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Dietary supplementation with citrus peel extract in transition period improves rumen microbial composition and ameliorates energy metabolism and lactation performance of dairy cows

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Journal of Animal Science and Biotechnology 2025年第1期16卷 441-454页

作者： lingxue Ju Qi Shao Zhiyuan fang Erminio Trevisi Meng Chen Yuxiang Song Wenwen Gao lin Lei Xinwei Li Guowen Liu Xiliang Du State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases Key Laboratory for Zoonosis Research of the Ministry of EducationInstitute of ZoonosisCollege of Veterinary MedicineJilin UniversityChangchun 130062China Department of Animal Sciences Food and NutritionFaculty of AgricultureFood and Environmental ScienceUniversitàCattolica del Sacro CuorePiacenza 29122Italy

Background During the transition period,excessive negative energy balance(NEB)lead to metabolic disorders and reduced milk *** microbes are responsible for resolving plant material and producing volatile fatty acids(VFA),which are the primary energy source for *** this study,we aimed to investigate the effect of citrus peel extract(CPE)supplementation on rumen microbiota composition,energy metabolism and milk performance of peri-partum dairy *** Dairy cows were fed either a basal diet(CON group)or the same basal diet supplemented with CPE via intragastric administration(4 g/d,CPE group)for 6 weeks(3 weeks before and 3 weeks after calving;n=15 per group).Samples of serum,milk,rumen fluid,adipose tissue,and liver were collected to assess the effects of CPE on rumen microbiota composition,rumen fermentation parameters,milk performance,and energy metabolic status of dairy *** CPE supplementation led to an increase in milk yield,milk protein and lactose contents,and serum glucose levels,while reduced serum concentrations of non-esterified fatty acid,β-hydroxybutyric acid,insulin,aspartate aminotransferase,alanine aminotransferase,and haptoglobin during the first month of *** supplemen-tation also increased the content of ruminal *** to the CON group,the abundance of Prevotellaceae,Methanobacteriaceae,Bacteroidales_RF16_group,and Selenomonadaceae was found increased,while the abun-dance of Oscillospiraceae,F082,Ruminococcaceae,Christensenellaceae,Muribaculaceae UCG-011,Saccharimona-daceae,Hungateiclostridiaceae,and Spirochaetaceae in the CPE group was found *** adipose tissue,CPE supplementation decreased lipolysis,and inflammatory response,while increased insulin *** the liver,CPE supplementation decreased lipid accumulation,increased insulin sensitivity,and upregulated expression of genes involved in *** Our findings suggest that CPE supplementation during the peripartum period

关键词： Adipose tissue Citrus peel extract Energy metabolism Liver Rumen microbiota

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Development and validation of a nomogram model for predicting overall survival in patients with gastric carcinoma

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World Journal of Gastrointestinal Oncology 2025年第2期17卷 132-143页

作者： Guan-Zhong Liang Xiao-Sheng Li Zu-Hai Hu Qian-Jie Xu fang Wu Xiang-lin Wu Hai-Ke Lei Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment Chongqing University Cancer HospitalChongqing 400030China Chongqing Cancer Multi-omics Big Data Application Engineering Research Center Chongqing University Cancer HospitalChongqing 400030China Department of Health Statistics School of Public HealthChongqing Medical UniversityChongqing 400016China Research Center for Medicine and Social Development School of Public HealthChongqing Medical UniversityChongqing 400016China The Research Center of Big Data Chongqing University Cancer HospitalChongqing 400030China

BACKGROUND The prevalence and mortality rates of gastric carcinoma are disproportionately elevated in China,with the disease's intricate and varied characteristics further amplifying its health *** forecasting of overall survival(OS)is of paramount importance for the clinical management of individuals afflicted with this *** To develop and validate a nomogram model that provides precise gastric cancer prevention and treatment guidance and more accurate survival outcome prediction for patients with gastric *** Data analysis was conducted on samples collected from hospitalized gastric cancer patients between 2018 and *** absolute shrinkage and selection operator,univariate,and multivariate Cox regression analyses were employed to identify independent prognostic factors.A nomogram model was developed to predict gastric cancer patient *** model's predictability and discriminative ability were evaluated via receiver operating characteristic *** evaluate the clinical utility of the model,Kaplan-Meier and decision curve analyses were *** A total of ten independent prognostic factors were identified,including body mass index,tumor-node-metastasis(TNM)stage,radiation,chemotherapy,surgery,albumin,globulin,neutrophil count,lactate dehydrogenase,and platelet-to-lymphocyte *** area under the curve(AUC)values for the 1-,3-,and 5-year survival prediction in the training set were 0.843,0.850,and 0.821,*** AUC values were 0.864,0.820,and 0.786 for the 1-,3-,and 5-year survival prediction in the validation set,*** model exhibited strong discriminative ability,with both the time AUC and time C-index exceeding *** with TNM staging,the model demonstrated superior clinical ***,a nomogram was developed via a web-based *** This study established and validated a novel nomogram model for predicting the OS of gastric cancer patients,which demonstrat

关键词： Gastric carcinoma Prediction Overall survival Nomogram Prospective

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Development and Application of Cavity-based Absorption Spectroscopy in Atmospheric Chemistry:Recent Progress

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Advances in Atmospheric Sciences 2025年第4期42卷 605-622页

作者： Weixiong ZHAO Nana YANG Renzhi HU Bo fang Jiacheng ZHOU Chuan lin Feihu CHENG Pinhua XIE Weijun ZHANG Anhui Institute of Optics and Fine Mechanics HFIPSChinese Academy of SciencesHefei 230031China School of Environmental Science and Optoelectronic Technology University of Science and Technology of ChinaHefei 230026China Institute of Environment Hefei Comprehensive National Science CenterHefei 230601China

Atmospheric chemistry research and atmospheric measurement techniques have mutually promoted each other and developed rapidly in China in recent ***-based absorption spectroscopy,which uses a high-finesse cavity to achieve very long absorption path-length,thereby achieving ultra-high detection sensitivity,plays an extremely important role in atmospheric chemistry *** on the Beer–Lambert law,this technology has the unique advantages of being non-destructive,chemical-free,and highly *** does not require any sample preparation and can quantitatively analyze atmospheric trace gases in real time and in *** this paper,we review the following:(1)key technological advances in different cavity-based absorption spectroscopy techniques,including cavity ring-down spectroscopy,cavityenhanced absorption spectroscopy,cavity attenuated phase shift spectroscopy,and their extensions;and(2)applications of these techniques in the detection of atmospheric reactive species,such as total peroxy radical,formaldehyde,and reactive nitrogen(e.g.,NOx,HONO,peroxy nitrates,and alkyl nitrates).The review systematically introduces cavity-based absorption spectroscopy techniques and their applications in atmospheric chemistry,which will help promote further communication and cooperation in the fields of laser spectroscopy and atmospheric chemistry.

关键词： cavity-based absorption spectroscopy atmospheric chemistry atmospheric reactive species

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Stir-Fried Semen Armeniacae Amarum Suppresses Aristolochic AcidⅠ-Induced Nephrotoxicity and DNA Adducts

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Chinese Journal of Integrative Medicine 2025年第2期31卷 142-152页

作者： LI Cheng-xian XIAO Xiao-he LI Xin-yu XIAO Da-ke WANG Yin-kang WANG Xian-ling ZHANG Ping LI Yu-rong NIU Ming BAI Zhao-fang School of Chinese Materia Medica Beijing University of Chinese MedicineBeijing(100102)China Department of Hepatology Military Institute of Chinese Materiathe Fifth Medical CentreGeneral Hospital of PLABeijing(100039)China National Key Laboratory of Kidney Beijing(100039)China School of Pharmacy Chengdu University of Traditional Chinese MedicineChengdu(610075)China School of Traditional Chinese Medicine Capital Medical UniversityBeijing(100069)China School of Traditional Chinese Medicine Southern Medical UniversityGuangzhou(510515)China Department of Pharmacy Medical Supplies Center of PLA General HospitalBeijing(100039)China Department of Military Patient Management the Fifth Medical Center of PLA General HospitalBeijing(100039)China Department of Hematology the Fifth Medical Center of Chinese PLA General HospitalBeijing(100071)China

Objective:To investigate the protective effects of stir-fried Semen Armeniacae Amarum(SAA)against aristolochic acidⅠ(AAⅠ)-induced nephrotoxicity and DNA adducts and elucidate the underlying mechanism involved for ensuring the safe use of Asari Radix et ***:In vitro,HEK293T cells overexpressing Flag-tagged multidrug resistance-associated protein 3(MRP3)were constructed by Lentiviral transduction,and inhibitory effect of top 10 common pairs of medicinal herbs with Asari Radix et Rhizoma in clinic on MRP3 activity was verified using a self-constructed fluorescence screening *** m RNA,protein expressions,and enzyme activity levels of NAD(P)H quinone dehydrogenase 1(NQO1)and cytochrome P4501A2(CYP1A2)were measured in differentiated Hepa RG *** toxicity after inhibition of AAⅠmetabolite transport was detected using cell counting kit-8 *** vivo,C57BL/6 mice were randomly divided into 5 groups according to a random number table,including:control(1%sodium bicarbonate),AAⅠ(10 mg/kg),stir-fried SAA(1.75 g/kg)and AAⅠ+stir-fried SAA(1.75 and 8.75 g/kg)groups,6 mice in each *** 7 days of continuous gavage administration,liver and kidney damages were assessed,and the protein expressions and enzyme activity of liver metabolic enzymes NQO1 and CYP1A2 were determined ***:In vivo,combination of 1.75 g/kg SAA and 10 mg/kg AAⅠsuppressed AAⅠ-induced nephrotoxicity and reduced d A-ALI formation by 26.7%,and these detoxification effects in a dose-dependent manner(P<0.01).Mechanistically,SAA inhibited MRP3 transport in vitro,downregulated NQO1 expression in vivo,increased CYP1A2 expression and enzymatic activity in vitro and in vivo,respectively(P<0.05 or P<0.01).Notably,SAA also reduced AAⅠ-induced hepatotoxicity throughout the detoxification process,as indicated by a 41.3%reduction in the number of liver adducts(P<0.01).Conclusions:Stirfried SAA is a novel drug candidate for the suppression of AAⅠ-induced liver and kidney dam

关键词： aristolochic acidⅠ stir-fried Semen Armeniacae Amarum detoxification principles of compatibility metabolic enzymes transporters

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Potential role of coagulation markers in early detection of bone metastasis in gastric cancer:A critical review

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World Journal of Gastrointestinal Oncology 2025年第3期17卷 461-463页

作者： Qing-Nan lin Qian Wu Chong Lv Jun Tang ling-Yun Zhao Ke-Yang Xu School of Clinical Medicine Zhejiang Chinese Medical UniversityHangzhou 310053Zhejiang ProvinceChina Department of Orthopedics Wuyi County Traditional Chinese Medicine HospitalJinhua 321200Zhejiang ProvinceChina Operating Room Wuyi County Traditional Chinese Medicine HospitalJinhua 321200Zhejiang ProvinceChina Faculty of Chinese Medicine and State Key Laboratory of Quality Research in Chinese MedicineMacao University of Science and TechnologyMacao 999078China Center for Cancer and Inflammation Research School of Chinese MedicineHong Kong Baptist UniversityHong Kong 999077China

This letter to the editor involves the article published in the World Journal of Gastrointestinal *** metastasis(BM)in gastric cancer(GC)is uncommon but can be prevalent in autopsy *** significantly impairs quality of life and is frequently underdiagnosed,as sensitive diagnostic tests are only performed after symptoms *** is crucial for the diagnosis of BM but is not routinely used for screening and is *** laboratory risk factors for BM in GC patients using multivariate analysis could be a more effective approach.

关键词： Gastric cancer Bone metastasis Coagulation markers Prothrombin time Activated partial thromboplastin time Fibrin degradation products Diagnostic indicators Oncology

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Water Quality,Influential Factors,and Management Strategies from 2016 to 2020 in the Yangtze River Economic Belt,China

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Chinese Geographical Science 2025年第1期35卷 175-186页

作者： lin Lanyu GUO Congrong CHEN Yanan HE Lihuan YAN Luyu fang Dekun MA Guangwen ZHANG Fengying LI Mingsheng China National Environmental Monitoring Centre Beijing 100012China Department of Health Ethics&SocietyCare and Public Health Research InstituteFaculty of HealthMedicine and Life SciencesMaastricht UniversityMaastricht 6200the Netherlands

The Yangtze River economic belt(YREB),China is important to the Chinese economy and for supporting sustainable *** the relationship between water quality indices and socioeconomic indicators could help improve aquatic environment management in the YREB and our understanding of the causes and effects of water quality variations in other large river *** this study,river water quality,factors affecting water quality,and management strategies,and correlations between water quality indices and socioeconomic indicators in the YREB during the 13th Five-Year Plan period(2016-2020)were *** single-factor evaluation method,constant price for GDP,and correlation analyses were *** results showed that:1)water quality in the YREB improved during the 13th Five-Year Plan *** number of aquatic environment sections meeting GradeⅠ-Ⅲwater quality standards increased by 13.1%and the number below Grade V decreased by 2.9%.2)The values of 12 indicators in the YREB exceeded relevant *** indicators with highest concentreation were the total phosphorus,chemical oxygen demand,ammonia nitrogen,and permanganate index,which were relatively high in downstream regions in Anhui Province,Jiangsu Province,and Shanghai Municipality.3)Ammonia nitrogen,chemical oxygen demand,and total phosphorus emissions per unit area and water extraction per unit area are relatively high in the three downstream regions mentioned above.4)Increased domestic sewage discharges have increased total wastewater discharges in the YREB.5)River water quality in the YREB strongly correlated with population,economic,and water resource indices and less strongly correlated with government investment,agriculture,meteorology,energy,and forestry *** confirmed the need to decrease wastewater discharges and non-point-source pollutant *** aquatic environment could be improved by taking reasonable measures to control population growth,adjusting the industrial str

关键词： water quality factors coping strategies Yangtze River economic belt(YREB),China

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Goat casein hydrolysates alleviated insomnia in mice via modulating the level of neurotransmitters and the composition of gut microbiota

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Food Science and Human Wellness 2025年第1期14卷 212-225页

作者： ling Mo Huijuan Jing Xiaojing Du Chaochao Zhao Yintao lin Jie Li Hongxin Wang State Key Laboratory of Food Science and Technology Jiangnan UniversityWuxi 214122China School of Food Science and Technology Jiangnan UniversityWuxi 214122China School of Public Health Guilin Medical UniversityGuilin 541199China Sweet Inn(Guangzhou)Technology Development Co. Ltd.Guangzhou 510075China

Insomnia is associated with neurotransmitters and intestinal *** studies have demonstrated the ameliorative effects of milk hydrolysates on insomnia,the underlying mechanisms require further *** this study,we investigated how papain hydrolysates of goat casein(CPH)and whey protein(WPH)affected mice's ***,we show that CPH effectively improved the total sleep time in 12 h and restoring neurotransmitters(5-hydroxytryptamine(5-HT),γ-aminobutyric acid(GABA),dopamine(DA),and norepinephrine(NE))in *** gut microbiota analysis revealed a significant increase in the relative abundance of Helicobacter and Escherichia-Shigella and a decrease in the relative abundance of Lactobacillus in the insomnia model mice(Model).Compared to the Model group,both CPH and WPH significantly increased the relative abundance of Akkermansia and Lactobacillus while lowering the relative abundance of Helicobacter and ***,while diazepam(DZP)increased mouse sleep duration,it also increased the relative abundance of Colidextribacter,Parasutterella,Muribaculaceae,and ***,the gene expression and protein expression of GABA_A receptor,cAMP-response element binding protein(CREB),and brain-derived neurotrophic factor(BDNF)were upregulated in the *** also discovered a link between intestinal gut microbiota and ***,our results suggest that goat milk hydrolysates,especially CPH,can effectively improve insomnia,providing a theoretical basis for further experimentation and individualized designs.

关键词： Goat casein Hydrolysates Insomnia Gut microbiota

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美国社会的“政治正确”之争及其选举效应

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世界经济与政治论坛 2025年第1期 40-55,171,172页

作者：林玲上海外国语大学英语学院、美国研究中心上海市200083

自20世纪60年代民权运动以来,大学校园作为美国社会“政治正确”之争的发源地与前沿阵地,呈现出进步派和保守派之间基于族裔、性别、性取向等系列问题的价值观分野与博弈。20世纪六七十年代,“政治正确”的早期发展对促进美国少数族群... 详细信息

自20世纪60年代民权运动以来,大学校园作为美国社会“政治正确”之争的发源地与前沿阵地,呈现出进步派和保守派之间基于族裔、性别、性取向等系列问题的价值观分野与博弈。20世纪六七十年代,“政治正确”的早期发展对促进美国少数族群平权与社会公正具有重要意义。近年来,随着“黑命亦命”反种族主义运动的高涨,左翼身份政治开始与“觉醒主义”“取消文化”合流,推动“政治正确”的激进化,进而激发了右翼的“反‘政治正确’”运动。与20世纪末集中于美国校园的“政治正确”论战不同,近年来的“政治正确”之争已远远溢出大学校园,呈现出与选举政治的深度结合,“反‘政治正确’”运动成为特朗普右翼民粹政治动员的重要策略。

关键词：政治正确觉醒主义取消文化反政治正确运动选举政治

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Association between fresh fruit intake and cardiovascular disease risk in patients with diabetes: A prospective cohort study

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中华医学杂志(英文版) 2025年第2期138卷 243-245页

作者： fang Xin Zhang Xingyi Yang Ze Zhang Yefa Huang Shaofeng Chen Tiehui Yu ling Zhong Wenling Department of Non-communicable Chronic Disease Control Fujian Provincial Center for Disease Control and Prevention Fuzhou Fujian China National Clinical Research Center of Cardiovascular Diseases NHC Key Laboratory of Clinical Research for Cardiovascular Medications State Key Laboratory of Cardiovascular Disease Fuwai Hospital National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China Department of Cardiology Fujian Provincial Hospital Fuzhou Fujian China

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高质量发展背景下的出版集团产业发展表现——基于主题图书、一般图书和教育图书的统计分析

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出版发行研究 2025年第1期 5-12页

作者：林玲中国新闻出版研究院

党的十九大报告作出“我国经济已由高速增长阶段转向高质量发展阶段”的科学论断,党的二十大报告进一步指出“高质量发展是全面建设社会主义现代化国家的首要任务”。对于出版业而言,主题出版重点图书和头部图书的出版情况是行业高质量... 详细信息

党的十九大报告作出“我国经济已由高速增长阶段转向高质量发展阶段”的科学论断,党的二十大报告进一步指出“高质量发展是全面建设社会主义现代化国家的首要任务”。对于出版业而言,主题出版重点图书和头部图书的出版情况是行业高质量发展的重要体现,而出版集团作为出版业的主力军,肩负着引领行业发展的艰巨使命。文章依据2022年图书出版统计数据,以36家图书出版集团为研究对象,通过考察各集团出版主题出版重点图书和头部图书的品种、印数及排名情况,对集团表现进行评析,进而提出有针对性的建议。

关键词：高质量发展出版集团图书出版分析

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