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Fast rate （≥ 250 beats/min） right ventricular burst stimulation is useful for ventricular tachycardia induction in arrhythmogenic right ventricular cardiomyopathy

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Journal of Geriatric Cardiology 2016年第1期13卷 70-74页

作者： ling-min wu Jing-Ru BAO Yan YAO Bing-Bo HOU Li-Hui ZHENG Shu ZHANG State Key Laboratory of Cardiovascular Disease Fuwai Hospital National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China Cardiovascular Center PLA Navy General Hospital Beijing China

Background One of the major challenges in arrhythmogenic right ventricular cardiomyopathy （ARVC） ablation is ventricular tachy-cardia （VT） non-inducibility. The study aimed to assess whether fast rate （≥ 250 beats/min） right ventricular burst stimulation was useful for VT induction in patients with *** Ninety-one consecutive ARVC patients with clinical sustained VT that underwent electro-physiological study were enrolled. The stimulation protocol was implemented at both right ventricular apex and outflow tract as follows： Step A, up to double extra-stimuli; Step B, incremental stimulation with low rate （＆lt; 250 beats/min）; Step C, burst stimulation with fast rate （≥ 250 beats/min）; Step D, repeated all steps above with intravenous infusion of *** A total of 76 patients had inducible VT （83.5%）, among which 49 were induced by Step C, 15 were induced by Step B, 8 and 4 by Step A and D, respectively. Clinical VTs were induced in 60 patients （65.9%）. Only two spontaneously ceased ventricular fibrillations were induced by Step C. Multivariate analysis showed that a narrower baseline QRS duration under sinus rhythm was independently associated with VT non-inducibility （OR： 1.1; 95% CI： 1.0-1.1;P = 0.019）.ConclusionFast rate （≥ 250 beats/min） right ventricular burst stimulation provides a useful supplemental method for VT induction in ARVC patients.

关键词： Burst stimulation Cardiomyopathy Right ventricular Ventricular tachycardia

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Relationship between red blood cell distribution width levels and atrial fibrillation in hypertensive patients

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Journal of Geriatric Cardiology 2020年第8期17卷 486-494页

作者： Li-Hui ZHENG Shang-Yu LIU Feng HU Zhi-Cheng HU Li-Shui SHEN ling-min wu Yan YAO Arrhythmia Center Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

Background Information on the relationship between red blood cell distribution width(RDW)and atrial fibrillation(AF)in patients with essential hypertension are *** study aimed to assess the relationship between AF and RDW in hypertensive *** We enrolled 432 hypertensive patients,including 350 AF patients and 82 patients as ***'demographic,clinical,laboratory and echocardiographic characteristics were *** AF patients were further divided into the persistent and paroxysmal AF *** were monitored to identify the cardiac rhythm during blood sampling,and based on the rhythm,the paroxysmal AF group was categorized into the presence(with AF rhythm during blood sampling)and absence(with sinus rhythm during blood sampling)*** The AF group had elevated RDW levels than the controls(12.7%±0.8%vs.12.4%±0.7%,P=0.002),and the persistent AF subgroup had higher RDW levels than the paroxysmal AF subgroup(12.9%±0.8%vs.12.6%±0.8%,P=0.007).Furthermore,in the paroxysmal AF group,the presence group had higher RDW levels than the absence group(13.0%±0.6%vs.12.5%±0.9%,P=0.001).There was no significant difference in RDW levels between the persistent AF subgroup and presence group of the paroxysmal AF subgroup(P=0.533)and between the absence group of the paroxysmal AF subgroup and control group(P=0.262).In multivariate regression analysis,in hypertensive patients,the presence of AF rhythm is an independent predictor for increased RDW concentration(P=0.001).Conclusions The RDW may be associated with the presence of AF rhythm,which implies the importance of maintaining the sinus rhythm in hypertensive patients.

关键词： Atrial fibrillation Hypertension Inflammation Red blood cell distribution width

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Association between big endothelin-1 and CHADS2/CHA2DS2-VASc scores in non-valvular atrial fibrillation

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Journal of Geriatric Cardiology 2019年第11期16卷 812-817页

作者： Li-Hui ZHENG Shang-Yu LIU Feng HU Er-Peng LIANG ling-min wu Hong-Lei WANG Ammar M Killu Yan YAO Clinical EP Lab&Arrhythmia Center Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina The First Affiliated Hospital College of Clinical Medicine of Henan University of Science and TechnologyLuoyangChina Department of Cardiovascular Medicine Mayo ClinicRochesterMNUSA

Background Endothelial function,as measured by big endothelin-1(ET-1),has been demonstrated to be useful in predicting adverse long-term events in patients with cardiovascular ***,there are little data about the association between big ET-1 and thromboembolism risk in atrial fibrillation(AF).We aimed to investigate the relationship between big ET-1 and CHADS2/CHA2DS2-VASc scores used for evaluating thromboembolic risk in patients with non-valvular *** The study population consisted of 238 consecutive AF patients(67.6%with paroxysmal AF and 32.4%with persistent AF).The patients were divided into two groups(high-or low-intermediate risk group)based on CHADS2 and CHA2 DS2-VASc scores(score≥2 orminant of high CHADS2/CHA2DS2-VASc scores[odds ratio(OR)=2.545 and OR=3.816;both P<0.05].Conclusions Our study indicates that in non-valvular AF,big ET-1 was significantly correlated with CHADS2/CHA2DS2-VASc scores and an independent predictor of high CHADS2/CHA2DS2-VASc *** ET-1 may serve as a useful marker for risk stratification in this setting.

关键词： Atrial fibrillation Cardiac risk factors Prevention Stroke

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Electronic structure and spin state regulation of vanadium nitride via a sulfur doping strategy toward flexible zinc-air batteries

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Journal of Energy Chemistry 2024年第2期89卷 239-249,I0007页

作者： Daijie Deng Honghui Zhang Jianchun wu Xing Tang min ling Sihua Dong Li Xu Henan Li Huaming Li Institute for Energy Research Institute of Quantum and Sustainable TechnologySchool of Chemistry and Chemical EngineeringSchool of Materials Science and EngineeringJiangsu Province and Education Ministry Co-Sponsored Synergistic Innovation Center of Modern Agricultural EquipmentJiangsu UniversityZhenjiang 212013JiangsuChina Key Laboratory of Radio Frequency and Micro-Nano Electronics of Jiangsu Province Nanjing 210023JiangsuChina Zhenjiang Kangyuan Electrical Appliance Co. Ltd.Zhenjiang 212013JiangsuChina College of Chemical and Biological Engineering Zhejiang UniversityHangzhou 310027ZhejiangChina YTO Group Corporation Dongfanghong(Henan)Agricultural Service Technology Co. Ltd.Luoyang 471033HenanChina

Owing to the distinctive structural characteristics,vanadium nitride(VN)is highly regarded as a catalyst for oxygen reduction reaction(ORR)in zinc-air batteries(ZABs).However,VN exhibits limited intrinsic ORR activity due to the weak adsorption ability to O-containing ***,the S-doped VN anchored on N,S-doped multi-dimensional carbon(S-VN/Co/NS-MC)was constructed using the solvothermal and in-situ doping *** sulfur atoms into VN species alters the electron spin state of vanadium in the S-VN/Co/NS-MC for regulating the adsorption energy of vanadium sites to oxygen *** introduced sulfur atoms polarize the V 3d_(z)^(2) electrons,shifting spin-down electrons closer to the Fermi level in the S-VN/Co/***,the introduction of sulfur atoms into VN species enhances the adsorption energy of vanadium sites for oxygen ****OOH dissociation transitions from being unspontaneous on the VN surface to a spontaneous state on the S-doped VN ***,the ORR barrier on the S-VN/Co/NS-MC surface is *** S-VN/Co/NS-MC demonstrates a higher half-wave potential and limiting current density compared to the VN/Co/*** S-VN/Co/NS-MC-based liquid ZABs display a power density of 195.7 m W cm^(-2),a specific capacity of 815.7 m A h g^(-1),and a cycling stability exceeding 250 *** S-VN/Co/NS-MC-based flexible ZABs are successfully employed to charge both a smart watch and a mobile *** approach holds promise for advancing the commercial utilization of VN-based catalysts in ZABs.

关键词： S-doped VN Electronic structures Spin state regulation Oxygen reduction reaction Zinc-air batteries

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Multi-instance partial-label learning: towards exploiting dual inexact supervision

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Science China(Information Sciences) 2024年第3期67卷 48-61页

作者： Wei TANG Weijia ZHANG min-ling ZHANG School of Computer Science and Engineering Southeast University Key Laboratory of Computer Network and Information Integration (Southeast University) Ministry of Education School of Information and Physical Sciences The University of Newcastle

Weakly supervised machine learning algorithms are able to learn from ambiguous samples or labels, e.g., multi-instance learning or partial-label learning. However, in some real-world tasks, each training sample is associated with not only multiple instances but also a candidate label set that contains one groundtruth label and some false positive labels. Specifically, at least one instance pertains to the ground-truth label while no instance belongs to the false positive labels. In this paper, we formalize such problems as multi-instance partial-label learning(MIPL). Existing multi-instance learning algorithms and partial-label learning algorithms are suboptimal for solving MIPL problems since the former fails to disambiguate a candidate label set, and the latter cannot handle a multi-instance bag. To address these issues, a tailored algorithm named MIPLGP, i.e., multi-instance partial-label learning with Gaussian processes, is *** first assigns each instance with a candidate label set in an augmented label space, then transforms the candidate label set into a logarithmic space to yield the disambiguated and continuous labels via an exclusive disambiguation strategy, and last induces a model based on the Gaussian processes. Experimental results on various datasets validate that MIPLGP is superior to well-established multi-instance learning and partial-label learning algorithms for solving MIPL problems.

关键词： machine learning multi-instance partial-label learning multi-instance learning partial-label learning Gaussian processes

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Relationships of High-sensitive C-reactive Protein ant P-wave Dispersion in Lone Atrial Fibrillation

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Chinese Medical Journal 2015年第11期 1450-1454页

作者： Li-Hui Zheng Yan Yao ling-min wu Kui-Jun Zhang Shu Zhang State Key Laboratory of Cardiovascular Disease Clinical EP Laboratory and Arrhythmia Center Fuwai Hospital National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100037 China

Background： Current evidence links atrial fibrillation （AF） to the inflammation. Inflammatory indexes such as high-sensitive C-reactive protein （hs-CRP） have been related to the development and persistence of AF. However, the role of inflammation in the atrial electrophysiological remodeling indexed by P-wave dispersion （Pa） remains unclear. Methods： The study consisted of 71 patients with lone paroxysmal AF （AF group） and 71 age- and gender-matched controls of paroxysmal supraventricular tachycardia without history of AF （control group）. Electrocardiography, P hs-CRP, and other clinical characteristics were compared between the two groups. Results： There was no significant difference between the two groups regarding age, gender, hyperlipidemia, etc. Compared to controls, left atrial diameter （44 ± 7 vs 39 ± 7 mm）, Pd （49 ± 13 vs 26 ± 8 ms）, and hs-CRP （2.17 [1.46-2.89] vs 1.12 [0.74-1.41] rag/L） were increased （P 〈 0.05）, respectively. Linear regression identified hs-CRP as an independent correlation ofPd level both in the total population and the AF group （r = 0.464 and 0.313; P 〈 0.001, respectively）. Multiple logistic regression revealed hs-C RP as an independent determinant of AF （odds ratio [OR] =l 5.430, 95% confidence interval： 6.031-39.476： P 〈0.001）. Further adjusted tbr Pd, both Pd and hs-CRP were independent predictors for AF, but the OR for hs-CRP in predicting AF has been attenuated from 15.430 to 6.246. Conclusions： In lone AF, P and plasma hs-CRP concentration are inter-associated and related to AF. The interaction between hs-CRP and AF may be mediated by Pe, suggesting an important role of inflammation in the atrial electrophysiological remodeling predisposing to AF.

关键词： Atrial Fibrillation High-sensitive C-reactive Protein Inflammation P-wave Dispersion

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Anisotropic swelling pressures of compacted GMZ bentonite infiltrated with salt solutions

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第9期16卷 3772-3785页

作者： Jing Ma Yong-Gui Chen ling-Yan Jia Wei-min Ye Dong-Bei wu Qiong Wang Department of Geotechnical Engineering College of Civil EngineeringTongji UniversityShanghai200092China State Key Laboratory of Disaster Reduction in Civil Engineering College of Civil EngineeringTongji UniversityShanghai200092China School of Chemical Science and Engineering Tongji UniversityShanghai200092China

In the high-level radioactive waste(HLW)deep geological repository,bentonite is compacted uniaxially,and then arranged vertically in engineered *** assembly scheme induces the initial anisotropy,and with hydration,it develops more evidently under chemical *** investigate the anisotropic swelling of compacted Gaomiaozi(GMZ)bentonite and the further response to saline effects,a series of constant-volume swelling pressure tests were *** showed that dry density enhanced the bentonite swelling and raised the final anisotropy,whereas saline inhibited the bentonite swelling but still promoted the final *** final anisotropy coefficient(ratio of radial to axial pressure)obeyed the Boltzmann sigmoid attenuation function,decreasing with concentration and dry density,converging to a minimum value of *** staged evolution of anisotropy coefficient was discovered,that saline inhibited the rise of the anisotropy coefficient(Dd)in the isotropic process greater than the valley(d1)in the anisotropic process,leading to the final anisotropy *** isotropic stage amplified the impact of soil structure rearrangement on the macro-swelling pressure ***,a new method for predicting swelling pressures of compacted bentonite was proposed,by expanding the equations of Gouy-Chapman theory with a dissipative wedge *** evolutionary function was constructed,revealing the correlation between the occurrence time and the pressure value due to the structure rearrangement and the former crystalline ***,a design reference for dry density was given,based on the chemical conditions around the pre-site in Beishan,*** anisotropy promoted by saline would cause a greater drop of radial pressure,making the previous threshold on axial swelling fail.

关键词： HLW deep geological repository Compacted GMZ bentonite Anisotropic swelling pressure Multi-scale structure Saline effect

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Glaucoma drainage device implantation and cyclophotocoagulation in the management of refractory glaucoma after Descemet-stripping automated endothelial keratoplasty

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International Journal of Ophthalmology(English edition) 2024年第2期17卷 257-264页

作者： min-Shu Wang Xue-Chuan Dong Mi-Yun Zheng Xiang Fan Ge-Ge Xiao Jing Hong ling-ling wu Department of Ophthalmology Peking University Third HospitalBeijing 100191China Key Laboratory of Restoration of Damaged Ocular Nerve Beijing 100191China NIMO Ophthalmology Research Institute Beijing 100176China Department of Ophthalmology the First Hospital of PutianTeaching HospitalFujian Medical UniversityPutian 351100Fujian ProvinceChina

AIM:To compare the surgical outcomes of glaucoma drainage device implantation(GDI)and trans-scleral neodymium:YAG cyclophotocoagulation(CPC)in the management of refractory glaucoma after Descemetstripping automated endothelial keratoplasty(DSAEK).METHODS:This retrospective study on observational case series enrolled 29 patients who underwent DSAEK and posterior anti-glaucoma surgery(15 with GDI and 14 with CPC).The main outcome measures were intraocular pressure(IOP),glaucoma surgery success rate(defined as IOP of 6–21 mm Hg without additional anti-glaucoma operation),number of glaucoma medications,endothelial graft status,and best-corrected visual acuity(BCVA).RESULTS:The mean follow-up time was 34.1 and 21.0mo for DSAEK or glaucoma surgeries,both for the GDI and CPC *** groups showed significant IOP reduction after glaucoma *** GDI group presented a significantly higher success rate in IOP control than the CPC group(60%vs 21.4%,P=0.03).Both procedures significantly decreased the number of glaucoma medications(P=0.03).Forty percent and 57%of cases in the GDI and the CPC group,respectively,experienced endothelial graft failure during follow-up(P=0.36).Significantly worse BCVA after surgery was observed in the CPC group but not in the GDI ***:Both GDI and CPC significantly decrease IOP in eyes with glaucoma after *** is preferable to CPC in refractory glaucoma cases after DSAEK,as it manifests a significantly higher success rate for IOP control,similar endothelial graft failure rate,and relatively preserves BCVA than CPC.

关键词： glaucoma drainage device implantation cyclophotocoagulation refractory glaucoma Descemetstripping automated endothelial keratoplasty

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Two-layer autonomous intelligence dynamic trajectory planning method based on shield-tunnel ring-geology interactions

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Underground Space 2024年第6期19卷 227-250页

作者： min Hu Bingjian wu Huiming wu Liefeng Pei SILC Business School Shanghai UniversityShanghai 201800China SHU-SUCG Research Centre for Building Industrialization Shanghai 201800China Shanghai Tunnel Engineering Co. Ltd.Shanghai 200032China

To solve the problem that current attitude planning methods do not fully consider the interaction and constraints among the shield,segmental tunnel ring,and geology,and cannot adapt to the changes in the actual engineering environment,or provide feasible long-term and short-term attitude planning,this paper proposes autonomous intelligent dynamic trajectory planning(AI-DTP)to provide tunnel ring and centimeter-layer planning targets for a self-driving shield to meet long-term accuracy and short-term ***-DTP introduces the Frenet coordinate system to solve the problem of inconsistent spatial representation of tunnel data,segmental tunnel ring location,and surrounding geological conditions,designs the long short-term memory attitude prediction model to accurately predict shield attitude change trend based on shield,tunnel,and geology,and uses a heuristic algorithm for trajectory ***-DTP provides ring-layer and centimeter-layer planning objectives that meet the needs of long-term accuracy and short-term correction of shield attitude *** the Hangzhou-Shaoxing Intercity Railroad Tunnel Project in China,the‘‘Zhiyu”shield equipped with the AI-DTP system was faster and more accurate than the manually controlled shield,with a smoother process and better quality of the completed tunnel.

关键词： Shield tunnel Trajectory planning Attitude control Self-driving Machine learning

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A mixed-valence polyoxometalate-based 3D inorganic framework cathode material for high-efficiency rechargeable AZIBs

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Rare Metals 2024年第8期43卷 3677-3691页

作者： Qing Han Hao-Ran Xiao Tao Zhou Bing-Chuan Li Liu Yang ling-ling Xie Xue-Jing Qiu Xian-Yong wu Li-min Zhu Xiao-Yu Cao School of Chemistry and Chemical Engineering Henan University of TechnologyZhengzhou 450001China Key Laboratory of High Specific Energy Materials for Electrochemical Power Sources of Zhengzhou City Zhengzhou 450001China College of Materials Engineering Henan University of EngineeringZhengzhou450007China School of Environmental Engineering Henan University of TechnologyZhengzhou 450001China Department of Chemistry University of Puerto Rico-Rio Piedras CampusSan JuanPR 00925USA

The global trend towards new energy storage systems has stimulated the development of electrochemical energy storage *** these technologies,rechargeable aqueous zinc-ion batteries(AZIBs)have attracted considerable interest as a potential alternative to lithium-ion batteries(LIBs)due to their affordable cost,environmental compatibility and high safety *** this study,a high-quality electrode for AZIBs has been successfully developed using a dehydrated mixed-valence polyoxometalate-based three-dimensional(3D)inorganic framework material known as[H_6Mn_(3)V^Ⅳ_(15)V-^Ⅴ_(4O)_(46)(H_2O)_(12)](3D-MnVO).This innovative 3D-MnVO material is built from the alternate connections of{V_(19)O_(46)}"sphere-shaped"clusters andμ_(2)-{Mn(H_(2)O)_(4)}bridges,where each{V_(19)O_(46)}cluster is surrounded by three pairs of vertically distributed{Mn(H_(2)O)_(4)}units,thus resulting in the 3D interpenetrating grid-like network from the infinite[-{V_(19)O_(46)}-μ_(2)-Mn(H_(2)O)_(4)-{V_(19)O_(46)}]_∞chains in three mutually perpendicular *** 3D framework structure of 3D-MnVO possesses abundant oxygen vacancies,spacious and multi-level interconnected channels for ion transport,which facilitates the efficient intercalation/deintercalation of hydrated Zn^(2+)into the pores of the primary structure via the intercalation capacitance *** a result,the 3D-MnVO electrode exhibits excellent diffusion rates and minimal interfacial *** a current density of 0.1 A·g^(-1),the 3D-MnVO cathode delivers a commendable discharge capacity of170.5 mAh·g^(-1)with 81.6%capacity retention after100 charge/discharge ***,even at a high current density of 1.0 A·g^(-1),the 3D-MnVO electrode delivers a remarkable reversible capacity of198.9 mAh·g^(-1).Our research results provide valuable insights into the development of advanced polyoxometalate-based 3D inorganic framework electrode materials for high-performance rechargeable AZIBs.

关键词： Cathode Polyoxometalate 3D inorganic framework Zinc-ion batteries Energy storage mechanism

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