buffer layer because of the adsorption priority and large steric hindrance effect,which contributes to limited rampant Zn^(2+)diffusion and mitigated hydrogen evolution and *** the introduction of 30 mmol/L SG in 2 mol/L ZnSO_(4)electrolyte,the Zn anode harvests a reversible cycling of 1200 h at 5 mA/cm^(2)and a high average Coulombic efficiency of Zn plating/stripping(99.6%).Full cells coupling Zn anode with V_(2)O_(5)·1.6H_(2)O or polyaniline cathode far surpass the SG additivefree batteries in terms of cycle stability and rate *** work provides an inspiration for design of a high-effective and low-cost electrolyte additive towards Zn-based energy storage devices.

关键词： Electrolyte additive Zn anode Sodium gluconate Adsorption Zn dendrite

Research and Application of Joint Interpretation Using P-Wave and PS-Wave in Tight Gas Exploration

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Journal of Earth Science 2024年第4期35卷 1402-1406页

作者： dong Wang meng Zhang Jing Wang Dan Chen Yao Zhao Jing Bai BGPInc. China National Petroleum CorporationZhuozhou 072751China Institute of Geophysics Chengdu University of TechnologyChengdu 610059China National Engineering Research Center of Oil and Gas Exploration Computer Software Zhuozhou 072751China

The exploration and development of tight sandstone gas reservoirs are controlled by high-quality river channel sand bodies on a large scale in Sichuan *** order to improve the accu-racy of sand body prediction and characterization,Multi-component exploration technology research has been carried out in Northwest Sichuan ***,based on the array acoustic logging data,a for-ward modeling has been established to analyze the seismic response characteristics of the PS-wave data and P-wave *** result shows that the response characteristics of the P-wave and PS-wave to the sand bodies with different impedance are *** then through the analysis of logging data,the effectiveness of the forward modeling has been *** the sandstone velocity is close to the sur-rounding rocks,the P-wave performs as a weak reflection,which may lead to reduce the identification range of the sand ***,the PS-wave exhibits strong reflection,which can identify this type of sand ***,by comparing and explaining the PS-wave data and P-wave data,and integrat-ing their attributes,the prediction accuracy of sand bodies is *** with the interpreta-tion of a single P-wave,the results can significantly expand the distribution range of sand bodies,lay-ing a foundation for improving the production capacity of single wells and reserve submission.

关键词： multi-component exploration tight gas sand body identification

Controlling the Reactivity of IBA-N_(3)by Switching Halogen Salts:Providing a Universal Strategy for Haloazidation of Alkenes

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Chinese Journal of Chemistry 2024年第16期42卷 1839-1845页

作者： Chen-Xi Xia Xin-Lei Sun Jinfeng Zhang Yue Ren Yan Yu Kuai Wang ling-Guo meng Key Laboratory of Green and Precise Synthetic Chemistry and Applications Ministry of Education/School of Chemistry and Materials ScienceHuaibeiNormal UniversityHuaibeiAnhui 235000China

Although various routes have been reported for haloazidation,unavoidable problems exist,such as environmentally unfriendly monomer halogen,the need for in situ generation of unstable halogen azides(XN3),applicability to one type of haloazidation and inability to precisely control ***,we developed a universal strategy for haloazidation of alkenes through controlling the reactivity of IBA-N_(3) by switching halogen salts,allowing for the synthesis of a diversity of halogen azide *** studies have shown that by tuning the reactivity of IBA-N_(3) via switching halogen salts,different intermediates can be controllably produced to achieve regioselectivityand chemoselectivity in thehaloazidationof alkenes.

关键词： Haloazidation Alkene IBA-N_(3) Halogen salts Difunctionalization Selectivity Radicals Synthetic methods

Association of DNA methylation/demethylation with the functional outcome of stroke in a hyperinflammatory state

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Neural Regeneration Research 2024年第10期19卷 2229-2239页

作者： Yubo Wang ling Zhang Tianjie Lyu Lu Cui Shunying Zhao Xuechun Wang meng Wang Yongjun Wang Zixiao Li Vascular Neurology Department of NeurologyBeijing Tiantan HospitalCapital Medical UniversityBeijingChina China National Clinical Research Center for Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina National Center for Healthcare Quality Management in Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Chinese Institute for Brain Research BeijingChina Research Unit of Artificial Intelligence in Cerebrovascular Disease Chinese Academy of Medical SciencesBeijingChina Beijing Engineering Research Center of Digital Healthcare for Neurological Diseases BeijingChina

Inflammation is closely related to stroke prognosis, and high inflammation status leads to poor functional outcome in stroke. DNA methylation is involved in the pathogenesis and prognosis of stroke. However, the effect of DNA methylation on stroke at high levels of inflammation is unclear. In this study, we constructed a hyperinflammatory cerebral ischemia mouse model and investigated the effect of hypomethylation and hypermethylation on the functional outcome. We constructed a mouse model of transient middle cerebral artery occlusion and treated the mice with lipopolysaccharide to induce a hyperinflammatory state. To investigate the effect of DNA methylation on stroke, we used small molecule inhibitors to restrain the function of key DNA methylation and demethylation enzymes. 2,3,5-Triphenyltetrazolium chloride staining, neurological function scores, neurobehavioral tests, enzyme-linked immunosorbent assay, quantitative reverse transcription PCR and western blot assay were used to evaluate the effects after stroke in mice. We assessed changes in the global methylation status by measuring DNA 5-mc and DNA 5-hmc levels in peripheral blood after the use of the inhibitor. In the group treated with the DNA methylation inhibitor, brain tissue 2,3,5-triphenyltetrazolium chloride staining showed an increase in infarct volume, which was accompanied by a decrease in neurological scores and worsening of neurobehavioral performance. The levels of inflammatory factors interleukin 6 and interleukin-1 beta in ischemic brain tissue and plasma were elevated, indicating increased inflammation. Related inflammatory pathway exploration showed significant overactivation of nuclear factor kappa B. These results suggested that inhibiting DNA methylation led to poor functional outcome in mice with high inflammation following stroke. Further, the effects were reversed by inhibition of DNA demethylation. Our findings suggest that DNA methylation regulates the inflammatory response in stroke

关键词： DNA demethylation DNA methylation DNMT3A functional outcome hyperinflammatory state interleukin neuroinflammation stroke TET2

基于水化学和氢氧同位素的泰安城区岩溶地下水补给来源及演化过程

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环境科学 2024年第4期45卷 2096-2106页

作者：孟令华中化地质矿山总局山东地质勘查院泰安271000

泰安市城区岩溶地下水较丰富,是重要的地下水供水水源地.基于泰安城区岩溶水和地表水的水化学和氢氧同位素(δD、δ^(18)O和~3H)特征,结合Gibbs图解、主要离子比值,揭示岩溶地下水补给来源、补给年代、循环更新能力及主要的水-岩作用演... 详细信息

泰安市城区岩溶地下水较丰富,是重要的地下水供水水源地.基于泰安城区岩溶水和地表水的水化学和氢氧同位素(δD、δ^(18)O和~3H)特征,结合Gibbs图解、主要离子比值,揭示岩溶地下水补给来源、补给年代、循环更新能力及主要的水-岩作用演化过程.结果表明,区内岩溶地下水阳离子以Ca^(2+)和Na^(+)为主,阴离子以HCO_(3)^(-)和SO_(4)^(2-)为主,K^(+)、NO_(3)^(-)、Cl^(-)、Na^(+)和SO_(4)^(2-)的变异系数较大,空间差异性较强,Ca^(2+)和HCO_(3)^(-)的含量较稳定.水化学类型复杂多变,主要为HCO_(3)·SO_(4)-Ca型、HCO_(3)·Cl-Ca型和HCO_(3)-Ca型.大气降水是岩溶地下水和地表水的主要补给来源,地下水在径流过程中经历了一定的蒸发作用,但影响性相对较小;岩溶地下水~3H含量介于3.0~5.4 TU之间,与现代水(指1952年核爆以后)水力联系密切,循环更新能力较强,更容易遭受污染,在开发利用时应加强水资源保护.岩溶地下水水化学演化特征受岩石风化作用、阳离子交替吸附作用和人类活动的共同影响,水化学成分主要来源于碳酸盐矿物及少量硅铝酸盐矿物的风化溶解,其演化主要受方解石等贫镁矿物的溶解作用影响,白云岩风化溶解作用影响较小.

关键词：岩溶地下水水化学特征氢氧同位素水-岩作用泰安城区

Early-onset and later-onset cancer:trends,risk factors,and prevention in Northern China

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Science China(Life Sciences) 2024年第9期67卷 1928-1940页

作者： Tong Liu Chen-An Liu Qing-Song Zhang Qi Zhang Yi-Ming Wang meng-meng Song Shi-Qi Lin Li Deng Shou-ling Wu Han-Ping Shi Department of Gastrointestinal Surgery Department of Clinical NutritionBeijing Shijitan HospitalCapital Medical UniversityBeijing 100038China National Clinical Research Center for Geriatric Diseases Xuanwu HospitalCapital Medical UniversityBeijing 100053China Key Laboratory of Cancer FSMP for State Market Regulation Beijing 100038China Laboratory for Clinical Medicine Capital Medical UniversityBeijing 100038China Department of General Surgery Kailuan General HospitalTangshan 063000China Department of Genetics Yale School of MedicineNew Haven 06510USA Department of Hepatobiliary Surgery Kailuan General HospitalTangshan 063000China Cardiovascular Research Institute University of CaliforniaSan Francisco 94158USA Department of Cardiology Kailuan General HospitalTangshan 063000China

The characteristics of early-onset(onset age<50 years)and later-onset(onset age≥50 years)cancers differ *** novel risk factors for both types of cancer is crucial for increasing awareness of cancer prevention and for reducing its *** study aimed to analyze the trends in incidence and risk factors for early-onset and late-onset *** conducted a prospective study by drawing data from the Kailuan *** study included 6,741 participants with cancer(624 with early-onset cancer and 6,117 with later-onset cancer)and 6,780 matched controls among the 186,249 participants who underwent Kailuan health examinations from 2006 to *** primary outcomes were cancer incidence rates,and associated risk factors for early-and later-onset *** Cox regression was used to calculate hazard ratios and 95% confidence intervals of each exposure factor for early-and later-onset cancer by cancer *** risk proportions were used to estimate the number of cases that could be prevented by eliminating a risk factor from the *** for liver cancer,incidence rates for nearly all types of cancer increased during the study ***,alcohol consumption,lipid metabolism disorders,hypertension,diabetes mellitus,fatty liver,and inflammation were associated with a significantly increased risk of cancer at multiple sites,but risk factors for cancer incidence differed by ***,alcohol consumption,inflammation,and hypertension were the major contributors to preventable *** incidence of several different types of cancer,including earlyonset cancer,is increasing in northeastern *** in risk factors between early-onset and later-onset malignancies may contribute to the divergence in the observed changes in incidence trends between these two specific types of cancer.

关键词： cancer early-onset later-onset trend risk factor prevention