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信息时代城市入口空间形态研究

新建筑 2002年第6期 43-46页

作者：陈剑宇凌峰陈纲伦华中科技大学建筑与城市规划学院武汉430074

在回顾城市入口空间形态的历史发展和解析人的认知需求的基础上,通过对城市入口空间概念的廓清,阐明城市入口空间形态及其存在的意义,提出信息时代的城市入口空间形态研究课题。城市入口是在城市与非城市之间作为空间界定标志而存在的,... 详细信息

在回顾城市入口空间形态的历史发展和解析人的认知需求的基础上,通过对城市入口空间概念的廓清,阐明城市入口空间形态及其存在的意义,提出信息时代的城市入口空间形态研究课题。城市入口是在城市与非城市之间作为空间界定标志而存在的,用以交换人流、物流、信息流,并可进行各种活动的空间。它不仅能够改善和丰富建筑和城市的整体环境、提高环境质量,作为文化和历史的载体,还能够增加城市特色和吸引力,为城市或区域带来繁荣与活力。21世纪,由于信息时代的到来,传统城市入口是仅仅针对人流、物流等实存物质而言的空间形态,它已无法解决当前日益强大的信息流问题。随着虚拟空间的出现,虚拟城市也在传媒网络中建立起来;进入城市的渠道已由单一的交通联系,转化为交通—媒介等多种方式的共存。体现传媒的介入成了信息时代城市入口空间形态的本质特征。

关键词：城市入口空间信息传媒

The emerging role of nitric oxide in the synaptic dysfunction of vascular dementia

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Neural Regeneration Research 2025年第2期20卷 402-415页

作者： Xiaorong Zhang Zhiying chen Yinyi Xiong Qin Zhou ling-Qiang Zhu Dan Liu Department of Pathology Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi ProvinceChina Jiujiang Clinical Precision Medicine Research Center JiujiangJiangxi ProvinceChina Center for Cognitive Science and Transdisciplinary Studies Jiujiang UniversityJiangxi ProvinceChina Department of Neurology Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi ProvinceChina Department of Rehabilitation Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi ProvinceChina Department of Pathophysiology School of Basic MedicineTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

With an increase in global aging,the number of people affected by cerebrovascular diseases is also increasing,and the incidence of vascular dementia-closely related to cerebrovascular risk-is increasing at an epidemic ***,few therapeutic options exist that can markedly improve the cognitive impairment and prognosis of vascular dementia *** in Alzheimer’s disease and other neurological disorders,synaptic dysfunction is recognized as the main reason for cognitive *** oxide is one of the ubiquitous gaseous cellular messengers involved in multiple physiological and pathological processes of the central nervous ***,nitric oxide has been implicated in regulating synaptic plasticity and plays an important role in the pathogenesis of vascular *** review introduces in detail the emerging role of nitric oxide in physiological and pathological states of vascular dementia and summarizes the diverse effects of nitric oxide on different aspects of synaptic dysfunction,neuroinflammation,oxidative stress,and blood-brain barrier dysfunction that underlie the progress of vascular ***,we propose that targeting the nitric oxide-sGC-cGMP pathway using certain specific approaches may provide a novel therapeutic strategy for vascular dementia.

关键词： endoplasmic reticulum stress endothelial nitric oxide synthase gene therapy nitric oxide NO-sGC-cGMP pathway synaptic dysfunction vascular dementia

氧化铁磁性纳米颗粒介导缺氧诱导因子1α shRNA质粒转染逆转A549/CDDP细胞对顺铂耐药的实验研究

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生物化学与生物物理进展 2010年第10期37卷 1090-1100页

作者：涂馨闵凌峰陈琼谢明萱何玲玲中南大学湘雅医院老年医学科呼吸内科长沙410008

评价了氧化铁磁性纳米颗粒作为缺氧诱导因子1α shRNA(HIF-1α shRNA)重组质粒载体进行体内体外转染的可行性及其逆转人肺腺癌耐药细胞株(A549/CDDP)顺铂耐性的效果,并初步探讨相关机制.在成功构建HIF-1α shRNA重组质粒后,分别利用氧... 详细信息

评价了氧化铁磁性纳米颗粒作为缺氧诱导因子1α shRNA(HIF-1α shRNA)重组质粒载体进行体内体外转染的可行性及其逆转人肺腺癌耐药细胞株(A549/CDDP)顺铂耐性的效果,并初步探讨相关机制.在成功构建HIF-1α shRNA重组质粒后,分别利用氧化铁磁性纳米颗粒及脂质体介导质粒转染A549/CDDP细胞及其移植瘤裸鼠动物模型,荧光显微镜检测转染效率,RT-PCR及细胞免疫化学检测转染后A549/CDDP细胞HIF-1α、多药耐药相关蛋白1(multidrug resistance1,MRP1)、肺耐药相关蛋白(lung resistance-related protein,LRP)mRNA及蛋白质表达,免疫组化检测转染后A549/CDDP移植瘤HIF-1α、MRP1及LRP蛋白表达,MTT法检测转染HIF-1α shRNA前后A549/CDDP细胞对顺铂的耐药性,并检测转染HIF-1α shRNA后A549/CDDP细胞移植瘤的肿瘤生长指数,HE染色检测纳米颗粒转染对裸鼠肝、肾及脑的组织学毒理作用.结果显示,氧化铁磁性纳米颗粒介导转染相对效率高于脂质体介导(P<0.01),HIF-1α shRNA转染A549/CDDP细胞后HIF-1α、MRP1、LRP mRNA及蛋白质表达下降,逆转A549/CDDP细胞对顺铂耐性82%,纳米颗粒介导HIF-1α shRNA转染A549/CDDP细胞移植瘤裸鼠动物模型后,移植瘤组织中HIF-1α、MRP1及LRP蛋白表达下降,转染HIF-1α shRNA后抑制移植瘤的生长,且与顺铂有协同效应,纳米颗粒转染后裸鼠肝、肾及脑组织无坏死.这些结果说明,纳米颗粒介导HIF-1α shRNA的体内体外转染效率高于脂质体,RNA干扰技术封闭HIF-1α基因可较大程度逆转耐顺铂人肺腺癌细胞的耐药性及其抑制瘤的生长,其作用可能与HIF-1α shRNA降低HIF-1α、MRP1及LRP表达有关,HIF-1α基因可作为逆转肺癌耐药治疗的有效靶点,磁性纳米颗粒介导HIF-1α shRNA质粒转染具有一定的生物安全性.

关键词：氧化铁磁性纳米颗粒肺肿瘤基因转染缺氧诱导因子1α(HIF-1d) RNA干扰

Re-Os isotopes and PGE geochemistry of black shales and intercalated Ni-Mo polymetallic sulfide bed from the Lower Cambrian Niutitang Formation, South China

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Progress in Natural Science:Materials International 2003年第10期 68-74页

作者： JIANG Shaoyong*, YANG Jinghong, ling Hongfei, feng Hongzhen, chen Yongquan and chen Jianhua(State Key Laboratory for Mineral Deposits Research, Department of Earth Sciences, Nanjing University, Nanjing 210093, China)

The Lower Cambrian Niutitang Formation consists of a thick black shale sequence with a regionally distributed conformable Ni Mo polymetallic sulfide horizon and a chert bed at its basal strata on theYangtze Platform, South China. In this paper, we discuss all available data on Re Os isotopes and Platinum Group Element (PGE) distribution pattern of the Ni Mo polymetallic sulfide ore and its host rocks (black shales, cherts, and phosphorites) from Guizhou and Hunan provinces. Our results show that the black shales and the Ni Mo sulfide ore have a high initial 187 Os/ 188 Os ratio of 0.78～0.86, indicating that the Early Cambrian ocean across the Yangtze Platform had a highly radiogenic Os value. This ratio is slightly lower than but still similar to present day seawater, possibly as a result of high continental weathering at that time. The Ni Mo sulfide ore yields a Re Os isochron of 537±10 Ma (MSWD=11.9), possibly representing the depositional age of the Niutitang Formation. The chondrite normalized PGE pattern, Pt anomaly (Pt/Pt *), Pt/Pd, Ir/Pd, Au/Ir and Re/Mo ratios of the Ni Mo sulfide ore and its host rocks from South China indicate a varying source contribution of the PGE and other metals for different rocks. It is suggested that the cherts and Ni Mo sulfide ore may have a significant proportion of PGE and probably other metals deriving from submarine hydrothermal fluids with a mantle signature.

关键词： Re Os isotopes PGE black shale Ni Mo sulfide Yangtze Platform South China.

Paleoceangraphic significance of redox-sensitive metals of black shales in the basal Lower Cambrian Niutitang Formation in Guizhou Province, South China

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Progress in Natural Science:Materials International 2004年第2期 56-61页

作者： YANG Jinghong, JIANG Shaoyong*, ling Hongfei, feng Hongzhen, chen Yongquan and chen Jianhua(State Key Laboratory for Mineral Deposits Research, Department of Earth Sciences, Nanjing University, Nanjing 210093, China)

Black shales of the Lower Cambrian Niutitang Formation occur widely on the Yangtze Platform. In this study, we analyzed black shales from two sections (Zhongnan and Zhijin) in Guizhou Province. The redox-sensitive metal concentration and distribution of black shales from the two sections provide good evidence for the anoxic conditions of the basal Cambrian ocean on the Yangtze Platform. Our geochemical data suggest that the black shales from the Zhongnan section may have deposited in a more strongly anoxic environment than the black shales in the Zhijin section.

关键词： redox-sensitive metals black shales Early Cambrian Yangtze Platform South China.

Ru doping triggering reconstruction of cobalt phosphide for coupling glycerol electrooxidation with seawater electrolysis

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Journal of Energy Chemistry 2025年第1期100卷 317-326页

作者： Binglu Deng Jie Shen Jinxing Lu Chuqiang Huang Zhuoyuan chen feng Peng Yunpeng Liu School of Materials Science and Hydrogen Energy Foshan University School of Chemistry and Chemical Engineering Guangzhou University Guangdong Key Laboratory for Hydrogen Energy Technologies

Seawater electrolysis is a promising approach for sustainable energy without relying on precious ***,the large-scale seawater electrolysis is hindered by low catalytic efficiency and severe anode corrosion caused by the harmful *** contrast to the oxygen evolution reaction （OER）and chlorin ion oxidation reaction （ClOR）,glycerol oxidation reaction （GOR） is more thermodynamically and kinetically favorable ***,a Ru doping cobalt phosphide （Ru-CoP2） is proposed as a robust bifunctional electrocatalyst for seawater electrolysis and GOR,for the concurrent productions of hydrogen and value-added *** in situ and ex situ characterization analyses demonstrated that Ru doping featured in the dynamic reconstruction process from Ru-CoP2to Ru-CoOOH,accounting for the superior GOR *** coupling GOR with hydrogen evolution was realized by employing Ru-CoP2as both anode and cathode,requiring only a low voltage of 1.43 V at 100 mA cm-2,which was 250 m V lower than that in alkaline *** work guides the design of bifunctional electrocatalysts for energy-efficient seawater electrolysis coupled with biomass resource upcycling.

关键词： Glycerol electrooxidation Hydrogen evolution Ru doping Cobalt phosphide Bifunctional electrocatalysts

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认证元器件使用讲座第二讲热熔断体(2)

家电科技 2006年第2期 70-71页

作者：陈凌峰广州北德技术服务有限公司

(续接本刊2006年第1期)⑤额定电压Ur标准对该参数的定义是'用于分类热熔断体的电压'.从定义看,该参数似乎实际意义不大.事实上,在检测热熔断体时,额定电压是一个重要的检测依据.根据标准要求,热熔断体在分断后,在一段时间内必须能够承... 详细信息

(续接本刊2006年第1期)⑤额定电压Ur标准对该参数的定义是'用于分类热熔断体的电压'.从定义看,该参数似乎实际意义不大.事实上,在检测热熔断体时,额定电压是一个重要的检测依据.根据标准要求,热熔断体在分断后,在一段时间内必须能够承受两倍的额定电压而不会出现重新导通的现象;在检测分断能力时,要求热熔断体在1.1倍额定电压的条件下能够安全地分断.

关键词：热熔断体元器件额定电压检测依据讲座认证标准要求分断能力实际意义定义

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认证元器件使用讲座第一讲热熔断体(1)

家电科技 2006年第1期 73-74页

作者：陈凌峰

中国是世界家电产品制造大国,中国生产的家电产品几乎到达世界上所有的国家和地区。通过认证来取得合格评定认证和规避技术贸易壁垒,早已经被许多厂家所认知。在认证时,使用认证的元件是许多厂家常见的选择。但是由于不了解元件认证的特... 详细信息

中国是世界家电产品制造大国,中国生产的家电产品几乎到达世界上所有的国家和地区。通过认证来取得合格评定认证和规避技术贸易壁垒,早已经被许多厂家所认知。在认证时,使用认证的元件是许多厂家常见的选择。但是由于不了解元件认证的特性,往往出现选择了认证的元件,仍然出现产品不符合标准要求的情况,或者由于不了解元件的特性,片面追求元件的个别参数过高,导致整机生产成本上升。本讲座的目的是为了使产品工程师方便快捷地了解元件的认证参数,以便在最短的时间内基本掌握其特性。本讲座的内容并不是对该元件的全面介绍,也不是相关元件标准的解释。对于元件的具体使用细节,特别是在元件的临界使用状态时,应当阅读相关的元件标准和厂家提供的产品技术规范。

关键词：热熔断体英文名称保护器件安全事故可复位热安全一次性器具

Bioinspired Passive Tactile Sensors Enabled by Reversible Polarization of Conjugated Polymers

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Nano-Micro Letters 2025年第1期17卷 361-377页

作者： feng He Sitong chen Ruili Zhou Hanyu Diao Yangyang Han Xiaodong Wu School of Mechanical Engineering Sichuan UniversityChengdu 610065People’s Republic of China School of Software Engineering Chongqing University of Posts and TelecommunicationsChongqing 400065People’s Republic of China State Key Laboratory of Polymer Materials Engineering Sichuan UniversityChengdu 610065People’s Republic of China

Tactile perception plays a vital role for the human body and is also highly desired for smart prosthesis and advanced *** to active sensing devices,passive piezoelectric and triboelectric tactile sensors consume less power,but lack the capability to resolve static ***,we address this issue by utilizing the unique polarization chemistry of conjugated polymers for the first time and propose a new type of bioinspired,passive,and bio-friendly tactile sensors for resolving both static and dynamic ***,to emulate the polarization process of natural sensory cells,conjugated polymers(including poly(3,4-ethylenedioxythiophen e):poly(styrenesulfonate),polyaniline,or polypyrrole)are controllably polarized into two opposite states to create artificial potential *** controllable and reversible polarization process of the conjugated polymers is fully in situ ***,a micro-structured ionic electrolyte is employed to imitate the natural ion channels and to encode external touch stimulations into the variation in potential difference *** with the currently existing tactile sensing devices,the developed tactile sensors feature distinct characteristics including fully organic composition,high sensitivity(up to 773 mV N^(−1)),ultralow power consumption(nW),as well as superior *** demonstrations,both single point tactile perception(surface texture perception and material property perception)and two-dimensional tactile recognitions(shape or profile perception)with high accuracy are successfully realized using self-defined machine learning *** tactile sensing concept innovation based on the polarization chemistry of conjugated polymers opens up a new path to create robotic tactile sensors and prosthetic electronic skins.

关键词： Passive tactile sensors Reversible polarization of conjugated polymers Tactile perception Machine learning algorithm Object recognition