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Efficacy of recombinant human epidermal growth factor plus sodium hyaluronate eye drops in diabetic dry eye post-cataract surgery

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World Journal of Diabetes 2024年第6期15卷 1234-1241页

作者： Jun-ling Li Jin Zhao zhen-Feng Guo Chang Xiao Xuan Liu Department of Ophthalmology Tianjin Beichen HospitalThe Affiliated Hospital of Nankai UniversityTianjin 300400China Department of Ophthalmology Xianyang First People’s HospitalXianyang 712000Shaanxi ProvinceChina

BACKGROUND Dry eye syndrome(DES)after diabetic cataract surgery can seriously affect the patient’s quality of ***,effective alleviation of symptoms in patients with this disease has important clinical *** To explore the clinical effect of recombinant human epidermal growth factor(rhEGF)plus sodium hyaluronate(SH)eye drops on DES after cataract surgery in patients with *** We retrospectively evaluated 82 patients with diabetes who experienced DES after cataract surgery at Tianjin Beichen Hospital,Affiliated Hospital of Nankai University between April 2021 and April *** were classified into an observation group(42 cases,rhEGF+SH eye drops)and a control group(40 cases,SH eye drops alone),depending on the different treatment *** therapeutic efficacy,dry eye symptom score,tear film breakup time(TFBUT),basic tear secretion score[assessed using Schirmer I test(SIt)],corneal fluorescein staining(FL)score,tear inflammatory markers,adverse reactions during treat-ment,and treatment satisfaction were compared between the two *** Therapeutic efficacy was higher in the observation group compared with the control *** groups showed improved TFBUT and dry eye,as well as improved SIt and FL scores after treatment,with a more pronounced improvement in the observation *** no marked differences in adverse reactions were observed between the two groups,treatment satisfaction was higher in the observation *** rhEGF+SH eye drops rendered clinical benefits to patients by effectively ameliorating dry eye and visual impairment with favorable efficacy,fewer adverse reactions,and high safety ***,this treatment should be promoted in clinical practice.

关键词： Recombinant human epidermal growth factor Sodium hyaluronate eye drops Diabetic patients Dry eye syndrome after cataract surgery Therapeutic efficacy

Enzyme-activatable disk-shaped nanocarriers augment tumor permeability for breast cancer combination therapy

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Nano Research 2024年第7期17卷 6400-6410页

作者： Hanming Zhang Honglin Gao Yicong Zhang Yikun Han Qing Lin Tao gong Xun Sun Zhirong Zhang ling Zhang Shiqi Huang Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry West China School of PharmacySichuan UniversityChengdu 610041China Med-X Center for Materials College of Polymer Science and EngineeringSichuan UniversityChengdu 610065China

Unique physiopathological characteristics of tumor tissues impose obstacles to the sufficient penetration of traditional nanomedicines,resulting in undesirable drug delivery efficacy and therapeutic ***,we constructed TRAIL-[NDHCPT]^(GAC),a synergistic hydroxycamptothecin(HCPT)and tumor necrosis factor-related apoptosis-inducing ligand(TRAIL)protein co-loaded disk-shaped nanocarrier withγ-glutamyl transpeptidase *** the novel nanodisks extravasated into the tumor interstitium,theγ-glutamyl transpeptidase overexpressed on the tumor cell membranes cleaved theγ-glutamyl portions of the nanodisk surface to produce positively charged amino *** a result,the cationic nanodisks possessed stronger tumor infiltration ability through transcytosis than anionic *** and TRAIL exerted synergistic antitumor effects with better overall therapeutic *** TRAIL-[ND-HCPT]^(GAC)system performed significantly better than free HCPT and remarkably prolonged the survival of breast tumor-bearing mice with no significant toxicity.

关键词： tumor penetration combination therapy charge reversal γ-glutamyl transpeptidase nanodisk

Efficacy comparison of multipoint and single point scanning panretinal laser photocoagulation in non-proliferative diabetic retinopathy treatment

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World Journal of Diabetes 2024年第8期15卷 1734-1741页

作者： Yang-Zhou Zhang Hua gong Juan Yang Ji-Pu Bu Hui-ling Yang Institute of Molecular Precision Medicine and Hunan Key Laboratory of Molecular Precision Medicine Xiangya HospitalCentral South UniversityChangsha 410008Hunan ProvinceChina Department of Ophthalmology Xingsheng HospitalYiyang 413200Hunan ProvinceChina Department of Ophthalmology Boshi Eye HospitalLiuyang 410300Hunan ProvinceChina Department of Ophthalmology Hunan Children‘s HospitalChangsha 410007Hunan ProvinceChina

BACKGROUND Non-proliferative diabetic retinopathy(NPDR)poses a significant challenge in diabetes management due to its microvascular changes in the *** photocoagulation,a conventional therapy,aims to mitigate the risk of progressing to proliferative diabetic retinopathy(PDR).AIM To compare the efficacy and safety of multi-spot vs single-spot scanning panretinal laser photocoagulation in NPDR *** Forty-nine NPDR patients(86 eyes)treated between September 2020 and July 2022 were *** were randomly allocated into single-spot(n=23,40 eyes)and multi-spot(n=26,46 eyes)*** outcomes,including bestcorrected visual acuity(BCVA),central macular thickness(CMT),and mean threshold sensitivity,were assessed at predetermined intervals over 12 *** reactions were also *** Energy levels did not significantly differ between groups(P>0.05),but the multi-spot group exhibited lower energy density(P0.05).CONCLUSION While energy intensity and safety were comparable between modalities,multi-spot scanning demonstrated lower energy density and showed superior short-term improvements in BCVA and CMT for NPDR patients,with reduced laser-induced damage.

关键词： Panretinal laser photocoagulation Non-proliferative diabetic retinopathy Efficacy comparison Multipoint Single point Treatment assessment

Apolipoprotein E4 interferes with lipid metabolism to exacerbate depression-like behaviors in 5xFAD mice

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Animal Models and Experimental Medicine 2024年第3期7卷 347-361页

作者： Yanju gong Mingfeng Li Min Liu Xinghan Wu Yanhong Li Chuan Qin ling Zhang iNHC Key Laboratory of Human Disease Comparative Medicine Beijing Engineering Research Center for Experimental Animal Models of Human Critical DiseasesInternational Center for Technology and lnnovation of Animal ModelComparative Medicine CenterInstitute of Laboratory Animal SciencesChinese Academy of Medical Sciences(CAMS)and Peking Union Medical College(PuMC)BeijingChina Changping National Laboratory(CPNL) BeijingChina

Background:Apolipoprotein E4(ApoE4)allele is the strongest genetic risk factor for late-onset Alzheimer's disease,and it can aggravate depressive symptoms in non-AD ***,the impact of ApoE4 on AD-associated depression-l ike behaviors and its underlying pathogenic mechanisms remain ***:This study developed a 5xFAD mouse model overexpressing human ApoE4(E4FAD).Behavioral assessments and synaptic function tests were conducted to explore the effects of ApoE4 on cognition and depression in 5xFAD *** in peripheral and central lipid metabolism,as well as the levels of serotonin(5-HT)andγ-aminobutyric acid(GABA)neurotransmitters in the prefrontal cortex,were *** addition,the protein levels of 24-dehydrocholesterol reductase/glycogen synthase kinase-3 beta/mammalian target of rapamycin(DHCR24/GSK3β/m TOR)and postsynaptic density protein 95/calmodulin-dependent protein kinase II/brain-derived neurotrophic factor(PSD95/CaMK-II/BDNF)were measured to investigate the molecular mechanism underlying the effects of ApoE4 on AD ***:Compared with 5xFAD mice,E4FAD mice exhibited more severe depressionlike behaviors and cognitive *** mice also exhibited increased amyloid-beta deposition in the hippocampus,increased astrocyte numbers,and decreased expression of depression-related neurotransmitters 5-HT and GABA in the prefrontal ***,lipid metabolism disorders were observed in E4FAD,manifesting as elevated low-density lipoprotein cholesterol and reduced high-density lipoprotein cholesterol in peripheral blood,decreased cholesterol level in the prefrontal cortex,and reduced expression of key enzymes and proteins related to cholesterol synthesis and *** expression of proteins related to the DHCR24/GSK3β/m TOR and PSD95/CaMK-II/BDNF pathways was also ***:This study found that ApoE4 overexpression exacerbates depressionlike behaviors in 5xFAD mice and confirmed that ApoE4 reduces co

关键词： 5xFAD mice Alzheimer's disease ApoE4 allele depression like

Aflatoxin B1 decreased flesh flavor and inhibited muscle development in grass carp(Ctenopharyngodon idella)

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Animal Nutrition 2024年第3期18卷 27-38页

作者： Xiang Ning He zhen zhen Zeng Wei Dan Jiang Pei Wu Yang Liu Sheng Yao Kuang ling Tang Shu Wei Li Lin Feng Xiao Qiu Zhou Animal Nutrition Institute Sichuan Agricultural UniversityChengdu 611130China Fish Nutrition and Safety Production University Key Laboratory of Sichuan Province Sichuan Agricultural UniversityChengdu 611130China Key Laboratory for Animal Disease-Resistance Nutrition Ministry of EducationMinistry of Agriculture and Rural AffairsKey Laboratory of Sichuan ProvinceChengdu 611130China Animal Nutrition Institute Sichuan Academy of Animal ScienceChengdu 610066China

In nature,aflatoxins,especially aflatoxin B1(AFB1),are the common mycotoxins,which cause serious health problems for humans and *** paper aimed to study the effects of AFB1 on flesh flavor and muscle development of grass carp(Ctenopharyngodon idella)and its *** were 1440 individual fish in total,with 6 treatments and each treatment replicated 3 *** 6 treatments were fed a control diet with different doses of AFB1(0.04,29.48,58.66,85.94,110.43 and 146.92μg/kg diet)for 60 ***1 increased myofiber diameter,as well as decreased myofiber density of grass carp muscle(Pling pathway in grass carp muscle(P<0.05).The mRNA and protein levels of myogenic regulatory factors were downregulated in grass carp muscle(P<0.05).Furthermore,the activities of matrix metalloproteinase-2(MMP-2)and matrix metalloproteinase-9(MMP-9)were increased(P<0.05),and the protein levels of phosphorylate-38 mitogen-activated protein kinase(p-p38MAPK),phosphorylate-c-Jun N-terminal kinase,urokinase-type plasminogen activator(uPA),MMP-2 and MMP-9 were upregulated(P<0.05),but collagenⅠ,lamininβ1 and fibronectin were downregulated(P<0.05)with the dietary AFB1 increased in the muscle of grass *** on the results of this study,we can draw the following conclusion:dietary AFB1 might damage flesh flavor and inhibit the muscle development through MAPK/uPA/MMP/extrac

关键词： Aflatoxin B1 Flesh flavor Muscle development Grass carp

Magmatic-tectonic response of the South China Craton to the Paleo-Pacific subduction during the Triassic:a new viewpoint based on Well NK-1

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Journal of Oceanology and Limnology 2024年第1期42卷 58-89页

作者： Chan WANG Hao LIU Gang LI zhen SUN Tingting gong Li MIAO Xiaowei ZHU Yunying ZHANG Weihai XU Wen YAN Key Laboratory of Ocean and Marginal Sea Geology South China Sea Institute of OceanologyChinese Academy of SciencesGuangzhou 510301China Southern Marine Science and Engineering Guangdong Laboratory(Guangzhou) Guangzhou 511458China Key Laboratory of Tectonic Controlled Mineralization and Oil Reservoir of Ministry of Natural Resources Chengdu University of TechnologyChengdu 610059China School of Earth Sciences and Resources China University of Geosciences(Beijing)Beijing 100083China College of Earth Science Chengdu University of TechnologyChengdu 610059China University of Chinese Academy of Sciences Beijing 100049China

The Nansha Block(NB)is one of the blocks separated from the southern margin of the South China Craton(SCC)by the western Pacific subduction,which contains rich information of geodynamic and tectonic *** reveal the essence of western Paleo-Pacific subduction during the Triassic period,Well NK-1 in this block was selected for petrographic study,and published research data from other cooperative teams were compared.A double-cycle pattern of basic to neutral magmatic volcanism was established,and 36 lithological rhythmic layers and representative cryptoexplosive breccia facies and welded tuff bands were *** with a reanalysis of published geochronological data,geochemical elements,and isotope geochemistry,we found that the rock assemblages could be divided into an intermediate-acid dacite(DA)series(SiO_(2)>65%)and basaltic(BA)series(Co<40μg/g),which was formed during the early Late Triassic((218.6±3.2)–(217.9±3.5)Ma).BA exhibits obvious calc-alkaline island-arc magmatic properties:(^(87)Sr/^(86)Sr)_i ratio ranging 0.70377–0.71118(average:0.70645),^(147)Sm/^(144)Nd ratio ranging 0.119–0.193(average:0.168),and chondrite-normalized rare earth element(REE)curves being flat,while DA exhibits remarkable characteristics of subducted island-arc andesitic magma:(^(87)Sr/^(86)Sr)_i ratio(0.70939–0.71129;average:0.71035),εNd(t)value(-6.2–-4.8;average:-5.6)andε_(Hf)(t)value(-2.9–-1.7,average:-2.2)show obvious crust-mantle mixing *** and DA reveal typical characteristics of island-arc magma systems and typeⅡenriched mantle(EM-Ⅱ)*** magma was likely resulted from the process whereby the continental crust frontal accretionary wedge was driven by the Paleo-Pacific slab subduction into the deep and began to melt,resulting in a large amount of melt(fluid)joined the asthenosphere on the side of the continental *** contrast,DA magma was likely resulted from the process whereby the plate front was forced to bend with increasing subducti

关键词： Paleo-Pacific tectonic domain tectonic evolution rift volcanic rock Nansha Block South China Craton

Data-Driven Design of Single-Atom Electrocatalysts with Intrinsic Descriptors for Carbon Dioxide Reduction Reaction

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Transactions of Tianjin University 2024年第5期30卷 459-469页

作者： Xiaoyun Lin Shiyu zhen Xiaohui Wang Lyudmila V.Moskaleva Peng Zhang Zhi-Jian Zhao Jinlong gong Key Laboratory for Green Chemical Technology of Ministry of Education School of Chemical Engineering and Technology Tianjin University Collaborative Innovation Center of Chemical Science and Engineering(Tianjin) School of Economics and Management Tianjin University of Technology and Education Department of Chemistry University of the Free State Haihe Laboratory of Sustainable Chemical Transformations National Industry-Education Platform of Energy Storage Tianjin University Joint School of National University of Singapore and Tianjin University International Campus of Tianjin University

The strategic manipulation of the interaction between a central metal atom and its coordinating environment in single-atom catalysts（SACs） is crucial for catalyzing the CO2reduction reaction（CO2RR）. However, it remains a major challenge. While density-functional theory calculations serve as a powerful tool for catalyst screening, their time-consuming nature poses limitations. This paper presents a machine learning（ML） model based on easily accessible intrinsic descriptors to enable rapid, cost-effective, and high-throughput screening of efficient SACs in complex systems. Our ML model comprehensively captures the influences of interactions between 3 and 5d metal centers and 8 C, N-based coordination environments on CO2RR activity and selectivity. We reveal the electronic origin of the different activity trends observed in early and late transition metals during coordination with N atoms. The extreme gradient boosting regression model shows optimal performance in predicting binding energy and limiting potential for both HCOOH and CO production. We confirm that the product of the electronegativity and the valence electron number of metals, the radius of metals, and the average electronegativity of neighboring coordination atoms are the critical intrinsic factors determining CO2RR activity. Our developed ML models successfully predict several high-performance SACs beyond the existing database, demonstrating their potential applicability to other systems. This work provides insights into the low-cost and rational design of high-performance SACs.

关键词： CO2 reduction reaction Density functional theory Electrocatalysts High-throughput screening Machine learning

B-cell-specific signatures reveal novel immunophenotyping and therapeutic targets for hepatocellular carcinoma

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World Journal of Gastroenterology 2024年第34期30卷 3894-3925页

作者： Ke-Quan Xu zheng gong Jia-ling Yang Chu-Qi Xia Jian-Yi Zhao Xi Chen Department of Hepatobiliary and Pancreatic Surgery Zhongnan Hospital of Wuhan UniversityWuhan 430071Hubei ProvinceChina Department of Pharmacy Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022Hubei ProvinceChina School of Basic Medical Sciences Nanjing Medical UniversityNanjing 211166Jiangsu ProvinceChina Department of Gastrointestinal Surgery The Second Affiliated Hospital of Kunming Medical UniversityKunming 650101Yunnan ProvinceChina Department of General Surgery Second People’s Hospital of Jiaozuo CityJiaozuo 454001Henan ProvinceChina

BACKGROUND Immunotherapy presents both promises and challenges in treating hepatocellular carcinoma(HCC)due to its complex immunological *** role of B cells,a key part of the immune system,remains uncertain in *** To identify B-cell-specific signatures and reveal novel immunophenotyping and therapeutic targets for *** Using the Tumor Immune Single-cell Hub 2 database,we identified B-cell-related genes(BRGs)in *** enrichment analysis was performed to explore the possible collaboration between B cells and T cells in *** conducted univariate Cox regression analysis using The Cancer Genome Atlas liver HCC collection dataset to find BRGs linked to HCC ***,least absolute shrinkage and selection operator regression was utilized to develop a prognostic model with 11 *** model was validated using the International Cancer Genome Consortium dataset and *** The risk score derived from the prognostic model emerged as an independent prognostic factor for *** of the immune microenvironment and cell infiltration revealed the immune status of various risk groups,supporting the cooperation of B and T cells in suppressing *** BRGs model identified new molecular subtypes of HCC,each with distinct immune *** sensitivity analysis identified targeted drugs effective for each HCC subtype,enabling precision therapy and guiding clinical *** We clarified the role of B cells in HCC and propose that the BRGs model offers promising targets for personalized immunotherapy.

关键词： B cell Hepatocellular carcinoma Immune microenvironment Immunotherapy Molecular subtype

New material of Coniopteris simplex from the Middle Jurassic of the Ordos Basin,Inner Mongolia,China and implications on its spatio-temporal distribution and paleogeography

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Journal of Palaeogeography 2024年第2期13卷 199-211页

作者： Yun-Feng Li Chang-Lu Zhang Fei Liang Xiao Tan Fan-Hao gong Chun-Lin Sun Tao Li Yu-ling Na Research Center of Paleontology and Stratigraphy Jilin UniversityChangchun 130026Jilin ProvinceChina College of Earth Sciences Jilin UniversityChangchun 130061Jilin ProvinceChina College of Paleontology Shenyang Normal UniversityShenyang 110034Liaoning ProvinceChina Key Lab of Evolution of Past Life in NE Asia Ministry of Natural ResourcesShenyang Normal UniversityShenyang 110034Liaoning ProvinceChina Shenyang Center of Geological Survey China Geological SurveyShenyang 110034Liaoning ProvinceChina

Coniopteris simplex is a common component in many Jurassic ***,due to morphological variations in sterile fronds and incomplete preservation of reproductive organs,its classification has been controversial for a long ***,we present new material collected from the Middle Jurassic Yan’an Formation in the Ordos Basin,Inner *** new material reveals important morphological characters,including hemi-dimorphic fronds,two forms of sterile pinnae,short-stalked sori and sporangia on fertile fronds,annulus of sporangium composed of about 30 cells,in situ rounded triangular spores with protruded suture,and the lips of trilete laesura encircled by one or two rows of small *** on these observations,we emended the diagnosis of this common *** spatio-temporal distribution of Coniopteris simplex shows that the iconic species was restricted to the paleolatitudes ranging from 19.5°N to 48.9°N in the Northern Hemisphere during the Early—Late Jurassic,mainly distributed in the tropical to paratropical zones,and the paleolongitude ranging from 9.6°E to 129.3°E,which may be limited by the opening of the Viking Corridor and the splitting of the Central Atlantic Ocean.

关键词： Coniopteris simplex Yan'an Formation Middle Jurassic Inner Mongolia Paleogeography