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LINC01268 promotes epithelial-mesenchymal transition,invasion and metastasis of gastric cancer via the PI3K/Akt signaling pathway and targeting MARCKS

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World Journal of Gastrointestinal Oncology 2023年第8期15卷 1366-1383页

作者： ling-han tang Peng-Cheng Ye Lin Yao Ya-Jun Luo Wang Tan Wan-Ping Xiang Zi-Lin Liu ling Tan Jiang-Wei Xiao Department of Gastrointestinal Surgery Clinical Medical College and the First Affiliated Hospital of Chengdu Medical CollegeChengdu 610000Sichuan ProvinceChina Department of Gastrointestinal Surgery The Affiliated Hospital of North Sichuan Medical CollegeNanchong 637000Sichuan ProvinceChina Department of Gastrointestinal Surgery Sichuan Cancer HospitalChengdu 610000Sichuan ProvinceChina Department of Gastrointestinal Surgery Yaan People’s HospitalYaan 625000Sichuan ProvinceChina Department of Thoracic Surgery The Affiliated Hospital of North Sichuan Medical CollegeNanchong 637000Sichuan ProvinceChina Department of Surgery People’s Hospital Affiliated to Chongqing Three Gorges Medical CollegeChongqing 404041China

BACKGROUND Long non-coding RNAs(lncRNAs)with differential expression characteristics have been found to be closely related to the tumorigenesis and development of gastric cancer(GC),but their specific mechanisms and roles still need to be further *** To investigate the expression of LINC01268 in GC and its mechanism of affecting GC *** Real-time quantitative polymerase chain reaction was used to detect the expression of LINC01268 in GC tissues,cell lines and *** Kaplan-Meier method was used to evaluate the value of LINC01268 in the prognostication of GC *** receiver operating characteristic curve was constructed to evaluate the value of LINC01268 in the diagnosis of *** migration and invasion assays and wound healing assays were used to confirm the effect of LINC01268 on the invasion and migration of GC *** regulatory relationship between LINC01268 and myristoylated alanine rich protein kinase C substrate(MARCKS),the PI3K/Akt signaling pathway,and the epithelial-mesenchymal transition(EMT)process in GC was demonstrated by western blot *** The expression of LINC01268 was increased in GC tissues and cell *** expression level of LINC01268 was significantly correlated with lymph node metastasis,TNM stage,and tumor differentiation in patients with ***-expression of LINC01268 indicated a poor prognosis for patients with GC,and it had a certain auxiliary diagnostic value for *** vitro functional experiments proved that the abnormal expression of LINC01268 further activated the PI3K/Akt signaling pathway and promoted EMT by targeting and regulating MARCKS and ultimately promoted the invasion and metastasis of *** This study elucidates that LINC01268 in GC may be an oncogene that further activates the PI3K/Akt signaling pathway and EMT by targeting and regulating MARCKS,and ultimately promotes the invasion and metastasis of ***01268 may be a potential effective target for the trea

关键词： Gastric cancer Long non-coding RNA LINC01268 Myristoylated alanine rich protein kinase C substrate Invasion Metastasis

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Decreased expression of the long non-coding RNA HOXD-AS2 promotes gastric cancer progression by targeting HOXD8 and activating PI3K/Akt signaling pathway

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World Journal of Gastrointestinal Oncology 2020年第11期12卷 1237-1254页

作者： Lin Yao Peng-Cheng Ye Wang Tan Ya-Jun Luo Wan-Ping Xiang Zi-Lin Liu Zhi-Ming Fu Fei Lu ling-han tang Jiang-Wei Xiao Department of Gastrointestinal Surgery Clinical Medical College and The First Affiliated Hospital of Chengdu Medical CollegeChengdu 610000Sichuan ProvinceChina The Hepatobiliary Research Institute North Sichuan Medical CollegeNanchong 637000Sichuan ProvinceChina Department of Gastrointestinal Surgery The Affiliated Hospital of North Sichuan Medical CollegeThe Hepatobiliary Research InstituteNorth Sichuan Medical CollegeNanchong 637000Sichuan ProvinceChina Department of Gastrointestinal Surgery Yaan People’s HospitalYaan 625000Sichuan ProvinceChina Department of Gastrointestinal Surgery The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400010China Department of Thoracic Surgery Nanchong Central HospitalNanchong 637000Sichuan ProvinceChina

BACKGROUND Long non-coding RNAs(lncRNAs) have been shown to be associated with many tumors. However, the specific mechanism of lncRNAs in the occurrence and development of gastric cancer(GC) has not been fully *** To explore the expression level and molecular mechanism of HOXD-AS2 in GC tissues and cells, and analyze its significance in the prognosis of *** Real-time quantitative PCR was used to detect the expression of HOXD-AS2 in 79 pairs of GC tissues and five cell lines. The pc HOXD-AS2 plasmid vector was constructed and transfected into SGC-7901 and SNU-1 GC cells. Matrigel Transwell and wound healing assays were used to confirm the effect of HOXDAS2 on invasion and migration of GC cells. Cell counting kit-8 assay and flow cytometry were used to verify the effect of HOXD-AS2 on the proliferation, cell cycle, and apoptosis of GC cells. The relevant regulatory mechanism between HOXD-AS2 and HOXD8 and PI3K/Akt signaling pathway was verified by Western blot *** The low expression of lncRNA HOXD-AS2 was associated with lymph node metastasis and tumor-node-metastasis stage in GC. In vitro functional experiments demonstrated that overexpression of HOXD-AS2 inhibited GC cell progression. Mechanistic studies revealed that HOXD-AS2 regulated the expression of its nearby gene HOXD8 and inhibited the activity of the PI3K/Akt signaling *** These results indicate that downregulation of HOXD-AS2 significantly promotes the progression of GC cells by regulating HOXD8 expression and activating the PI3K/Akt signaling pathway. HOXD-AS2 may be a novel diagnostic biomarker and effective therapeutic target for GC.

关键词： Long non-coding RNA Gastric cancer HOXD-AS2 HOXD8 PI3K/Akt Progression

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Potential role of tanycyte-derived neurogenesis in Alzheimer's disease

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Neural Regeneration Research 2025年第6期20卷 1599-1612页

作者： Guibo Qi han tang Jianian Hu Siying Kang Song Qin Department of Anatomy Histologyand EmbryologySchool of Basic Medical SciencesFudan UniversityShanghaiChina State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science Fudan UniversityShanghaiChina

Tanycytes, specialized ependymal cells located in the hypothalamus, play a crucial role in the generation of new neurons that contribute to the neural circuits responsible for regulating the systemic energy balance. The precise coordination of the gene networks controlling neurogenesis in naive and mature tanycytes is essential for maintaining homeostasis in adulthood. However, our understanding of the molecular mechanisms and signaling pathways that govern the proliferation and differentiation of tanycytes into neurons remains limited. This article aims to review the recent advancements in research into the mechanisms and functions of tanycyte-derived neurogenesis. Studies employing lineage-tracing techniques have revealed that the neurogenesis specifically originating from tanycytes in the hypothalamus has a compensatory role in neuronal loss and helps maintain energy homeostasis during metabolic diseases. Intriguingly,metabolic disorders are considered early biomarkers of Alzheimer's disease. Furthermore,the neurogenic potential of tanycytes and the state of newborn neurons derived from tanycytes heavily depend on the maintenance of mild microenvironments, which may be disrupted in Alzheimer's disease due to the impaired blood–brain barrier ***, the specific alterations and regulatory mechanisms governing tanycyte-derived neurogenesis in Alzheimer's disease remain unclear. Accumulating evidence suggests that tanycyte-derived neurogenesis might be impaired in Alzheimer's disease, exacerbating neurodegeneration. Confirming this hypothesis, however, poses a challenge because of the lack of long-term tracing and nucleus-specific analyses of newborn neurons in the hypothalamus of patients with Alzheimer's disease. Further research into the molecular mechanisms underlying tanycyte-derived neurogenesis holds promise for identifying small molecules capable of restoring tanycyte proliferation in neurodegenerative diseases. This line of investigation could pro

关键词： Alzheimer's disease blood–brain barrier ependymoglial cells hypothalamus metabolic diseases neural stem cells neurogenesis neuroinflammatory diseases neurons tanycyte

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Deciphering fungal metabolon coupling tandem inverse-electrondemand Diels-Alder reaction and semipinacol rearrangement for the biosynthesis of spiro polycyclic alkaloids

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Science China Chemistry 2025年第01期 288-296页

作者： Shuai Liu Wen-Qiang Xu Ying-Tong Di Man-Cheng tang Ding-Kang Chen Ming-Ming Cao Yao-Wen Chang Hong-Yu tang Chun-Mao Yuan Jun-Bo Yang Zhi-Li Zuo han Guo Zi-Fei Xu Ying Zeng Yun-Dong Wu Xiao-Jiang Hao Key Laboratory of Phytochemistry and Natural Medicines (Chinese Academy of Sciences) Kunming Institute of Botany Chinese Academy of Sciences University of Chinese Academy of Sciences Lab of Computational Chemistry and Drug Design State Key Laboratory of Chemical Oncogenomics Peking University Shenzhen Graduate School Shenzhen Bay Laboratory State Key Laboratory of Microbial Metabolism School of Life Sciences & Biotechnology Shanghai Jiao Tong University State Key Laboratory of Functions and Applications of Medicinal Plants Guizhou Medical University Molecular Biology Experimental Center Germplasm Bank of Wild Species in Southwest China Kunming Institute of Botany Chinese Academy of Sciences Yunnan Key Laboratory for Wild Plant Resources Kunming Institute of Botany Chinese Academy of Sciences Research Unit of Chemical Biology of Natural Anti-Virus Products Chinese Academy of Medical Sciences

In the intricate process of natural product biosynthesis, a metabolon can enhance metabolic flux by associating sequential enzymes. A fungal metabolon, comprising of flavin-dependent monooxygenase Spe F and P450 monooxygenase Spe G, is identified in the biosynthesis of spiro polycyclic alkaloids(+)-notoamide B and its diastereomer(+)-versicolamide B. Using notoamide E as a substance, Spe F/Spe G metabolon can control the stereoselectivity of its 2,3-epoxidation, followed by hydrogen atom ion at C-17 to generate reactive epoxide tau-m A with dienyl iminium unit. Subsequently,(+)-notoamide B and(+)-versicolamide B are produced via tandem nonenzymatic inverse-electron-demand Diels-Alder reaction and semipinacol rearrangement. This provides the first example of metabolon in the biosynthesis of spiro-prenylated indole alkaloids.

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The lining responses for shallow mountain tunnels subjected to frost heaving

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Journal of Mountain Science 2022年第2期19卷 529-546页

作者： ling Xian-zhang YU Yuan tang Liang GENG Lin han Xiao School of Civil Engineering Harbin Institute of TechnologyHarbin 150090China State Key Laboratory for Geomechanics and Deep Underground Engineering Xuzhou 221008China State Key Laboratory of Frozen Soil Engineering Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 730000China Railway Engineering Research Institute China Academy of Railway Sciences CorporationBeijing 100081China Beijing Tieke Special Engineering Technology Corporation Limited Beijing 100081China

Mountain tunnels in cold regions are vulnerable to adverse effects of freezing ***,it is necessary to identify the lining responses of shallow mountain tunnels subjected to freezing *** quantify the influence of freezing action and key design parameters(such as cross-sectional shape;lining thickness;and waterproof measures)on the lining response,a thermal-hydro-mechanical coupled finite element(FE)model is established and ***,specific consideration is given to the lining internal force and resulting axial *** the influences of the cross-sectional shape,concrete parameters,and waterproof measures on the lining responses are ***,the rectangular tunnel has the worst security;the circular tunnel is the *** the other hand,when the thermal conductivity is less than 2.2[W/(m·K)],a greater thermal conductivity will cause a greater risk of damage to the ***,the drainage plate can reduce the value of minimum axial stresses,whether frozen or not,even eliminating the tensiondamaged ***,this study helps to estimate the lining responses and prevent frost damages for shallow mountain tunnels during freezing period.

关键词： Coupled thermal-hydro-mechanical model Mountain tunnel in the cold region Lining responses Cross-sectional shape Freezing action

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Synthesis and Luminescence Properties of(Y, Gd)(P, V)O_4:Eu^(3+), Bi^(3+) Red Nano-phosphors with Enhanced Photoluminescence by Bi^(3+), Gd^(3+) Doping

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Nano-Micro Letters 2013年第2期5卷 117-123页

作者： Yong Pu Ke tang Da-Chuan Zhu Tao han Cong Zhao ling-ling Peng College of Material Science and Engineering Sichuan University College of Information Engineering Chengdu University of Technology Chongqing Key Laboratory of Micro/Nano Materials Engineering and Technology

A series of(Y_(1-y), Gdy)_(0.95-x)(P_y, V_(1-y))O_4 :0.05Eu^(3+), xBi^(3+)+phosphors have been successfully prepared by a subsection method. The crystal structure, surface morphology and luminescence properties were investigated. It was found that the sintered samples crystallized in a tetragonal crystal system with space group I_(41)/amd(a = b = 0.7119 nm, c = 0.6290 nm). The products presented rod-like morphology with length of 100-150 nm and width of 50-100 nm. A maximum peak at 619 nm(~5D_0 →~7F_2) was observed in emission spectrum of the phosphors. It was also found that co-doping of Bi^(3+)+, P5+and Gd^(3+)ions into YVO_4:Eu^(3+)can not only made the right edge of the excitation band shift to the long-wavelength region, but also increased the emission intensity at 619 nm sharply and decreased the lifetime of fluorescence decay. These results may expand the application scope of the phosphors.

关键词： (Y,Gd)(P,V)O4:Eu3+,Bi3+ Rod-like Red phosphors Photoluminescence Doping

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Metallogenic Model of Bauxite in Central Guizhou Province:an Example of Lindai Deposit

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Acta Geologica Sinica(English Edition) 2013年第6期87卷 1630-1642页

作者： ling Kunyue ZHU Xiaoqing WANG Zhonggang han Tao tang Haoshu CHEN Wenyi Institute of Geochemistry Chinese Academy of Sciences University of Chinese Academy of Sciences Institute of Geology Guizhou Bureau of Geology and Minerals

The bauxites in central Guizhou are hosted by the Lower Carboniferous Jiujialu *** characteristics of the Lindai bauxite deposit indicate that the underlying Shilengshui Formation dolomite is the precursor rock of mineral *** simulation experiments show that Si is most likely to migrate with groundwater,the migration rate of which is several magnitude higher than Al and Fe under nature conditions （pH=3-9）.The neutral and acid nonreducing condition is the most conducive to the Al rich and Si removal,while the acid reducing conditions is the most conducive to the Al rich and Fe *** the process of bauxite formation,coal beds overlying the Al-bearing rock series or other rock formation rich in organic materials can produce acid reducing groundwater,which are important for the bauxite ***,propose the metallogenic model of the bauxite in central Guizhou Province and put forward three new words which are ＂original bauxite material＂,＂bauxite material＂ and ＂original bauxite＂.

关键词： bauxite groundwater geochemistrial characteristics weathering simulation experiments Central Guizhou Province

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Oxidized low-density lipoprotein receptor 1:a novel potential therapeutic target for intracerebral hemorrhage

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Neural Regeneration Research 2022年第8期17卷 1795-1801页

作者： Hui-Yuan Zhang Xi Lu Yue-han Hao ling tang Zhi-Yi He Department of Neurology The First Hospital of China Medical UniversityShenyangLiaoning ProvinceChina

Oxidized low-density lipoprotein receptor 1(OLR1)is upregulated in neurons and participates in hypertension-induced neuronal ***1 deletion exerts protective effects on cerebral damage induced by hypertensive-induced ***,OLR1 is likely involved in the progress of intracerebral *** this study,we examined the potential role of OLR1 in intracerebral hemorrhage using a rat ***1 small interfering RNA(10μL;50 pmol/μL)was injected into the right basal ganglia to knock down ***-four hours later,0.5 U collagenase type VII was injected to induce intracerebral *** found that knockdown of OLR1 attenuated neurological behavior impairment in rats with intracerebral hemorrhage and reduced hematoma,neuron loss,inflammatory reaction,and oxidative stress in rat brain *** also found that silencing of OLR1 suppressed ferroptosis induced by intracerebral hemorrhage and the p38 signaling ***,silencing OLR1 exhibits protective effects against secondary injury of intracerebral *** findings suggest that OLR1 may be a novel potential therapeutic target for intracerebral hemorrhage.

关键词： ferroptosis inflammation intracerebral hemorrhage neurological behavior neuroprotection novel therapeutic target oxidative stress oxidized low-density lipoprotein receptor 1 p38 signaling pathway secondary brain injury

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核心结合因子α1在BMP-2调控细胞外基质蛋白表达中的作用

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上海口腔医学 2008年第6期17卷 611-615页

作者：余擎朱庆林孙汉堂田宇何文喜肖明振第四军医大学口腔医学院牙体牙髓科陕西西安710032

目的:探讨核心结合因子α1(cbfa1)在BMP-2调控体外培养的牙乳头细胞表达细胞外基质蛋白中的作用。方法:采用反义核酸技术,体外阻断培养的牙乳头细胞中cbfα1的表达,分别用RT-PCR、Western印迹等方法观察200ng/mLBMP-2作用6h后细胞中相... 详细信息

目的:探讨核心结合因子α1(cbfa1)在BMP-2调控体外培养的牙乳头细胞表达细胞外基质蛋白中的作用。方法:采用反义核酸技术,体外阻断培养的牙乳头细胞中cbfα1的表达,分别用RT-PCR、Western印迹等方法观察200ng/mLBMP-2作用6h后细胞中相关基质蛋白,碱性磷酸酶(ALP)、骨钙素(OC)、骨连蛋白(ON)、骨桥素(OPN)、骨涎蛋白(BSP)、牙本质基质蛋白1(DMP-1)以及牙本质涎磷蛋白(DSPP)的表达,采用SPSS11.0软件包对数据进行方差分析。结果:外源性BMP-2能明显上调牙乳头细胞中ALP、OC含量以及OPN、BSP和ON的表达,当反义阻断cbfα1的表达时,ALP、OC、OPN和BSP的表达显著降低(P<0.01)。结论:cbfα1参与了BMP-2调控体外培养的牙乳头细胞表达细胞外基质蛋白的信号转导过程。

关键词：核心结合因子α1 细胞外基质蛋白反义核酸

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Large-eddy simulation of suspended sediment transport in turbulent channel flow

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Journal of Hydrodynamics 2013年第1期25卷 48-55页

作者： ZHU Hai WANG ling-ling tang Hong-wu College of Water Conservancy and Hydropower Engineering Hohai University

The numerical simulation of the non-cohesive sediment transport in a turbulent channel flow with a high concentration is a challenging but practical task. A modified coherent dynamic eddy model of the Large Eddy Simulation （LES） with a pick-up function is used in the present study to simulate the sediment erosion and the deposition in a turbulent channel flow. The rough wall model is used instead of the LES with the near-wall resolution to obtain the reasonable turbulent flow characteristics while avoiding the high costs in the computation. Good results are obtained, and are used to analyze the sediment transport properties. The results show that the streamwise vortices play an important role in the riverbed erosion and the sediment pick-up, which may serve as guidelines for the sediment management and the water environment protection engineering.

关键词： Large Eddy Simulation (LES) sediment suspension pick-up function turbulent channel flow

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