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Tungsten 2024年第1期6卷 114-123页

作者： Jin-Hui Wang Shao-Wei Yang Fu-Bin Ma Yi-Ke Zhao Shi-Nuo Zhao zheng-Yu Xiong Dong Cai Hai-Dong Shen Kai Zhu Qiu-Yu Zhang Yue-ling Cao Tian-Shuai Wang He-Peng Zhang Research and Development Institute of Northwestern Polytechnical University in Shenzhen Shenzhen 518057China Xi’an Key Laboratory of Functional Organic Porous Materials School of Chemistry and Chemical EngineeringNorthwestern Polytechnical UniversityXi’an 710129China School of Power and Energy Northwestern Polytechnical UniversityXi’an 710129China Chongqing Science and Technology Innovation Center of Northwestern Polytechnical University Chongqing 401135China

Developing cost-effective electrocatalysts with high activity and stability especially at high current density is of great significance for the large-scale commercial application of electrochemical water splitting to hydrogen production but still remains challenging.Herein,we report an effective confinement pyrolysis strategy to fabricate embedded ruthenium-cobalt nanoclusters supported on N-doped porous two-dimensional carbon nanosheets(RuCo@CN).Markedly,the embedded structure can effectively prevent the migration,agglomeration,and leaching of nanoparticles,thus endowing the RuCo@CN catalyst with high stability.To be exact,high stability with up to 650 h can be achieved at high current density(-500 and-1000 mA·cm^(-2)).Besides,the RuCo@CN catalysts also exhibit highly reactive with low overpotentials of only 11mV at-10 mA·cm^(-2).Density functional theory calculations reveal that the introduction of cobalt reduces the decomposition barrier of H_(2)O for RuCo@CN alloy,thus promoting hydrogen evolution reaction.

关键词： Hydrogen evolution reaction Confinement pyrolysis strategy Mosaic structure Stability

多发性肌炎/皮肌炎相关间质性肺病治疗的研究进展

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上海交通大学学报（医学版） 2024年第4期44卷 531-536页

作者：郑晓峰徐凌上海交通大学医学院附属第六人民医院呼吸与危重症医学科上海200233

多发性肌炎/皮肌炎(polymyositis/dermatomyositis,PM/DM)是一组病因未明,以骨骼肌炎症浸润为特征的异质性自身免疫性疾病。PM/DM患者中间质性肺病(interstitial lung disease,ILD)的发病率较高,合并ILD是影响PM和DM患者预后的最重要因... 详细信息

多发性肌炎/皮肌炎(polymyositis/dermatomyositis,PM/DM)是一组病因未明,以骨骼肌炎症浸润为特征的异质性自身免疫性疾病。PM/DM患者中间质性肺病(interstitial lung disease,ILD)的发病率较高,合并ILD是影响PM和DM患者预后的最重要因素。现有证据表明PM/DM相关ILD异质性大,需要结合ILD的起病形式、进展速度、病变受累范围、实验室检查、是否存在预后不良因素以及对治疗的反应等进行个体化施治。文章总结了近年来PM/DM相关ILD在治疗方面的研究进展,包括传统治疗药物的选择、用药时机、临床上在该领域尝试的新的相关用药(如生物制剂、Janus激酶抑制剂)、静脉输注免疫球蛋白、抗纤维化药物,以及潜在的有效的非药物治疗方法,旨在帮助临床医师更好地制定PM/DMILD治疗方案,从而改善患者的预后。

关键词：多发性肌炎皮肌炎间质性肺病药物治疗

High formability Mg-Zn-Gd wire facilitates ACL reconstruction via its swift degradation to accelerate intra-tunnel endochondral ossification

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Journal of Magnesium and Alloys 2024年第1期12卷 295-315页

作者： Xuan He Ye Li Hongwei Miao Jiankun Xu Michael Tim-yun Ong Chenmin Wang Lizhen zheng Jiali Wang Le Huang Haiyue Zu Zhi Yao Jie Mi Bingyang Dai Xu Li Patrick Shu-hang Yung Guangyin Yuan ling Qin Musculoskeletal Research Laboratory of Department of Orthopaedics&Traumatology and Innovative Orthopaedic Biomaterial and Drug Translational Research Laboratory of Li Ka Shing Institute of Health Sciences The Chinese University of Hong KongHong KongChina National Engineering Research Center of Light Alloy Net Forming School of Materials Science&EngineeringShanghai Jiao Tong UniversityShanghaiChina Department of Orthopaedics and Traumatology Li Ka Shing Faculty of MedicineThe University of Hong KongHong KongChina Orthopaedic Department Peking University Third HospitalBeijingChina Department of Rehabilitation Sciences The Hong Kong Polytechnic UniversityHong KongChina

After reconstructing the anterior cruciate ligament(ACL),unsatisfactory bone tendon interface healing may often induce tunnel enlargement at the early healing stage.With good biological features and high formability,Magnesium-Zinc-Gadolinium(ZG21)wires are developed to bunch the tendon graft for matching the bone tunnel during transplantation.Microstructure,tensile strength,degradation,and cytotoxicity of ZG21 wire are evaluated.The rabbit model is used for assessing the biological effects of ZG21 wire by Micro-CT,histology,and mechanical test.The SEM/EDS,immunochemistry,and in vitro assessments are performed to investigate the underlying mechanism.Material tests demonstrate the high formability of ZG21 wire as surgical suture.Micro-CT shows ZG21 wire degradation accelerates tunnel bone formation,and histologically with earlier and more fibrocartilage regeneration at the healing interface.The mechanical test shows higher ultimate load in the ZG21 group.The SEM/EDS presents ZG21 wire degradation triggered calcium phosphate(Ca-P)deposition.IHC results demonstrate upregulation of Wnt3a,BMP2,and VEGF at the early phase and TGFβ3 and Type II collagen at the late phase of healing.In vitro tests also confirmed the Ca-P in the metal extract could elevate the expression of Wnt3a,βcatenin,ocn and opn to stimulate osteogenesis.Ex vivo tests of clinical samples indicated suturing with ZG21 wire did not weaken the ultimate loading of human tendon tissue.In conclusion,the ZG21 wire is feasible for tendon graft bunching.Its degradation products accelerated intra-tunnel endochondral ossification at the early healing stage and therefore enhanced bone-tendon interface healing in ACL reconstruction.

关键词： Magnesium wire ACL reconstruction Magnesium alloy Biomaterials Endochondral ossification

Cell softness reveals tumorigenic potential via ITGB8/AKT/glycolysis signaling in a mice model of orthotopic bladder cancer

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Chinese Medical Journal 2024年第2期137卷 209-221页

作者： Shi Qiu Yaqi Qiu linghui Deng ling Nie Liming Ge Xiaonan zheng Di Jin Kun Jin Xianghong Zhou Xingyang Su Boyu Cai Jiakun Li Xiang Tu Lina Gong Liangren Liu Zhenhua Liu Yige Bao Jianzhong Ai Tianhai Lin Lu Yang Qiang Wei Department of Urology Institute of UrologyNational Clinical Research Center for Geriatrics and Center of Biomedical Big DataWest China Hospital of Sichuan UniversityChengduSichuan 610041China Department of Molecular Oncology Institute of Oncology Research(IOR)Oncology Institute of Southern Switzerland(IOSI)Bellinzona 6500Switzerland Department of Science and Drug Technology University of TurinTurinItaly National Clinical Research Center of Geriatrics The Center of Gerontology and GeriatricsWest China HospitalSichuan UniversityChengduSichuan 610000China Department of Pathology West China HospitalSichuan UniversityChengduSichuan 610041China Department of Pharmaceutics and Bioengineering School of Chemical EngineeringSichuan UniversityChengduSichuan 610000China

Background:Bladder cancer,characterized by a high potential of tumor recurrence,has high lifelong monitoring and treatment costs.To date,tumor cells with intrinsic softness have been identified to function as cancer stem cells in several cancer types.Nonetheless,the existence of soft tumor cells in bladder tumors remains elusive.Thus,our study aimed to develop a microbarrier microfluidic chip to efficiently isolate deformable tumor cells from distinct types of bladder cancer cells.Methods:The stiffness of bladder cancer cells was determined by atomic force microscopy(AFM).The modified microfluidic chip was utilized to separate soft cells,and the 3D Matrigel culture system was to maintain the softness of tumor cells.Expression patterns of integrinβ8(ITGB8),protein kinase B(AKT),and mammalian target of rapamycin(mTOR)were determined by Western blotting.Double immunostaining was conducted to examine the interaction between F-actin and tripartite motif containing 59(TRIM59).The stem-cell-like characteristics of soft cells were explored by colony formation assay and in vivo studies upon xenografted tumor models.Results:Using our newly designed microfluidic approach,we identified a small fraction of soft tumor cells in bladder cancer cells.More importantly,the existence of soft tumor cells was confirmed in clinical human bladder cancer specimens,in which the number of soft tumor cells was associated with tumor relapse.Furthermore,we demonstrated that the biomechanical stimuli arising from 3D Matrigel activated the F-actin/ITGB8/TRIM59/AKT/mTOR/glycolysis pathways to enhance the softness and tumorigenic capacity of tumor cells.Simultaneously,we detected a remarkable up-regulation in ITGB8,TRIM59,and phospho-AKT in clinical bladder recurrent tumors compared with their non-recurrent counterparts.Conclusions:The ITGB8/TRIM59/AKT/mTOR/glycolysis axis plays a crucial role in modulating tumor softness and stemness.Meanwhile,the soft tumor cells become more sensitive to chemotherapy after stiffening,that offers new insights fo

关键词： Soft tumor cells 3D Matrigel Stemness Non-muscle invasive bladder neoplasms Microfluidic analytical techniques

PRaG 3.0 therapy for human epidermal growth factor receptor 2-positive metastatic pancreatic ductal adenocarcinoma:A case report

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World Journal of Gastroenterology 2024年第9期30卷 1237-1249页

作者： Yue-Hong Kong Mei-ling Xu Jun-Jun Zhang Guang-Qiang Chen Zhi-Hui Hong Hong Zhang Xiao-Xiao Dai Yi-Fu Ma Xiang-Rong Zhao Chen-Yang Zhang Rong-zheng Chen Peng-Fei Xing Li-Yuan Zhang Center for Cancer Diagnosis and Treatment The Second Affiliated Hospital of Soochow UniversitySuzhou 215000Jiangsu ProvinceChina Department of Radiotherapy&Oncology The Second Affiliated Hospital of Soochow UniversitySuzhou 215000Jiangsu ProvinceChina Institution of Radiotherapy&Oncology Soochow UniversitySuzhou 215000Jiangsu ProvinceChina Department of Radiology The Second Affiliated Hospital of Soochow UniversitySuzhou 215000Jiangsu ProvinceChina Department of Nuclear Medicine The Second Affiliated Hospital of Soochow UniversitySuzhou 215000Jiangsu ProvinceChina Department of Clinical Laboratory The Second Affiliated Hospital of Soochow UniversitySuzhou 215000Jiangsu ProvinceChina Department of Pathology The Second Affiliated Hospital of Soochow UniversitySuzhou 215000Jiangsu ProvinceChina

BACKGROUND Pancreatic ductal adenocarcinoma(PDAC)is a highly fatal disease with limited effective treatment especially after first-line chemotherapy.The human epidermal growth factor receptor 2(HER-2)immunohistochemistry(IHC)positive is associated with more aggressive clinical behavior and shorter overall survival in PDAC.CASE SUMMARY We present a case of multiple metastatic PDAC with IHC mismatch repair proficient but HER-2 IHC weakly positive at diagnosis that didn’t have tumor regression after first-line nab-paclitaxel plus gemcitabine and PD-1 inhibitor treatment.A novel combination therapy PRaG 3.0 of RC48(HER2-antibody-drug conjugate),radio-therapy,PD-1 inhibitor,granulocyte-macrophage colony-stimulating factor and interleukin-2 was then applied as second-line therapy and the patient had confirmed good partial response with progress-free-survival of 6.5 months and overall survival of 14.2 month.She had not developed any grade 2 or above treatment-related adverse events at any point.Percentage of peripheral CD8^(+) Temra and CD4^(+) Temra were increased during first two activation cycles of PRaG 3.0 treatment containing radiotherapy but deceased to the baseline during the maintenance cycles containing no radiotherapy.CONCLUSION PRaG 3.0 might be a novel strategy for HER2-positive metastatic PDAC patients who failed from previous first-line approach and even PD-1 immunotherapy but needs more data in prospective trials.

关键词： Pancreatic ductal adenocarcinoma PRaG 3.0 therapy Human epidermal growth factor receptor 2 Novel combination therapy Case report

乡村人才振兴与乡村经济高质量发展——基于高校毕业生返乡就业分析

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经济问题 2024年第2期 91-97页

作者：郑直孔令海长春师范大学数学学院吉林长春130032 南京林业大学马克思主义学院江苏南京210037

乡村振兴战略的实施促进乡村经济逐渐走向高质量发展的道路。在这个过程中,高校毕业生的返乡就业成为推动乡村经济发展的重要力量,为乡村的经济发展注入了新的活力。乡村人才振兴和乡村经济高质量发展是相互促进、相辅相成的,为乡村经... 详细信息

乡村振兴战略的实施促进乡村经济逐渐走向高质量发展的道路。在这个过程中,高校毕业生的返乡就业成为推动乡村经济发展的重要力量,为乡村的经济发展注入了新的活力。乡村人才振兴和乡村经济高质量发展是相互促进、相辅相成的,为乡村经济的持续发展提供了强有力的支撑。只有实现两者的协同发展,才能更好地推动乡村振兴战略的实施,实现农村经济社会的全面发展。只有通过培养和引进大量优秀人才,才能推动乡村产业升级、科技创新和文化繁荣,从而实现乡村振兴战略的目标。此外,乡村人才的培养和引进还能为乡村振兴全面发展提供坚实保障。高校毕业生可以通过自己的行动和影响力,改变村民们对乡村振兴的认识和态度,激发他们的积极性和创造力。

关键词：乡村人才振兴乡村经济高质量发展高校毕业生

Active Collision Avoidance System Design Based on Model Predictive Control with Varying Sampling Time

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Automotive Innovation 2020年第1期3卷 62-72页

作者： Wanying Xue ling zheng Automobile Engineering Department Chongqing UniversityChongqing 400044China The State Key Laboratory of Mechanical Transmission Chongqing 400044China

In active collision avoidance,the trajectory tracking controller determines the deviation from the reference path and the vehicle stability.The main objective of this study was to reduce the tracking error and improve the tracking performance in collision avoidance.Unlike the previously proposed model predictive control(MPC)strategies with constant sampling time,an improved MPC controller with varying sampling time based on the hierarchical control framework was proposed in this paper.Compared with the original MPC tracking controller,the improved MPC controller demonstrated better adaptive capability for the varying road adhesion coefficients and vehicle speed on a curved road.The simulation results revealed that the hierarchical control framework generated an optimal trajectory for collision avoidance in real-time by minimizing the potential field energy.

关键词： Active collision avoidance Improved MPC controller Varying sampling time Tracking control

Identification of Key Blood Biomarkers Linking Di(2-ethylhexyl)Phthalate and Autoimmune Diseases in Adolescents Mice

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Biomedical and Environmental Sciences 2024年第5期37卷 521-525页

作者： XU Xiao Mei LI Xiao Lu HU Die CAI Xiao Yue LI Qi Meng zheng Yuan Zhuo CAI Yang QI Yin Yin XU Tao ZHAO ling Li NING Xia Department of Infectious Diseases Anhui Provincial Children’s HospitalHefei 231000AnhuiChina Department of Toxicology School of Public HealthKey Laboratory of Environmental Toxicology of Anhui Higher Education InstitutesAnhui Medical UniversityHefei 231000AnhuiChina School of Biology Food and EnvironmentHefei UniversityHefei 230601AnhuiChina

Di(2-ethylhexyl)phthalate(DEHP)is a widely used plasticizer known for its reproductive developmental and immune system toxicity,mainly through esophagal,dermal,and respiratory exposure^([1-3]).Maternal exposure to DEHP during pregnancy can lead to adverse birth outcomes in offspring,including impacts on the thyroid system of adolescent offspring^([2-4]).

关键词： Blood respiratory pregnancy

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基于数据滤波的随机梯度辨识方法

控制与决策 2024年第7期39卷 2259-2266页

作者：丁锋郑嘉芸张霄徐玲江南大学物联网工程学院

针对有色噪声干扰下的随机系统,利用数据滤波技术,对输入输出数据进行滤波,将具有滑动平均噪声的原始系统转换为白噪声干扰下的系统,提出有限脉冲响应滑动平均系统的滤波增广随机梯度算法,并对该算法进行收敛性分析.此外,为了提高参数... 详细信息

针对有色噪声干扰下的随机系统,利用数据滤波技术,对输入输出数据进行滤波,将具有滑动平均噪声的原始系统转换为白噪声干扰下的系统,提出有限脉冲响应滑动平均系统的滤波增广随机梯度算法,并对该算法进行收敛性分析.此外,为了提高参数估计的精度和加快算法的收敛速度,使用多新息辨识理论提出滤波多新息增广随机梯度算法,并分析其收敛性.与增广随机梯度算法相比,所提出的滤波增广随机梯度算法和滤波多新息增广随机梯度算法可以得到更高精度的参数估计.最后,通过仿真实例表明了所提出算法的有效性.

关键词：参数估计多新息辨识数据滤波随机系统随机梯度收敛性分析

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考虑车辆运动预测的AEB系统控制策略

重庆大学学报 2024年第5期47卷 47-56页

作者：韦民祥郑玲杨威重庆大学机械传动国家重点实验室重庆400044

针对自动紧急制动(autonomous emergency braking,AEB)系统弯道适应性差及舒适性不佳的问题,提出了一种基于高斯过程运动预测,考虑变曲率弯道和制动舒适性的AEB系统控制策略。基于三次样条曲线建立行车道路模型,对前车进行定位,并计算... 详细信息

针对自动紧急制动(autonomous emergency braking,AEB)系统弯道适应性差及舒适性不佳的问题,提出了一种基于高斯过程运动预测,考虑变曲率弯道和制动舒适性的AEB系统控制策略。基于三次样条曲线建立行车道路模型,对前车进行定位,并计算相对曲线距离。考虑车辆运动的非线性特性以及时间效应,建立基于高斯过程理论的车辆运动预测模型,设计了基于预测碰撞时间的分级预警与制动控制策略。联合仿真结果表明:提出的控制策略能够有效实现车辆的避撞,解决了AEB系统在复杂动态工况下的弯道适应性和制动舒适性问题。

关键词：驾驶辅助系统自动紧急制动高斯过程碰撞时间

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