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Coagulation indices and fibrinogen degradation products as predictive biomarkers for tumor-node-metastasis staging and metastasis in gastric cancer

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 110-120页

作者： Yi-Qing Shen Qiu-Wan Wei Yi-Ren Tian Yun-zhi ling Min Zhang Clinical Laboratory Civil Aviation Shanghai HospitalGubei Branch of Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200000China Clinical Laboratory Tongji Hospital of Tongji UniversityShanghai 200000China

BACKGROUND Gastric cancer(GC)is a prevalent malignancy with a substantial health burden and high mortality rate,despite advances in prevention,early detection,and *** with the global average,Asia,notably China,reports disproportionately high GC *** disease often progresses asymptoma-tically in the early stages,leading to delayed diagnosis and compromised ***,it is crucial to identify early diagnostic biomarkers and enhance treatment strategies to improve patient outcomes and reduce *** Retrospectively analyzed the clinical data of 148 patients with GC treated at the Civil Aviation Shanghai Hospital between December 2022 and December *** associations of coagulation indices-partial thromboplastin time(APTT),prothrombin time(PT),thrombin time(TT),fibrinogen,fibrinogen degradation products(FDP),fasting blood glucose,and D-dimer(D-D)with TNM stage and distant metastasis were *** Prolongation of APTT,PT,and TT was significantly correlated with the GC TNM ***,abnormal coagulation system activation was closely related to disease *** FDP and D-D were significantly associated with distant metastasis in GC(P<0.05),suggesting that increased fibrinolytic activity contributes to increased metastatic *** Our Results reveal coagulation indices,FDPs as GC biomarkers,reflecting abnormal coagulation/fibrinolysis,aiding disease progression,metastasis prediction,and helping clinicians assess thrombotic risk for early intervention and personalized treatment plans.

关键词： Coagulation indexes Fibrinogen degradation products Gastric cancer Tumor-node-metastasis staging Distant metastasis

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基于小波模糊神经网络的陀螺仪故障诊断技术

上海交通大学学报 2003年第1期37卷 141-144页

作者：樊春玲金志华田蔚风上海交通大学电子信息学院上海200030

为了提高陀螺仪故障检测灵敏度 ,分析了陀螺漂移特性 ,指出随机漂移是影响陀螺仪精度的主要漂移误差 ,也是影响性能可靠性的主要因素 .针对此 ,提出了一种小波模糊神经网络故障诊断模型 .此模型运用串联方式将小波分析、模糊逻辑和神经... 详细信息

为了提高陀螺仪故障检测灵敏度 ,分析了陀螺漂移特性 ,指出随机漂移是影响陀螺仪精度的主要漂移误差 ,也是影响性能可靠性的主要因素 .针对此 ,提出了一种小波模糊神经网络故障诊断模型 .此模型运用串联方式将小波分析、模糊逻辑和神经网络融合在一起 ,充分发挥它们各自的优点 ,并对陀螺仪实测数据仿真 .仿真结果表明 ,采用小波分析提取陀螺的常值漂移 ,简单有效 ;运用神经网络对陀螺的误差和故障建模 ,使故障诊断具有自适应、自学习的能力 ,并且增强了故障诊断的容错能力 ;将模糊逻辑用于判决中。

关键词：陀螺仪故障诊断小波模糊神经网络随机漂移小波分析模糊逻辑惯性导航系统

Induced pluripotent stem cell-related approaches to generate dopaminergic neurons for Parkinson's disease

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Neural Regeneration Research 2025年第11期20卷 3193-3206页

作者： ling-Xiao Yi Hui Ren Woon Genevieve Saw Li Zeng Eng King Tan zhi Dong Zhou National Neuroscience Institute Singapore Nanyang Technology University Singapore Department of Neurology Singapore General HospitalSingapore Signature Research Program in Neuroscience and Behavioral Disorders Duke-NUS Medical SchoolSingapore

The progressive loss of dopaminergic neurons in affected patient brains is one of the pathological features of Parkinson's disease,the second most common human neurodegenerative *** the detailed pathogenesis accounting for dopaminergic neuron degeneration in Parkinson's disease is still unclear,the advancement of stem cell approaches has shown promise for Parkinson's disease research and *** induced pluripotent stem cells have been commonly used to generate dopaminergic neurons,which has provided valuable insights to improve our understanding of Parkinson's disease pathogenesis and contributed to anti-Parkinson's disease *** current review discusses the practical approaches and potential applications of induced pluripotent stem cell techniques for generating and differentiating dopaminergic neurons from induced pluripotent stem *** benefits of induced pluripotent stem cell-based research are *** dopaminergic neuron differentiation protocols from induced pluripotent stem cells are *** emerging three-dimension-based brain organoid models compared with conventional two-dimensional cell culture are ***,limitations,challenges,and future directions of induced pluripotent stem cell–based approaches are analyzed and proposed,which will be significant to the future application of induced pluripotent stem cell-related techniques for Parkinson's disease.

关键词： dopaminergic neurons induced pluripotent stem cells Parkinson's disease stem cell approaches

Social function scores and influencing factors in patients with residual depressive symptoms

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World Journal of Psychiatry 2025年第1期15卷 117-127页

作者： Zong-ling Liao Xiao-Li Pu zhi-Yi Zheng Jie Luo Department 1 of Psychiatry Gele Mountain Hospital of Chongqing Mental Health CenterChongqing 400030China Department of Psychology Chongqing Jiangjin District Psychiatric HospitalChongqing 402260China Department of Psychiatry Chongqing Third Social Welfare InstituteChongqing 400036China Women and Children’s Mental Health Center Affiliated Hospital of Chongqing Population and Family Planning Research InstituteChongqing 400020China

BACKGROUND At present,the influencing factors of social function in patients with residual depressive symptoms are still *** depressive symptoms are highly harmful,leading to low mood in patients,affecting work and interpersonal communication,increasing the risk of recurrence,and adding to the burden on *** the influencing factors of their social function is of great *** To explore the social function score and its influencing factors in patients with residual depressive *** This observational study surveyed patients with residual depressive symptoms(case group)and healthy patients undergoing physical examinations(control group).Participants were admitted between January 2022 and December *** functioning was assessed using the Sheehan Disability Scale(SDS),and scores were compared between *** influencing SDS scores in patients with residual depressive symptoms were analyzed by applying multiple linear regression while using the receiver operating characteristic curve,and these RESULTS The SDS scores of the 158 patients with depressive symptoms were 11.48±*** with the control group,the SDS scores and all items in the case group were *** scores were higher in patients with relapse,discon-tinuous medication,drug therapy alone,severe somatic symptoms,obvious residual symptoms,and anxiety scores≥*** history,medication compliance,therapy method,and residual symptoms correlated positively with SDS scores(r=0.354,0.414,0.602,and 0.456,respectively).Independent influencing factors included disease history,medication compliance,therapy method,somatic symptoms,residual symptoms,and anxiety scores(P<0.05).The areas under the curve for predicting social functional impairment using these factors were 0.713,0.559,0.684,0.729,0.668,and 0.628,respectively,with sensitivities of 79.2%,61.8%,76.8%,81.7%,63.6%,and 65.5%and specificities of 83.3%,87.5%,82.6%,83.3%,86.7%,and 92.1%,respectively.C

关键词： Depressive Residual symptoms Social function Influence factors

Drosophila models used to simulate human ATP1A1 gene mutations that cause Charcot-Marie-Tooth type 2 disease and refractory seizures

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Neural Regeneration Research 2025年第1期20卷 265-276页

作者： Yao Yuan lingqi Yu Xudong Zhuang Dongjing Wen jin He jingmei Hong Jiayu Xie Shengan ling Xiaoyue Du Wenfeng Chen Xinrui Wang Institute of Life Sciences College of Biological Science and EngineeringFuzhou UniversityFuzhouFujian ProvinceChina NHC Key Laboratory of Technical Evaluation of Fertility Regulation for Non-human Primate(Fujian Maternity and Child Health Hospital) FuzhouFujian ProvinceChina Medical Research Center Fujian Maternity and Child Health HospitalCollege of Clinical Medicine for Obstetrics&Gynecology and PediatricsFujian Medical UniversityFuzhouFujian ProvinceChina Department of Neurology and Institute of Neurology of The First Affiliated Hospital Institute of Neuroscienceand Fujian Key Laboratory of Molecular NeurologyFujian Medical UniversityFuzhouFujian ProvinceChina

Certain amino acids changes in the human Na^(+)/K^(+)-ATPase pump,ATPase Na^(+)/K^(+)transporting subunit alpha 1(ATP1A1),cause Charcot-Marie-Tooth disease type 2(CMT2)disease and refractory *** develop in vivo models to study the role of Na^(+)/K^(+)-ATPase in these diseases,we modified the Drosophila gene homolog,Atpα,to mimic the human ATP1A1 gene mutations that cause *** located within the helical linker region of human ATP1A1(I592T,A597T,P600T,and D601F)were simultaneously introduced into endogenous Drosophila Atpαby CRISPR/Cas9-mediated genome editing,generating the Atpα^(TTTF)*** addition,the same strategy was used to generate the corresponding single point mutations in flies(Atpα^(I571T),Atpα^(A576T),Atpα^(P579T),and Atpα^(D580F)).Moreover,a deletion mutation(Atpα^(mut))that causes premature termination of translation was generated as a positive *** these alleles,we found two that could be maintained as homozygotes(Atpα^(I571T)and Atpα^(P579T)).Three alleles(Atpα^(A576T),Atpα^(P579)and Atpα^(D580F))can form heterozygotes with the Atpαmut *** found that the Atpαallele carrying these CMT2-associated mutations showed differential phenotypes in *** heterozygous for Atpα^(TTTF)mutations have motor performance defects,a reduced lifespan,seizures,and an abnormal neuronal *** Drosophila models will provide a new platform for studying the function and regulation of the sodium-potassium pump.

关键词： ATP1A1 Atpα bang-sensitive paralysis Charcot-Marie-Tooth disease type 2 CRISPR/Cas9 homology-directed repair Na^(+)/K^(+)-ATPase point mutation seizures sodium pump

Kangfuxin solution alleviates esophageal stenosis after endoscopic submucosal dissection:A natural ingredient strategy

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World Journal of Gastroenterology 2025年第1期31卷 110-125页

作者： Xin Zhou Dan Ma Yi-Xiang He jing jin Hong-Lian Wang Yun-Feng Wang Fan Yang Jian-Qin Liu Jie Chen zhi Li Department of Spleen and Stomach Diseases the Affiliated Traditional Chinese Medicine HospitalSouthwest Medical UniversityLuzhou 646000Sichuan ProvinceChina The Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Digestive System Diseases of Luzhou City The Affiliated Traditional Medicine HospitalSouthwest Medical UniversityLuzhou 646000Sichuan ProvinceChina Department of Gastroenterology Changhai HospitalNaval Medical UniversityShanghai 20082China Research Center of Integrated Chinese and Western Medicine The Affiliated Traditional Chinese Medicine HospitalSouthwest Medical UniversityLuzhou 646000Sichuan ProvinceChina School of Integrated Traditional Chinese and Western Clinical Medicine North Sichuan Medical CollegeNanchong637100Sichuan ProvinceChina

BACKGROUND Esophageal stricture ranks among the most significant complications following endoscopic submucosal dissection(ESD).Excessive fibrotic repair is a typical pathological feature leading to stenosis after *** To examine the effectiveness and underlying mechanism of Kangfuxin solution(KFX)in mitigating excessive fibrotic repair of the esophagus *** Pigs received KFX at 0.74 mL/kg/d for 21 days after esophageal full circumferential *** examinations occurred on days 7 and 21 *** vitro,recombinant transforming growth factor(TGF)-β1(5 ng/mL)induced a fibrotic microenvironment in primary esophageal fibroblasts(pEsF).After 24 hours of KFX treatment(at 1.5%,1%,and 0.5%),expression ofα-smooth muscle actin-2(ACTA2),fibronectin(FN),and type collagen I was *** signaling was analyzed,including TGF-β1,Smad2/3,and phosphor-smad2/3(p-Smad2/3).RESULTS Compared to the Control group,the groups treated with KFX and prednisolone exhibited reduced esophageal stenosis,lower weight loss rates,and improved food tolerance 21 d after *** treatment,Masson staining revealed thinner and less dense collagen fibers in the submucosal ***,the expression of fibrotic effector molecules was notably ***,KFX downregulated the transduction levels of fibrotic functional molecules such as TGF-β1,Smad2/3,and p-Smad2/*** vitro,pEsF exposed to TGF-β1-induced fibrotic microenvironment displayed increased fibrotic activity,which was reversed by KFX treatment,leading to reduced activation of ACTA2,FN,and collagen *** 1.5%KFX treatment group showed decreased expression of p-Smad 2/3 in TGF-β1-activated *** KFX showed promise as a therapeutic option for post-full circumferential esophageal ESD strictures,potentially by suppressing fibroblast fibrotic activity through modulation of the TGF-β1/Smads signaling pathway.

关键词： Kangfuxin solution Natural component Endoscopic submucosal dissection Esophagus stricture Fibrosis

红芪多糖对糖尿病心肌病db/db小鼠心肌损伤的改善作用

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中国临床药理学杂志 2017年第5期33卷 418-422页

作者：和彩玲金智生张花治王东旭南向萍石桂珍甘肃中医学院中医临床学院兰州730000

目的研究红芪多糖(HPS)对糖尿病心肌病(DC)db/db小鼠心肌组织中过氧化物酶体增值物激活受体γ(PPAR-γ)及葡萄糖转运蛋白4(GLu T4)在心肌组织表达的影响。方法根据体重大小将6周龄的雄性db/db小鼠随机分为5组:模型组(0.9%Na Cl 0.2 m L... 详细信息

目的研究红芪多糖(HPS)对糖尿病心肌病(DC)db/db小鼠心肌组织中过氧化物酶体增值物激活受体γ(PPAR-γ)及葡萄糖转运蛋白4(GLu T4)在心肌组织表达的影响。方法根据体重大小将6周龄的雄性db/db小鼠随机分为5组:模型组(0.9%Na Cl 0.2 m L·d^(-1))、对照组(罗格列酮,4 mg·kg^(-1)·d^(-1))、大中小3个剂量(HPS 200,100,50 mg·kg^(-1)·d^(-1))实验组;正常组(0.9%Na Cl0.2 m L·d^(-1))为同周龄同背景非转基因db/m小鼠12只。连续灌胃8周。于给药前及给药后第2,4,6,8周末,检测小鼠血糖浓度;第8周末处死小鼠,心脏取血并分离血清。用生化法检测血脂及心肌组织中超氧化物歧化酶(SOD)与还原型谷胱甘肽(GSH-PX)活性及丙二醛(MDA)含量;用反转录聚合酶链式反应、蛋白质印迹法检测心肌组织PPAR-γ及Glu T-4 mRNA和蛋白的表达。结果给药8周后,与模型组的血糖为(23.17±2.55)mmol·L^(-1)、三酰甘油(TG)为(5.78±0.50)mmol·L^(-1)、总胆固醇(TC)为(5.93±0.60)mmol·L^(-1)比较,高、中2个剂量实验组和对照组的血糖分别为(16.49±3.64),(17.80±4.40),(16.76±3.25),mmol·L^(-1);这3组的TG分别为(1.59±0.43),(4.02±0.54),(1.12±0.32)mmol·L^(-1);这3组的TC分别为(2.77±0.40),(4.65±0.58),(4.85±0.48)mmol·L^(-1),差异均有统计学意义(P<0.05或P<0.01)。与模型组的SOD为(140.70±1.04)mg·m L^(-1)、GSH-PX为(110.91±0.82)U·mg^(-1)、MDA为(7.20±0.49)nmol·mg^(-1)比较,这3组的SOD分别为(145.81±0.99),(142.21±1.09),(145.70±1.10)mg·m L^(-1),活性显著增强;这3组的GSH-PX分别为(114.94±0.78),(112.10±0.86),(114.84±0.86)U·mg^(-1),活性显著增强;这3组的MDA分别为(5.82±0.52),(6.62±0.67),(5.80±0.52)nmol·mg^(-1),含量显著下降,差异均有统计学意义(P<0.05或P<0.01)。与模型组的PPAR-γmRNA和PPAR-γ蛋白表达分别为0.34±0.11,0.75±0.12、GLu T4 mRNA和GLu T4蛋白表达分别为0.26±0.01,0.42±0.02比较,3个剂量实验组和对照组的PPAR-γmRNA和PPAR-γ蛋白表达分别为0.76±0.06,0.56±0.08,0.45±0.08,0.79±0.10;1.78±0.08,1.44±0.07,1.07±0.05,1.63±0.02。这4组的GLu T4 mRNA和GLu T4蛋白表达分别为0.68±0.05,0.48±0.03,0.49±0.03,0.93±0.05;0.61±0.01,0.45±0.02,0.42±0.01,0.59±0.01,差异均有统计学意义(P<0.01),尤以高剂量组为显著。结论 HPS可降低db/db小鼠的血糖、血脂,同时上调PPAR-γ及Glu T-4的表达,从而改善模型鼠糖、脂代谢紊乱,减缓糖尿病心肌病的病程进展。

关键词：糖尿病心肌病红芪多糖 db/db小鼠过氧化物酶体增殖物激活受体γ 葡萄糖转运蛋白4

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MRI对膝关节内侧副韧带损伤的诊断价值

实用放射学杂志 2006年第5期22卷 567-568页

作者：赵海玲王之平金洪先温岭市第一人民医院CTMRI室浙江温岭市第一人民医院CTMRI室浙江温岭317500

目的探讨MR I对膝关节内侧副韧带(MCL)损伤的诊断价值。方法回顾性分析20例临床可疑MCL损伤患者的MR I资料,并和手术结果作对照。结果20例MCL损伤中,Ⅰ级损伤2例,Ⅱ级损伤9例,Ⅲ级损伤9例。MR I诊断MCLⅡ、Ⅲ级损伤与手术表现符合率分别... 详细信息

目的探讨MR I对膝关节内侧副韧带(MCL)损伤的诊断价值。方法回顾性分析20例临床可疑MCL损伤患者的MR I资料,并和手术结果作对照。结果20例MCL损伤中,Ⅰ级损伤2例,Ⅱ级损伤9例,Ⅲ级损伤9例。MR I诊断MCLⅡ、Ⅲ级损伤与手术表现符合率分别为88.9%和100%。结论MR I对MCL损伤的诊断准确性高,可为临床制订治疗方案提供可靠依据。

关键词：膝关节侧副韧带磁共振成像

The CUSUM statistic of change point under NA sequences

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Applied Mathematics(A Journal of Chinese Universities) 2021年第4期36卷 512-520页

作者： ling jin LI Xiao-qin YANG Wen-zhi JIAO Jian-ling School of Management Hefei University of TechnologyHefei 230009China Center for Applied Mathematics School of Mathematical SciencesAnhui UniversityHefei 230061China

In this paper,we investigate the CUSUM statistic of change point under the neg-atively associated(NA)*** establishing the consistency estimators for mean and covariance functions respectively,the limit distribution of the CUSUM statistic is proved to be a standard Brownian bridge,which extends the results obtained under the case of an indepen-dent normal sample and the moving average ***,the finite sample properties of the CUSUM statistic are given to show the efficiency of the method by simulation studies and an application on a real data analysis.

关键词： CUSUM statistic limit distribution NA sequences Brownian bridge