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Senktide blocks aberrant RTN3 interactome to retard memory decline and tau pathology in social isolated Alzheimer’s disease mice

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Protein & Cell 2024年第4期15卷 261-284页

作者： He-Zhou Huang Wen-Qing Ai Na Wei ling-Shuang Zhu zhi-Qiang Liu Chao-Wen Zhou Man-Fei Deng Wen-Tao Zhang Jia-Chen Zhang Chun-Qing Yang Ya-Zhuo Hu zhi-Tao Han Hong-Hong Zhang Jian-Jun Jia Jing Wang Fang-Fang Liu Ke Li Qi Xu Mei Yuan Hengye Man Ziyuan Guo Youming Lu Kai Shu ling-Qiang Zhu Dan Liu Department of Pathophysiology School of Basic MedicineTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Medical Genetics School of Basic MedicineTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Pathology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450002China Department of Pathology School of Basic MedicineZhengzhou UniversityZhengzhou 450002China The Second Affiliated Hospital Department of NeurologyHengyang Medical SchoolUniversity of South ChinaHengyang 421001China Beijing Key Laboratory of Aging and Geriatrics National Clinical Research Center for Geriatric DiseaseInstitute of GeriatricsChinese PLA General Hospital and Chinese PLA Medical AcademyBeijing 100853China Department of Neurosurgery Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Neurology Union HospitalHuazhong University of Science and TechnologyWuhan 430022China Department of Biology Boston UniversityBostonMA 02215USA Center for Stem Cell and Organoid Medicine(CuSTOM) Division of Developmental BiologyCincinnati Children’s Hospital Medical CenterCincinnatiOH 45229USA

Sporadic or late-onset Alzheimer’s disease(LOAD)accounts for more than 95%of Alzheimer’s disease(AD)cases without any family *** genome-wide association studies have identified associated risk genes and loci for LOAD,numerous studies suggest that many adverse environmental factors,such as social isolation,are associated with an increased risk of ***,the underlying mechanisms of social isolation in AD progression remain *** the current study,we found that 7 days of social isolation could trigger pattern separation impairments and presynaptic abnormalities of the mossy fibre-CA3 circuit in AD *** also revealed that social isolation disrupted histone acetylation and resulted in the downregulation of 2 dentate gyrus(DG)-enriched miRNAs,which simultaneously target reticulon 3(RTN3),an endoplasmic reticulum protein that aggregates in presynaptic regions to disturb the formation of functional mossy fibre boutons(MFBs)by recruiting multiple mitochondrial and vesicle-related ***,the aggregation of RTN3 also recruits the PP2A B subunits to suppress PP2A activity and induce tau hyperphosphorylation,which,in turn,further elevates RTN3 and forms a vicious ***,using an artificial intelligence-assisted molecular docking approach,we determined that senktide,a selective agonist of neurokinin3 receptors(NK3R),could reduce the binding of RTN3 with its ***,application of senktide in vivo effectively restored DG circuit disorders in socially isolated AD *** together,our findings not only demonstrate the epigenetic regulatory mechanism underlying mossy fibre synaptic disorders orchestrated by social isolation and tau pathology but also reveal a novel potential therapeutic strategy for AD.

关键词： Alzheimer’s disease memory impairment synaptic disorder tau pathology

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The Bright Single Pulse Emission from PSR B1133+16

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Research in Astronomy and Astrophysics 2024年第4期24卷 253-261页

作者： Jun Tan zhi-Gang Wen Zhen Wang Xue-Feng Duan Hong-Guang Wang Na Wang Vishal Gajjar Jian-Ping Yuan Rai Yuen Wen-Ming Yan Jian-ling Chen Wei Han Hui Wang Cheng-Bing Lyu Ai-Jun Dong Maths and Information Technology School Yuncheng UniversityYuncheng 044000China Xinjiang Astronomical Observatory Chinese Academy of SciencesUrumqi 830011China Xinjiang Key Laboratory of Radio Astrophysics Urumqi 830011China School of Physics and Materials Science Guangzhou UniversityGuangzhou 510006China Space Science Laboratory University of CaliforniaBerkeley 94710USA Department of Physics and Electronic Engineering Yuncheng UniversityYuncheng 044000China School of Physics and Electronic Science Guizhou Normal UniversityGuiyang 550025China

We have conducted a comprehensive investigation into the bright single pulse emission from PSR B1133+16using the Giant Metrewave Radio *** time resolution data(61μs)were obtained at a center frequency of 322 MHz with a bandwidth of 32 MHz over a continuous observation period of 7.45 hr.A total of 1082 bright pulses were sporadically detected with peak flux densities ranging from 10 to 23 times stronger than the average pulse ***,no giant pulse-like emission with a relative pulse energy larger than 10 and extremely short duration was detected,indicating that these bright pulses cannot be categorized as giant pulse *** majority of these bright pulses are concentrated in pulse phases at both the leading and trailing windows of the average pulse profile,with an occurrence ratio of approximately *** pulse energy distribution for all individual pulses can be described by a combination of two Gaussian components and a cutoff power-law with an index of α=-*** updated nulling fraction of 15.35%±0.45% was determined from the energy *** emission of individual pulses follows a log-normal distribution in peak flux density *** is imperative that regular phase drifting in bright pulse sequence is identified in both the leading and trailing components for the first *** physical mechanisms are discussed in detail to provide insights into these observations.

关键词： (stars:)pulsars:general (stars:)pulsars:individual(PSR B1133+16) methods:observational methods:data analysis

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Eruptive xanthomas in a patient with severe hypertriglyceridemia:A case report

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World Journal of Clinical Cases 2024年第16期12卷 2842-2846页

作者： Ci Ren ling Zhu Yan-Chao niu Lian-Yu Tu Zhou-Feng Jin Jian Zhang Department of Dermatological Surgery Shenyang Seventh People’s HospitalShenyang 110003Liaoning ProvinceChina Department of Medical Technology Sichuan Nursing Vocational CollegeChengdu 610100Sichuan ProvinceChina Department of Dermatovenereology Chengdu Second People’s HospitaChengdu 610021Sichuan ProvinceChina Department of Plastic Surgery Shenyang Mingliu Plastic Surgery and Aesthetics HospitalShenyang 110000Liaoning ProvinceChina

BACKGROUND Xanthomatosis,a metabolic disorder causing yellow growths(xanthomas),poses challenges in lipid *** case study introduces the first documented instance within China's Yi population,emphasizing the need to explore dietary habits and treatment strategies tailored to this specific *** SUMMARY Xanthomatosis is a metabolic disorder where lipid metabolism goes awry,resulting in the development of yellowish growths called xanthomas.A male patient,47 years of age,from China's Yi population,who is obese,visited our dermatology clinic complaining of widespread,non-painful rashes that have been present for two *** patient works as a chef and has a diet that frequently includes oily and greasy *** case represents the initial documentation of xanthomatosis within the Yi population in China,offering a theoretical foundation for understanding dietary patterns and treatment options specific to the Yi *** The first report of xanthomatosis in the Yi population in China lays a theoretical foundation for understanding Yi dietary patterns and treatment.

关键词： Eruptive xanthomas Hypertriglyceridemia Yi ethnicity Dermatology Chef Case report

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Establishment and performance analysis of a new multiplex detection method for influenza an and B virus antigen

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World Journal of Clinical Cases 2024年第23期12卷 5338-5345页

作者： Cheng-Jing Xia Bao-Hua Li Yan-Ni Guo Xiao-He Zhou Run-ling Zhang Ying-No niu Department of Clinical Laboratory West WingShenzhen Hospital(Guangming)of University of Chinese Academy of SciencesShenzhen 518106Guangdong ProvinceChina Laboratory Nanjing Vazyme Biotech Co.LtdNanjing 210033Jiangsu ProvinceChina

BACKGROUND Influenza A and B virus detection is pivotal in epidemiological surveillance and disease *** and accurate diagnostic techniques are crucial for timely clinical intervention and outbreak *** dot-encoded microspheres have been widely used in *** integration of quantum dot-encoded microspheres with flow cytometry is a well-established technique that enables rapid ***,establishing a multiplex detection method for influenza A and B virus antigens based on flow cytometry quantum dot microspheres will help in disease *** To establish a codetection method of influenza A and B virus antigens based on flow cytometry quantum dot-encoded microsphere technology,which forms the foundation for the assays of multiple respiratory virus *** Different quantum dot-encoded microspheres were used to couple the monoclonal antibodies against influenza A and *** known influenza A and B antigens were detected both separately and simultaneously on a flow cytometer,and the detection conditions were optimized to establish the influenza A and B antigen codetection method,which was utilized for their detection in clinical *** results were compared with the fluorescence quantitative polymerase chain reaction(PCR)method to validate the clinical performance of this *** The limits of detection of this method were 26.1 and 10.7 pg/mL for influenza A and B antigens,respectively,which both ranged from 15.6 to 250000 pg/*** the clinical sample evaluation,the proposed method well correlated with the fluorescent quantitative PCR method,with positive,negative,and overall compliance rates of 57.4%,100%,and 71.6%,*** A multiplex assay for quantitative detection of influenza A and B virus antigens has been established,which is characterized by high sensitivity,good specificity,and a wide detection range and is promising for clinical applications.

关键词： Influenza A Influenza B Quantum dot microspheres Antigen detection Multiplex detection

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新时期小额信贷与相对贫困治理:理论逻辑与案例证据

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华南师范大学学报（社会科学版） 2024年第1期 41-55,205页

作者：罗玲吴本健牛林漪中央民族大学经济学院北京100081

国际上小额信贷扶贫面临着金融机构“寻租、财务不可持续、腐败”和借款人“利率高、过度负债”等问题,而中国2014年创新设计的扶贫小额信贷对“支持贫困群众发展生产发挥了重要作用,要继续坚持”。进入全面建成小康社会的新时期,扶贫... 详细信息

国际上小额信贷扶贫面临着金融机构“寻租、财务不可持续、腐败”和借款人“利率高、过度负债”等问题,而中国2014年创新设计的扶贫小额信贷对“支持贫困群众发展生产发挥了重要作用,要继续坚持”。进入全面建成小康社会的新时期,扶贫小额信贷转为脱贫人口小额信贷,目标由“解决绝对贫困”转向“缓解相对贫困、推进共同富裕”。从理论上分析新时期小额信贷管理制度改革、服务方式创新对相对贫困的影响,发现:新时期小额信贷一方面通过管理制度改革化解现实困境,包括通过转变支持对象、规范贷款用途化解“过度需求”“借款者金融素养缺乏”等问题,通过改革贷款利率、放宽贷款金额限制化解“财务难以可持续”难题,增加信贷供给;另一方面通过服务方式数字化转型缓解“财务难以可持续”难题,提升服务质量,增加信贷供给,优化风险管理,进而缓解收入、机会、能力和主观维度的相对贫困。利用宁夏回族自治区盐池县小额信贷数据进行案例分析,发现:盐池县在落实新时期小额信贷相关政策的基础上,通过建立整村授信数据库、实施网格化管理和动态监测等创新举措,促使相对贫困群体“贷得到”“用得好”“还得上”小额信贷,显著缓解了相对贫困。因此,应继续坚持新时期小额信贷,改革优化管理制度,利用数字技术优化服务,推动其在支持相对贫困群体发展中继续发挥重要作用。

关键词：新时期小额信贷相对贫困治理农村金融

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资源与能力匹配下的中小企业数字化转型研究

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科学学研究 2024年第4期42卷 766-777页

作者：牛璐陈志军刘振山东大学管理学院山东济南250100 山东大学国际创新转化学院山东青岛266237

中小企业的数字化转型是我国数字中国建设中的重要组成部分。虽然已有研究在中小企业数字化转型对效率和绩效提升等方面的检验已取得较大突破,但忽视了其转型前因的探索,特别是多种前因要素的综合影响对中小企业数字化转型模式选择的作... 详细信息

中小企业的数字化转型是我国数字中国建设中的重要组成部分。虽然已有研究在中小企业数字化转型对效率和绩效提升等方面的检验已取得较大突破,但忽视了其转型前因的探索,特别是多种前因要素的综合影响对中小企业数字化转型模式选择的作用尚不明晰。本研究基于中小企业资源和能力相对有限的重要特征,从资源与能力匹配的视角,探究不同要素禀赋组合下中小企业会构建何种数字化转型模式。通过对128家中小企业的问卷调查,借助fsQCA方法进行前因的组态分析,研究结果表明:(1)企业资源和动态能力之间存在“多重并发”的效应,可以通过不同的组合路径实现7种数字化模式的转型发展;(2)将7类模式进一步聚类并提出适用于资源实力较强而动态能力较弱的资源推动型辅助价值链转型、资源实力均衡但动态能力突出的能力拉动型增值价值链转型以及小型及微型企业适用的并行式数字化转型。研究丰富了中小企业数字化转型中前因要素的研究,并为中小企业的数字化转型实践提供了参考。

关键词：中小企业数字化转型资源动态能力

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Enhanced conductivity and weakened magnetism in Pb-doped Sr2IrO4

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Chinese Physics B 2024年第1期33卷 696-701页

作者：岳智来甄伟立牛瑞焦珂珂朱文卡皮雳张昌锦 High Magnetic Field Laboratory Hefei Institutes of Physical ScienceChinese Academy of Sciences Science Island Branch of Graduate School University of Science and Technology of China Collaborative Innovation Center of Advanced Microstructures Nanjing University

Group IV element Pb has been selected as the dopant to dope at the Sr site of Sr2IrO4. It is exciting to find that the single-phase crystal structure could be maintained with a high Pb doping level of up to x=0.3 in Sr2-xPbxIrO4. The mapping data obtained from energy-dispersive x-ray spectroscopy analyses give solid evidence that the Pb ions are uniformly distributed in the Sr2IrO4matrix. The incorporation of Pb leads to a moderate depression of the canted antiferromagnetic ordering state. The electrical conductivity could be greatly enhanced when the Pb doping content is higher than x=*** present results give a fresh material base to explore new physics in doped Sr2IrO4systems.

关键词： iridates doping conductivity magnetism

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高熵型MnCuNiFeZn阻尼合金的高温阻尼行为与相变特征

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材料工程 2024年第1期52卷 193-199页

作者：梅玲牛红康丁双东田青超上海大学省部共建高品质特殊钢冶金与制备国家重点实验室上海200444 南通东凯精密科技有限公司江苏南通226534

制备了新型MnCuNiFeZn高熵阻尼合金,利用X射线衍射仪、扫描电镜、透射电镜、动态热机械分析仪(DMA)与热膨胀仪等研究其微观组织、阻尼特性以及相变特征。研究表明,在固溶以及不同时效工艺下,MnCuNiFeZn合金均为单一母相,合金晶粒大小均... 详细信息

制备了新型MnCuNiFeZn高熵阻尼合金,利用X射线衍射仪、扫描电镜、透射电镜、动态热机械分析仪(DMA)与热膨胀仪等研究其微观组织、阻尼特性以及相变特征。研究表明,在固溶以及不同时效工艺下,MnCuNiFeZn合金均为单一母相,合金晶粒大小均匀,呈现出高位错密度特征。随着时效时间的延长,合金常温下发生磁性转变,但常温段的内耗值很低;在673 K以上的高温域,MnCuNiFeZn合金因相变使得内耗值急剧提高。

关键词： Mn基高熵合金内耗相变高温阻尼性能

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喷淋水膜对固体表面红外辐射抑制研究

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红外与毫米波学报 2024年第2期43卷 279-287页

作者：杨斌刘志凌韩磊李智伟王振安一峰黄志锋武汉大学动力与机械学院湖北武汉430072 中国舰船研究设计中心湖北武汉430064

本文为揭示喷淋水膜对固体表面的红外辐射抑制机理并建立准确的红外辐射计算方法,开展了水膜对固体表面红外辐射影响规律的理论和实验研究,表明在8~12μm波段,水膜厚度大于100μm时,覆盖水膜固体表面的红外辐射特征主要取决于水膜的红... 详细信息

本文为揭示喷淋水膜对固体表面的红外辐射抑制机理并建立准确的红外辐射计算方法,开展了水膜对固体表面红外辐射影响规律的理论和实验研究,表明在8~12μm波段,水膜厚度大于100μm时,覆盖水膜固体表面的红外辐射特征主要取决于水膜的红外辐射。建立了覆盖水膜固体表面的红外辐射传输模型,对文献中常用计算方法的结果精度进行了分析。采用水膜自由表面温度计算红外辐射误差小于0.3%,而采用固体表面温度计算红外辐射最大误差达8.32%。

关键词：水膜固体表面喷淋降温红外辐射

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团体心理辅导对初中生生命意义感的干预研究

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忻州师范学院学报 2024年第4期40卷 130-134页

作者：周玲王静刘智忻州师范学院教育系

为探讨团体心理辅导对初中生生命意义感的影响，采用实验组、对照组前后测的实验设计，选取X中学的40名初中生作为研究对象，对实验组学生进行干预，对照组学生无任何实验处理。运用SPSS20.0对前、后测的生命意义感数据进行统计分析。... 详细信息

为探讨团体心理辅导对初中生生命意义感的影响，采用实验组、对照组前后测的实验设计，选取X中学的40名初中生作为研究对象，对实验组学生进行干预，对照组学生无任何实验处理。运用SPSS20.0对前、后测的生命意义感数据进行统计分析。结果显示：团体心理辅导干预前，两组被试的生命意义感基线水平一致；干预后，实验组的生命意义感及各维度的测量值与对照组相比有明显差异(p<0.05);实验组后测的生命意义感及各维度的得分均高于前测，差异显著(p<0.05)。团体心理辅导对改善初中生生命意义感是有效的，可以在初中生生命教育有关活动中进行推广，服务于高质量教育发展阶段初中生的生命教育。

关键词：生命意义感团体心理辅导初中生

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