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RNF187 governs the maintenance of mouse GC-2 cell development by facilitating histone H3 ubiquitination at K57/80

Asian Journal of Andrology 2024年第3期26卷 272-281页

作者： Bing-Ya Xu xiang-ling yu Wen-Xin Gao Ting-Ting Gao Hao-yue Hu Tian-Tian Wu Cong Shen Xiao-Yan Huang Bo Zheng Yi-Bo Wu Human Reproductive and Genetic Center Affiliated Hospital of Jiangnan UniversityWuxi 214122China State Key Laboratory of Reproductive Medicine Department of Histology and EmbryologySchool of Basic Medical SciencesNanjing Medical UniversityNanjing 211166China Changzhou Maternal and Child Health Care Hospital Changzhou Medical CenterNanjing Medical UniversityChangzhou 213000China State Key Laboratory of Reproductive Medicine Center for Reproduction and GeneticsSuzhou Municipal HospitalThe Affiliated Suzhou Hospital of Nanjing Medical UniversityGusu SchoolNanjing Medical UniversitySuzhou 215002China

RING finger 187(RNF187),a ubiquitin-ligating(E3)enzyme,plays a crucial role in the proliferation of cancer ***,it remains unclear whether RNF187 exhibits comparable functionality in the development of germline *** investigate thepotential involvement of RNF187 in germ cell development,we conducted interference and overexpression assays using GC-2 cells,a mouse spermatocyte-derived cell *** findings reveal that the interaction between RNF187 and histone H3 increases theviability,proliferation,and migratory capacity of GC-2 ***,we provide evidence demonstrating that RNF187 interactswith H3 and mediates the ubiquitination of H3 at lysine 57(K57)or lysine 80(K80),directly or indirectly resulting in increasedcellular *** is a study to report the role of RNF187 in maintaining the development of GC-2 cells by mediatinghistone H3 ubiquitination,thus highlighting the involvement of the K57 and K80 residues of H3 in the epistatic regulation of *** discoveries provide a new theoretical foundation for further comprehensive investigations into the functionof RNF187 in the reproductive system.

关键词： GC-2 cell histone H3 RNF187 ubiquitination

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A Convenient Synthesis of cis and trans-(±)-4-Amino-1-[2-(hydroxyl-methyl)-1,3-oxathiolan-5-yl]-2(1H)-pyrimidinone

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Chinese Chemical Letters 2006年第4期17卷 431-433页

作者： Yi SHEN ling xiang Yong DENG yu Guo ZHONG Department of Medicinal Chemistry West China School of Pharmacy Sichuan University Chengdu 610041

A convenient synthesis of cis-（±） isomer 1 and trans-（±） isomer 2 of lamivudine starting from benzoyloxyacetaldehyde and 1,4-dithiane-2,5-diol is described. The key steps include chlorination of oxathiolane lactol 5 by SOCl2/DMF, followed by coupling with silylated N^4- acetylcytosine and deprotection. The overall yield was 42.6 % and 20,1%, respectively.

关键词： Lamivudine geometrical isomer cis-(±) isomer trans-(±) isomer synthesis.

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黄河-渭河交汇处水流结构与河道演变实测结果分析

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水电能源科学 2024年第6期42卷 68-72页

作者：林昊张汇明张同强徐磊王平万安凌宇翔河海大学水灾害防御全国重点实验室江苏南京210098 河海大学水利水电学院江苏南京210098 河海大学水利部水循环与水动力系统重点实验室江苏南京210098 黄河水利委员会三门峡库区水文水资源局河南三门峡472000

黄河-渭河交汇处是黄河流域典型的大型河道交汇处之一,亦是中下游水动力和泥沙输移的重要控制节点。为进一步认识该处大宽深比、高含沙、复杂地形条件下的三维水流结构及河道演变规律,运用声学多普勒流速剖面仪(ADCP)对该交汇处15个横... 详细信息

黄河-渭河交汇处是黄河流域典型的大型河道交汇处之一,亦是中下游水动力和泥沙输移的重要控制节点。为进一步认识该处大宽深比、高含沙、复杂地形条件下的三维水流结构及河道演变规律,运用声学多普勒流速剖面仪(ADCP)对该交汇处15个横断面的流场进行现场测量,采用动能校正系数(α)和动量校正系数(β)分析水动力调整过程。通过遥感影像数据提取河道平面形态,分析交汇处及上下游的河道演变规律。结果表明,黄河-渭河交汇处可观测到明显的停滞区、最大流速区、流速恢复区等水动力特征区;拐角处未发现明显分离区,主要是因为该处河道过渡平顺。黄河与渭河交汇初期,由于流速差异大和河道缩窄导致流速不均匀性较强,α、β分别约为1.5、1.2,随着河道向下游展宽,流速不均匀性迅速减小。交汇处断面内存在较强的二次流,其流速可达主流流速的1/8,并向下游衰减。遥感研究表明交汇处所属黄河河段不稳定,且存在顶点的岸线淤长和对岸的岸线后退现象。

关键词：黄河-渭河河流交汇 ADCP 水流结构二次流河道演变

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A New Prognostic Model Covering All Stages of Intrahepatic Cholangiocarcinoma

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Journal of Clinical and Translational Hepatology 2022年第2期10卷 254-262页

作者： Shuang-Nan Zhou Shan-Shan Lu Da-Wei Ju ling-xiang yu Xiao-Xiao Liang Xiao xiang Suthat Liangpunsakul Lewis R.Roberts Yin-Ying Lu Ning Zhang Department of Infectious Disease the Fifth Medical Center of Chinese PLA General HospitalBeijingChina Department of Liver Disease the Fifth Medical Center of Chinese PLA General HospitalBeijingChina Beijing Advanced Innovation Center for Soft Matter Science and Engineering College of Life Science and TechnologyBeijing University of Chemical TechnologyBeijingChina Central Theater Command General Hospital of The Chinese People’s Liberation Army WuhanHubeiChina Beijing Chaoyang Integrative Medicine Emergency Medical Center BeijingChina BeiGene(Beijing)Co.Ltd BeijingChina Division of Gastroenterology and Hepatology Department of MedicineIndiana University School of MedicineINUSA Department of Biochemistry and Molecular Biology Indiana University School of MedicineIndianapolisINUSA Division of Gastroenterology and Hepatology Mayo Clinic College of Medicine and ScienceRochesterMNUSA

Background and Aims:Intrahepatic cholangiocarcinoma(ICC)is the second most common primary hepatic malignancy that causes a poor *** aimed to identify its prognostic factors and to develop a nomogram that will predict survival of ICC patients among all ***:A total of 442 patients with pathology-proven ICC registered at the Fifth Medical Center of PLA General Hospital between July 2007 and December 2019 were *** were followed for survival status until June 30,2020.A prognostic model visualized as a nomogram was constructed in the training cohort using multivariate cox model,and was then validated in the validation ***:The median age was 55 *** a median follow-up of 50.4 months,337 patients *** median survival was 11.6 months,with 1-,3-and 5-year survival rates of 48.3%,22.7%and 16.2%,*** associated with overall survival were multiple tumors,lymph node involvement,vascular invasion,distant metastasis,decreased albumin,elevated lactate dehydrogenase(LDH),decreased iron,elevated fi-brinogen,elevated CA125 and elevated CA19-9.A nomo-gram predicting survival of ICC patients at the time of di-agnosis achieved a Harrel’s c-statistic of 0.758,significantly higher than the 0.582 of the TNM stage *** median survivals of those within the low,mid and high-risk subgroups were 35.6,12.1 and 6.2 months,***:A nomogram based on imaging data and serum biomarkers at diagnosis showed good ability to predict survival in patients with all stages of *** studies are needed to validate the prognostic capability of our new model.

关键词： Intrahepatic cholangiocarcinoma Prognostic model Nomogram Risk stratification

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Highly efficient nitrogen fixation over S-scheme heterojunction photocatalysts with enhanced active hydrogen supply

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National Science Review 2024年第5期11卷 315-325页

作者： Tong Bao Yamin Xi Chaoqi Zhang Peiyang Du Yitong xiang Jiaxin Li ling yuan Chengzhong yu Chao Liu School of Chemistry and Molecular Engineering East China Normal University Australian Institute for Bioengineering and Nanotechnology The University of Queensland

Photocatalytic N2fixation is a promising strategy for ammonia（NH3） synthesis;however,it suffers from relatively low ammonia yield due to the difficulty in the design of photocatalysts with both high charge transfer efficiency and desirable N2adsorption/activation ***,an S-scheme CoSx/ZnS heterojunction with dual active sites is designed as an efficient N2fixation *** CoSx/ZnS heterojunction exhibits a unique pocket-like nanostructure with small ZnS nanocrystals adhered on a single-hole CoSxhollow *** the heterojunction,the ele ctronic interaction between ZnS and CoSxcreates electron-deficient Zn sites with enhanced N2chemisorption and electron-sufficient Co sites with active hydrogen supply for N2hydrogenation,cooperatively reducing the energy barrier for *** combination with the promoted photogenerated electron-hole separation of the S-scheme heterojunction and facilitated mass transfer by the pocket-like nanostructure,an excellent N2fixation performance with a high NH3yield of 1175.37 μmol g-1h-1is *** study provides new insights into the design of hetero junction photocatalysts for N2fixation.

关键词： photocatalysis nitrogen fixation S-scheme heterojunction active hydrogen ammonia

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Prognostic analysis of patients with combined hepatocellularcholangiocarcinoma after radical resection:A retrospective multicenter cohort study

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World Journal of Gastroenterology 2022年第41期28卷 5968-5981页

作者： Ge Zhang Bo-Wen Chen Xiao-Bo Yang Huai-yuan Wang Xu Yang Fu-Cun Xie xiang-Qi Chen ling-xiang yu Jie Shi Yin-Ying Lu Hai-Tao Zhao Department of Liver Surgery State Key Laboratory of Complex Severe and Rare Diseases Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College 302 Clinical Medical School Peking University Senior Department of Hepatology The 5^(th) Medical Center of the PLA General Hospital Guangdong Key Laboratory of Epigenetics College of Life Sciences and Oceanography Shenzhen University Department of Pathology Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College

BACKGROUND Combined hepatocellular-cholangiocarcinoma(cHCC-CCA)is a form of rare primary liver cancer that combines intrahepatic cholangiocarcinoma(ICC)and hepatocellular *** To investigate overall survival(OS)and recurrence-free survival(RFS)after radical resection in patients with cHCC-CCA,and the clinicopathological factors affecting prognosis in two center hospitals of *** We reviewed consecutive patients with cHCC-CCA who received radical resection between January 2005 and September 2021 at Peking Union Medical College and the 5th Medical Center of the PLA General Hospital *** follow-up and clinicopathological characteristics were systematic collected for baseline and prognostic *** Our study included 95 patients who received radical *** majority of these patients were male and 82.7%of these patients were infected with *** mean tumor size was 4.5 cm,and approximately 40%of patients had more than one *** median OS was 26.8(95%CI:18.5-43.0)mo,and the median RFS was 7.27(95%CI:5.83-10.3)*** predictors of OS were CA19-9≥37 U/mL(HR=8.68,P=0.002),Child-Pugh score>5(HR=5.52,P=0.027),tumor number>1(HR=30.85,P=0.002),tumor size and transarterial chemoembolization(TACE)after surgery(HR=0.2,P=0.005).CONCLUSION The overall postoperative survival of cHCC-CCA patients is poor,and most patients experience relapse within a short period of time after *** tumor biomarker(CA19-9,alphafetoprotein)levels,tumor size,and Child-Pugh score can significantly affect *** TACE after surgery prolongs RFS,suggesting that TACE is a possible option for postoperative adjuvant therapy in patients with cHCC-CCA.

关键词： Combined hepatocellular-cholangiocarcinoma Radical resection Clinicopathological factor Integrated nomogram Multicenter cohort

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Review of Iron-Based Catalysts for Carbon Dioxide Fischer-Tropsch Synthesis

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Transactions of Tianjin University 2024年第2期30卷 178-197页

作者： Ji-yue Jia yu-ling Shan Yong-Xiao Tuo Hao Yan xiang Feng De Chen State Key Laboratory of Heavy Oil Processing China University of PetroleumQingdao 266580China College of Chemical Engineering Qingdao University of Science and TechnologyQingdao 266042China Department of Chemical Engineering Norwegian University of Science and Technology7491 TrondheimNorway

Capturing and utilizing CO_(2)from the production process is the key to solving the excessive CO_(2)emission problem. CO_(2)hydrogenation with green hydrogen to produce olefins is an effective and promising way to utilize CO_(2)and produce valuable chemicals. The olefins can be produced by CO_(2)hydrogenation through two routes, i.e., CO_(2)-FTS (carbon dioxide Fischer- Tropsch synthesis) and MeOH (methanol-mediated), among which CO_(2)-FTS has significant advantages over MeOH in practical applications due to its relatively high CO_(2)conversion and low energy consumption potentials. However, the CO_(2)-FTS faces challenges of difficult CO_(2)activation and low olefins selectivity. Iron-based catalysts are promising for CO_(2)-FTS due to their dual functionality of catalyzing RWGS and CO-FTS reactions. This review summarizes the recent progress on iron-based catalysts for CO_(2)hydrogenation via the FTS route and analyzes the catalyst optimization from the perspectives of additives, active sites, and reaction mechanisms. Furthermore, we also outline principles and challenges for rational design of high-performance CO_(2)-FTS catalysts.

关键词： CO_(2)hydrogenation Olefins CO_(2)-FTS Iron-based catalysts

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Long non-coding ribonucleic acid W5 inhibits progression and predicts favorable prognosis in hepatocellular carcinoma

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World Journal of Gastroenterology 2021年第1期27卷 55-68页

作者： Guang-Lin Lei Hong-Xia Fan Cheng Wang Yan Niu Tie-ling Li ling-xiang yu Zhi-Xian Hong Jin Yan Xi-Liang Wang Shao-Geng Zhang Ming-Ji Ren Peng-Hui Yang Fifth Medical Center of Chinese PLA General Hospital Beijing 100039China College of Basic Medicine Inner Mongolia Medical UniversityHohhot 010110Inner MongoliaChina First Medical Center of Chinese PLA General Hospital Beijing 100853China State Key Laboratory of Pathogens and Biosecurity Beijing Institute of Microbiology and EpidemiologyBeijing 100071China

BACKGROUND Accumulating evidence has revealed that several long non-coding ribonucleic acids(lncRNAs)are crucial in the progress of hepatocellular carcinoma(HCC).AIM To classify a long non-coding RNA,i.e.,lncRNA W5,and to determine the clinical significance and potential roles of lncRNA W5 in *** The results showed that lncRNA W5 expression was significantly downregulated in HCC cell lines and *** of the association between lncRNA W5 expression levels and clinicopathological features suggested that low lncRNA W5 expression was related to large tumor size(P<0.01),poor histological grade(P<0.05)and serious portal vein tumor thrombosis(P<0.05).Furthermore,Kaplan-Meier survival analysis showed that low expression of lncRNA W5 predicts poor overall survival(P=0.016).RESULTS Gain-of-loss function experiments,including cell counting kit8 assays,colony formation assays,and transwell assays,were performed in vitro to investigate thebiological roles of lncRNA *** vitro experiments showed that ectopic overexpression of lncRNA W5 suppressed HCC cell proliferation,migration and invasion;conversely,silencing of lncRNA W5 promoted cell proliferation,migration and *** addition,acting as a tumor suppressor gene in HCC,lncRNA W5 inhibited the growth of HCC xenograft tumors in *** These results showed that lncRNA W5 is down-regulated in HCC,and it may suppress HCC progression and predict poor clinical outcomes in patients with *** W5 may serve as a potential HCC prognostic biomarker in addition to a therapeutic target.

关键词： Hepatocellular carcinoma Long non-coding ribonucleic acid Long noncoding ribonucleic acid W5

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A Strong,Tough,and Self-Healing Strengthening Thioctic Acid-based Elastomer for Highly Reliable Flexible Strain Sensor

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Chinese Journal of Polymer Science 2024年第10期42卷 1610-1618,I0016页

作者： Xin-yu Chen yu-Bing Fu Xue-ling Yan Lan Liu School of Materials Science and Engineering Key Lab of Guangdong Province for High Property and Functional Polymer MaterialsSouth China University of TechnologyGuangzhou510641China

Elastomers with high strength and toughness,excellent self-healing properties,and biocompatibility have broad application prospects in wearable electronics and other fields,but preparing it remains a *** this work,we propose a highly adaptable strategy by introducing the small molecule crosslinking agent of triethanolamine(TEA)to the poly(thioctic acid)(PTA)chains and preparing the PAx Ey elastomers using a simple synthesis *** strategy stabilizes the PTA chains by constructing multiple non-covalent cross-linked dynamic networks,endowing materials with excellent strength and toughness(tensile strength of 288 kPa,toughness of 278.2 kJ/m3),admirable self-healing properties(self-healing efficiency of 121.6%within 7 h at 70℃),and good *** PAx Ey elastomers can also be combined with MWNTs to become flexible strain sensors,which can be used to monitor human joint movements with high sensitivity,repeatable responses,and stability.

关键词： Thioctic acid Ion clusters Multiple dynamic networks Self-healing strengthening Flexible strain sensor

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A nonlocal dispersal and time delayed HIV infection model with general incidences

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Applied Mathematics(A Journal of Chinese Universities) 2024年第3期39卷 448-457页

作者： WU Peng ZHANG yu-huai WANG ling School of Sciences Hangzhou Dianzi UniversityHangzhou 310018China School of Humanities and Management Zhejiang Chinese Medical UniversityHangzhou 311402China Public Foundational Courses Department Nanjing Vocational University of Industry TechnologyNanjing 210023China

Biologically,because of the impact of reproduction period and nonlocal dispersal of HIV-infected cells,time delay and spatial heterogeneity should be *** this paper,we establish an HIV infection model with nonlocal dispersal and infection ***,applying the theory of Fourier transformation and von Foerster rule,we transform the model to an integrodifferential equation with nonlocal time delay and *** well-posedness,positivity,and boundedness of the solution for the model are studied.

关键词： HIV model nonlocal dispersal time delay general incidences

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