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冠状动脉微循环阻力指数的应用与进展

中国介入心脏病学杂志 2024年第2期32卷 96-100页

作者：任凌彤艾虎北京医院心内科国家老年医学中心中国医学科学院老年医学研究院北京100730 北京大学医学部第五临床医学院北京100730

随着对冠状动脉相关疾病研究的深入,人们逐渐认识到冠状动脉微循环障碍对于心血管疾病的发生、发展、疗效及预后等具有重要影响,冠状动脉微循环疾病在缺血性心脏病中受到越来越多的重视。由于无法直接通过影像学观察到冠状动脉微血管,... 详细信息

随着对冠状动脉相关疾病研究的深入,人们逐渐认识到冠状动脉微循环障碍对于心血管疾病的发生、发展、疗效及预后等具有重要影响,冠状动脉微循环疾病在缺血性心脏病中受到越来越多的重视。由于无法直接通过影像学观察到冠状动脉微血管,目前临床上出现了一些评价冠状动脉微循环功能的指标,其中微循环阻力指数被广泛用于冠状动脉微循环功能评价。基于计算流体力学的微循环阻力指数测定技术准确、安全、简单易行,应用前景广泛。本文就微循环阻力指数的建立、发展、临床应用、进展进行综述。

关键词：微循环阻力指数冠状动脉微循环功能障碍计算流体力学

重组人干扰素α1b雾化吸入联合布地奈德对反复上呼吸道感染患儿的治疗效果

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临床医学工程 2024年第7期31卷 845-846页

作者：仝玲古健鹏河南省唐河县人民医院儿科河南南阳473400 郑州大学医学院河南郑州450052

目的分析重组人干扰素α1b雾化吸入联合布地奈德对反复上呼吸道感染(RURTI)患儿的治疗效果。方法选取2022年6月至2023年6月我院收治的90例RURTI患儿,随机分为联合组(n=45)和单一组(n=45),单一组予以匹多莫德治疗,联合组予以重组人干扰素... 详细信息

目的分析重组人干扰素α1b雾化吸入联合布地奈德对反复上呼吸道感染(RURTI)患儿的治疗效果。方法选取2022年6月至2023年6月我院收治的90例RURTI患儿,随机分为联合组(n=45)和单一组(n=45),单一组予以匹多莫德治疗,联合组予以重组人干扰素α1b雾化吸入联合布地奈德治疗。对比两组的临床疗效、症状消失时间及不良反应。结果联合组总有效率为93.33%,高于单一组的75.56%(P0.05)。结论重组人干扰素α1b雾化吸入联合布地奈德治疗RURTI患儿可提高临床疗效,缩短发热、咽喉肿痛、咳嗽、肺啰音消失时间,安全性良好。

关键词：反复上呼吸道感染重组人干扰素α1b 布地奈德

吲哚菁绿荧光显像技术在胃癌全胃切除术中评估食管空肠吻合口血供的应用价值

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中国现代普通外科进展 2024年第9期27卷 724-727页

作者：祁旺张同领新沂市人民医院胃肠外科江苏新沂221400

分析胃癌全胃切除术中吲哚菁绿荧光显像技术评估食管空肠吻合口血供情况对减少术后吻合口瘘的作用。采用回顾性队列研究方法,收集2020年1月—2024年3月在新沂市人民医院胃肠外科接受腹腔镜全胃切除伴食管空肠吻合手术的60例胃癌患者的... 详细信息

分析胃癌全胃切除术中吲哚菁绿荧光显像技术评估食管空肠吻合口血供情况对减少术后吻合口瘘的作用。采用回顾性队列研究方法,收集2020年1月—2024年3月在新沂市人民医院胃肠外科接受腹腔镜全胃切除伴食管空肠吻合手术的60例胃癌患者的临床资料。根据是否使用吲哚菁绿显示吻合口血供情况,分为吲哚菁绿(ICG)组(n=24)和对照组(n=36),观察吲哚菁绿荧光显影情况并对比两组术中情况、术后并发症情况及术后恢复情况。在手术时间、术中出血量、淋巴结清除数目等术中情况的比较中,两组差异无统计学意义(P>0.05)。术后并发症的比较中,ICG组吻合口瘘发生率低于对照组(4.2%比11.1%,P=0.340);而在切口感染、吻合口出血、肠梗阻等其他并发症的比较中,两组差异无统计学意义(P>0.05)。术后住院时间比较,ICG组少于对照组[(10.5±3.5)d比(14.5±3.6)d,P=0.04]。胃癌全胃切除术中采用吲哚菁绿荧光显像技术评估吻合口血供情况,可以在一定程度上降低吻合口瘘发生率,提高手术安全性,缩短住院时间,有临床推广价值。

关键词：腹腔镜全胃切除术吲哚菁绿食管空肠吻合口瘘

开口型压型钢板-ECC组合楼板受力性能试验研究及数值模拟

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建筑科学与工程学报 2024年第4期41卷 20-30页

作者：白亮宋莉莎许卓轩凌童廖芳芳长安大学建筑工程学院陕西西安710061

为研究开口型压型钢板-工程增强水泥基复合材料(ECC)组合楼板的受力性能,对开口型压型钢板-ECC组合楼板试件进行静力加载试验及数值模拟,研究了试件破坏模式、端部滑移、荷载-挠度曲线、压型钢板应变分布及承载能力;利用ABAQUS有限元程... 详细信息

为研究开口型压型钢板-工程增强水泥基复合材料(ECC)组合楼板的受力性能,对开口型压型钢板-ECC组合楼板试件进行静力加载试验及数值模拟,研究了试件破坏模式、端部滑移、荷载-挠度曲线、压型钢板应变分布及承载能力;利用ABAQUS有限元程序对试件受弯承载性能进行模拟,数值模拟结果与试验结果符合较好;在此基础上,分析了ECC截面高度、ECC抗拉强度、压型钢板厚度及剪跨比对组合楼板受弯承载性能的影响。基于ECC受拉应变硬化特性,建立了考虑ECC受拉作用的开口型压型钢板-ECC组合楼板受弯承载力计算公式。结果表明:对于纵向剪切破坏的试件,压型钢板的受拉作用未得到完全发挥,加载后期试件端部发生明显滑移;在其他参数相同的情况下,端部配置栓钉及抗剪钢筋的试件发生弯曲破坏,压型钢板达到全截面屈服,其峰值承载力为纵向剪切破坏试件的2.1倍~2.31倍;ECC截面高度在几个因素中对组合楼板受弯承载力的影响最为显著;所建立的计算公式能够较好地预测该类组合楼板的受弯承载力。

关键词：开口型压型钢板 ECC 组合楼板受弯承载力试验研究数值模拟

结合生态网络解析白洋淀浮游生物生态位和种间联结性特征

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环境科学 2024年第9期45卷 5298-5307页

作者：霍笑康王永刚周灵同王书航姜霞陈珂王鹏飞中国环境科学研究院湖泊水污染治理与生态修复技术国家工程实验室国家环境保护湖泊污染控制重点实验室北京100012 兰州理工大学生命科学与工程学院兰州730050 青海省生态环境监测中心西宁810002

为了解白洋淀浮游生物群落结构及其优势种的生态位特征,于2022年春季(3月)、夏季(7月)和秋季(9月)对白洋淀浮游生物进行采样调查.通过构建生态网络图并结合非度量多维尺度分析(NMDS)解析3个季节浮游生物群落结构变化特征,并运用改进的Le... 详细信息

为了解白洋淀浮游生物群落结构及其优势种的生态位特征,于2022年春季(3月)、夏季(7月)和秋季(9月)对白洋淀浮游生物进行采样调查.通过构建生态网络图并结合非度量多维尺度分析(NMDS)解析3个季节浮游生物群落结构变化特征,并运用改进的Levins公式和Petraitis指数评估了浮游生物优势种的生态位宽度和生态位重叠度,通过卡方检验和种间联结性系数判断总体和优势种种间联结度.结果表明,浮游生物在整个淀区的生态位宽度较窄.浮游动物以轮虫为主,浮游植物主要是硅藻门、蓝藻门和绿藻门.浮游生物的群落变化具有明显的季节性特征.与夏秋季相比,春季浮游生物种类较少,种间联通度较低.夏季浮游动物优势种重叠度高,种间竞争加剧,而浮游植物的种间重叠在3个季节均处于较低水平.夏秋季节浮游植物各优势种种间的联结性均呈显著正联结关系(W>χ20.05),群落结构稳定.浮游动物和浮游植物的跨域生态网络在秋季表现出较高的负相关性比例,尤其在浮游动物的桡足类和枝角类与浮游植物的绿藻门和蓝藻门之间.白洋淀浮游生物的物种丰富,季节性差异明显,优势种以窄生态位为主,浮游生物群落总体处于较稳定的状态,桡足类和枝角类与绿藻和蓝藻之间存在较强的捕食关系.

关键词：白洋淀浮游生物生态网络生态位种间联结

Hepatic epithelioid hemangioendothelioma after thirteen years'follow-up:A case report and review of literature

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World Journal of Clinical Cases 2022年第18期10卷 6119-6127页

作者： Wei-Fang Mo Yu-ling tong Department of General Practice The 2^(nd) Affiliated Hospital of Zhejiang UniversitySchool of MedicineHangzhou 310009Zhejiang ProvinceChina

BACKGROUND Hepatic epithelioid hemangioendothelioma(EHE)is a rare vascular endothelial cell tumor of the liver,consisting of epithelioid and histiocyte-like vascular endothelial cells in mucus or a fibrotic *** is usually positive for vascular markers,such as factor VIII-related antigen,CD31,and *** EHE can have a varied clinical course;treatment includes liver transplantation,liver resection,chemotherapy,and radiation *** SUMMARY A 46-year-old woman with abdominal discomfort and elevated serum carcinoembryonic antigen was found to have multiple low-density lesions in the liver and lung on computed tomography(CT)*** ultrasound-guided fine needle aspiration biopsy revealed a fibrous stroma with dendritic cells,containing intracellular *** staining found that the tumor cells were positive for CD34,CD31,and factor VIII-related *** patient received four courses of combined chemotherapy and was followed-up for 13 years,at which time the patient was in stable condition without disease progression and a confined neoplasm,as evidenced by CT *** The histology and immunohistochemical characteristics of hepatic EHE are well *** may be effective in patients with extrahepatic lesions.

关键词： Epithelioid hemangioendothelioma Liver neoplasm Immunohistochemistry Antineoplastic combined chemotherapy protocols Treatment Case report

Association of serum pepsinogen with degree of gastric mucosal atrophy in an asymptomatic population

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World Journal of Clinical Cases 2021年第31期9卷 9431-9439页

作者： Hao-Lei Cai Yu-ling tong Department of Surgery The Second Affiliated Hospital of Zhejiang University School of MedicineHangzhou 310009Zhejiang ProvinceChina International Healthcare Center The Second Affiliated Hospital of Zhejiang University School of MedicineHangzhou 310009Zhejiang ProvinceChina

BACKGROUND Atrophic gastritis is a precancerous lesion of the *** has been reported that pepsinogen(PG)can reflect the morphology and function of the gastric mucosa,and it is therefore used as a marker for the early diagnosis of atrophic *** To evaluate the diagnostic value of serum PG for degree of gastric mucosal atrophy in asymptomatic Chinese upon physical *** Medical data were collected from subjects who underwent transnasal gastroscopy between October 2016 and October *** each study subject,serum PG levels and presence of Helicobacter pylori(***)infection were *** was evaluated using the Operative Link for Gastritis Assessment(OLGA)classification and Operative Link on Gastric Intestinal Metaplasia Assessment(OLGIM)*** statistical analyses were carried out using SPSS statistical *** A total of 2256 subjects were enrolled and 1922 cases were finally included in the *** on the OLGA grading system,the levels of PGI were slightly decreased,while those of PGII were slightly *** PGI/PGII ratio(PGR)was reduced with increasing *** association between PG and OLGA grading was higher compared with that between PG and the OLGIM grading *** with the OLGA-0 group,a statistically significant difference was observed in the mean age of OLGA-Ⅰ,Ⅲ,and Ⅳ groups(P<0.05).In the ***-positive subjects,the PGR levels were notably lower in the OLGA-Ⅰ,Ⅱ,and Ⅲ groups compared with the OLGA-0 group(P<0.05).***-positive subjects exhibited significantly higher PGI and PGII serum levels and a significantly lower PGR compared with ***-negative patients in different OLGA groups(P<0.05).CONCLUSION Serum PG levels may represent a non-invasive screening marker for gastric mucosal atrophy in asymptomatic subjects.

关键词： Pepsinogen Helicobacter pylori Operative Link for Gastritis Assessment Atrophic gastritis Gastric mucosal atrophy Biomarker

Ruin Probabilities for a Risk Model with Two Classes of Claims

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Acta Mathematica Sinica,English Series 2010年第9期26卷 1749-1760页

作者： tong ling LV Jun Yi GUO Xin ZHANG Department of Mathematics China Agricultural University Beijing 100083 P. R. China School of Mathematical Sciences Nankai University Tianjin 300071 P. R. China

In this paper we consider a risk model with two kinds of claims, whose claims number processes are Poisson process and ordinary renewal process respectively. For this model, the surplus process is not Markovian, however, it can be Markovianized by introducing a supplementary process, We prove the Markov property of the related vector processes. Because such obtained processes belong to the class of the so-called piecewise-deterministic Markov process, the extended infinitesimal generator is derived, exponential martingale for the risk process is studied. The exponential bound of ruin probability in iafinite time horizon is obtained.

关键词： Markov vector process piecewise-deterministic Markov process (PDMP) infinitesimal generator exponential martingale ruin probability

The characteristics of liver injury induced by Amanita and clinical value of α-amanitin detection

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Hepatobiliary & Pancreatic Diseases International 2022年第3期21卷 257-266页

作者： Li-Ying Lin Ya-ling tong Yuan-Qiang Lu Department of Emergency Medicine the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China The Key Laboratory for Diagnosis and Treatment of Aging and Physic-chemical Injury Diseases of Zhejiang Province Hangzhou 310003China

Background:Amanita poisoning as a foodborne disease has raised concerning mortality *** the interval between mushroom ingestion and medical intervention could greatly influence the outcomes of Amanita poisoning patients,while treatment is highly dependent on a confirmed *** this end,we developed an early detection-guided intervention strategy by optimizing diagnostic process with performingα-amanitin detection,and further explored whether this strategy influenced the progression of Amanita ***:This study was a retrospective analysis of 25 Amanita poisoning *** patients in the detection group were diagnosed mainly based onα-amanitin detection,and 12 patients were diagnosed essentially on the basis of mushroom consumption history,typical clinical patterns and mushroom identification(conventional group).Amanita poisoning patients received uniform therapy,in which plasmapheresis was executed once confirming the diagnosis of Amanita *** compared the demographic baseline,clinical and laboratory data,treatment and outcomes between the two groups,and further explored the predictive value ofα-amanitin concentration in ***:Liver injury induced by Amanita appeared worst at the fourth day and alanine aminotransferase(ALT)rose higher than aspartate aminotransferase(AST).The mortality rate was 7.7%(1/13)in the detection group and 50.0%(6/12)in the conventional group(P=0.030),since patients in the detection group arrived hospital much earlier and received plasmapheresis at the early stage of *** early detection-guided intervention helped alleviate liver impairment caused by Amanita and decreased the peak AST as well as ***,the predictive value ofα-amanitin concentration in serum was still considered ***:In the management of mushroom poisoning,consideration should be given to the rapid detection ofα-amanitin in suspected Amanita poisoning patients and the immediate initiation of medi

关键词： Mushroom poisoning α-amanitin Detection Acute liver failure Early diagnosis and intervention